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For: Dong S, Zhan ZY, Cao HY, Wu C, Bian YQ, Li JY, Cheng GH, Liu P, Sun MY. Urinary metabolomics analysis identifies key biomarkers of different stages of nonalcoholic fatty liver disease. World J Gastroenterol 2017; 23(15): 2771-2784 [PMID: 28487615 DOI: 10.3748/wjg.v23.i15.2771]
URL: https://www.wjgnet.com/1007-9327/full/v23/i15/2771.htm
Number Citing Articles
1
En Ying Tan, Mark D. Muthiah, Arun J. Sanyal. Metabolomics at the cutting edge of risk prediction of MASLD. Cell Reports Medicine 2024; 5(12) doi: 10.1016/j.xcrm.2024.101853
2
Kara Wegermann, Catherine Howe, Ricardo Henao, Ying Wang, Cynthia D. Guy, Manal F. Abdelmalek, Anna Mae Diehl, Cynthia A. Moylan. Serum Bile Acid, Vitamin E, and Serotonin Metabolites Are Associated With Future Liver‐Related Events in Nonalcoholic Fatty Liver Disease. Hepatology Communications 2021; 5(4) doi: 10.1002/hep4.1665
3
Shumin Zhan, Xuelian Zhou, Junfen Fu. Noninvasive Urinary Biomarkers for Obesity-Related Metabolic Diseases: Diagnostic Applications and Future Directions. Biomolecules 2025; 15(5) doi: 10.3390/biom15050633
4
Xuechun Liu, Lei Han, Shenghua Bi, Xueli Ding, Qi Sheng, Yueping Jiang, Ge Guan, Qinghui Niu, Xue Jing. Differential metabolites in cirrhotic patients with hepatitis B and muscle mass loss. Frontiers in Nutrition 2023; 10 doi: 10.3389/fnut.2023.1068779
5
Rui Su, Hui-Ling Fu, Qian-Xue Zhang, Chen-Yan Wu, Guan-Yu Yang, Jun-Jie Wu, Wen-Jie Cao, Jin Liu, Zhong-Ping Jiang, Cong-Jun Xu, Yong Rao, Ling Huang. Amplifying hepatic L-aspartate levels suppresses CCl4-induced liver fibrosis by reversing glucocorticoid receptor β-mediated mitochondrial malfunction. Pharmacological Research 2024; 206 doi: 10.1016/j.phrs.2024.107294
6
Lucia Carulli, Giulia Zanca, Filippo Schepis, Erica Villa. RETRACTED: The OMICs Window into Nonalcoholic Fatty Liver Disease (NAFLD). Metabolites 2019; 9(2) doi: 10.3390/metabo9020025
7
Ying Zhu, Qingce Zang, Zhigang Luo, Jiuming He, Ruiping Zhang, Zeper Abliz. An Organ-Specific Metabolite Annotation Approach for Ambient Mass Spectrometry Imaging Reveals Spatial Metabolic Alterations of a Whole Mouse Body. Analytical Chemistry 2022; 94(20) doi: 10.1021/acs.analchem.2c00557
8
Cynthia X. Hou, Amelia Brasnett, Patrick Rabe, Christopher J. Schofield, Lennart Brewitz. Structural and functional consequences of aspartate/asparagine-β-hydroxylase variants causing Traboulsi syndrome. Journal of Biological Chemistry 2026; 302(2) doi: 10.1016/j.jbc.2025.111008
9
Dragana Savic, Leanne Hodson, Stefan Neubauer, Michael Pavlides. The Importance of the Fatty Acid Transporter L-Carnitine in Non-Alcoholic Fatty Liver Disease (NAFLD). Nutrients 2020; 12(8) doi: 10.3390/nu12082178
10
Sean P. Kilroe, Zachary D. Von Ruff, Emily J. Arentson-Lantz, Trevor B. Romsdahl, Jennifer J. Linares, Hanna Kalenta, Erik D. Marchant, Elena Volpi, Douglas Paddon-Jones, William K. Russell, Blake B. Rasmussen. Human skeletal muscle disuse atrophy has profound and negative effects on the muscle metabolome and lipidome. American Journal of Physiology-Endocrinology and Metabolism 2025; 328(6) doi: 10.1152/ajpendo.00012.2025
11
Tao Tang, Ya Li, Jie Wang, Mauricio A. Elzo, Jiahao Shao, Yanhong Li, Siqi Xia, Huimei Fan, Xianbo Jia, Songjia Lai. Untargeted Metabolomics Reveals Intestinal Pathogenesis and Self-Repair in Rabbits Fed an Antibiotic-Free Diet. Animals 2021; 11(6) doi: 10.3390/ani11061560
12
Xuemei Wang, Benchen Rao, Haiyu Wang, Chao Liu, Zhigang Ren, Zujiang Yu. Serum metabolome alterations in patients with early nonalcoholic fatty liver disease. Bioscience Reports 2022; 42(10) doi: 10.1042/BSR20220319
13
Abraham Joseph Pellissery, Poonam Gopika Vinayamohan, Leya Susan Viju, Divya Joseph, Kumar Venkitanarayanan. Advances and Challenges in Urine Laboratory Analysis. 2024;  doi: 10.5772/intechopen.109808
14
Runbin Sun, Haokai Zhao, Shuzhen Huang, Ran Zhang, Zhenyao Lu, Sijia Li, Guangji Wang, Jiye Aa, Yuan Xie. Prediction of Liver Weight Recovery by an Integrated Metabolomics and Machine Learning Approach After 2/3 Partial Hepatectomy. Frontiers in Pharmacology 2021; 12 doi: 10.3389/fphar.2021.760474
15
Xuehua Yan, Hongbing Liu, Meng Huang, Yujie Zhang, Binfang Zeng. Integrative proteomics and metabolomics explore the effect and mechanism of Qiyin granules on improving nonalcoholic fatty liver disease. Heliyon 2024; 10(5) doi: 10.1016/j.heliyon.2024.e27075
16
Application of Metabolomics in Diagnosis and Treatment of Chronic Liver Diseases. Critical Reviews in Analytical Chemistry 2022; 52(5) doi: 10.1080/10408347.2020.1842172
17
George V. Dedoussis, Athina I. Amanatidou. NAFLD and NASH. 2020;  doi: 10.1007/978-3-030-37173-9_10
18
Lili Niu, Karolina Sulek, Catherine G. Vasilopoulou, Alberto Santos, Nicolai J. Wewer Albrechtsen, Simon Rasmussen, Florian Meier, Matthias Mann. Defining NASH from a Multi-Omics Systems Biology Perspective. Journal of Clinical Medicine 2021; 10(20) doi: 10.3390/jcm10204673
19
Anastasiia Driuchina, Jukka Hintikka, Marko Lehtonen, Pekka Keski-Rahkonen, Thomas O’Connell, Risto Juvonen, Juho Kuula, Antti Hakkarainen, Jari A. Laukkanen, Elina Mäkinen, Sanna Lensu, Kirsi H. Pietiläinen, Satu Pekkala, Elizabeth K. Mallott, Avery August. Identification of Gut Microbial Lysine and Histidine Degradation and CYP-Dependent Metabolites as Biomarkers of Fatty Liver Disease. mBio 2023; 14(1) doi: 10.1128/mbio.02663-22
20
Ji-Hee Haam, Yun Kyong Lee, Eunkyung Suh, Young-Sang Kim. Characteristics of Urine Organic Acid Metabolites in Nonalcoholic Fatty Liver Disease Assessed Using Magnetic Resonance Imaging with Elastography in Korean Adults. Diagnostics 2022; 12(5) doi: 10.3390/diagnostics12051199
21
Mingzhe Zhu, Meng Li, Wenjun Zhou, Guangbo Ge, Li Zhang, Guang Ji. Metabolomic Analysis Identifies Glycometabolism Pathways as Potential Targets of Qianggan Extract in Hyperglycemia Rats. Frontiers in Pharmacology 2020; 11 doi: 10.3389/fphar.2020.00671
22
Diren Beyoğlu, Yury V. Popov, Jeffrey R. Idle. Metabolomic Hallmarks of Obesity and Metabolic Dysfunction-Associated Steatotic Liver Disease. International Journal of Molecular Sciences 2024; 25(23) doi: 10.3390/ijms252312809
23
Xiangnan Ren, Wu Fan, Zixing Shao, Kaiyun Chen, Xuefeng Yu, Qionglin Liang. A metabolomic study on early detection of steroid-induced avascular necrosis of the femoral head. Oncotarget 2018; 9(8) doi: 10.18632/oncotarget.24150
24
Isabelle Alldritt, Paul L. Greenhaff, Daniel J. Wilkinson. Metabolomics as an Important Tool for Determining the Mechanisms of Human Skeletal Muscle Deconditioning. International Journal of Molecular Sciences 2021; 22(24) doi: 10.3390/ijms222413575
25
Ambrin Farizah Babu, Susanne Csader, Ville Männistö, Milla-Maria Tauriainen, Heikki Pentikäinen, Kai Savonen, Anton Klåvus, Ville Koistinen, Kati Hanhineva, Ursula Schwab. Effects of exercise on NAFLD using non-targeted metabolomics in adipose tissue, plasma, urine, and stool. Scientific Reports 2022; 12(1) doi: 10.1038/s41598-022-10481-9
26
Yang Chen, Yiran Wang, Tianjiao Shen, Nan Wang, Xiao Bai, Qiyang Li, Siyue Fang, Zhe He, Changhao Sun, Rennan Feng. Serum metabolic signatures and MetalnFF diagnostic score for mild and moderate metabolic dysfunction-associated steatotic liver disease. Journal of Pharmaceutical and Biomedical Analysis 2025; 260 doi: 10.1016/j.jpba.2025.116772
27
Da Jung Kim, Seonghae Yoon, Sang Chun Ji, Jinho Yang, Yoon-Keun Kim, SeungHwan Lee, Kyung-Sang Yu, In-Jin Jang, Jae-Yong Chung, Joo-Youn Cho. Ursodeoxycholic acid improves liver function via phenylalanine/tyrosine pathway and microbiome remodelling in patients with liver dysfunction. Scientific Reports 2018; 8(1) doi: 10.1038/s41598-018-30349-1
28
Qiang Yang, Ai-hua Zhang, Jian-hua Miao, Hui Sun, Ying Han, Guang-li Yan, Fang-fang Wu, Xi-jun Wang. Metabolomics biotechnology, applications, and future trends: a systematic review. RSC Advances 2019; 9(64) doi: 10.1039/C9RA06697G
29
Sihyang Jo, Jin-Mo Kim, Minshu Li, Han Sun Kim, Yong Jin An, Sunghyouk Park. TAT as a new marker and its use for noninvasive chemical biopsy in NASH diagnosis. Molecular Medicine 2024; 30(1) doi: 10.1186/s10020-024-00992-8
30
Carolina Castillo-Castro, Alexandro José Martagón-Rosado, Rocio Ortiz-Lopez, Luis Felipe Garrido-Treviño, Melissa Villegas-Albo, Francisco Javier Bosques-Padilla. Promising diagnostic biomarkers of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: From clinical proteomics to microbiome. World Journal of Hepatology 2021; 13(11): 1494-1511 doi: 10.4254/wjh.v13.i11.1494
31
Mingmei Shao, Yifei Lu, Hongjiao Xiang, Junmin Wang, Guang Ji, Tao Wu. Application of metabolomics in the diagnosis of non-alcoholic fatty liver disease and the treatment of traditional Chinese medicine. Frontiers in Pharmacology 2022; 13 doi: 10.3389/fphar.2022.971561
32
Maria Del Ben, Diletta Overi, Licia Polimeni, Guido Carpino, Giancarlo Labbadia, Francesco Baratta, Daniele Pastori, Valeria Noce, Eugenio Gaudio, Francesco Angelico, Carmine Mancone. Overexpression of the Vitronectin V10 Subunit in Patients with Nonalcoholic Steatohepatitis: Implications for Noninvasive Diagnosis of NASH. International Journal of Molecular Sciences 2018; 19(2) doi: 10.3390/ijms19020603
33
Elisa Gurian, Pablo Giraudi, Natalia Rosso, Claudio Tiribelli, Deborah Bonazza, Fabrizio Zanconati, Michela Giuricin, Silvia Palmisano, Nicolò de Manzini, Valter Sergo, Alois Bonifacio. Differentiation between stages of non-alcoholic fatty liver diseases using surface-enhanced Raman spectroscopy. Analytica Chimica Acta 2020; 1110 doi: 10.1016/j.aca.2020.02.040
34
Zohre Mozduri, Nathalie Marty-Gasset, Bara Lo, Ali Akbar Masoudi, Mireille Morisson, Cécile Canlet, Julien Arroyo, Agnès Bonnet, Cécile M. D. Bonnefont. Identification of Plasmatic Biomarkers of Foie Gras Qualities in Duck by Metabolomics. Frontiers in Physiology 2021; 12 doi: 10.3389/fphys.2021.628264
35
Yuri A. Lawrence, Blake C. Guard, Jörg M. Steiner, Jan S. Suchodolski, Jonathan A. Lidbury, Juan J. Loor. Untargeted metabolomic profiling of urine from healthy dogs and dogs with chronic hepatic disease. PLOS ONE 2019; 14(5) doi: 10.1371/journal.pone.0217797
36
Niama Ezzaidi, Xiang Zhang, Olabisi Oluwabukola Coker, Jun Yu. New insights and therapeutic implication of gut microbiota in non-alcoholic fatty liver disease and its associated liver cancer. Cancer Letters 2019; 459 doi: 10.1016/j.canlet.2019.114425
37
Qian Feng, Yuanmeng Li, Yuwei Yang, Jiafu Feng. Urine Metabolomics Analysis in Patients With Normoalbuminuric Diabetic Kidney Disease. Frontiers in Physiology 2020; 11 doi: 10.3389/fphys.2020.578799
38
Shimaa Abdelsattar, Hiba S. Al-Amodi, Hala F. M. Kamel, Mahmoud Nazih, Arwa Fadel Flemban, Sabry M. Abdelmegeed, Naglaa Abdelmawgoud Ahmed, Ehab Darwish, Ayman Ahmed Sakr, Yousef M. Abdelgawad, Basma M. Abdelgawad, Inas Moaz, Elaf Abozeid, Hanan M. Bedair, Mai Abozeid, Mervat Abdelkreem, Shimaa K. Zween. Machine learning-based identification of targeted metabolomic biomarkers for early diagnosis and fibrosis-stage discrimination in metabolic dysfunction-associated steatotic liver disease. Frontiers in Nutrition 2026; 13 doi: 10.3389/fnut.2026.1849329
39
Aihua Zhang, Qiang Yang, Hui Sun, Xijun Wang. Mass Spectrometry‐Based Metabolomics in Clinical and Herbal Medicines. 2021;  doi: 10.1002/9783527835751.ch1
40
Yanjie Zhang, Yajun Sun, Qin Miao, Shilong Guo, Qi Wang, Tianyuan Shi, Xinsheng Guo, Shuai Liu, Guiding Cheng, Chuansheng Wang, Ruiling Zhang. Serum metabolomics analysis in patients with alcohol dependence. Frontiers in Psychiatry 2023; 14 doi: 10.3389/fpsyt.2023.1151200
41
42
Eugenia Carril, María Pilar Valdecantos, Borja Lanzón, Santiago Angulo, Ángela M. Valverde, Joanna Godzien, Francisco Javier Rupérez. Metabolic impact of partial hepatectomy in the non-alcoholic steatohepatitis animal model of methionine-choline deficient diet. Journal of Pharmaceutical and Biomedical Analysis 2020; 178 doi: 10.1016/j.jpba.2019.112958
43
Lars Ove Dragsted, Kajetan Trošt. The Human Gut-Liver-Axis in Health and Disease. 2019;  doi: 10.1007/978-3-319-98890-0_10
44
Lu Yu, Liping Wang, Fangchao Hu, Liyang Liu, Ziyun Wu. Development of a short-term mouse model of early MASLD for non-invasive pathophysiological tracking via urinary metabolomics and micro-CT. Life Sciences 2026; 402 doi: 10.1016/j.lfs.2026.124540
45
George N. Ioannou, G. A. Nagana Gowda, Danijel Djukovic, Daniel Raftery. Distinguishing NASH Histological Severity Using a Multiplatform Metabolomics Approach. Metabolites 2020; 10(4) doi: 10.3390/metabo10040168
46
Jose Rodríguez-Morató, Óscar J Pozo, Josep Marcos. Targeting Human Urinary Metabolome by LC–MS/MS: A Review. Bioanalysis 2018; 10(7) doi: 10.4155/bio-2017-0285
47
Mojgan Masoodi, Amalia Gastaldelli, Tuulia Hyötyläinen, Enara Arretxe, Cristina Alonso, Melania Gaggini, Julia Brosnan, Quentin M. Anstee, Oscar Millet, Pablo Ortiz, Jose M. Mato, Jean-Francois Dufour, Matej Orešič. Metabolomics and lipidomics in NAFLD: biomarkers and non-invasive diagnostic tests. Nature Reviews Gastroenterology & Hepatology 2021; 18(12) doi: 10.1038/s41575-021-00502-9
48
Xiao-jun Gou, Shanshan Gao, Liang Chen, Qin Feng, Yi-yang Hu. A Metabolomic Study on the Intervention of Traditional Chinese Medicine Qushi Huayu Decoction on Rat Model of Fatty Liver Induced by High-Fat Diet. BioMed Research International 2019; 2019 doi: 10.1155/2019/5920485
49
Wonseok Lee, Da Kyung Hwang, Hyun Young Kim, David A. Brenner. Precision pathophysiology in steatotic liver disease. Clinical and Molecular Hepatology 2026; 32(Suppl) doi: 10.3350/cmh.2026.0490
50
Brianna Cyr, Robert W. Keane, Juan Pablo de Rivero Vaccari. ASC, IL-18 and Galectin-3 as Biomarkers of Non-Alcoholic Steatohepatitis: A Proof of Concept Study. International Journal of Molecular Sciences 2020; 21(22) doi: 10.3390/ijms21228580
51
Wei-ting Cheng, Si-ya Pei, Jie Wu, Yan-jie Wang, Yong-wen Yang, Mei-fang Xiao, Jun Chen, Yuan-yuan Wang, Li Wu, Ze-bing Huang. Cannabinoid-2 receptor depletion promotes non-alcoholic fatty liver disease in mice via disturbing gut microbiota and tryptophan metabolism. Acta Pharmacologica Sinica 2025; 46(6) doi: 10.1038/s41401-025-01495-w
52
Danial Efendy Goon, Sharaniza Ab-Rahim, Amir Hakimi Mohd Sakri, Musalmah Mazlan, Jen Kit Tan, Mardiana Abdul Aziz, Norizal Mohd Noor, Effendi Ibrahim, Siti Hamimah Sheikh Abdul Kadir. Untargeted serum metabolites profiling in high-fat diet mice supplemented with enhanced palm tocotrienol-rich fraction using UHPLC-MS. Scientific Reports 2021; 11(1) doi: 10.1038/s41598-021-00454-9
53
Heng Yuan, Eun-Soo Jung, Soo-Wan Chae, Su-Jin Jung, James W. Daily, Sunmin Park. Biomarkers for Health Functional Foods in Metabolic Dysfunction-Associated Steatotic Liver Disorder (MASLD) Prevention: An Integrative Analysis of Network Pharmacology, Gut Microbiota, and Multi-Omics. Nutrients 2024; 16(18) doi: 10.3390/nu16183061
54
David S. Wishart. Metabolomics for Investigating Physiological and Pathophysiological Processes. Physiological Reviews 2019; 99(4) doi: 10.1152/physrev.00035.2018
55
Diren Beyoğlu, Jeffrey R. Idle. Metabolomic and Lipidomic Biomarkers for Premalignant Liver Disease Diagnosis and Therapy. Metabolites 2020; 10(2) doi: 10.3390/metabo10020050
56
Ashraf Abbass Basuni, Dina Sweed, Mohammed Fathey Elgazzar, Ashraf Khalil. Exploring serum bile acids as potential noninvasive biomarkers for nonalcoholic fatty liver disease. Egyptian Liver Journal 2024; 14(1) doi: 10.1186/s43066-024-00378-9
57
Ying Zhang, Jitao Sun, Xue Zhang, Qiu Zhong, Ping Hao, Wen Yin, Baoying Chen, Qianfei Wei, Hong Shen, Ying Zhang, Xiaonan Yang, Xingjian Yu, Xin Wu, Weijie Qu, Yi Wu. Structural characterisation of hawthorn polysaccharide and its mechanisms of action against non-alcoholic fatty liver disease. International Journal of Biological Macromolecules 2025; 319 doi: 10.1016/j.ijbiomac.2025.145713
58
Stefano Gitto, Filippo Schepis, Pietro Andreone, Erica Villa. Study of the Serum Metabolomic Profile in Nonalcoholic Fatty Liver Disease: Research and Clinical Perspectives. Metabolites 2018; 8(1) doi: 10.3390/metabo8010017
59
Huikuan Chu, Yi Duan, Ling Yang, Bernd Schnabl. Small metabolites, possible big changes: a microbiota-centered view of non-alcoholic fatty liver disease. Gut 2019; 68(2) doi: 10.1136/gutjnl-2018-316307
60
Kara Wegermann, Joseph E Lucas, Laura Dubois, Rebecca Mangus, Zhong Li, Cynthia A Moylan, Keyur Patel, Susanna Naggie. Plasma Lipid Metabolites Differentiate Metabolic From Viral Chronic Liver Disease. The Journal of Infectious Diseases 2025; 232(2) doi: 10.1093/infdis/jiaf270
61
Nikolaos Perakakis, Konstantinos Stefanakis, Christos S. Mantzoros. The role of omics in the pathophysiology, diagnosis and treatment of non-alcoholic fatty liver disease. Metabolism 2020; 111 doi: 10.1016/j.metabol.2020.154320
62
Liyan Liu, Jinhui Zhao, Runan Zhang, Xuemei Wang, Yan Wang, Yang Chen, Rennan Feng. Serum untargeted metabolomics delineates the metabolic status in different subtypes of non-alcoholic fatty liver disease. Journal of Pharmaceutical and Biomedical Analysis 2021; 200 doi: 10.1016/j.jpba.2021.114058
63
Ying Xiao, Zhinian Wu, Yangyang Hu, Caiyan Zhao, Yadong Wang. Comparative analysis of serum amino acid levels and their potential as biomarkers in liver cirrhosis: a systematic review and meta-analysis. Critical Public Health 2026; 36(1) doi: 10.1080/09581596.2025.2608537
64
Wei-Wei Li, Yan Yang, Qi-Gang Dai, Li-Li Lin, Tong Xie, Li-Li He, Jia-Lei Tao, Jin-Jun Shan, Shou-Chuan Wang. Non-invasive urinary metabolomic profiles discriminate biliary atresia from infantile hepatitis syndrome. Metabolomics 2018; 14(7) doi: 10.1007/s11306-018-1387-z
65
Emma J. Robinson, Matthew C. Taddeo, Xin Chu, Weixing Shi, Craig Wood, Christopher Still, Virginia G. Rovnyak, David Rovnyak. Aqueous Metabolite Trends for the Progression of Nonalcoholic Fatty Liver Disease in Female Bariatric Surgery Patients by Targeted 1H-NMR Metabolomics. Metabolites 2021; 11(11) doi: 10.3390/metabo11110737
66
Pankaj Prabhakar, Vijay Marakala, Dhanya Sacheendran, Thomas George, Rhea Katherine D'souza, Princy Louis Palatty, Manjeshwar Shrinath Baliga. Ginger (Zingiber officinale Roscoe; Family: Zingiberaceae) in Non-Alcoholic Fatty Liver Disease: Review on the Existing Scientific Evidence and Way Forward. Current Nutrition & Food Science 2024; 20(7) doi: 10.2174/1573401319666230913122317
67
Ahmad Moolla, Jasper de Boer, David Pavlov, Amin Amin, Angela Taylor, Lorna Gilligan, Beverly Hughes, John Ryan, Eleanor Barnes, Zaki Hassan‐Smith, Jane Grove, Guruprasad P. Aithal, An Verrijken, Sven Francque, Luc Van Gaal, Matthew J. Armstrong, Phillip N. Newsome, Jeremy F. Cobbold, Wiebke Arlt, Michael Biehl, Jeremy W. Tomlinson. Accurate non‐invasive diagnosis and staging of non‐alcoholic fatty liver disease using the urinary steroid metabolome. Alimentary Pharmacology & Therapeutics 2020; 51(11) doi: 10.1111/apt.15710