| For: | Wang ZF, Ma DG, Zhu Z, Mu YP, Yang YY, Feng L, Yang H, Liang JQ, Liu YY, Liu L, Lu HW. Astragaloside IV inhibits pathological functions of gastric cancer-associated fibroblasts. World J Gastroenterol 2017; 23(48): 8512-8525 [PMID: 29358859 DOI: 10.3748/wjg.v23.i48.8512] |
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| URL: | https://www.wjgnet.com/1007-9327/full/v23/i48/8512.htm |
| Number | Citing Articles |
| 1 |
Ling Shen, Yuancheng Li, Guiying Hu, Xinli Song, Xiaoshuang Wang, Xiaoqi Li, Xiaoyuan Xu. Astragaloside IV suppresses the migration and EMT progression of cervical cancer cells by inhibiting macrophage M2 polarization through TGFβ/Smad2/3 signaling. Functional & Integrative Genomics 2023; 23(2) doi: 10.1007/s10142-023-01017-z
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| 2 |
Heng Zou, Yanli Li, Xiaomin Liu, Zong Wu, Jingjing Li, Zhongliang Ma. Roles of plant‐derived bioactive compounds and relatedmicroRNAsin cancer therapy. Phytotherapy Research 2021; 35(3) doi: 10.1002/ptr.6883
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| 3 |
Fanglong Wu, Jin Yang, Junjiang Liu, Ye Wang, Jingtian Mu, Qingxiang Zeng, Shuzhi Deng, Hongmei Zhou. Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer. Signal Transduction and Targeted Therapy 2021; 6(1) doi: 10.1038/s41392-021-00641-0
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| 4 |
Zhenhua Cui, Qingxin Shang. Mechanistic insights into the antitumor effects of astragaloside IV and astragalus polysaccharide in digestive system cancers. Frontiers in Pharmacology 2025; 16 doi: 10.3389/fphar.2025.1691011
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| 5 |
Liangxing Zhou, Mengpeng Li, Zhengbin Chai, Junli Zhang, Kuan Cao, Lei Deng, Yanming Liu, Cun Jiao, Gang-Ming Zou, Jibiao Wu, Fabin Han. Anticancer effects and mechanisms of astragaloside‑IV (Review). Oncology Reports 2022; 49(1) doi: 10.3892/or.2022.8442
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| 6 |
Liangjun Yang, Wei Liu, Zhipeng Hu, Maoyi Yang, Jiali Li, Xiangzhen Fan, Huafeng Pan. A Systems Pharmacology Approach for Identifying the Multiple Mechanisms of Action of the Wei Pi Xiao Decoction for the Treatment of Gastric Precancerous Lesions. Evidence-Based Complementary and Alternative Medicine 2019; 2019 doi: 10.1155/2019/1562707
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| 7 |
Sudharma Banerjee, Stella Nau, Steven N. Hochwald, Huisheng Xie, Jianliang Zhang. Anticancer properties and mechanisms of botanical derivatives. Phytomedicine Plus 2023; 3(1) doi: 10.1016/j.phyplu.2022.100396
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| 8 |
Kaidi Fan, Xu Lian, Weicong Zhang, Xuemei Qin, Yuetao Liu. Riboflavin metabolism involved into comparison of therapeutic action of wild-simulated and transplanted Astragali Radix to treat chronic atrophic gastritis rats based on endogenous-xenobiotics metabolism. Chinese Herbal Medicines 2025; 17(3) doi: 10.1016/j.chmed.2025.03.006
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| 9 |
Tianyi Zhang, Qinchang Zhang, Shunji Liu, Lisha Zhou, Haibo Cheng, Dongdong Sun, Yang Sun. Reprogramming Cancer-associated Fibroblast: the Emerging Role of Traditional Chinese Medicine. Cancer Bioscience 2026; doi: 10.1016/j.cbs.2026.100003
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| 10 |
Feiya Sheng, Siyu Yang, Mi Li, Jiaojiao Wang, Lianghong Liu, Lele Zhang. Research Progress on the Anti-Cancer Effects of Astragalus membranaceus Saponins and Their Mechanisms of Action. Molecules 2024; 29(14) doi: 10.3390/molecules29143388
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| 11 |
Yuanda Liu, Changfeng Li, Yaoping Lu, Chang Liu, Wei Yang. Tumor microenvironment-mediated immune tolerance in development and treatment of gastric cancer. Frontiers in Immunology 2022; 13 doi: 10.3389/fimmu.2022.1016817
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| 12 |
Rujing Chen, Leaf Huang, Kaili Hu. Natural products remodel cancer-associated fibroblasts in desmoplastic tumors. Acta Pharmaceutica Sinica B 2020; 10(11) doi: 10.1016/j.apsb.2020.04.005
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| 13 |
Xiao Hua Li, Jae Kwang Kim, Sang Un Park. Heterologous Expression of Three Transcription Factors Differently Regulated Astragalosides Metabolic Biosynthesis in Astragalus membranaceus Hairy Roots. Plants 2022; 11(14) doi: 10.3390/plants11141897
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| 14 |
Yash Chhabra, Ashani T. Weeraratna. Fibroblasts in cancer: Unity in heterogeneity. Cell 2023; 186(8) doi: 10.1016/j.cell.2023.03.016
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| 15 |
Dan Liang, Lu Liu, Yunjie Zhao, Zhenyi Luo, Yadi He, Yanping Li, Shiyun Tang, Jianyuan Tang, Nianzhi Chen. Targeting extracellular matrix through phytochemicals: a promising approach of multi-step actions on the treatment and prevention of cancer. Frontiers in Pharmacology 2023; 14 doi: 10.3389/fphar.2023.1186712
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| 16 |
Ying Yang, Wen-Jian Meng, Zi-Qiang Wang. Cancer Stem Cells and the Tumor Microenvironment in Gastric Cancer. Frontiers in Oncology 2022; 11 doi: 10.3389/fonc.2021.803974
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| 17 |
Zhiyuan Li, Jinfeng Qi, Tiankang Guo, Junliang Li. Research progress of Astragalus membranaceus in treating peritoneal metastatic cancer. Journal of Ethnopharmacology 2023; 305 doi: 10.1016/j.jep.2022.116086
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| 18 |
Alexandru A. Sabo, Maria Dudau, George L. Constantin, Tudor C. Pop, Christoph-M. Geilfus, Alessio Naccarati, Mihnea P. Dragomir. Two Worlds Colliding: The Interplay Between Natural Compounds and Non-Coding Transcripts in Cancer Therapy. Frontiers in Pharmacology 2021; 12 doi: 10.3389/fphar.2021.652074
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| 19 |
Plant bioactive compounds driven microRNAs (miRNAs): A potential source and novel strategy targeting gene and cancer therapeutics. Non-coding RNA Research 2024; 9(4) doi: 10.1016/j.ncrna.2024.06.003
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| 20 |
Zhen-fei Wang, Da-guang Ma, Ling Wang, Li Feng, Jian-wei Fu, Ying Li, Dan-ting Wang, Yong-feng Jia. Paeoniflorin Inhibits Migration- and Invasion-Promoting Capacities of Gastric Cancer Associated Fibroblasts. Chinese Journal of Integrative Medicine 2019; 25(11) doi: 10.1007/s11655-018-2985-3
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| 21 |
Bulent B. Altunkeser, Abdullah Tuncez, Bahadir Ozturk, Huseyin Tezcan, Muhammet S. Ates, Canan Yilmaz, Muhammed U. Yalcin, Nazif Aygul, Kenan Demir. Comparative effects of high-dose atorvastatin versus rosuvastatin on lipid parameters, oxidized low-density lipoprotein, and proprotein convertase subtilisin kexin 9 in acute coronary syndrome. Coronary Artery Disease 2019; 30(4) doi: 10.1097/MCA.0000000000000715
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| 22 |
Wei Liu, Han Chen, Dongsheng Wang. Protective role of astragaloside IV in gastric cancer through regulation of microRNA-195-5p-mediated PD-L1. Immunopharmacology and Immunotoxicology 2021; 43(4) doi: 10.1080/08923973.2021.1936013
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| 23 |
Xue Wang, ShouYang Gao, LiYou Song, Ming Liu, ZiQian Sun, JunBao Liu. Astragaloside IV antagonizes M2 phenotype macrophage polarization-evoked ovarian cancer cell malignant progression by suppressing the HMGB1–TLR4 axis. Molecular Immunology 2021; 130 doi: 10.1016/j.molimm.2020.11.014
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| 24 |
Xiao Lei, Bo-da Zhang, Ji-gang Ren, Fang-li Luo. Astragaloside suppresses apoptosis of the podocytes in rats with diabetic nephropathy via miR-378/TRAF5 signaling pathway. Life Sciences 2018; 206 doi: 10.1016/j.lfs.2018.05.037
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| 25 |
Peiyuan Li, Huan Zhang, Tao Chen, Yajing Zhou, Jiaoyang Yang, Jin Zhou. Cancer-associated fibroblasts promote proliferation, angiogenesis, metastasis and immunosuppression in gastric cancer. Matrix Biology 2024; 132 doi: 10.1016/j.matbio.2024.06.004
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| 26 |
J.J. Tibenda, Y. Du, Y. Nan, S. Huang, G. Chen, N. Ning, X. Li, Y. Yang, L. Yuan. Astragalus Mongholicus: A Review of its Pharmacological Mechanisms Against Gastric Cancer. Journal of Herbal Medicine 2024; 45 doi: 10.1016/j.hermed.2024.100881
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| 27 |
Lili Li, Qin Wang, Yinghao He, Liangjie Sun, Yan Yang, Xiaonan Pang. Astragaloside IV suppresses migration and invasion of TGF-β1-induced human hepatoma HuH-7 cells by regulating Nrf2/HO-1 and TGF-β1/Smad3 pathways. Naunyn-Schmiedeberg's Archives of Pharmacology 2022; 395(4) doi: 10.1007/s00210-021-02199-8
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| 28 |
Yan Yang, Yue Cheng, Yanfei Mu, Xianjun Tang, Xiaosong Mu. Lentinan inhibits cell invasion via M2 polarization of tumor‐associated macrophages and Wnt/β‐catenin signaling in non‐small cell lung cancer. Chemical Biology & Drug Design 2024; 103(3) doi: 10.1111/cbdd.14507
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| 29 |
Haibo Liu, Shicheng Luo, Xiaofeng Sha, Zhiping Chen, Dongdong Yang. Astragaloside IV inhibits pathological functions of gastric cancer-associated fibroblasts through regulation of the HOXA6/ZBTB12 axis. Acta Pharmaceutica 2023; 73(3) doi: 10.2478/acph-2023-0033
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| 30 |
Ruixi Zhou, Tiankang Guo, Junliang Li. Research progress on the antitumor effects of astragaloside IV. European Journal of Pharmacology 2023; 938 doi: 10.1016/j.ejphar.2022.175449
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| 31 |
Kuan-Jung Chiu, Hsin-Ying Clair Chiou, Chi-Han Huang, Pin-Chun Lu, Hui-Ru Kuo, Jiunn-Wei Wang, Ming-Hong Lin. Natural Compounds Targeting Cancer-Associated Fibroblasts against Digestive System Tumor Progression: Therapeutic Insights. Biomedicines 2022; 10(3) doi: 10.3390/biomedicines10030713
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| 32 |
Chao Hu, Qiong Li, Song-Nan Gong, Xiao-Jie Zou, Jia-Yue Xu, Hai-Feng Ying, Lan Zheng. Astragaloside IV: a potential nemesis for gastric cancer. Frontiers in Pharmacology 2025; 16 doi: 10.3389/fphar.2025.1636341
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| 33 |
万理 吉. Research Progress on TCM Treatment of Gastric Cancer Microenvironment. Traditional Chinese Medicine 2024; 13(01) doi: 10.12677/TCM.2024.131025
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| 34 |
Sonali Sahoo, Ananya Kashyap, Dillip Kumar Muduly, Sanjeeb Kumar Sahoo. Phytonanomedicine: An Assessment of Therapeutic Relevance in Cancer Through Targeting Cancer‐Associated Fibroblast in Tumor Microenvironment. Phytotherapy Research 2026; 40(3) doi: 10.1002/ptr.70194
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| 35 |
Ziqi Yan, Hongming Zheng, Jieni Feng, Yiting Li, Zhifan Hu, Yuan Wu, Guibin Liao, Taosheng Miao, Zexin Qiu, Qiaolan Mo, Jia Li, Ailin Lai, Yue Lu, Bin Chen. Causal links between circulatory inflammatory cytokines and risk of digestive polyps: a Mendelian randomization analysis. Frontiers in Pharmacology 2024; 15 doi: 10.3389/fphar.2024.1405503
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| 36 |
In-Hye Ham, Dagyeong Lee, Hoon Hur. Role of Cancer-Associated Fibroblast in Gastric Cancer Progression and Resistance to Treatments. Journal of Oncology 2019; 2019 doi: 10.1155/2019/6270784
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| 37 |
Vittoria Graziani, Monica Scognamiglio, Assunta Esposito, Antonio Fiorentino, Brigida D’Abrosca. Chemical diversity and biological activities of the saponins isolated from Astragalus genus: focus on Astragaloside IV. Phytochemistry Reviews 2019; 18(4) doi: 10.1007/s11101-019-09626-y
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| 38 |
Tianlong Liu, Fan Yang, Jing Liu, Mingjie Zhang, Jianjun Sun, Yunfeng Xiao, Zhibin Xiao, Haiyan Niu, Ruilian Ma, Yi Wang, Xiaolei Liu, Yu Dong. Astragaloside IV reduces cardiomyocyte apoptosis in a murine model of coxsackievirus B3-induced viral myocarditis. Experimental Animals 2019; 68(4) doi: 10.1538/expanim.19-0037
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| 39 |
Ye Li, Longyun Wang, Wenzhe Ma, Jibiao Wu, Qibiao Wu, Changgang Sun. Paracrine signaling in cancer-associated fibroblasts: central regulators of the tumor immune microenvironment. Journal of Translational Medicine 2025; 23(1) doi: 10.1186/s12967-025-06744-4
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| 40 |
Biju Balakrishnan, Qi Liang, Kevin Fenix, Bunu Tamang, Ehud Hauben, Linlin Ma, Wei Zhang. Combining the Anticancer and Immunomodulatory Effects of Astragalus and Shiitake as an Integrated Therapeutic Approach. Nutrients 2021; 13(8) doi: 10.3390/nu13082564
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| 41 |
Dandan Gao, Liguang Fang, Cun Liu, Mengrui Yang, Xiaoyun Yu, Longyun Wang, Wenfeng Zhang, Changgang Sun, Jing Zhuang. Microenvironmental regulation in tumor progression: Interactions between cancer-associated fibroblasts and immune cells. Biomedicine & Pharmacotherapy 2023; 167 doi: 10.1016/j.biopha.2023.115622
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| 42 |
Chencong Zhou, Kaihan Wu, Meng Gu, Yushang Yang, Jiatao Tu, Xuan Huang. Reversal of chemotherapy resistance in gastric cancer with traditional Chinese medicine as sensitizer: potential mechanism of action. Frontiers in Oncology 2025; 15 doi: 10.3389/fonc.2025.1524182
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| 43 |
Yanyang Liu, Xuefei Yu, Huize Shen, Yangjian Hong, Gaofeng Hu, Wenyuan Niu, Jiaming Ge, Jie Xuan, Jiang-Jiang Qin, Qinglin Li. Mechanisms of traditional Chinese medicine in the treatment and prevention of gastric cancer. Phytomedicine 2024; 135 doi: 10.1016/j.phymed.2024.156003
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| 44 |
Rana M. Alsaffar, Shafat Ali, Summya Rashid, Shahzada Mudasir Rashid, Sabhiya Majid, Muneeb U. Rehman. Immunomodulation: An immune regulatory mechanism in carcinoma therapeutics. International Immunopharmacology 2021; 99 doi: 10.1016/j.intimp.2021.107984
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| 45 |
Zhipeng Cao, Zhilin Wang, Li Yang, Tian Li, Xueshu Tao, Xing Niu. Reshaping the immune microenvironment and reversing immunosenescence by natural products: Prospects for immunotherapy in gastric cancer. Seminars in Cancer Biology 2025; 110 doi: 10.1016/j.semcancer.2025.02.002
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| 46 |
Wenhao Liao, Jing Wang, Yuchen Li. Natural products based on Correa's cascade for the treatment of gastric cancer trilogy: Current status and future perspective. Journal of Pharmaceutical Analysis 2025; 15(2) doi: 10.1016/j.jpha.2024.101075
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| 47 |
Zhiyang Zhou, Sixuan Guo, Shuhui Lai, Tao Wang, Yao Du, Junping Deng, Shun Zhang, Ge Gao, Jiangnan Zhang. Integrated single-cell and bulk RNA sequencing analysis identifies a cancer-associated fibroblast-related gene signature for predicting survival and therapy in gastric cancer. BMC Cancer 2023; 23(1) doi: 10.1186/s12885-022-10332-w
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| 48 |
XingHui Zhu, ShuJie Wang, Lie Xie, DongMei Chen, MingRui Zhao, XiaoMing Liu, ZhiChao Fan, CiSong Cheng. Application of Traditional Chinese Medicine in Inhibiting the PD-1/PD-L1 Pathway in the Treatment of Gastric and Colon Cancers. Natural Product Communications 2024; 19(6) doi: 10.1177/1934578X241258914
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