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Niu C, Li B, Wan H, Jin W, Zhang Z, Zhang W, Li X. Antrum Preservation Versus Antrum Resection in Laparoscopic Sleeve Gastrectomy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J INVEST SURG 2025; 38:2477099. [PMID: 40096744 DOI: 10.1080/08941939.2025.2477099] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/04/2024] [Accepted: 03/04/2025] [Indexed: 03/19/2025]
Abstract
PURPOSE To compare the effects of laparoscopic sleeve gastrectomy (LSG) with antrum preservation (AP) and antrum resection (AR) on weight loss and postoperative complications. METHODS A meta-analysis of randomized controlled trials (RCTs) followed PRISMA guidelines. The databases searched included PubMed, Web of Science, Embase Medline, and the Cochrane Library up to October 2022. Extracted data included operation time, hospital stay, excess weight loss, total weight loss, body mass index (BMI), weight, and complications. RESULTS Eleven RCTs were included with 843 patients: 422 with AR and 421 with AP. The AR group exhibited higher total weight loss at 3 months (p = 0.02), 6 months (p < 0.001), and 1 year (p < 0.001) postoperatively. They also showed greater excess weight loss at 6 months (p < 0.001), 1 year (p < 0.001), and 2 years (p = 0.03). BMI reduction was more significant in the AR group at 3 (p = 0.007) and 6 months (p < 0.001). The AR group lost weight more rapidly at 3 months (p = 0.05), 6 months (p = 0.04), and 1 year (p < 0.001). No significant differences were found in operation time, hospital stay, bleeding, staple line disruption, Clavien-Dindo complications, or remission rates of diabetes, hypertension, arthritis/back pain, hyperlipidemia, or gastroesophageal reflux disease (p > 0.05). CONCLUSION LSG with AR offers better short-term weight loss than AP without increasing surgical complications, but the long-term effects and complications need further investigation in larger RCTs.
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Affiliation(s)
- Chao Niu
- Department of General Surgery, Affiliated Hospital of Yunnan University, Kunming, P R. China
| | - Bo Li
- Department of General Surgery, Affiliated Hospital of Yunnan University, Kunming, P R. China
| | - Hongwei Wan
- Department of General Surgery, Affiliated Hospital of Yunnan University, Kunming, P R. China
| | - Wendi Jin
- Department of General Surgery, Affiliated Hospital of Yunnan University, Kunming, P R. China
| | - Zhiping Zhang
- Department of General Surgery, Affiliated Hospital of Yunnan University, Kunming, P R. China
| | - Wanfu Zhang
- Department of General Surgery, Affiliated Hospital of Yunnan University, Kunming, P R. China
| | - Xiaogang Li
- Department of General Surgery, Affiliated Hospital of Yunnan University, Kunming, P R. China
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Li W, Kuhar S, Seo JH, Mittal R. Modeling the Effect of Sleeve Gastrectomy on Gastric Digestion in Stomach: Insights From Multiphase Flow Modeling. J Biomech Eng 2025; 147:061007. [PMID: 40192645 DOI: 10.1115/1.4068373] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/30/2024] [Indexed: 05/06/2025]
Abstract
The geometry and motility of the stomach play a critical role in the digestion of ingested liquid meals. Sleeve gastrectomy, a common type of bariatric surgery used to reduce the size of the stomach, significantly alters the stomach's anatomy and motility, which impacts gastric emptying and digestion. In this study, we use an imaging data-based computational model, StomachSim, to investigate the consequences of sleeve gastrectomy. The pre-operative stomach anatomy was derived from imaging data, and the postsleeve gastrectomy shapes were generated for different resection volumes. We investigate the effect of sleeve sizes and motility patterns on gastric mixing and emptying. Simulations were conducted using an immersed-boundary flow solver, modeling a liquid meal to analyze changes in gastric mixing and emptying rates. The results reveal that different degrees of volume reduction and impaired gastric motility have complex effects on stomach's mixing and emptying functions, which are important factors in gastric health of the patient. Specifically, the total gastric liquid emptying rates increased by 21% with a 30% volume reduction and by 51% with reductions exceeding 50%, due to altered intragastric pressure. Additionally, impaired motility functions resulted in slower mixing, leading to delayed food emptying. These findings provide insights into the biomechanical effects of sleeve gastrectomy on gastric digestion and emptying functions, highlighting the potential of computational models to inform surgical planning and postoperative management.
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Affiliation(s)
- Weixuan Li
- Department of Mechanical Engineering, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218
| | - Sharun Kuhar
- Department of Mechanical Engineering, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218
- Johns Hopkins University
| | - Jung-Hee Seo
- Department of Mechanical Engineering, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218
| | - Rajat Mittal
- Department of Mechanical Engineering, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218
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3
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Berardo A, Polese L, Carniel EL, Toniolo I. How does sutures pattern influence stomach motility after endoscopic sleeve gastroplasty? A computational study. Updates Surg 2024; 76:2833-2839. [PMID: 38954375 PMCID: PMC11628582 DOI: 10.1007/s13304-024-01917-0] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/11/2024] [Accepted: 06/18/2024] [Indexed: 07/04/2024]
Abstract
The relatively recent adoption of Endoscopic Sleeve Gastroplasty (ESG) amongst obese patients has gained approval within the surgical community due to its notable benefits, including significant weight loss, safety, feasibility, repeatability, and potential reversibility. However, despite its promising clinical outcomes and reduced invasiveness, there is still a lack of standardised procedures for performing ESG. Multiple suture patterns and stitching methods have been proposed over time, yet rational tools to quantify and compare their effects on gastric tissues are absent. To address this gap, this study proposed a computational approach. The research involved a case study analyzing three distinct suture patterns (C-shaped, U-shaped and Z-shaped) using a patient-specific computational stomach model generated from magnetic resonance imaging. Simulations mimicked food intake by placing wire features in the intragastric cavity to replicate sutures, followed by applying a linearly increasing internal pressure up to 15 mmHg. The outcomes facilitated comparisons between suture configurations based on pressure-volume behaviours and the distribution of maximum stress on biological tissues, revealing the U-shaped as the more effective in terms of volume reduction, even if with reduced elongation strains and increased tissues stresses, whereas the Z-shaped is responsible of the greatest stomach shortness after ESG. In summary, computational biomechanics methods serve as potent tools in clinical and surgical settings, offering insights into aspects that are challenging to explore in vivo, such as tissue elongation and stress. These methods allow for mechanical comparisons between different configurations, although they might not encompass crucial clinical outcomes.
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Affiliation(s)
- Alice Berardo
- Department of Civil, Environmental and Architectural Engineering, University of Padova, Padua, Italy
- Centre for Mechanics of Biological Materials, University of Padova, Padua, Italy
| | - Lino Polese
- Centre for Mechanics of Biological Materials, University of Padova, Padua, Italy
- Department of Surgery, Oncology and Gastroenterology, University of Padova, Padua, Italy
| | - Emanuele Luigi Carniel
- Centre for Mechanics of Biological Materials, University of Padova, Padua, Italy.
- Department of Industrial Engineering, University of Padova, Via Venezia 1, 35131, Padua, Italy.
| | - Ilaria Toniolo
- Centre for Mechanics of Biological Materials, University of Padova, Padua, Italy
- Department of Industrial Engineering, University of Padova, Via Venezia 1, 35131, Padua, Italy
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Weerarathna IN, Kumar P, Luharia A, Mishra G. Engineering with Biomedical Sciences Changing the Horizon of Healthcare-A Review. Bioengineered 2024; 15:2401269. [PMID: 39285709 PMCID: PMC11409512 DOI: 10.1080/21655979.2024.2401269] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/30/2023] [Revised: 03/20/2024] [Accepted: 07/18/2024] [Indexed: 01/16/2025] Open
Abstract
In the dynamic realm of healthcare, the convergence of engineering and biomedical sciences has emerged as a pivotal frontier. In this review we go into specific areas of innovation, including medical imaging and diagnosis, developments in biomedical sensors, and drug delivery systems. Wearable biosensors, non-wearable biosensors, and biochips, which include gene chips, protein chips, and cell chips, are all included in the scope of the topic that pertains to biomedical sensors. Extensive research is conducted on drug delivery systems, spanning topics such as the integration of computer modeling, the optimization of drug formulations, and the design of delivery devices. Furthermore, the paper investigates intelligent drug delivery methods, which encompass stimuli-responsive systems such as temperature, redox, pH, light, enzyme, and magnetic responsive systems. In addition to that, the review goes into topics such as tissue engineering, regenerative medicine, biomedical robotics, automation, biomechanics, and the utilization of green biomaterials. The purpose of this analysis is to provide insights that will enhance continuing research and development efforts in engineering-driven biomedical breakthroughs, ultimately contributing to the improvement of healthcare. These insights will be provided by addressing difficulties and highlighting future prospects.
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Affiliation(s)
- Induni N. Weerarathna
- School of Allied Health Sciences, Department of Biomedical Sciences, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India
| | - Praveen Kumar
- Department of Computer Science and Medical Engineering, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India
| | - Anurag Luharia
- Department of Radio Physicist and Radio Safety, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India
| | - Gaurav Mishra
- Department of Radio Diagnosis, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India
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Mascolini MV, Carniel EL. In silico assessment of the reliability and performance of artificial sphincter for urinary incontinence. Artif Organs 2024; 48:1112-1125. [PMID: 38895983 DOI: 10.1111/aor.14805] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/07/2024] [Revised: 03/07/2024] [Accepted: 06/02/2024] [Indexed: 06/21/2024]
Abstract
BACKGROUND The standard artificial urinary sphincter (AUS) is an implantable device for the treatment of urinary incontinence by applying a pressure loading around the urethra through an inflatable cuff, often inducing no-physiological stimulation up to tissue degenerative phenomena. A novel in silico approach is proposed to fill the gap of the traditional procedures by providing tools to quantitatively assess AUS reliability and performance based on AUS-urethra interaction. METHODS The approach requires the development of 3D numerical models of AUS and urethra, and experimental investigations to define their mechanical behaviors. Computational analyses are performed to simulate the urethral lumen occlusion by AUS inflation under different pressures, and the lumen opening by applying an intraluminal pressure progressively increased under the AUS action (Abaqus Explicit solver). The AUS reliability is evaluated in terms of tissue stimulation by the mechanical fields potentially responsible for vasoconstriction and tissue damage, while the performance by the intraluminal pressure that causes the lumen opening for a specific occlusive pressure, showing the maximum urethral pressure for which continence is guaranteed. RESULTS The present study implemented the procedure considering the gold standard AMS 800 and a novel patented AUS. Results provided the comparison between two sphincteric devices and the evaluation of the influence of different building materials and geometrical features on the AUS functionality. CONCLUSIONS The approach was developed for the AUS, but it could be adapted also to artificial sphincters for the treatment of other anatomical dysfunctions, widening the analyzable device configurations and reducing experimental and ethical efforts.
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Affiliation(s)
- Maria Vittoria Mascolini
- Department of Industrial Engineering, University of Padova, Padova, Italy
- Centre for Mechanics of Biological Materials, University of Padova, Padova, Italy
| | - Emanuele Luigi Carniel
- Department of Industrial Engineering, University of Padova, Padova, Italy
- Centre for Mechanics of Biological Materials, University of Padova, Padova, Italy
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Mascolini MV, Toniolo I, Carniel EL, Fontanella CG. Ex vivo, in vivo and in silico studies of corneal biomechanics: a systematic review. Phys Eng Sci Med 2024; 47:403-441. [PMID: 38598066 PMCID: PMC11166853 DOI: 10.1007/s13246-024-01403-2] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/09/2023] [Accepted: 02/08/2024] [Indexed: 04/11/2024]
Abstract
Healthy cornea guarantees the refractive power of the eye and the protection of the inner components, but injury, trauma or pathology may impair the tissue shape and/or structural organization and therefore its material properties, compromising its functionality in the ocular visual process. It turns out that biomechanical research assumes an essential role in analysing the morphology and biomechanical response of the cornea, preventing pathology occurrence, and improving/optimising treatments. In this review, ex vivo, in vivo and in silico methods for the corneal mechanical characterization are reported. Experimental techniques are distinct in testing mode (e.g., tensile, inflation tests), samples' species (human or animal), shape and condition (e.g., healthy, treated), preservation methods, setup and test protocol (e.g., preconditioning, strain rate). The meaningful results reported in the pertinent literature are discussed, analysing differences, key features and weaknesses of the methodologies adopted. In addition, numerical techniques based on the finite element method are reported, incorporating the essential steps for the development of corneal models, such as geometry, material characterization and boundary conditions, and their application in the research field to extend the experimental results by including further relevant aspects and in the clinical field for diagnostic procedure, treatment and planning surgery. This review aims to analyse the state-of-art of the bioengineering techniques developed over the years to study the corneal biomechanics, highlighting their potentiality to improve diagnosis, treatment and healing process of the corneal tissue, and, at the same, pointing out the current limits in the experimental equipment and numerical tools that are not able to fully characterize in vivo corneal tissues non-invasively and discourage the use of finite element models in daily clinical practice for surgical planning.
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Affiliation(s)
- Maria Vittoria Mascolini
- Department of Industrial Engineering, University of Padova, Padova, Italy
- Centre for Mechanics of Biological Materials, University of Padova, Padova, Italy
| | - Ilaria Toniolo
- Department of Industrial Engineering, University of Padova, Padova, Italy.
- Centre for Mechanics of Biological Materials, University of Padova, Padova, Italy.
| | - Emanuele Luigi Carniel
- Department of Industrial Engineering, University of Padova, Padova, Italy
- Centre for Mechanics of Biological Materials, University of Padova, Padova, Italy
| | - Chiara Giulia Fontanella
- Department of Industrial Engineering, University of Padova, Padova, Italy
- Centre for Mechanics of Biological Materials, University of Padova, Padova, Italy
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Papenkort S, Borsdorf M, Kiem S, Böl M, Siebert T. Regional differences in stomach stretch during organ filling and their implications on the mechanical stress response. J Biomech 2024; 168:112107. [PMID: 38677029 DOI: 10.1016/j.jbiomech.2024.112107] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/07/2023] [Revised: 03/25/2024] [Accepted: 04/15/2024] [Indexed: 04/29/2024]
Abstract
As part of the digestive system, the stomach plays a crucial role in the health and well-being of an organism. It produces acids and performs contractions that initiate the digestive process and begin the break-up of ingested food. Therefore, its mechanical properties are of interest. This study includes a detailed investigation of strains in the porcine stomach wall during passive organ filling. In addition, the observed strains were applied to tissue samples subjected to biaxial tensile tests. The results show inhomogeneous strains during filling, which tend to be higher in the circumferential direction (antrum: 13.2%, corpus: 22.0%, fundus: 67.8%), compared to the longitudinal direction (antrum: 4.8%, corpus: 24.7%, fundus: 50.0%) at a maximum filling of 3500 ml. Consequently, the fundus region experienced the greatest strain. In the biaxial tensile experiments, the corpus region appeared to be the stiffest, reaching nominal stress values above 400 kPa in the circumferential direction, whereas the other regions only reached stress levels of below 50 kPa in both directions for the investigated stretch range. Our findings gain new insight into stomach mechanics and provide valuable data for the development and validation of computational stomach models.
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Affiliation(s)
- Stefan Papenkort
- Department of Sport and Motion Science, University of Stuttgart, Stuttgart, Germany
| | - Mischa Borsdorf
- Department of Sport and Motion Science, University of Stuttgart, Stuttgart, Germany
| | - Simon Kiem
- Department of Sport and Motion Science, University of Stuttgart, Stuttgart, Germany.
| | - Markus Böl
- Institute of Mechanics and Adaptronics, Technische Universität Braunschweig, Braunschweig, Germany
| | - Tobias Siebert
- Department of Sport and Motion Science, University of Stuttgart, Stuttgart, Germany; Stuttgart Center for Simulation Science, University of Stuttgart, Stuttgart, Germany
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8
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Toniolo I, Pirini P, Perretta S, Carniel EL, Berardo A. Endoscopic versus laparoscopic bariatric procedures: A computational biomechanical study through a patient-specific approach. COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE 2024; 243:107889. [PMID: 37944398 DOI: 10.1016/j.cmpb.2023.107889] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 07/10/2023] [Revised: 10/25/2023] [Accepted: 10/25/2023] [Indexed: 11/12/2023]
Abstract
BACKGROUND AND OBJECTIVES Within the framework of computational biomechanics, finite element models of the gastric district could be seen as a potential clinical tool not only to study the effects apported by bariatric surgery, but also to compare different surgical techniques such as the new emerging Endoscopic Sleeve Gastroplasty (ESG) with respect to well-established ones (such as the Laparoscopic Sleeve Gastrectomy, LSG). METHODS This work realized a fully computational comparison between the outcomes obtained from 10 patient-specific stomach models, which were used to simulate ESG, and the complementary results obtained from models representing the post-LSG of the same subjects. Specifically, once the ESG was simulated, a mechanical stimulus was applied by increasing an intragastric pressure up to a maximum of 5 kPa, in order to replicate the process of food intake, as well as for post-LSG models. RESULTS Results revealed non negligible differences between the techniques also within the same subject. In particular, not only LSG could lead to a greater reduction in the stomach volume (about 77 % at baseline, which is strictly linked to weight loss), but also influence the gastric distension (12 % less than pre-operative models). On the contrary, if ESG would be performed, a more similar pre-operative mechanical stimulation of the gastric walls may be seen (difference of about 1 %), thus preserving the mechanosensation, but the detriment of the volume reduction (about 56 % at baseline, and even decreases with increasing pressure). Moreover, since results suggested ESG may be more influenced by the pre-operative gastric cavity than LSG, a predictive model was proposed to support the surgical planning and the estimation of the volume reduction after ESG. CONCLUSIONS ESG and LSG have substantial differences in their protocols and post-surgical effects. This work pointed out that variations between the two procedures may be observed also from a computational point of view, especially when including patient-specific geometries. These insights support gastric modelling as a valuable tool to evaluate, design and critically compare emerging bariatric surgical procedures, not only from empirical aspects and clinical outcomes, but also from a mechanical point of view.
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Affiliation(s)
- Ilaria Toniolo
- Department of Civil, Environmental and Architectural Engineering, University of Padova, Italy; Centre for Mechanics of Biological Materials, University of Padova, Italy
| | - Paola Pirini
- Department of Civil, Environmental and Architectural Engineering, University of Padova, Italy
| | - Silvana Perretta
- IHU Strasbourg, Strasbourg, France; IRCAD France, Strasbourg, France; Department of Digestive and Endocrine Surgery, NHC, Strasbourg, France
| | - Emanuele Luigi Carniel
- Centre for Mechanics of Biological Materials, University of Padova, Italy; Department of Industrial Engineering, University of Padova, Italy.
| | - Alice Berardo
- Department of Civil, Environmental and Architectural Engineering, University of Padova, Italy; Centre for Mechanics of Biological Materials, University of Padova, Italy; Department of Biomedical Sciences, University of Padova, Italy.
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Toniolo I, Mascolini MV, Carniel EL, Fontanella CG. Artificial sphincters: An overview from existing devices to novel technologies. Artif Organs 2023; 47:617-639. [PMID: 36374175 DOI: 10.1111/aor.14434] [Citation(s) in RCA: 4] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/29/2022] [Revised: 09/21/2022] [Accepted: 10/11/2022] [Indexed: 11/16/2022]
Abstract
Artificial sphincters (ASs) are used to replace the function of the biological sphincters in case of severe urinary and fecal incontinence (UI and FI), and gastroesophageal reflux disease (GERD). The design of ASs is established on different mechanisms, e.g., magnetic forces or hydraulic pressure, with the final goal to achieve a implantable and durable AS. In clinical practice, the implantation of in-commerce AS is considered a reasonable solution, despite the sub-optimal clinical outcomes. The failure of these surgeries is due to the malfunction of the devices (between 46 and 51%) or the side effects on the biological tissues (more than 38%), such as infection and atrophy. Concentrating on this latter characteristic, particular attention has been given to the interaction between the biological tissues and AS, pointing out the closing mechanism around the duct and the effect on the tissues. To analyze this aspect, an overview of existing commercial/ready-on-market ASs for GERD, UI, and FI, together with the clinical outcomes available from the in-commerce AS, is given. Moreover, this invited review discusses ongoing developments and future research pathways for creating novel ASs. The application of engineering principles and design concepts to medicine enhances the quality of healthcare and improves patient outcomes. In this context, computational methods represent an innovative solution in the design of ASs, proving data on the occlusive force and pressure necessary to guarantee occlusion and avoid tissue damage, considering the coupling between different device sizes and individual variability.
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Affiliation(s)
- Ilaria Toniolo
- Department of Industrial Engineering, University of Padova, Padova, Italy
- Centre for Mechanics of Biological Materials, University of Padova, Padova, Italy
| | - Maria Vittoria Mascolini
- Department of Industrial Engineering, University of Padova, Padova, Italy
- Centre for Mechanics of Biological Materials, University of Padova, Padova, Italy
| | - Emanuele Luigi Carniel
- Department of Industrial Engineering, University of Padova, Padova, Italy
- Centre for Mechanics of Biological Materials, University of Padova, Padova, Italy
| | - Chiara Giulia Fontanella
- Department of Industrial Engineering, University of Padova, Padova, Italy
- Centre for Mechanics of Biological Materials, University of Padova, Padova, Italy
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Toniolo I, Berardo A, Gagner M, Foletto M, Carniel EL. Unveiling the effects of key factors in enhancing gastroesophageal reflux: A fluid-structure analysis before and after laparoscopic sleeve gastrectomy. COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE 2023; 231:107409. [PMID: 36780716 DOI: 10.1016/j.cmpb.2023.107409] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 09/19/2022] [Revised: 02/03/2023] [Accepted: 02/06/2023] [Indexed: 06/18/2023]
Abstract
BACKGROUND AND OBJECTIVES Gastro-oesophageal reflux disease (GERD) consists in the passage of gastric acid content from the stomach to the oesophagus, causing burns and deteriorating the quality of life. Laparoscopic Sleeve Gastrectomy (LSG) could induce de novo GERD and worsen pre-existing GERD because of the higher gastric pressurisation, reduction of stomach volume and a wider His-angle. In the proposed work, various computational gastric 2D models were developed to understand the effects of variables such as the His-angle, the antral dimension, and the bolus viscosity on the reflux increase. METHODS Fluid-Structure Interaction (FSI) computational models which couple the solid mechanics of the gastric wall, and the fluid domain of the bolus, have been developed to shed light on biomechanical aspects of GERD after LSG. A closure was imposed to the lower oesophageal sphincter (LES) mimicking what happens physiologically after food intake. RESULTS Results showed that the configuration prone to higher reflux flow was the post-surgical 65° model with a staple line starting directly from the pylorus without antral preservation, for all considered viscosities. Increasing viscosity, reflux flow decreased. Post-surgical refluxes were higher than pre-ones and decreased with increasing antrum preservation. CONCLUSIONS These results could be a starting point for analysis of anatomical features, bariatric surgery and GERD occurrence. Further studies based on 3D geometries need to be performed.
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Affiliation(s)
- Ilaria Toniolo
- Department of Industrial Engineering, University of Padova, Italy; Centre for Mechanics of Biological Materials, University of Padova, Italy
| | - Alice Berardo
- Centre for Mechanics of Biological Materials, University of Padova, Italy; Department of Civil, Environmental and Architectural Engineering, University of Padova, Italy; Department of Biomedical Sciences, University of Padova, Italy.
| | - Michel Gagner
- Department of Surgery, Hôpital du Sacré-Coeur de Montréal, Canada
| | - Mirto Foletto
- Centre for Mechanics of Biological Materials, University of Padova, Italy; Department of Surgery, Oncology and Gastroenterology, University of Padova, Italy; IFSO Bariatric Centre of Excellence, Policlinico Universitario, University of Padova, Italy
| | - Emanuele Luigi Carniel
- Department of Industrial Engineering, University of Padova, Italy; Centre for Mechanics of Biological Materials, University of Padova, Italy
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Biomechanics of Hollow Organs: Experimental Testing and Computational Modeling. Bioengineering (Basel) 2023; 10:bioengineering10020175. [PMID: 36829669 PMCID: PMC9952441 DOI: 10.3390/bioengineering10020175] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/23/2022] [Accepted: 01/24/2023] [Indexed: 01/31/2023] Open
Abstract
Hollow organs are visceral organs that are hollow tubes or pouches (such as the intestine or the stomach, respectively) or that include a cavity (such as the heart) and which subserve a vital function [...].
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