| For: | Luo X, Luo SZ, Xu ZX, Zhou C, Li ZH, Zhou XY, Xu MY. Lipotoxic hepatocyte-derived exosomal miR-1297 promotes hepatic stellate cell activation through the PTEN signaling pathway in metabolic-associated fatty liver disease. World J Gastroenterol 2021; 27(14): 1419-1434 [PMID: 33911465 DOI: 10.3748/wjg.v27.i14.1419] |
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| URL: | https://www.wjgnet.com/1007-9327/full/v27/i14/1419.htm |
| Number | Citing Articles |
| 1 |
Albert Gibert-Ramos, María Andrés-Rozas, Raül Pastó, Pablo Alfaro-Retamero, Sergi Guixé-Muntet, Jordi Gracia-Sancho. Sinusoidal communication in chronic liver disease. Clinical and Molecular Hepatology 2025; 31(1) doi: 10.3350/cmh.2024.0734
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| 2 |
Danna Xie, Baolin Qian, Xun Li. Nucleic acids and proteins carried by exosomes from various sources: Potential role in liver diseases. Frontiers in Physiology 2022; 13 doi: 10.3389/fphys.2022.957036
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| 3 |
Luping Wang, Yi Huang, Jingrong Chen, Jialu Gao, Sihan Chen, Mingqi Zhao, Jiguo Lin, Shunqing Zhou, Yannan Shen, Yunyun Cheng. Dynamic crosstalk between HSCs and liver microenvironment: multicellular interactions in the regulation of liver fibrosis. Frontiers in Cell and Developmental Biology 2025; 13 doi: 10.3389/fcell.2025.1635763
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| 4 |
Hong Li, Tingli Liu, Yongchun Yang, William C. Cho, Robin J. Flynn, Majid Fasihi Harandi, Houhui Song, Xuenong Luo, Yadong Zheng. Interplays of liver fibrosis-associated microRNAs: Molecular mechanisms and implications in diagnosis and therapy. Genes & Diseases 2023; 10(4) doi: 10.1016/j.gendis.2022.08.013
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| 5 |
Ezhilarasan Devaraj, Elumalai Perumal, Raghunandhakumar Subramaniyan, Najimi Mustapha. Liver fibrosis: Extracellular vesicles mediated intercellular communication in perisinusoidal space. Hepatology 2022; 76(1) doi: 10.1002/hep.32239
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| 6 |
Chi Wang, Xiaotian Zhang, Guohao Liu, Cheng Zhang, Pengju Li, Pan He, Sha Liu, Hong Ji, Haibo Yu. Selenium alleviates high-fat diet induced hepatocyte lipid accumulation via exosome miR-22/FGFR1 pathway in grass carp. The Journal of Nutritional Biochemistry 2025; 141 doi: 10.1016/j.jnutbio.2025.109907
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| 7 |
Xinsong Hu, Yifei Chen, Hao Ying, Cong He, Yangyang Ren, Yiqing Tian, Youwen Tan. Metabolic-associated fatty liver disease (MAFLD) promotes the progression of hepatocellular carcinoma by enhancing KIF20A expression. International Immunopharmacology 2025; 154 doi: 10.1016/j.intimp.2025.114589
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| 8 |
Qiaohui Shen, Ming Yang, Song Wang, Xingyu Chen, Sulan Chen, Rui Zhang, Zhuang Xiong, Yan Leng. The pivotal role of dysregulated autophagy in the progression of non-alcoholic fatty liver disease. Frontiers in Endocrinology 2024; 15 doi: 10.3389/fendo.2024.1374644
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| 9 |
Samaneh Salehipour Bavarsad, Mohammad Taha Jalali, Darioush Bijan Nejad, Behnam Alypoor, Hossein Babaahmadi Rezaei, Narges Mohammadtaghvaei. TGFβ1-Pretreated Exosomes of Wharton Jelly Mesenchymal Stem Cell as a Therapeutic Strategy for Improving Liver Fibrosis. Hepatitis Monthly 2022; 22(1) doi: 10.5812/hepatmon-123416
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| 10 |
Yu Zheng, Long Xie, Dejun Yang, Kaipei Luo, Xiaofang Li. Small-molecule natural plants for reversing liver fibrosis based on modulation of hepatic stellate cells activation: An update. Phytomedicine 2023; 113 doi: 10.1016/j.phymed.2023.154721
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| 11 |
Liang'en Chen, Xiangshi Ye, Lixian Yang, Jiangsha Zhao, Jia You, Yuxiong Feng. Linking fatty liver diseases to hepatocellular carcinoma by hepatic stellate cells. Journal of the National Cancer Center 2024; 4(1) doi: 10.1016/j.jncc.2024.01.002
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| 12 |
Congjian Shi, Shuang Hu, Shen Liu, Xiaodi Jia, Yubin Feng. Emerging role of exosomes during the pathogenesis of viral hepatitis, non-alcoholic steatohepatitis and alcoholic hepatitis. Human Cell 2024; 38(1) doi: 10.1007/s13577-024-01158-8
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| 13 |
Xiang Liu, Yijia Shao, Jiazichao Tu, Jiapan Sun, Bing Dong, Zhichao Wang, Jianrong Zhou, Long Chen, Jun Tao, Jimei Chen. TMAO-Activated Hepatocyte-Derived Exosomes Impair Angiogenesis via Repressing CXCR4. Frontiers in Cell and Developmental Biology 2022; 9 doi: 10.3389/fcell.2021.804049
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| 14 |
Xingtao Zhao, Xinyan Xue, Zhifu Cui, Felix Kwame Amevor, Yan Wan, Ke Fu, Cheng Wang, Cheng Peng, Yunxia Li. microRNAs‐based diagnostic and therapeutic applications in liver fibrosis. WIREs RNA 2023; 14(4) doi: 10.1002/wrna.1773
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| 15 |
Eleni Myrto Trifylli, Sotirios P. Fortis, Anastasios G. Kriebardis, Nikolaos Papadopoulos, Evangelos Koustas, Panagiotis Sarantis, Spilios Manolakopoulos, Melanie Deutsch. Extracellular Vesicles as Biomarkers in Chronic Hepatobiliary Diseases: An Overview of Their Interplay. International Journal of Molecular Sciences 2025; 26(13) doi: 10.3390/ijms26136333
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| 16 |
Samar A. Zailaie, Basmah B. Khoja, Jumana J. Siddiqui, Mohammad H. Mawardi, Emily Heaphy, Amjad Aljagthmi, Consolato M. Sergi. Investigating the Role of Non-Coding RNA in Non-Alcoholic Fatty Liver Disease. Non-Coding RNA 2024; 10(1) doi: 10.3390/ncrna10010010
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| 17 |
Rong-Ping Fan, Li-Ping Gou, Jin-Fang Ma, Jing-Min Yang, Jack Isaac Wood, Rui-Ning Zhang, Xiang-Hui Fu, Nan-Wei Tong. Extracellular Vesicle-Mediated Local and Systemic Communication in Metabolic Diseases. International Journal of Molecular Sciences 2026; 27(18) doi: 10.3390/ijms27188287
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| 18 |
Xiaona Zhao, Xinxin Kong, Zhoujun Cui, Zejin Zhang, Minghui Wang, Guoqing Liu, Honggang Gao, Jing Zhang, Wei Qin. Communication between nonalcoholic fatty liver disease and atherosclerosis: Focusing on exosomes. European Journal of Pharmaceutical Sciences 2024; 193 doi: 10.1016/j.ejps.2024.106690
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| 19 |
Elena Grossini, Mohammad Mostafa Ola Pour, Sakthipriyan Venkatesan. The Role of Extracellular Vesicles in the Pathogenesis of Metabolic Dysfunction-Associated Steatotic Liver Disease and Other Liver Diseases. International Journal of Molecular Sciences 2025; 26(11) doi: 10.3390/ijms26115033
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| 20 |
Ruichao Lan, Jun Lin, Shuai Chen, Zhi Lu, Yihang Gong, Siwei Tan, Xianzhi Liu, Weiling He. Communication initiated by hepatocytes: The driver of HSC activation and liver fibrosis. Hepatology Communications 2025; 9(8) doi: 10.1097/HC9.0000000000000753
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| 21 |
Yadi Wang, Liangliang Wu, Zhaozhi Li, Panfeng Huang, Yin Luo, Zhezhen Liao, Jiaoyang Li, Xiao Jiang, Jin Zhu, Shuyan Li, Li Ran, Fei Yang, Jianghua Liu, Yan Lu, Xinhua Xiao. Palmitoylation-mediated exosomal trafficking of nuclear protein NAT10 potentiates liver fibrosis in MASH. Hepatology 2026; doi: 10.1097/HEP.0000000000001785
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| 22 |
Bootsakorn Boonkaew, Nantawat Satthawiwat, Bianca C. Pachane, Lucy M. Brett, Pisit Tangkijvanich, Chaiyaboot Ariyachet. Palmitic acid reduces LDLR-dependent uptake of macrophage-derived extracellular vesicles by hepatoma cells. Non-coding RNA Research 2025; 13 doi: 10.1016/j.ncrna.2025.04.007
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| 23 |
Marwa Matboli, Shaimaa Hamady, Maha Saad, Radwa Khaled, Abdelrahman Khaled, Eman MF. Barakat, Sayed Ahmed Sayed, SaraH.A. Agwa, Ibrahim Youssef. Innovative approaches to metabolic dysfunction-associated steatohepatitis diagnosis and stratification. Non-coding RNA Research 2025; 10 doi: 10.1016/j.ncrna.2024.10.002
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| 24 |
Xiaojie Hu, Qinglin Ge, Yunting Zhang, Bowen Li, Erli Cheng, Yinghong Wang, Yan Huang. A review of the effect of exosomes from different cells on liver fibrosis. Biomedicine & Pharmacotherapy 2023; 161 doi: 10.1016/j.biopha.2023.114415
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| 25 |
Youli Yao, Da Chen, Zengchang Yue. The regulatory role and mechanism of exosomes in hepatic fibrosis. Frontiers in Pharmacology 2023; 14 doi: 10.3389/fphar.2023.1284742
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| 26 |
Joonyub Lee, Won Gun Choi, Marie Rhee, Seung-Hwan Lee. Extracellular Vesicle-Mediated Network in the Pathogenesis of Obesity, Diabetes, Steatotic Liver Disease, and Cardiovascular Disease. Diabetes & Metabolism Journal 2025; 49(3) doi: 10.4093/dmj.2025.0184
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| 27 |
Qing-Yuan Li, Tao Gong, Yi-Ke Huang, Lan Kang, Charlotte A Warner, He Xie, Li-Min Chen, Xiao-Qiong Duan. Role of noncoding RNAs in liver fibrosis. World Journal of Gastroenterology 2023; 29(9): 1446-1459 doi: 10.3748/wjg.v29.i9.1446
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| 28 |
Huiyan Zuo, Xiuqing Huang, Xuelin Sun, Yong Man, Fangzhi Xu, Tao Shen, Jian Li, Lin Dou. Exosomes Derived From Bone Marrow Macrophages of HFD‐Fed Mice Regulating AKT/GSK Pathway in Hepatocytes via miR‐222‐5p. The FASEB Journal 2026; 40(1) doi: 10.1096/fj.202501513RR
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| 29 |
Wei Jiang, Youhui Xu, Jou-Chen Chen, Yi-Hung Lee, Yushin Hu, Chang-Hai Liu, Enqiang Chen, Hong Tang, Hua Zhang, Dongbo Wu. Role of extracellular vesicles in nonalcoholic fatty liver disease. Frontiers in Endocrinology 2023; 14 doi: 10.3389/fendo.2023.1196831
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| 30 |
Jing Li, Jingwen Fang, Xiaohong Jiang, Yujing Zhang, Antonio Vidal-Puig, Chen-Yu Zhang. RNAkines are secreted messengers shaping health and disease. Trends in Endocrinology & Metabolism 2024; 35(3) doi: 10.1016/j.tem.2023.12.004
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| 31 |
Agata Wawrzkiewicz-Jałowiecka, Anna Lalik, Agnieszka Lukasiak, Monika Richter-Laskowska, Paulina Trybek, Maciej Ejfler, Maciej Opałka, Sonia Wardejn, Domenico V. Delfino. Potassium Channels, Glucose Metabolism and Glycosylation in Cancer Cells. International Journal of Molecular Sciences 2023; 24(9) doi: 10.3390/ijms24097942
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| 32 |
Andrea Barrientos-Riosalido, Monica Real, Laia Bertran, Carmen Aguilar, Salomé Martínez, David Parada, Margarita Vives, Fàtima Sabench, David Riesco, Daniel Del Castillo, Cristóbal Richart, Teresa Auguet. Increased Hepatic ATG7 mRNA and ATG7 Protein Expression in Nonalcoholic Steatohepatitis Associated with Obesity. International Journal of Molecular Sciences 2023; 24(2) doi: 10.3390/ijms24021324
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| 33 |
Shihui Li, Fuji Yang, Fang Cheng, Ling Zhu, Yongmin Yan. Lipotoxic hepatocyte derived LIMA1 enriched small extracellular vesicles promote hepatic stellate cells activation via inhibiting mitophagy. Cellular & Molecular Biology Letters 2024; 29(1) doi: 10.1186/s11658-024-00596-4
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| 34 |
Xiang Liu, Jiazichao Tu, Ziqin Zhou, Bingxin Huang, Jianrong Zhou, Jimei Chen, Jianqin Wei. TMAO-Activated Hepatocyte-Derived Exosomes Are Widely Distributed in Mice with Different Patterns and Promote Vascular Inflammation. Cardiology Research and Practice 2022; 2022 doi: 10.1155/2022/5166302
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| 35 |
Yufei Liu, Yuhong Zheng, Yang Yang, Ke Liu, Jianying Wu, Peiyang Gao, Chuantao Zhang. Exosomes in liver fibrosis: The role of modulating hepatic stellate cells and immune cells, and prospects for clinical applications. Frontiers in Immunology 2023; 14 doi: 10.3389/fimmu.2023.1133297
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| 36 |
Bootsakorn Boonkaew, Denita Charoenthanakitkul, Nuchanart Suntornnont, Chaiyaboot Ariyachet, Pisit Tangkijvanich. Extracellular vesicles in metabolic dysfunction-associated steatotic liver disease: From intercellular signaling to clinical translation. World Journal of Hepatology 2025; 17(9): 108259 doi: 10.4254/wjh.v17.i9.108259
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| 37 |
Ali Mahmoudi, Alexandra E. Butler, Tannaz Jamialahmadi, Amirhossein Sahebkar. The role of exosomal miRNA in nonalcoholic fatty liver disease. Journal of Cellular Physiology 2022; 237(4) doi: 10.1002/jcp.30699
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| 38 |
Tanghua Li, Jiapeng Jiao, Haoteng Ke, Wenshan Ouyang, Luobin Wang, Jin Pan, Xin Li. Role of exosomes in the development of the immune microenvironment in hepatocellular carcinoma. Frontiers in Immunology 2023; 14 doi: 10.3389/fimmu.2023.1200201
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| 39 |
Junbin Chen, Yudi Ding, Ke Zhang, Qingjun Guo, Zenghui Qin, Jiexian Wang, Huiyu Luo, Longying Zha. Steatotic hepatocyte-derived exosomes increase free fatty acids uptake by transporting miR-122-5p to target ATP6V1H-mediated CD36 translocation in hepatocytes. Clinical Science 2026; 140(7) doi: 10.1042/CS20261179
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| 40 |
Yunsheng Dong, Lei Xiong, Nina Zhu, Zihan Wang, Hanqi Xia, Chen Cheng, Jianshang Huang, Yiran Han, Abduxukur Rahman, Junhao Zhao, Chonggui Jiang, Li Zuo, Hua Wang. Extracellular Vesicles in Nonalcoholic Fatty Liver Disease: Mechanisms and Therapeutic Opportunities. iNew Medicine 2025; 1(1) doi: 10.1002/inm3.3
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| 41 |
Xinyi Zhao, Junyan Zhu, Tianyi Zhang, Wenrong Xu, Hui Qian. Extracellular Vesicles in Liver Fibrosis: Pathogenic Messengers, Diagnostic Biomarkers, and Therapeutic Nanovectors. Pharmaceutics 2026; 18(2) doi: 10.3390/pharmaceutics18020230
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| 42 |
Maria Teresa Koenen, Elisa Fabiana Brandt, Dawid Marcin Kaczor, Tim Caspers, Alexandra Catharina Anna Heinzmann, Petra Fischer, Daniel Heinrichs, Theresa Hildegard Wirtz, Christian Trautwein, Rory R Koenen, Marie-Luise Berres. Extracellular Vesicles from Steatotic Hepatocytes Provoke Pro-Fibrotic Responses in Cultured Stellate Cells. Biomolecules 2022; 12(5) doi: 10.3390/biom12050698
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| 43 |
Zihan Wang, Zixuan Cao, Yunsheng Dong, Yi Hong, Li Zuo, Hua Wang. Hepatocyte–hepatic stellate cell interactions in liver fibrosis: Mechanisms and therapeutic implications. Hepatology Communications 2026; 10(2) doi: 10.1097/HC9.0000000000000893
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| 44 |
Chanbin Lee, Jinsol Han, Youngmi Jung. Pathological Contribution of Extracellular Vesicles and Their MicroRNAs to Progression of Chronic Liver Disease. Biology 2022; 11(5) doi: 10.3390/biology11050637
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| 45 |
Jin-Mei Yao, Hua-Zhong Ying, Huan-Huan Zhang, Fen-Sheng Qiu, Jun-Qi Wu, Chen-Huan Yu. Exosomal RBP4 potentiated hepatic lipid accumulation and inflammation in high-fat-diet-fed mice by promoting M1 polarization of Kupffer cells. Free Radical Biology and Medicine 2023; 195 doi: 10.1016/j.freeradbiomed.2022.12.085
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| 46 |
Shahin Alizadeh-Fanalou, Mohsen Khosravi, Fatemeh Alian, Shirin Rokhsartalb-Azar, Ali Nazarizadeh, Maryam Karimi-Dehkordi, Forogh Mohammadi. Dual role of microRNA-1297 in the suppression and progression of human malignancies. Biomedicine & Pharmacotherapy 2021; 141 doi: 10.1016/j.biopha.2021.111863
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| 47 |
Le Li, Zhijun Zhu. Pharmacological modulation of ferroptosis as a therapeutic target for liver fibrosis. Frontiers in Pharmacology 2023; 13 doi: 10.3389/fphar.2022.1071844
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| 48 |
Yu Lei, Mei Liu, Xiang Tao. Extracellular Vesicles: Orchestrators of Intrahepatic and Systemic Crosstalk in Metabolic Dysfunction-Associated Steatotic Liver Disease. Pharmaceutics 2026; 18(1) doi: 10.3390/pharmaceutics18010116
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| 49 |
Sinéad M Mullin, Aidan J Kelly, Méabh B Ní Chathail, Suzanne Norris, Christopher E Shannon, Helen M Roche. Macronutrient Modulation in Metabolic Dysfunction-Associated Steatotic Liver Disease—the Molecular Role of Fatty Acids compared with Sugars in Human Metabolism and Disease Progression. Advances in Nutrition 2025; 16(3) doi: 10.1016/j.advnut.2025.100375
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| 50 |
Zihui Yu, Rong Zhou, Shunyong He. miR-885-5p regulates fibrogenic phenotypes in TGF-β1-treated LX-2 cells via targeting NR5A2, with clinical association with MAFLD. Archives of Biochemistry and Biophysics 2026; doi: 10.1016/j.abb.2026.111017
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| 51 |
Chun-Liang Chen, Yu-Cheng Lin. Autophagy Dysregulation in Metabolic Associated Fatty Liver Disease: A New Therapeutic Target. International Journal of Molecular Sciences 2022; 23(17) doi: 10.3390/ijms231710055
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| 52 |
Qingfu Dong, Haolin Bao, Jiangang Wang, Wujiang Shi, Xinlei Zou, Jialin Sheng, Jianjun Gao, Canghai Guan, Haoming Xia, Jinglin Li, Pengcheng Kang, Yi Xu, Yunfu Cui, Xiangyu Zhong. Liver fibrosis and MAFLD: the exploration of multi-drug combination therapy strategies. Frontiers in Medicine 2023; 10 doi: 10.3389/fmed.2023.1120621
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| 53 |
Xiaoyan Qi, Jinping Lai. Exosomal microRNAs and Progression of Nonalcoholic Steatohepatitis (NASH). International Journal of Molecular Sciences 2022; 23(21) doi: 10.3390/ijms232113501
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| 54 |
Jun Yang, Xiaolei Tang, Liang Chen, Junjie Hu, Shan Li, Ming Yuan, Xianxiang Tian, Zhenpeng Qiu. Liver-derived Exosomal miRNA in NAFLD: Mechanisms of Action, Biomarkers, and Therapeutic Applications. Current Medicinal Chemistry 2025; 32(18) doi: 10.2174/0109298673276581231210170332
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| 55 |
Ji Sun, Dianbao Zhang, Yiling Li. Extracellular Vesicles in Pathogenesis and Treatment of Metabolic Associated Fatty Liver Disease. Frontiers in Physiology 2022; 13 doi: 10.3389/fphys.2022.909518
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| 56 |
Shihui Li, Fang Cheng, Zhuan Zhang, Ruizi Xu, Honglei Shi, Yongmin Yan. The role of hepatocyte-derived extracellular vesicles in liver and extrahepatic diseases. Biomedicine & Pharmacotherapy 2024; 180 doi: 10.1016/j.biopha.2024.117502
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| 57 |
Shi-Lin Cheng, Jun Hao, Hong-Yan Qin. Role of miRNA signalling in the pathogenesis of MASLD. Frontiers in Pharmacology 2026; 17 doi: 10.3389/fphar.2026.1756805
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| 58 |
Hongjian Lu, Ronghua Zhang, Shukun Zhang, Yufeng Li, Yankun Liu, Yanan Xiong, Xiaohan Yu, Tao Lan, Xin Li, Meimei Wang, Zhiyong Liu, Guangling Zhang, Jingwu Li, Shuang Chen. HSC-derived exosomal miR-199a-5p promotes HSC activation and hepatocyte EMT via targeting SIRT1 in hepatic fibrosis. International Immunopharmacology 2023; 124 doi: 10.1016/j.intimp.2023.111002
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| 59 |
Martí Ortega-Ribera, Mrigya Babuta, Gyongyi Szabo. Sinusoidal Cells in Liver Diseases. 2024; doi: 10.1016/B978-0-323-95262-0.00002-4
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| 60 |
Jiehao Chen, Jing Li, Xin Yin, Zheng Fu, Xi Chen, Chen-Yu Zhang. EV-encapsulated extracellular microRNAs as orchestrators of systemic communication in immunity and inflammation. Immunity & Inflammation 2026; 2(1) doi: 10.1007/s44466-026-00042-4
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| 61 |
Zhiping Wan, Xiaoan Yang, Xiaoquan Liu, Yinfang Sun, Piaojian Yu, Fen Xu, Hong Deng. M2 macrophage-derived exosomal microRNA-411-5p impedes the activation of hepatic stellate cells by targeting CAMSAP1 in NASH model. iScience 2022; 25(7) doi: 10.1016/j.isci.2022.104597
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| 62 |
Genevieve Schwarz, Xuechen Ren, Wen Xie, Haitao Guo, Yong Jiang, Jinyu Zhang. Engineered exosomes: a promising drug delivery platform with therapeutic potential. Frontiers in Molecular Biosciences 2025; 12 doi: 10.3389/fmolb.2025.1583992
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