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Wells ML, Tse JR, Cahalane AM, Gupta A. Computed Tomography Imaging for Suspected Gastrointestinal Bleeding and Bowel Ischemia. Radiol Clin North Am 2025; 63:361-374. [PMID: 40221180 DOI: 10.1016/j.rcl.2024.10.001] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 04/14/2025]
Abstract
Computed tomography (CT) is one of the main diagnostic methods for assessing both acute gastrointestinal bleeding (GIB) and bowel ischemia due to its widespread availability, excellent spatial resolution, and high accuracy. While endoscopy is the preferred diagnostic tool for workup of upper GIB, CT is used in select instances as a complementary modality or when endoscopy is impractical. For lower GIB, CT is one of the first-line imaging tools. Mesenteric ischemia is primarily diagnosed with CT, which can exquisitely assess the vasculature and demonstrate bowel findings of ischemia or infarction.
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Affiliation(s)
- Michael L Wells
- Department of Radiology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA.
| | - Justin R Tse
- Department of Radiology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA, USA
| | - Alexis M Cahalane
- Division of Interventional Radiology, Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
| | - Avneesh Gupta
- Department of Radiology, Boston University School of Medicine, 820 Harrison Avenue, Boston, MA 02118, USA
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Reintam Blaser A, Koitmäe M, Laisaar KT, Forbes A, Kase K, Kiisk E, Murruste M, Reim M, Starkopf J, Tamme K. Radiological diagnosis of acute mesenteric ischemia in adult patients: a systematic review and meta-analysis. Sci Rep 2025; 15:9875. [PMID: 40119151 PMCID: PMC11928508 DOI: 10.1038/s41598-025-94846-w] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/20/2025] [Accepted: 03/17/2025] [Indexed: 03/24/2025] Open
Abstract
Computed tomography (CT) is widely used in diagnosing acute mesenteric ischemia (AMI), but robust identification of distinctive subtypes and stages of progression is lacking. Systematic literature search in PubMed, Cochrane Library, Web of Science and Scopus was conducted in May 2024. Studies including at least 10 adult patients and reporting radiological diagnosis of AMI versus no AMI or transmural ischemia versus no transmural ischemia were included. Meta-analyses on sensitivity and specificity of different radiological features in diagnosing AMI were conducted. From 2628 titles, 490 studies underwent full text review, and 81 were included in 14 meta-analyses. Diagnostic accuracy of CT angiography (CTA) was high - sensitivity of 92.0% and specificity of 98.8% (I2 45% and 79%, respectively), but lower for other CT protocols (sensitivity 75.8 and specificity 90.5; I2 83%). In most included studies, distinction of subtypes and severity of AMI (non-transmural or transmural) was not possible. Amongst the non-vascular features, absent/reduced bowel wall enhancement provided the best prognostic value (sensitivity 57.9 and specificity 90.1). CTA is the method of choice for diagnosing AMI with high diagnostic accuracy. None of the non-vascular features alone is sufficiently reliable to diagnose AMI or its progression to transmural necrosis, whereas a combination of different radiological features conveys a potential.
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Affiliation(s)
- Annika Reintam Blaser
- Institute of Clinical Medicine, University of Tartu, Tartu, Estonia.
- Department of Intensive Care Medicine, Lucerne Cantonal Hospital, Lucerne, Switzerland.
| | - Merli Koitmäe
- Institute of Mathematics and Statistics, University of Tartu, Tartu, Estonia
- Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia
| | - Kaja-Triin Laisaar
- Institute of Family Medicine and Public Health, University of Tartu, Tartu, Estonia
| | - Alastair Forbes
- Institute of Clinical Medicine, University of Tartu, Tartu, Estonia
| | - Karri Kase
- Institute of Clinical Medicine, University of Tartu, Tartu, Estonia
- Department of General and Plastic Surgery, Tartu University Hospital, Tartu, Estonia
| | - Ele Kiisk
- Institute of Family Medicine and Public Health, University of Tartu, Tartu, Estonia
| | - Marko Murruste
- Institute of Clinical Medicine, University of Tartu, Tartu, Estonia
- Department of General and Plastic Surgery, Tartu University Hospital, Tartu, Estonia
| | - Martin Reim
- Department of Radiology, Tartu University Hospital, Tartu, Estonia
| | - Joel Starkopf
- Institute of Clinical Medicine, University of Tartu, Tartu, Estonia
- Department of Anaesthesiology and Intensive Care, Tartu University Hospital, Tartu, Estonia
| | - Kadri Tamme
- Institute of Clinical Medicine, University of Tartu, Tartu, Estonia
- Department of Anaesthesiology and Intensive Care, Tartu University Hospital, Tartu, Estonia
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Tolonen M, Vikatmaa P. Diagnosis and management of acute mesenteric ischemia: What you need to know. J Trauma Acute Care Surg 2025:01586154-990000000-00933. [PMID: 40107963 DOI: 10.1097/ta.0000000000004585] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 03/22/2025]
Abstract
ABSTRACT Acute mesenteric ischemia (AMI) is associated with high mortality rates. There are multiple challenges to establishing an accurate early diagnosis and providing state-of-the-art care for AMI patients. A high index of suspicion is key for early diagnosis. Once suspicion is raised, a triphasic computed tomography angiography is the essential diagnostic tool. Avoiding delays, using hybrid operating rooms and contemporary revascularization techniques for arterial occlusive AMI, can significantly improve the prognosis. Regional health care systems should be developed to direct AMI patients into centers with sufficient capabilities for providing all aspects of care at all hours. The acute care surgeon has a central role in performing laparotomies and bowel resections when needed and coordinating the management flow in close collaboration with vascular surgeons and interventional radiologists for prompt and effective revascularization. A significant share of patients with an arterial occlusive AMI can be managed by endovascular revascularization without the need for a laparotomy. There are no reliable tools for predicting transmural bowel necrosis, and individual assessment and clinical experience are very important in decision-making when choosing between laparotomy and close observation. During laparotomy, an atherosclerotic occlusion at the root of the superior mesenteric artery can be stented by using a retrograde open mesenteric or percutaneous approach, and surgical bypass is seldom needed. Using hospital-specific management pathways is very useful for the standardization of care in arterial occlusive AMI. In venous AMI, systemic anticoagulation is sufficient in most cases. In patients whose symptoms do not resolve, there are various options for endovascular and surgical revascularization. In nonocclusive mesenteric ischemia, prevention by maintaining sufficient abdominal perfusion pressure is key. High-level evidence is scarce, but with current knowledge, the prognosis of AMI patients has plenty of room for improvement.
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Affiliation(s)
- Matti Tolonen
- From the Department of Abdominal Surgery (M.T.), HUS Abdominal Center; and Department of Vascular Surgery (P.V.), Abdominal Center, Helsinki University Hospital, University of Helsinki, Helsinki, Finland
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Kendle A, Kaide C. Abdominal Pain-Specific Legal Risk. Emerg Med Clin North Am 2025; 43:93-113. [PMID: 39515947 DOI: 10.1016/j.emc.2024.05.027] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/16/2024]
Abstract
Abdominal pain accounts for approximately 10% of emergency department visits and 4% to 6% of litigation. Clinical history and examination are important, as all diagnostic testing has limitations. Specific pathologies, such as appendicitis, warrant a review of factors increasing risk. In all cases, documentation of prompt communication with consultants can be protective in the event of any unforeseen delays in care. Careful attention should be paid to special populations including patients with cancer, diabetes, and patients with postsurgical, geriatric, and bariatric surgery.
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Affiliation(s)
- Andrew Kendle
- Department of Emergency Medicine at the University of California at San Francisco Medical Center, 521 Parnassus Avenue, San Francisco, CA 94143, USA.
| | - Colin Kaide
- Department of Emergency Medicine at the Ohio State University, 776 Prior Hall, 376 West 10th Avenue, Columbus, OH 43210, USA
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Song L, Zhang X, Zhang J, Wu J, Wang J, Wang F. Deep learning-assisted diagnosis of acute mesenteric ischemia based on CT angiography images. Front Med (Lausanne) 2025; 12:1510357. [PMID: 39926426 PMCID: PMC11802816 DOI: 10.3389/fmed.2025.1510357] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/12/2024] [Accepted: 01/02/2025] [Indexed: 02/11/2025] Open
Abstract
Purpose Acute Mesenteric Ischemia (AMI) is a critical condition marked by restricted blood flow to the intestine, which can lead to tissue necrosis and fatal outcomes. We aimed to develop a deep learning (DL) model based on CT angiography (CTA) imaging and clinical data to diagnose AMI. Methods A retrospective study was conducted on 228 patients suspected of AMI, divided into training and test sets. Clinical data (medical history and laboratory indicators) was included in a multivariate logistic regression analysis to identify the independent factors associated with AMI and establish a clinical factors model. The arterial and venous CTA images were utilized to construct DL model. A Fusion Model was constructed by integrating clinical factors into the DL model. The performance of the models was assessed using receiver operating characteristic (ROC) curves and decision curve analysis (DCA). Results Albumin and International Normalized Ratio (INR) were associated with AMI by univariate and multivariate logistic regression (P < 0.05). In the test set, the area under ROC curve (AUC) of the clinical factor model was 0.60 (sensitivity 0.47, specificity 0.86). The AUC of the DL model based on CTA images reached 0.90, which was significantly higher than the AUC values of the clinical factor model, as confirmed by the DeLong test (P < 0.05). The Fusion Model also showed exceptional performance in terms of AUC, accuracy, sensitivity, specificity, and precision, with values of 0.96, 0.94, 0.94, 0.95, and 0.98, respectively. DCA indicated that the Fusion Model provided a greater net benefit than those of models based solely on imaging and clinical information across the majority of the reasonable threshold probabilities. Conclusion The incorporation of CTA images and clinical information into the model markedly enhances the diagnostic accuracy and efficiency of AMI. This approach provides a reliable tool for the early diagnosis of AMI and the subsequent implementation of appropriate clinical intervention.
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Affiliation(s)
- Lei Song
- Department of Interventional Therapy, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China
| | - Xuesong Zhang
- Department of Interventional Therapy, The Second Affiliated Hospital of Dalian Medical University, Dalian, China
| | - Jian Zhang
- Department of Interventional Therapy, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China
| | - Jie Wu
- Department of Interventional Therapy, The Second Affiliated Hospital of Dalian Medical University, Dalian, China
| | - Jinkai Wang
- Department of Interventional Therapy, The Second Affiliated Hospital of Dalian Medical University, Dalian, China
| | - Feng Wang
- Department of Interventional Therapy, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China
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Molyneux K, Beck-Esmay J, Koyfman A, Long B. High risk and low prevalence diseases: Mesenteric ischemia. Am J Emerg Med 2023; 65:154-161. [PMID: 36638612 DOI: 10.1016/j.ajem.2023.01.001] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/24/2022] [Revised: 12/19/2022] [Accepted: 01/02/2023] [Indexed: 01/06/2023] Open
Abstract
INTRODUCTION Mesenteric ischemia is a rare, frequently misdiagnosed, serious condition that carries with it a high rate of morbidity and mortality. OBJECTIVE This review highlights the pearls and pitfalls of mesenteric ischemia, including presentation, diagnosis, and management in the emergency department (ED) based on current evidence. DISCUSSION Mesenteric ischemia is an abdominal vascular emergency that includes superior mesenteric arterial embolism, arterial thrombosis, venous mesenteric ischemia, and non-occlusive mesenteric ischemia. It is associated with a variety of risk factors including older age, cardiovascular disease, hypercoagulable state, and end-stage renal disease. The presentation depends on the underlying pathophysiology. While arterial embolic disease may present with sudden, severe pain, the early stages of the disease and other forms can present with vague symptoms, including generalized abdominal pain, weight loss, vomiting, and diarrhea. Laboratory testing can suggest the disease with leukocytosis and elevated lactate, but normal values should not be used to exclude the diagnosis. The imaging modality of choice is triple phase computed tomography with non-contrast, arterial, and delayed phases. The initial ED management includes fluid resuscitation, symptomatic therapy, broad-spectrum antibiotics, and anticoagulation. Emergent consultation with a multidisciplinary team including diagnostic and interventional radiologists and cardiovascular and general surgeons is necessary for definitive treatment. CONCLUSIONS An understanding of mesenteric ischemia can assist emergency clinicians in diagnosing and managing this disease.
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Affiliation(s)
- Kevin Molyneux
- Department of Emergency Medicine, Columbia University Irving Medical Center, 622 W 168th St, New York, NY 10032, USA
| | - Jennifer Beck-Esmay
- Department of Emergency Medicine, Mount Sinai Morningside - Mount Sinai West, 1111 Amsterdam Ave, New York, NY 10025, USA.
| | - Alex Koyfman
- Department of Emergency Medicine, UT Southwestern, Dallas, TX, USA
| | - Brit Long
- SAUSHEC, Department of Emergency Medicine, Brooke Army Medical Center, Fort Sam Houston, TX, USA.
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Olson MC, Bach CR, Wells ML, Andrews JC, Khandelwal A, Welle CL, Fidler JL. Imaging of Bowel Ischemia: An Update, From the AJR Special Series on Emergency Radiology. AJR Am J Roentgenol 2023; 220:173-185. [PMID: 35946859 DOI: 10.2214/ajr.22.28140] [Citation(s) in RCA: 4] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/25/2023]
Abstract
Acute mesenteric ischemia is a life-threatening condition that results from abrupt reduction in or cessation of blood flow to the bowel. Characterized by nonspecific abdominal symptoms, mesenteric ischemia is infrequently encountered and commonly misdiagnosed, with potentially catastrophic consequences. Prompt clinical diagnosis and early implementation of therapeutic interventions are critical to improving patient outcomes. Because cross-sectional imaging plays a key role in the diagnosis of mesenteric ischemia, radiologists must be familiar with the varied imaging manifestations of intestinal ischemia. Thus, the objectives of this article are to review the various types and common causes of mesenteric ischemia and to describe its spectrum of multimodality imaging findings, with special attention to novel imaging techniques and emerging diagnoses.
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Affiliation(s)
- Michael C Olson
- Department of Radiology, Mayo Clinic College of Medicine, Mayo Clinic, 200 1st St SW, Rochester, MN 55902
| | - Corrie R Bach
- Department of Radiology, Mayo Clinic College of Medicine, Mayo Clinic, 200 1st St SW, Rochester, MN 55902
| | - Michael L Wells
- Department of Radiology, Mayo Clinic College of Medicine, Mayo Clinic, 200 1st St SW, Rochester, MN 55902
| | - James C Andrews
- Department of Radiology, Mayo Clinic College of Medicine, Mayo Clinic, 200 1st St SW, Rochester, MN 55902
| | - Ashish Khandelwal
- Department of Radiology, Mayo Clinic College of Medicine, Mayo Clinic, 200 1st St SW, Rochester, MN 55902
| | - Christopher L Welle
- Department of Radiology, Mayo Clinic College of Medicine, Mayo Clinic, 200 1st St SW, Rochester, MN 55902
| | - Jeff L Fidler
- Department of Radiology, Mayo Clinic College of Medicine, Mayo Clinic, 200 1st St SW, Rochester, MN 55902
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Jing Y, Xu J, Chen B, Xia D, Xia D, Tian Y, Xia W, Lu C, Wu Y. Superior mesenteric artery embolism after radiofrequency ablation in regularly anticoagulated patients with paroxysmal atrial fibrillation: a case report. BMC Cardiovasc Disord 2023; 23:56. [PMID: 36710320 PMCID: PMC9885642 DOI: 10.1186/s12872-023-03066-5] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/07/2022] [Accepted: 01/12/2023] [Indexed: 01/31/2023] Open
Abstract
BACKGROUND Superior mesenteric artery embolism (SMAE) is a rare cause of acute abdomen, and the fatality rate is extremely high if it is not diagnosed and treated in time. Due to the lack of knowledge and experience of nonspecialist physicians, it is easy to misdiagnose. Radiofrequency ablation (RFA) has become the first-line treatment strategy for atrial fibrillation (AF). Thromboembolic events are some of the major complications after RFA, whereas SMAE is rarely reported. CASE PRESENTATION A 70 year-old woman with paroxysmal AF who regularly took anticoagulant drugs for 3 months experienced abdominal pain after RFA. At the outset, she was misdiagnosed as mechanical intestinal obstruction. When the patient presented with blood in the stool, abdominal enhancement computed tomography was conducted and showed a small bowel perforation. Immediate laparotomy was performed, and the final diagnosis was SMAE. CONCLUSION It is suggested that for unexplained abdominal pain after RFA of AF, the possibility of SMAE should be considered, and a targeted examination should be carried out in time to confirm the diagnosis and give appropriate treatment.
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Affiliation(s)
- Yongle Jing
- grid.417024.40000 0004 0605 6814Department of Cardiology, Tianjin First Central Hospital, No. 24, Fukang Road, 300192 Tianjin, China
| | - Jianqiang Xu
- grid.417024.40000 0004 0605 6814Department of Cardiology, Tianjin First Central Hospital, No. 24, Fukang Road, 300192 Tianjin, China
| | - Bingwei Chen
- grid.417024.40000 0004 0605 6814Department of Cardiology, Tianjin First Central Hospital, No. 24, Fukang Road, 300192 Tianjin, China
| | - Dasheng Xia
- grid.417024.40000 0004 0605 6814Department of Cardiology, Tianjin First Central Hospital, No. 24, Fukang Road, 300192 Tianjin, China
| | - Dachuan Xia
- grid.417024.40000 0004 0605 6814Department of Cardiology, Tianjin First Central Hospital, No. 24, Fukang Road, 300192 Tianjin, China
| | - Yunpeng Tian
- grid.417024.40000 0004 0605 6814Department of Cardiology, Tianjin First Central Hospital, No. 24, Fukang Road, 300192 Tianjin, China
| | - Wei Xia
- grid.417024.40000 0004 0605 6814Department of Cardiology, Tianjin First Central Hospital, No. 24, Fukang Road, 300192 Tianjin, China
| | - Chengzhi Lu
- grid.417024.40000 0004 0605 6814Department of Cardiology, Tianjin First Central Hospital, No. 24, Fukang Road, 300192 Tianjin, China
| | - Yuli Wu
- grid.417024.40000 0004 0605 6814Department of Anesthesiology, Tianjin First Central Hospital, No. 24, Fukang Road, Tianjin, 300192 China
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An Unusual Presentation of Superior Mesenteric Venous Occlusion in Mild COVID-19. Indian J Clin Biochem 2022; 38:275-278. [PMID: 35966150 PMCID: PMC9363859 DOI: 10.1007/s12291-022-01067-3] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/27/2022] [Accepted: 07/03/2022] [Indexed: 11/29/2022]
Abstract
SARS-CoV-2, an etiological agent of COVID-19, has been reported to inflict remarkably diverse manifestations in different subjects across the globe. Though patients with COVID-19 predominantly have fever, respiratory and constitutional symptoms, atypical presentations are becoming increasingly evident. COVID-19 may predispose to both venous and arterial thromboembolism due to excessive inflammation, hypoxia, immobilization, and diffuse intravascular coagulation in moderate to severe symptomatic cases. In this case report, we are reporting thromboembolic complications of COVID-19 in a mild symptomatic subject incidentally diagnosed with mesenteric venous occlusion with no abdominal symptoms. Early recognition of the abdominal symptoms, diagnosis, initiation of anticoagulants, and timely surgical intervention may improvise the outcome in a patient with COVID-19 infection-induced mesenteric thrombosis. Superior mesenteric artery and venous thrombosis may lead to subsequent ischemia necessitating emergency laparotomy. Thus, the usage of low-dose anticoagulants in all the patients of COVID-19 irrespective of the categorization into mild, moderate, and severe COVID-19 disease should be considered.
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Transvaginal US vs. CT in non-pregnant premenopausal women presenting to the ED: clinical impact of the second examination when both are performed. Abdom Radiol (NY) 2022; 47:2209-2219. [PMID: 35394154 PMCID: PMC8990505 DOI: 10.1007/s00261-022-03504-6] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/23/2021] [Revised: 03/17/2022] [Accepted: 03/18/2022] [Indexed: 11/03/2022]
Abstract
Objective To determine the clinical impact of the second examination when both CT and TVUS are obtained in the same ED visit for acute pelvic/lower abdominal symptoms in non-pregnant premenopausal women. Methods 200 consecutive non-pregnant premenopausal women (mean age, 31.8 years; range, 18–49 years) who underwent both ED-based TVUS and abdominopelvic CT evaluation for acute symptoms over a 12 month period were included; 107 women had TVUS first, followed by CT; 93 women had CT first. All relevant clinical, radiologic, and pathologic findings were reviewed to establish a final diagnosis. Any additional clinical impact provided by the second imaging test was assessed by two experienced abdominal radiologists. Results Initial TVUS was interpreted as normal (n = 63) or mentioned incidental findings (n = 11) in 69% (74/107); subsequent CT established a non-gynecologic GI/GU etiology in 25 (34%). For 37% (34/93) of CT exams interpreted as normal, TVUS added no new information. In 32 cases (34%), TVUS further excluded ovarian torsion/adnexal pathology when initial CT was indeterminate/equivocal. Overall, CT following TVUS provided a key new or alternative diagnosis in 26% (28/107), whereas TVUS after CT provided a relevant new/alternative diagnosis in only 1/93 cases (p < 0.001). In nine cases (8%), CT confirmed a positive US diagnosis but detected relevant additional diagnostic information. Conclusion CT following negative TVUS frequently identified a non-gynecologic cause of acute pelvic or lower abdominal symptoms in non-pregnant premenopausal women, whereas the main benefit of TVUS after CT was more confident exclusion of ovarian torsion.
Graphical abstract ![]()
Supplementary Information The online version contains supplementary material available at 10.1007/s00261-022-03504-6.
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The experience from a case of acute superior mesenteric artery embolism caused by constipation after hemorrhoid surgery. Asian J Surg 2022; 45:2420-2422. [DOI: 10.1016/j.asjsur.2022.05.076] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/02/2022] [Accepted: 05/13/2022] [Indexed: 12/24/2022] Open
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Bergamini C, Alemanno G, Giordano A, Pantalone D, Fontani G, Di Bella AM, Iacopini V, Prosperi P, Martellucci J. The role of bed-side laparoscopy in the management of acute mesenteric ischemia of recent onset in post-cardiac surgery patients admitted to ICU. Eur J Trauma Emerg Surg 2022; 48:87-96. [PMID: 32951071 DOI: 10.1007/s00068-020-01500-3] [Citation(s) in RCA: 4] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/02/2020] [Accepted: 09/08/2020] [Indexed: 11/26/2022]
Abstract
PURPOSE Acute mesenteric ischemia with non-occlusive mechanism (NOMI) is a possible complication after cardiac surgery in patients admitted to Intensive Care Unit (ICU). Since the diagnosis is often difficult with CT-scan, some authors have evaluated the role of bed-side diagnostic laparoscopy (DL). We aimed to contribute to this topic with a personal series. METHODS We retrospectively evaluated patients admitted to ICU after cardiac surgery since 2009 up to 2019, successively operated on for a suspected NOMI of recent onset with non-conclusive CT. They were divided into laparoscopic (Ls) and laparotomic (Lt) group, depending on whether or not they had a DL. They were compared for the CT false-positive (FP) and true-positive (TP) rate and the surgical outcome. RESULTS Seventy-three patients were enrolled. Lt included 30 patients (41%), Ls 43 (59%). The overall FP were 38 (52%), with a higher incidence in Ls. There was no difference in the mortality rate. The morbidity rate was higher in Lt, and especially in Lt-FP. The TP were 35 (47.9%). The mean operating time (OT) in the Lt-TP group was similar to the sum of the mean OT of the laparotomies plus that of the laparoscopies in the Ls-TP group. Conversely, when considering only laparotomic procedures, the Lt-TP had higher mean OT, such as an increased blood loss CONCLUSIONS: Post-cardiosurgical patients admitted to ICU have a relatively high rate of NOMI, in which CT-scan is often initially non-conclusive. Our data and those from the literature seem to show that in such cases bed-side DL may be an advantageous and safe procedure to avoid needless laparotomy and enables a more tailored open surgery.
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Affiliation(s)
- Carlo Bergamini
- Department of Emergency Surgery, University Hospital of Careggi, Largo Brambilla n° 3, 50134, Florence, Italy.
| | - Giovanni Alemanno
- Department of Emergency Surgery, University Hospital of Careggi, Largo Brambilla n° 3, 50134, Florence, Italy
| | - Alessio Giordano
- Department of Emergency Surgery, University Hospital of Careggi, Largo Brambilla n° 3, 50134, Florence, Italy
| | - Desiré Pantalone
- Medical School, Department of Surgery, University of Florence, Largo Brambilla n° 3, 50134, Florence, Italy
| | - Giovanni Fontani
- Medical School, Department of Surgery, University of Florence, Largo Brambilla n° 3, 50134, Florence, Italy
| | - Anna Maria Di Bella
- Medical School, Department of Surgery, University of Florence, Largo Brambilla n° 3, 50134, Florence, Italy
| | - Veronica Iacopini
- Medical School, Department of Surgery, University of Florence, Largo Brambilla n° 3, 50134, Florence, Italy
| | - Paolo Prosperi
- Department of Emergency Surgery, University Hospital of Careggi, Largo Brambilla n° 3, 50134, Florence, Italy
| | - Jacopo Martellucci
- Department of Emergency Surgery, University Hospital of Careggi, Largo Brambilla n° 3, 50134, Florence, Italy
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Khripun AI, Pryamikov AD, Mironkov AB, Abashin MV, Sazhin IV, Stepanenko KV, Savkina KV, Motylev EN. [Gas in superior mesenteric artery and celiac axis as a rare CT-sign of extensive bowel necrosis]. Khirurgiia (Mosk) 2022:98-105. [PMID: 35920229 DOI: 10.17116/hirurgia202208198] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 06/15/2023]
Abstract
The authors report endovascular treatment of acute thromboembolic occlusion of superior mesenteric artery in a 75-year-old patient whose postoperative period was complicated by massive reperfusion and translocation syndrome. Contrast-enhanced CT in 12 hours after successful thrombectomy from superior mesenteric artery revealed CT signs of irreversible bowel lesion, i.e. gas in hepatic veins, intestinal wall and mesenteric veins, bowel wall thinning. In addition, CT revealed extremely rare sign of severe acute mesenteric ischemia (gas in superior mesenteric artery and celiac axis). We found no description of gas in celiac axis following acute mesenteric ischemia in available literature.
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Affiliation(s)
- A I Khripun
- Pirogov Russian National Research Medical University, Moscow, Russia
| | - A D Pryamikov
- Pirogov Russian National Research Medical University, Moscow, Russia
- Buyanov Moscow City Clinical Hospital, Moscow, Russia
| | - A B Mironkov
- Pirogov Russian National Research Medical University, Moscow, Russia
- Buyanov Moscow City Clinical Hospital, Moscow, Russia
| | - M V Abashin
- Pirogov Russian National Research Medical University, Moscow, Russia
- Buyanov Moscow City Clinical Hospital, Moscow, Russia
| | - I V Sazhin
- Pirogov Russian National Research Medical University, Moscow, Russia
- Buyanov Moscow City Clinical Hospital, Moscow, Russia
| | | | - K V Savkina
- Buyanov Moscow City Clinical Hospital, Moscow, Russia
| | - E N Motylev
- Buyanov Moscow City Clinical Hospital, Moscow, Russia
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Tran LM, Andraska E, Haga L, Sridharan N, Chaer RA, Eslami MH. Hospital-based Delays to Revascularization Increase Risk of Post-operative Mortality and Short Bowel Syndrome in Acute Mesenteric Ischemia. J Vasc Surg 2021; 75:1323-1333.e3. [PMID: 34634418 DOI: 10.1016/j.jvs.2021.09.033] [Citation(s) in RCA: 10] [Impact Index Per Article: 2.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/13/2021] [Accepted: 09/13/2021] [Indexed: 01/16/2023]
Abstract
OBJECTIVE Acute mesenteric ischemia (AMI) is a surgical emergency for which delays in treatment have been closely associated with high morbidity and mortality. Although the duration of ischemia as a determinant of outcomes for AMI is well known, the objective of this study was to identify hospital-based determinants of delayed revascularization and their effects on post-operative morbidity and mortality in AMI. METHODS All patients who underwent any surgery for acute mesenteric ischemia (AMI) from a multi-center hospital system between 2010 and 2020 were divided into two groups based on timeliness of mesenteric revascularization after presentation. Early revascularization (ER) was defined as having both vascular consultation ≤ 12 hours of presentation and vascular surgery performed at the patient's initial operation. Delayed revascularization (DR) was defined as having either delays to vascular consultation or vascular surgery. A retrospective review of demographic and post-operative data was performed. Effect of DR on major post-operative outcomes including 30-day and 2-year mortality, total length of bowel resection, and development of short bowel syndrome were analyzed. Effects of delayed vascular consultation alone, delayed vascular surgery alone, no revascularization during admission, and admitting service on outcomes were also examined on sub-group analyses. RESULTS A total of 212 patients were analyzed. 99 patients received ER while the remaining 113 patients experienced a delay to revascularization after hospital presentation. Among the DR group, 55 (25.9%) patients had delayed vascular consultation while vascular surgery was deferred until after the initial operation in 37 (17.4%) patients. 51 (24.0%) patients were never revascularized during admission. DR was a significant predictor of 30-day (odds ratio (OR) 2.09, 95% confidence interval (CI) [1.4-4.9], P=0.03) and 2-year mortality (hazard ratio (HR) 1.55, CI [1.0-2.3], P= 0.04). DR was also independently associated with increased bowel resection length (OR 7.47, P <0.01) and post-operative short bowel syndrome (OR 2.4, P=0.03) on multivariate analyses. When examined separately on sub-group analysis, both delayed vascular consultation (OR 3.38, P=0.03) and vascular surgery (OR 4.31, P <0.01) independently increased risk of 30-day mortality. Hospital discharge after AMI without mesenteric revascularization was associated with increased risk of short bowel syndrome (OR 2.94, P <0.01) and late mortality (HR 1.60, P=0.04). CONCLUSIONS Delayed vascular consultation and vascular surgery are both significant hospital-based determinants of post-operative mortality and short bowel syndrome in AMI. Timing-based management protocols which emphasize routine evaluation by a vascular surgeon and early, definitive mesenteric revascularization should be established and widely adopted for all patients with clinically suspected AMI at presentation.
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Affiliation(s)
- Lillian M Tran
- Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pa
| | - Elizabeth Andraska
- Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pa; Heart and Vascular Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pa
| | - Lindsey Haga
- Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pa; Heart and Vascular Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pa
| | - Natalie Sridharan
- Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pa; Heart and Vascular Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pa
| | - Rabih A Chaer
- Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pa; Heart and Vascular Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pa
| | - Mohammad H Eslami
- Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pa; Heart and Vascular Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pa.
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15
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Abstract
Ischemic bowel disease (ISBODI) includes colon ischemia, acute mesenteric ischemia (AMI) and chronic mesenteric ischemia (CMI). Epidemiologically, colon ischemia is the most common type followed by AMI and CMI. There are various risk factors for the development of ISBODI. Abdominal pain is the common presenting symptom of each type. High clinical suspicion is essential in ordering appropriate tests. Imaging studies and colonoscopy with biopsy are the main diagnostic tests. Treatment varies from conservative measures to surgical resection and revascularization. Involvement of multidisciplinary team is essential in managing ISBODI. Although open surgery with revascularization plays an important role, recently there is an increasing interest in percutaneous endovascular treatment.
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Affiliation(s)
- Monjur Ahmed
- Department of Medicine, Division of Gastroenterology and Hepatology, Thomas Jefferson University, Philadelphia, PA 19107, United States
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16
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Abstract
PURPOSE OF REVIEW To summarize current evidence on acute mesenteric ischemia (AMI) in critically ill patients, addressing pathophysiology, definition, diagnosis and management. RECENT FINDINGS A few recent studies showed that a multidiscipliary approach in specialized centers can improve the outcome of AMI. Such approach incorporates current knowledge in pathophysiology, early diagnosis with triphasic computed tomography (CT)-angiography, immediate endovascular or surgical restoration of mesenteric perfusion, and damage control surgery if transmural bowel infarction is present. No specific biomarkers are available to detect early mucosal injury in clinical setting. Nonocclusive mesenteric ischemia presents particular challenges, as the diagnosis based on CT-findings as well as vascular management is more difficult; some recent evidence suggests a possible role of potentially treatable stenosis of superior mesenteric artery and beneficial effect of vasodilator therapy (intravenous or local intra-arterial). Medical management of AMI is supportive, including aiming of euvolemia and balanced systemic oxygen demand/delivery. Enteral nutrition should be withheld during ongoing ischemia-reperfusion injury and be started at low rate after revascularization of the (remaining) bowel is convincingly achieved. SUMMARY Clinical suspicion leading to tri-phasic CT-angiography is a mainstay for diagnosis. Diagnosis of nonocclusive mesenteric ischemia and early intestinal injury remains challenging. Multidisciplinary team effort may improve the outcome of AMI.
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Affiliation(s)
- Annika Reintam Blaser
- Department of Anaesthesiology and Intensive Care, University of Tartu, Tartu, Estonia
- Department of Intensive Care Medicine, Lucerne Cantonal Hospital, Lucerne, Switzerland
| | - Stefan Acosta
- Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden
| | - Yaseen M Arabi
- Intensive Care Department, King Abdulaziz Medical City, College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia
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Anglaret S, Dallongeville A, Beaussier H, Touloupas C, Boulay I, Tardivel AM, Béranger S, Silvera S, Chatellier G, Ronot M, Zins M. Influence of clinical suspicion on CT accuracy of acute mesenteric ischemia: Retrospective study of 362 patients. Eur J Radiol 2021; 138:109652. [PMID: 33740626 DOI: 10.1016/j.ejrad.2021.109652] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/02/2021] [Revised: 03/07/2021] [Accepted: 03/09/2021] [Indexed: 10/21/2022]
Abstract
PURPOSE Acute mesenteric ischemia (AMI) may be underdiagnosed when not clinically suspected before CT is performed. We assessed the influence of a clinical suspicion of AMI on the CT accuracy. METHOD This retrospective single-centre study included patients who underwent CT in 2014-2019 and had clinically suspected AMI and/or confirmed AMI. CT protocols were adapted based on each patient's presentation and on findings from unenhanced images. The CT protocol was considered optimal for AMI when it included arterial and portal venous phases. CT protocols, accuracy of reports, and outcomes were compared between the groups with and without suspected AMI before CT. RESULTS Of the 375 events, 337 (90 %) were suspected AMI and 66 (18 %) were AMI, including 28 (42 %) with and 38 without suspected AMI. These two groups did not differ significantly regarding the medical history, clinical presentation, or laboratory tests. The CT protocol was more often optimal for AMI in the group with suspected AMI (26/28 [93 %] vs. 28/38 [74 %], p = 0.046). Diagnostic accuracy was not different between groups with and without suspected AMI (26/28 [93 %] vs. 34/38 [90 %], p = 1.00). However, it was lower in the group without suspicion of AMI when the CT protocol was not optimal for AMI (27/28 [96 %] vs 7/10 [70 %], p = 0.048). CONCLUSIONS The negative influence of not clinically suspecting AMI can be mitigated by using a tailored CT protocol.
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Affiliation(s)
- S Anglaret
- Imagerie médicale, Groupe hospitalier Paris Saint-Joseph, 185 rue Raymond Losserand, 75014, Paris, France
| | - A Dallongeville
- Imagerie médicale, Groupe hospitalier Paris Saint-Joseph, 185 rue Raymond Losserand, 75014, Paris, France
| | - H Beaussier
- Unité de recherche clinique, Groupe hospitalier Paris Saint-Joseph, 185 rue Raymond Losserand, 75014, Paris, France
| | - C Touloupas
- Imagerie médicale, Groupe hospitalier Paris Saint-Joseph, 185 rue Raymond Losserand, 75014, Paris, France
| | - I Boulay
- Imagerie médicale, Groupe hospitalier Paris Saint-Joseph, 185 rue Raymond Losserand, 75014, Paris, France
| | - A M Tardivel
- Imagerie médicale, Groupe hospitalier Paris Saint-Joseph, 185 rue Raymond Losserand, 75014, Paris, France
| | - S Béranger
- Imagerie médicale, Groupe hospitalier Paris Saint-Joseph, 185 rue Raymond Losserand, 75014, Paris, France
| | - S Silvera
- Imagerie médicale, Groupe hospitalier Paris Saint-Joseph, 185 rue Raymond Losserand, 75014, Paris, France
| | - G Chatellier
- Unité de recherche clinique, Groupe hospitalier Paris Saint-Joseph, 185 rue Raymond Losserand, 75014, Paris, France
| | - M Ronot
- Imagerie médicale, Hôpital Beaujon AP-HP, 100 Boulevard du Général Leclerc, 92110, Clichy, France
| | - M Zins
- Imagerie médicale, Groupe hospitalier Paris Saint-Joseph, 185 rue Raymond Losserand, 75014, Paris, France.
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18
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Amaravathi U, Balamurugan N, Muthu Pillai V, Ayyan SM. Superior Mesenteric Arterial and Venous Thrombosis in COVID-19. J Emerg Med 2021; 60:e103-e107. [PMID: 33581991 PMCID: PMC7833911 DOI: 10.1016/j.jemermed.2020.12.016] [Citation(s) in RCA: 20] [Impact Index Per Article: 5.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/24/2020] [Revised: 12/07/2020] [Accepted: 12/15/2020] [Indexed: 12/16/2022]
Abstract
Background Patients with coronavirus disease 2019 (COVID-19) commonly present with fever, constitutional symptoms, and respiratory symptoms. However, atypical presentations are also well known. Though isolated mesenteric arterial occlusion associated with COVID-19 has been reported in literature, combined superior mesenteric arterial and venous thrombosis is rare. We report a case of combined superior mesenteric arterial and venous occlusion associated with COVID-19 infection. Case Report We report a case of a 45-year-old man who was a health care worker who presented to the emergency department with severe abdominal pain. The clinical examination was unremarkable, but imaging revealed acute mesenteric ischemia caused by superior mesenteric artery and superior mesenteric vein occlusion. Imaging of the chest was suggestive of COVID-19 infection, which was later confirmed with reverse transcription polymerase chain reaction of his nasopharyngeal swab. To date, only 1 case of combined superior mesenteric artery and superior mesenteric vein thrombosis caused by COVID-19 has been reported. Why Should an Emergency Physician Be Aware of This? During the COVID-19 pandemic it is important to keep mesenteric ischemia in the differential diagnosis of unexplained abdominal pain. Routinely adding high-resolution computed tomography of the chest to abdominal imaging should be considered in patients with acute abdomen because it can help to identify COVID-19 immediately. © 2020 Elsevier Inc.
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Affiliation(s)
- Uthayakumar Amaravathi
- Department of Emergency Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India
| | - Nathan Balamurugan
- Department of Emergency Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India
| | - Vivekanandan Muthu Pillai
- Department of Emergency Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India
| | - S Manu Ayyan
- Department of Emergency Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India
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19
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Acosta S, Salim S. Management of Acute Mesenteric Venous Thrombosis: A Systematic Review of Contemporary Studies. Scand J Surg 2020; 110:123-129. [PMID: 33118463 PMCID: PMC8258716 DOI: 10.1177/1457496920969084] [Citation(s) in RCA: 17] [Impact Index Per Article: 3.4] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/24/2022]
Abstract
Background and Aims: Acute mesenteric venous thrombosis accounts for up to 20% of all patients with acute mesenteric ischemia in high-income countries. Acute mesenteric venous thrombosis is nowadays relatively more often diagnosed with intravenous contrast-enhanced computed tomography in the portal phase than at explorative laparotomy No high-quality comparative studies between anticoagulation alone, endovascular therapy, or surgery exists. The aim of the present systematic review was to offer a contemporary overview on management. Materials and Methods: Eleven relevant published original studies with series of at least ten patients were retrieved from a Pub Med search between 2015 and 2020 using the Medical Subject Heading term “mesenteric venous thrombosis.” Results: When MVT is diagnosed early, immediate anticoagulation with either unfractionated heparin or subcutaneous low-molecular-weight heparin should commence. Surgeons need to be aware of the importance to scrutinize the computed tomography images themselves for assessment of secondary intestinal abnormalities to mesenteric venous thrombosis and the risk of bowel resection and worse prognosis. Progression toward peritonitis is an indication for explorative laparotomy and assessment of bowel viability. Frank transmural small bowel necrosis should be resected and bowel anastomosis may be delayed for several days until second look. Meanwhile, intravenous full-dose unfractionated heparin should be given at the end of the first operation. Postoperative major intra-abdominal or gastrointestinal bleeding occurs rarely, but the heparin effect can instantaneously be reversed by protamine sulfate. Patients who do not improve during conservative therapy with anticoagulation alone but without developing peritonitis may be subjected to endovascular therapy in expert centers. When the patient’s intestinal function has recovered, with or without bowel resection, switch from parenteral unfractionated heparin or low-molecular-weight heparin therapy to oral anticoagulation can be performed. There is a trend that direct oral anticoagulants are increasingly used instead of vitamin K antagonists. Up to now, direct oral anticoagulants have been shown to be equally effective with the same rate of bleeding complications. Patients with no strong permanent trigger factor for mesenteric venous thrombosis such as intra-abdominal cancer should undergo blood screening for inherited and acquired thrombophilia. Conclusion: Early diagnosis with emergency computed tomography with intravenous contrast-enhancement and imaging in the portal phase and anticoagulation therapy is necessary to be able to have a succesful non-operative succesful course.
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Affiliation(s)
- S Acosta
- Department of Clinical Sciences, Lund University, Malmö, Sweden.,Vascular Center, Department of Cardiothoracic and Vascular Surgery, Skåne University Hospital, Malmö, Sweden
| | - S Salim
- Department of Clinical Sciences, Lund University, Malmö, Sweden
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20
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Acute mesenteric ischemia: A review of the main imaging techniques and signs. RADIOLOGIA 2020. [DOI: 10.1016/j.rxeng.2020.02.004] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/17/2022]
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21
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Isquemia mesentérica aguda: Revisión de las principales técnicas y signos radiológicos. RADIOLOGIA 2020; 62:336-348. [DOI: 10.1016/j.rx.2020.02.001] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.6] [Reference Citation Analysis] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/27/2019] [Revised: 01/15/2020] [Accepted: 02/11/2020] [Indexed: 12/11/2022]
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22
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MDCT in the Setting of Suspected Colonic Diverticulitis: Prevalence and Diagnostic Yield for Diverticulitis and Alternative Diagnoses. AJR Am J Roentgenol 2020; 215:39-49. [DOI: 10.2214/ajr.19.21852] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/28/2022]
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23
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Abstract
OBJECTIVE. The purpose of this article is to provide an overview of the diagnostic and prognostic roles of CT in the management of acute mesenteric ischemia. CONCLUSION. Acute mesenteric ischemia is defined as inadequate blood supply to the gastrointestinal tract resulting in ischemic and inflammatory injury. The prognosis is poor without treatment. Contrast-enhanced CT has become the cornerstone of diagnosis to identify features of vascular disorders and of intestinal ischemic injury and to visualize bowel necrosis.
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24
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Olson MC, Fletcher JG, Nagpal P, Froemming AT, Khandelwal A. Mesenteric ischemia: what the radiologist needs to know. Cardiovasc Diagn Ther 2019; 9:S74-S87. [PMID: 31559155 DOI: 10.21037/cdt.2018.09.06] [Citation(s) in RCA: 33] [Impact Index Per Article: 5.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/12/2022]
Abstract
Acute mesenteric ischemia (AMI) is a life-threatening condition that often presents with abdominal pain. Early diagnosis with contrast-enhanced computed tomography and revascularization can reduce the overall mortality in AMI. This article reviews practical etiological classification, pathophysiology of imaging manifestations and common pitfalls in intestinal ischemia.
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Affiliation(s)
| | | | - Prashant Nagpal
- Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
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25
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Baliyan V, Shaqdan K, Hedgire S, Ghoshhajra B. Vascular computed tomography angiography technique and indications. Cardiovasc Diagn Ther 2019; 9:S14-S27. [PMID: 31559151 DOI: 10.21037/cdt.2019.07.04] [Citation(s) in RCA: 32] [Impact Index Per Article: 5.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/11/2022]
Abstract
Non-invasive cross-sectional imaging techniques play a crucial role in the assessment of the vascular disease processes. Computed tomography angiography (CTA) is an imaging method of choice for a wide range of vascular diseases that span across different vascular territories. A diagnostic quality CTA requires a robust imaging protocol tailored according to the physiologic state and vascular area of interest. This review article is aimed to provide an overview of the technical considerations and clinical applications of CTA.
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Affiliation(s)
- Vinit Baliyan
- Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
| | - Khalid Shaqdan
- Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
| | - Sandeep Hedgire
- Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
| | - Brian Ghoshhajra
- Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
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26
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Gopee-Ramanan P, Patlas MN, Pindiprolu B, Katz DS. Utility of biphasic multi-detector computed tomography in suspected acute mesenteric ischemia in the emergency department. Emerg Radiol 2019; 26:523-529. [DOI: 10.1007/s10140-019-01698-9] [Citation(s) in RCA: 5] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/26/2019] [Accepted: 05/31/2019] [Indexed: 01/08/2023]
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27
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Salim S, Zarrouk M, Elf J, Gottsäter A, Ekberg O, Acosta S. Improved Prognosis and Low Failure Rate with Anticoagulation as First-Line Therapy in Mesenteric Venous Thrombosis. World J Surg 2018; 42:3803-3811. [PMID: 29777267 PMCID: PMC6182753 DOI: 10.1007/s00268-018-4667-x] [Citation(s) in RCA: 12] [Impact Index Per Article: 1.7] [Reference Citation Analysis] [Abstract] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/16/2023]
Abstract
BACKGROUND Monotherapy with anticoagulation has been considered as first-line therapy in patients with mesenteric venous thrombosis (MVT). The aim of this study was to evaluate outcome, prognostic factors, and failure rate of anticoagulation as monotherapy, and to identify when bowel resection was needed. METHODS Retrospective study of consecutive patients with MVT diagnosed between 2000 and 2015. RESULTS The overall incidence rate of MVT was 1.3/100,000 person-years. Among 120 patients, seven died due to autopsy-verified MVT without bowel resection and 15 underwent immediate bowel resection without prior anticoagulation therapy. The remaining 98 patients received anticoagulation monotherapy, whereof 83 (85%) were treated successfully. Fifteen patients failed on anticoagulation monotherapy, of whom seven underwent bowel resection and eight endovascular therapy. Endovascular therapy was followed by bowel resection in three patients. Two late bowel resections were performed due to intestinal stricture. The 30-day mortality rate was 19.0% in the former (2000-2007) and 3.2% in the latter (2008-2015) part of the study period (p = 0.006). Age ≥75 years (OR 12.4, 95% CI [2.5-60.3]), management during the former as opposed to the latter time period (OR 8.4, 95% CI [1.3-54.7]), and renal insufficiency at admission (OR 8.0, 95% CI [1.2-51.6]) were independently associated with increased mortality in multivariable analysis. CONCLUSIONS Short-term prognosis in patients with MVT has improved. Contemporary data show that monotherapy with anticoagulation is an effective first choice in MVT patients.
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Affiliation(s)
- S Salim
- Department of Clinical Sciences, Lund University, Malmö, Sweden
- Vascular Centre, Department of Cardio-Thoracic and Vascular Surgery, Skåne University Hospital, 205 02, Malmö, Sweden
| | - M Zarrouk
- Department of Clinical Sciences, Lund University, Malmö, Sweden
- Vascular Centre, Department of Cardio-Thoracic and Vascular Surgery, Skåne University Hospital, 205 02, Malmö, Sweden
| | - J Elf
- Department of Clinical Sciences, Lund University, Malmö, Sweden
- Vascular Centre, Department of Cardio-Thoracic and Vascular Surgery, Skåne University Hospital, 205 02, Malmö, Sweden
| | - A Gottsäter
- Department of Clinical Sciences, Lund University, Malmö, Sweden
- Vascular Centre, Department of Cardio-Thoracic and Vascular Surgery, Skåne University Hospital, 205 02, Malmö, Sweden
| | - O Ekberg
- Department of Translational Medicine, Division of Medical Radiology, Lund University, Malmö, Sweden
| | - S Acosta
- Department of Clinical Sciences, Lund University, Malmö, Sweden.
- Vascular Centre, Department of Cardio-Thoracic and Vascular Surgery, Skåne University Hospital, 205 02, Malmö, Sweden.
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28
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Low-Dose CT for Evaluation of Suspected Urolithiasis: Diagnostic Yield for Assessment of Alternative Diagnoses. AJR Am J Roentgenol 2018; 210:557-563. [DOI: 10.2214/ajr.17.18552] [Citation(s) in RCA: 10] [Impact Index Per Article: 1.4] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/23/2022]
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Wang Z, Chen JQ, Liu JL, Tian L. A Novel Scoring System for Diagnosing Acute Mesenteric Ischemia in the Emergency Ward. World J Surg 2017; 41:1966-1974. [PMID: 28321558 DOI: 10.1007/s00268-017-3984-9] [Citation(s) in RCA: 6] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/31/2022]
Abstract
BACKGROUND Early diagnosis of acute mesenteric ischemia (AMI) based on clinical judgment has been proved to be too difficult. Therefore, it is important for identifying clinical parameters that can differentiate AMI from other acute abdomen upon presentation. METHODS We analyzed a database of 106 consecutive patients admitted to the emergency ward for suspected AMI in whom diagnosis of AMI was confirmed by laparotomy, CT angiography or mesenteric angiography. The patients' demographics, previous history, clinical signs, results of laboratory investigations and ultrasonography were collected. Diagnostic cutoff value of quantitative indexes was derived from the receiver operating curve. Multivariate logistic regression was used to identify risk factors for AMI and formulated these risk factors into a scoring system. RESULTS A total of 45 patients (42.5%) were confirmed to have AMI. Compared with other acute abdomen, AMI had significantly increased level of white blood cell (Odds ratio (OR) 16.11, 95% confidence interval (CI) 1.10-235.34), red cell distribution width (OR 27.65, 95% CI 1.53-501.02), mean platelet volume (OR 16.06, 95% CI 1.48-174.50) and D-dimer (OR 42.91, 95% CI 2.56-718.09). A diagnostic score was calculated by adding points assigned to the four parameters, and a cutoff score of four best identified patients with AMI, with sensitivity, specificity, positive and negative predictive values of 97.8, 91.8, 89.8 and 98.2%, respectively. CONCLUSION This scoring system based on easily available parameters could be used as a useful tool for differentiating AMI from other acute abdomen in the emergency ward. Prospective studies with large sample remain needed for validating the results.
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Affiliation(s)
- Zhen Wang
- Department of Gastrointestinal Surgery, The First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, 530021, Guangxi Zhuang Autonomous Region, China.
| | - Jun-Qiang Chen
- Department of Gastrointestinal Surgery, The First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, 530021, Guangxi Zhuang Autonomous Region, China.
| | - Jin-Lu Liu
- Department of Gastrointestinal Surgery, The First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, 530021, Guangxi Zhuang Autonomous Region, China
| | - Lei Tian
- Department of Gastrointestinal Surgery, The First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, 530021, Guangxi Zhuang Autonomous Region, China
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