Academic Content and Language Evaluation of This Article
Citation of this article
Corresponding Author of This Article
Research Domain of This Article
Article-Type of This Article
Open-Access Policy of This Article
Times Cited Counts in Google of This Article
Number of Hits and Downloads for This Article
- Total Article Views (9196)
All Articles published online
|
Publishing Process of This Article
|
Aug 14, 2014 (publication date) through Jul 10, 2025
Times Cited of This Article
Journal Information of This Article
Publication Name
World Journal of Gastroenterology
ISSN
1007-9327
Publisher of This Article
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
| For: | Han LL, Lv Y, Guo H, Ruan ZP, Nan KJ. Implications of biomarkers in human hepatocellular carcinoma pathogenesis and therapy. World J Gastroenterol 2014; 20(30): 10249-10261 [PMID: 25132742 DOI: 10.3748/wjg.v20.i30.10249] |
|---|---|
| URL: | https://www.wjgnet.com/1007-9327/full/v20/i30/10249.htm |
| Number | Citing Articles |
| 1 |
Jiaming Qi, Jiaxing Zhou, Xu-Qing Tang, Yaolai Wang. Gene Biomarkers Derived from Clinical Data of Hepatocellular Carcinoma. Interdisciplinary Sciences: Computational Life Sciences 2020; 12(2): 226 doi: 10.1007/s12539-020-00366-8
|
| 2 |
Lin Chen, Feihu Chu, Yali Cao, Jianguo Shao, Feng Wang. Serum miR-182 and miR-331-3p as diagnostic and prognostic markers in patients with hepatocellular carcinoma. Tumor Biology 2015; 36(10): 7439 doi: 10.1007/s13277-015-3430-2
|
| 3 |
Ahmad Khan, Xiaobo Zhang. Function of the Long Noncoding RNAs in Hepatocellular Carcinoma: Classification, Molecular Mechanisms, and Significant Therapeutic Potentials. Bioengineering 2022; 9(8): 406 doi: 10.3390/bioengineering9080406
|
| 4 |
Hai-Feng Zhang, Wei Li, Yi-Di Han. LINC00261 suppresses cell proliferation, invasion and Notch signaling pathway in hepatocellular carcinoma. Cancer Biomarkers 2018; 21(3): 575 doi: 10.3233/CBM-170471
|
| 5 |
Wei Song, Yuejun Gu, Sen Lu, Huazhang Wu, Zhenxing Cheng, Jiaojiao Hu, Yanyan Qian, Ying Zheng, Hong Fan. LncRNA TRERNA1 facilitates hepatocellular carcinoma metastasis by dimethylating H3K9 in the CDH1 promoter region via the recruitment of the EHMT2/SNAI1 complex. Cell Proliferation 2019; 52(4) doi: 10.1111/cpr.12621
|
| 6 |
Areeg M. Dabbish, Hana M. Abdelzaher, Moustafa Abohawya, Samir Shamma, Yosra H. Mahmoud, Amr Maged, Mohamed Manaa, Mohamed Hassany, Firas Kobeissy, Omid Bazgir, Hassan El-Fawal, Hassan M. E. Azzazy, Anwar Abdelnaser. Prognostic MicroRNA Panel for HCV-Associated HCC: Integrating Computational Biology and Clinical Validation. Cancers 2022; 14(13): 3036 doi: 10.3390/cancers14133036
|
| 7 |
Wenlong Wu, Quancheng Wang, Dandan Han, Jianhui Li, Ye Nie, Dongnan Guo, Long Yang, Kaishan Tao, Xuan Zhang, Kefeng Dou. Prognostic value of preoperative inflammatory markers in patients with hepatocellular carcinoma who underwent curative resection. Cancer Cell International 2021; 21(1) doi: 10.1186/s12935-021-02204-3
|
| 8 |
Yajing Shen, Jiajun Chen, Jinyu Wu, Tiandong Li, Chuncheng Yi, Keyan Wang, Peng Wang, Changqing Sun, Hua Ye. Combination of an Autoantibody Panel and Alpha-Fetoprotein for Early Detection of Hepatitis B Virus-Associated Hepatocellular Carcinoma. Cancer Prevention Research 2024; 17(5): 227 doi: 10.1158/1940-6207.CAPR-23-0311
|
| 9 |
Yao-Li Chen, Shih-Hsuan Chan, Ping-Yi Lin, Pei-Yi Chu. The expression of a tumor suppressor gene JDP2 and its prognostic value in hepatocellular carcinoma patients. Human Pathology 2017; 63: 212 doi: 10.1016/j.humpath.2017.03.003
|
| 10 |
Zhaobo Liu, Min Wu, Dongdong Lin, Ning Li. Des-gamma-carboxyprothrombin is a favorable biomarker for the early diagnosis of alfa-fetoprotein-negative hepatitis B virus-related hepatocellular carcinoma. Journal of International Medical Research 2020; 48(2) doi: 10.1177/0300060520902575
|
| 11 |
Jing Lv, Hong-xia Fan, Xiao-pei Zhao, Ping Lv, Jing-yi Fan, Yi Zhang, Min Liu, Hua Tang. Long non-coding RNA Unigene56159 promotes epithelial–mesenchymal transition by acting as a ceRNA of miR-140-5p in hepatocellular carcinoma cells. Cancer Letters 2016; 382(2): 166 doi: 10.1016/j.canlet.2016.08.029
|
| 12 |
Bin Zheng, MS, Heng Wang, MS, Jin-xue Wang, MS, Zheng-hong Liu, MS, Pu Zhang, MD, Dahong Zhang, MD. The Clinical Significance of RMI2 in Hepatocellular Carcinoma. Technology in Cancer Research & Treatment 2021; 20 doi: 10.1177/15330338211045496
|
| 13 |
Zhuo Han, Keming Li, Jinyu Wu, Keyan Wang, Cuipeng Qiu, Hua Ye, Chi Cui, Chunhua Song, Kaijuan Wang, Jianxiang Shi, Peng Wang, Jianying Zhang. Diagnostic Value of Rna for Hepatocellular Carcinoma: A Network Meta-Analysis. Biomarkers in Medicine 2021; 15(18): 1755 doi: 10.2217/bmm-2021-0327
|
| 14 |
X Zhu, Q Feng, X Ge, B Hu. Using conventional contrast-enhanced MRI semi-quantitative analysis to distinguish alpha-fetoprotein-negative small hepatocellular carcinoma without cirrhosis and small focal nodular hyperplasia. International Journal of Radiation Research 2024; 22(3): 625 doi: 10.61186/ijrr.22.3.625
|
| 15 |
Yu Liu, Ye Yang, Tianlong Wang, Li Wang, Xin Wang, Tiemin Li, Yue Shi, Yawei Wang. Long non-coding RNA CCAL promotes hepatocellular carcinoma progression by regulating AP-2α and Wnt/β-catenin pathway. International Journal of Biological Macromolecules 2018; 109: 424 doi: 10.1016/j.ijbiomac.2017.12.110
|
| 16 |
Zhao Liu, Mi Chen, Lin-Ka Xie, Ting Liu, Zhen-Wei Zou, Yong Li, Peng Chen, Xin Peng, Charlie Ma, Wen-Jie Zhang, Pin-Dong Li. CLCA4 inhibits cell proliferation and invasion of hepatocellular carcinoma by suppressing epithelial-mesenchymal transition via PI3K/AKT signaling. Aging 2018; 10(10): 2570 doi: 10.18632/aging.101571
|
| 17 |
Yi-Qun Che, Yue Zhang, Han-Bing Li, Di Shen, Wei Cui. Serum KLKB1 as a Potential Prognostic Biomarker for Hepatocellular Carcinoma Based on Data-Independent Acquisition and Parallel Reaction Monitoring. Journal of Hepatocellular Carcinoma 2021; : 1241 doi: 10.2147/JHC.S325629
|
| 18 |
Lijun Zhao, Kexin Hu, Jianzhong Cao, Pan Wang, Jun Li, Kewu Zeng, Xiaodong He, Peng-Fei Tu, Tanjun Tong, Limin Han. lncRNA miat functions as a ceRNA to upregulate sirt1 by sponging miR-22-3p in HCC cellular senescence. Aging 2019; 11(17): 7098 doi: 10.18632/aging.102240
|
| 19 |
Ying Cao, Jianbo Cao, Binbin Yu, Shusheng Wang, Lili Liu, Li Tao, Wanping Sun. Berbamine induces SMMC-7721 cell apoptosis via upregulating p53, downregulating survivin expression and activating mitochondria signaling pathway. Experimental and Therapeutic Medicine 2017; doi: 10.3892/etm.2017.5637
|
| 20 |
Jiali Meng, Yuanchao Wei, Qing Deng, Ling Li, Xiaolong Li. Study on the expression of TOP2A in hepatocellular carcinoma and its relationship with patient prognosis. Cancer Cell International 2022; 22(1) doi: 10.1186/s12935-021-02439-0
|
| 21 |
Chen Yang, Boburjon Turgunov, Fandong Zhu, Yang Xia, Jianfeng Zhou, Zhenhua Zhao. A T2 weighted imaging-based radiomics nomogram for the classification of hepatic blood-rich lesions: hepatocellular carcinoma and benign liver lesions. Discover Oncology 2025; 16(1) doi: 10.1007/s12672-025-02868-7
|
| 22 |
Huifang Peng, Zhijian Yan, Xinhua Zeng, Sheng Zhang, Hongwei Jiang, Heqing Huang, Huiqin Zhuo. Serum and tissue proteomic signatures of patients with hepatocellular carcinoma using 2‑D gel electrophoresis. Molecular Medicine Reports 2019; doi: 10.3892/mmr.2019.10311
|
| 23 |
Maissa El Raziky, Hanan Abdel Hafez, Aisha Elsharkawy, Tarek Ahmed Moneer, Suzan M. EL-Sheikh, Rabab M. Maher, Sahar A. Sharaf. Serum level of cytokeratin 19 as a diagnostic and prognostic marker in patients with HCV-related hepatocellular carcinoma. Egyptian Liver Journal 2021; 11(1) doi: 10.1186/s43066-021-00125-4
|
| 24 |
Fabio Giannone, Nevena Slovic, Patrick Pessaux, Catherine Schuster, Thomas F. Baumert, Joachim Lupberger. Inflammation-related prognostic markers in resected hepatocellular carcinoma. Frontiers in Oncology 2023; 13 doi: 10.3389/fonc.2023.1267870
|
| 25 |
Tian Hu, Jincheng Li, Chuhong Zhang, Xiu lv, Sai Li, Sha He, Hanxing Yan, Yixi Tan, Mingsheng Lei, Meiling Wen, Jianhong Zuo. The potential value of microRNA-4463 in the prognosis evaluation in hepatocellular carcinoma. Genes & Diseases 2017; 4(2): 116 doi: 10.1016/j.gendis.2017.03.003
|
| 26 |
Fengjuan Cheng, Guanhua Qian, Xianyun Fang, Jingjie Sun, Siyuan Chen, Rongjuan Chen, Shangjing Liu, Zhaodi Li, Kejia Wu, Shiming Jiang, Yong Chen, Ni Tang, Juan Chen, Changzhu Duan. HBx promotes hepatocarcinogenesis by enhancing phosphorylation and blocking ubiquitinylation of UHRF2. Hepatology International 2021; 15(3): 707 doi: 10.1007/s12072-021-10172-z
|
| 27 |
ZhenYu Feng, ZhenYu Ye, JiaMing Xie, Wei Chen, Wei Li, ChunGen Xing. Study on the mechanism of LOXL1-AS1/miR-3614-5p/YY1 signal axis in the malignant phenotype regulation of hepatocellular carcinoma. Biology Direct 2021; 16(1) doi: 10.1186/s13062-021-00312-8
|
| 28 |
Gang Chi, Jinhong Pei, Xueqing Li, Xujiong Li, Hui Pang, Jia Cui, Dongkai Wu, Gexi Qu, Yuan He. SMYD5 acts as a potential biomarker for hepatocellular carcinoma. Experimental Cell Research 2022; 414(2): 113076 doi: 10.1016/j.yexcr.2022.113076
|
| 29 |
Massimiliano Berretta, Carla Cavaliere, Lara Alessandrini, Brigida Stanzione, Gaetano Facchini, Luca Balestreri, Tiziana Perin, Vincenzo Canzonieri. Serum and tissue markers in hepatocellular carcinoma and cholangiocarcinoma: clinical and prognostic implications. Oncotarget 2017; 8(8): 14192 doi: 10.18632/oncotarget.13929
|
| 30 |
Riccardo Di Santo, Maria Vaccaro, Sabrina Romanò, Flavio Di Giacinto, Massimiliano Papi, Gian Ludovico Rapaccini, Marco De Spirito, Luca Miele, Umberto Basile, Gabriele Ciasca. Machine Learning-Assisted FTIR Analysis of Circulating Extracellular Vesicles for Cancer Liquid Biopsy. Journal of Personalized Medicine 2022; 12(6): 949 doi: 10.3390/jpm12060949
|
| 31 |
Si Ying Tang, Ying Xu, Cong Cong Jiao, Meng Hui Jiang, Nan Kong, Hao Ding, Lian Hua Cui, Jin-Mei Piao. Clinical significance of cylindromatosis expression in primary hepatocellular carcinoma. Arab Journal of Gastroenterology 2023; 24(1): 58 doi: 10.1016/j.ajg.2022.11.001
|
| 32 |
Cunhua Shao, Gongpan Liu, Xiaobin Zhang, Anyun Li, Xingjun Guo. <p>Long Noncoding RNA RMRP Suppresses the Tumorigenesis of Hepatocellular Carcinoma Through Targeting microRNA-766</p>. OncoTargets and Therapy 2020; : 3013 doi: 10.2147/OTT.S243736
|
| 33 |
Xuekai Hu, Jiayun Wei, Pinyan Liu, Qiuxia Zheng, Yue Zhang, Qichen Zhang, Jia Yao, Jingman Ni. Organoid as a promising tool for primary liver cancer research: a comprehensive review. Cell & Bioscience 2024; 14(1) doi: 10.1186/s13578-024-01287-5
|
| 34 |
Zhiquan Zhang, Bao Lei, Wei Chai, Ruhai Liu, Tiejun Li. Increased expression of insulin-like growth factor-1 receptor predicts poor prognosis in patients with hepatocellular carcinoma. Medicine 2019; 98(44): e17680 doi: 10.1097/MD.0000000000017680
|
| 35 |
Marwa Sayed Abdel-Tawab, Hanan Fouad, Doaa Mahmoud Khalil, Saeed Shaaban, Shaymaa Nafady, Hanan Hosni Moawad, Heba Ahmed Mostafa, Soha Mahmoud Abdel-Salam, Naglaa Adly Abd Elazeem, Alaa A. Mohamed. The role of miRNA-29b1, MMP-2, MMP-9 mRNAs, and proteins in early diagnosis of HCC. Egyptian Journal of Medical Human Genetics 2023; 24(1) doi: 10.1186/s43042-023-00434-w
|
| 36 |
Long Liu, Qi Wang, Xiaohong Zhao, Yuxi Huang, Yuyi Feng, Yu Zhang, Zheping Fang, Shaowei Li. Establishment and validation of nomogram model for the diagnosis of AFP-negative hepatocellular carcinoma. Frontiers in Oncology 2023; 13 doi: 10.3389/fonc.2023.1131892
|
| 37 |
Gang Chen, Dongdong Wang, Xiongqi Zhao, Jun Cao, Yingpeng Zhao, Fan Wang, Jianhua Bai, Ding Luo, Li Li. miR-155-5p modulates malignant behaviors of hepatocellular carcinoma by directly targeting CTHRC1 and indirectly regulating GSK-3β-involved Wnt/β-catenin signaling. Cancer Cell International 2017; 17(1) doi: 10.1186/s12935-017-0469-8
|
| 38 |
Po-Li Wei, Chien-Yu Huang, Yu-Jia Chang, Yi-Hsien Hsieh. Propyl gallate inhibits hepatocellular carcinoma cell growth through the induction of ROS and the activation of autophagy. PLOS ONE 2019; 14(1): e0210513 doi: 10.1371/journal.pone.0210513
|
| 39 |
Song He, Xiao-Wu Hu, Dong Wang, Ling-Fei Han, De-chun Zhang, Cheng Wei. Accuracy of microRNAs for the diagnosis of hepatocellular carcinoma: A systematic review and meta-analysis. Clinics and Research in Hepatology and Gastroenterology 2016; 40(4): 405 doi: 10.1016/j.clinre.2016.02.001
|
| 40 |
Eman A. E. Badr, Elshaymaa I. Elmongy, Rasha Galal Mostafa, Ibrahim El-Tantawy El-Sayed, Abd El-Naser Abd El-Ati Gad Allah, Asmaa Khairy Ahmed, Yasser A. S. Elghobashy. The Role of LINC01564, RAMS11, CBX4 and TOP2A in Hepatocellular Carcinoma. Biomedicines 2022; 11(1): 56 doi: 10.3390/biomedicines11010056
|
| 41 |
Zhenggang Wu, Xi Long, Shui Ying Tsang, Taobo Hu, Jian-Feng Yang, Wai Kin Mat, Hongyang Wang, Hong Xue. Genomic subtyping of liver cancers with prognostic application. BMC Cancer 2020; 20(1) doi: 10.1186/s12885-020-6546-8
|
| 42 |
GUOJUN SUN, SHUQIN ZHANG, YANRU XIE, ZIYU ZHANG, WENJING ZHAO. Gallic acid as a selective anticancer agent that induces apoptosis in SMMC-7721 human hepatocellular carcinoma cells. Oncology Letters 2016; 11(1): 150 doi: 10.3892/ol.2015.3845
|
| 43 |
Shanshan Chen, Hao Chen, Shanshan Gao, Shili Qiu, Hu Zhou, Mingxia Yu, Jiancheng Tu. Differential expression of plasma microRNA‐125b in hepatitis B virus‐related liver diseases and diagnostic potential for hepatitis B virus‐induced hepatocellular carcinoma. Hepatology Research 2017; 47(4): 312 doi: 10.1111/hepr.12739
|
| 44 |
Ping Luo, Sanyun Wu, Yalan Yu, Xinliang Ming, Shuo Li, Xuelan Zuo, Jiancheng Tu. Current Status and Perspective Biomarkers in AFP Negative HCC: Towards Screening for and Diagnosing Hepatocellular Carcinoma at an Earlier Stage. Pathology & Oncology Research 2020; 26(2): 599 doi: 10.1007/s12253-019-00585-5
|
| 45 |
Xiaorong Deng, Weiwei Wei, Niangen Huang, Yumeng Shi, Mingwen Huang, Yehong Yan, Dongjian Li, Jilin Yi, Xinbao Wang. Tumor repressor gene chondroadherin oppose migration and proliferation in hepatocellular carcinoma and predicts a good survival. Oncotarget 2017; 8(36): 60270 doi: 10.18632/oncotarget.19811
|
| 46 |
Abeer Ahmed ALrefai, Sara Kamal Rizk, Ahmed Kamal Khamis, Zeinab A Kasemy, Mona Salah Eldin Habieb. Utility of a microRNA panel in diagnosis and prognosis of hepatitis C–associated hepatocellular carcinoma. Laboratory Medicine 2024; 55(3): 310 doi: 10.1093/labmed/lmad081
|
| 47 |
Yuheng Zhang, Jun Li, Shuai Wang, Faji Yang, Yuan Zhou, Yang Liu, Wei Zhu, Xiaolei Shi. HBx‑associated long non‑coding RNA activated by TGF‑β promotes cell invasion and migration by inducing autophagy in primary liver cancer. International Journal of Oncology 2019; doi: 10.3892/ijo.2019.4908
|
| 48 |
Mizelle D'Silva, Jai Young Cho, Ho-Seong Han, Yoo-Seok Yoon, Hae Won Lee, Jun Suh Lee, Boram Lee, Moonhwan Kim. Long-term surgical outcomes of Non alcoholic fatty liver disease associated hepatocellular carcinoma. Surgical Oncology 2022; 41: 101730 doi: 10.1016/j.suronc.2022.101730
|
| 49 |
Zhikun Lin, Ruiping He, Haifeng Luo, Chang Lu, Zhen Ning, Yuanhang Wu, Chuanchun Han, Guang Tan, Zhongyu Wang. RETRACTED ARTICLE: Integrin-β5, a miR-185-targeted gene, promotes hepatocellular carcinoma tumorigenesis by regulating β-catenin stability. Journal of Experimental & Clinical Cancer Research 2018; 37(1) doi: 10.1186/s13046-018-0691-9
|
| 50 |
Branislava Ranković, Nina Hauptman. Circulating microRNA Panels for Detection of Liver Cancers and Liver-Metastasizing Primary Cancers. International Journal of Molecular Sciences 2023; 24(20): 15451 doi: 10.3390/ijms242015451
|
| 51 |
Yu Lin, Qianyi Wang, Minxuan Feng, Jize Lao, Changmeng Wu, Houlong Luo, Ling Ji, Yong Xia. A cost-effective predictive tool for AFP-negative focal hepatic lesions of retrospective study: enhancing clinical triage and decision-making. PeerJ 2025; 13: e19150 doi: 10.7717/peerj.19150
|
| 52 |
Yang Zhang, Fangfang Jin, Yuan Wu, Bingyu Wang, Jingri Xie, Yu Li, Yujia Pan, Zhaolan Liu, Wenjuan Shen. Prognostic impact of gamma-glutamyl transpeptidase to platelets ratio on hepatocellular carcinoma patients who have undergone surgery: a meta-analysis and systematic review. European Journal of Gastroenterology & Hepatology 2023; 35(8): 803 doi: 10.1097/MEG.0000000000002572
|
| 53 |
Ling-Juan Luo, Li-Ping Zhang, Chun-Yan Duan, Bei Wang, Na-Na He, Patima Abulimiti, Yan Lin. The inhibition role of miR-22 in hepatocellular carcinoma cell migration and invasion via targeting CD147. Cancer Cell International 2017; 17(1) doi: 10.1186/s12935-016-0380-8
|