| For: | Stocco G, Pelin M, Franca R, De Iudicibus S, Cuzzoni E, Favretto D, Martelossi S, Ventura A, Decorti G. Pharmacogenetics of azathioprine in inflammatory bowel disease: A role for glutathione-S-transferase? World J Gastroenterol 2014; 20(13): 3534-3541 [PMID: 24707136 DOI: 10.3748/wjg.v20.i13.3534] |
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| URL: | https://www.wjgnet.com/1007-9327/full/v20/i13/3534.htm |
| Number | Citing Articles |
| 1 |
Laura Wilson, Stephanie Tuson, Lufang Yang, Dustin Loomes. Real-World Use of Azathioprine Metabolites Changes Clinical Management of Inflammatory Bowel Disease. Journal of the Canadian Association of Gastroenterology 2021; 4(3) doi: 10.1093/jcag/gwaa005
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| 2 |
M M T J Broekman, D R Wong, G J A Wanten, H M Roelofs, C J van Marrewijk, O H Klungel, A L M Verbeek, P M Hooymans, H-J Guchelaar, H Scheffer, L J J Derijks, M J H Coenen, D J de Jong. The glutathione transferase Mu null genotype leads to lower 6-MMPR levels in patients treated with azathioprine but not with mercaptopurine. The Pharmacogenomics Journal 2018; 18(1) doi: 10.1038/tpj.2016.87
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| 3 |
Gabriele Stocco, Stefano Martelossi, Serena Arrigo, Arrigo Barabino, Marina Aloi, Massimo Martinelli, Erasmo Miele, Daniela Knafelz, Claudio Romano, Samuele Naviglio, Diego Favretto, Eva Cuzzoni, Raffaella Franca, Giuliana Decorti, Alessandro Ventura. Multicentric Case–Control Study on Azathioprine Dose and Pharmacokinetics in Early-onset Pediatric Inflammatory Bowel Disease. Inflammatory Bowel Diseases 2017; 23(4) doi: 10.1097/MIB.0000000000001051
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| 4 |
Femke Crouwel, Hans J C Buiter, Nanne K de Boer. The Thiopurine Tale: An Unexpected Journey. Journal of Crohn's and Colitis 2022; 16(7) doi: 10.1093/ecco-jcc/jjac004
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| 5 |
Tiphaine Adam de Beaumais, Simon Lorrain, Naura Mamhoudi, Mathieu Simonin, Christine Martinez Vinson, Yves Medard, Arnaud Petit, Evelyne Jacqz‐Aigrain. Key factors associated with 6‐thioguanine and 6‐methylmercaptopurine nucleotide concentrations in children treated by thiopurine for acute leukaemia and inflammatory bowel disease. British Journal of Clinical Pharmacology 2024; 90(1) doi: 10.1111/bcp.15894
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| 6 |
Tiphaine Adam de Beaumais, Yves Medard, Océane Amblard, Lauriane Goldwirt, Mathieu Simonin, Christine Martinez Vinson, Arnaud Petit, Evelyne Jacqz-Aigrain. Improved HPLC Quantification of 6-Mercaptopurine Metabolites in Red Blood Cells: Monitoring Data and Literature Analysis. International Journal of Molecular Sciences 2022; 23(19) doi: 10.3390/ijms231911885
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| 7 |
Ewa Dudzińska, Magdalena Gryzinska, Katarzyna Ognik, Paulina Gil-Kulik, Janusz Kocki, Vladimir Jakovljevic. Oxidative Stress and Effect of Treatment on the Oxidation Product Decomposition Processes in IBD. Oxidative Medicine and Cellular Longevity 2018; 2018(1) doi: 10.1155/2018/7918261
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| 8 |
Ewa Dudzińska, Aneta Strachecka, Paulina Gil-Kulik, Janusz Kocki, Jacek Bogucki, Natalya Shemedyuk, Magdalena Gryzinska. Influence of the Treatment Used in Inflammatory Bowel Disease on the Protease Activities. International Journal of General Medicine 2020; doi: 10.2147/IJGM.S267036
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| 9 |
Mirjana Stojšić, Ognjen Ležakov, Sanja Ćeranić, Nikola Stojšić, Marko Rajković, Savina Marković, Milica Kovačević, Nina Brkić. TPMT and HLA-DQ Allelic Variants in Relation to Drug Response, Safety and Need for Therapy Optimization in Pediatric Inflammatory Bowel Disease. Children 2025; 12(10) doi: 10.3390/children12101334
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| 10 |
K. Wallisch, L.A. Trepanier. Incidence, Timing, and Risk Factors of Azathioprine Hepatotoxicosis in Dogs. Journal of Veterinary Internal Medicine 2015; 29(2) doi: 10.1111/jvim.12543
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| 11 |
E.H.M. van der Heijden, A.A. Kruize, T.R.D.J. Radstake, J.A.G. van Roon. Optimizing conventional DMARD therapy for Sjögren's syndrome. Autoimmunity Reviews 2018; 17(5) doi: 10.1016/j.autrev.2018.03.003
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| 12 |
Marie Allard, Nicolas Vignal, Aude Loiseau, Hélène Sauvageon, Yves Médard, Alain Plé, Evelyne Jacqz‐Aigrain, Samia Mourah, Lauriane Goldwirt. Development and Validation of Simultaneous Quantification of 6TGN and 6MMPN in Whole Blood Using LC–MS/MS: An Application to Therapeutic Drug Monitoring in Hematological Malignancies and in Inflammatory Bowel Diseases. Biomedical Chromatography 2026; 40(9) doi: 10.1002/bmc.70583
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| 13 |
Loredana Serpe, Roberto Canaparo, Maria Gabriella Scordo, Edoardo Spina. Pharmacogenetics of drug-metabolizing enzymes in Italian populations. Drug Metabolism and Personalized Therapy 2015; 30(2) doi: 10.1515/dmdi-2014-0028
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| 14 |
Teresa Martínez-Sena, Erika Moro, Marta Moreno-Torres, Guillermo Quintás, Jan Hengstler, José V. Castell. Metabolomics-based strategy to assess drug hepatotoxicity and uncover the mechanisms of hepatotoxicity involved. Archives of Toxicology 2023; 97(6) doi: 10.1007/s00204-023-03474-8
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| 15 |
Raffi Lev‐Tzion, Paul Renbaum, Rachel Beeri, Oren Ledder, Raphael Mevorach, Amir Karban, Eduard Koifman, Edna Efrati, Aleixo M. Muise, Yehuda Chowers, Dan Turner. Rac1 Polymorphisms and Thiopurine Efficacy in Children With Inflammatory Bowel Disease. Journal of Pediatric Gastroenterology and Nutrition 2015; 61(4) doi: 10.1097/MPG.0000000000000820
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| 16 |
Won Jung, Kyung-Eun Lee. An Update on Sjöl;gren’s Syndrome for Oral Medicine Specialists. Journal of Oral Medicine and Pain 2021; 46(4) doi: 10.14476/jomp.2021.46.4.99
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| 17 |
Marianna Lucafò, Raffaella Franca, Davide Selvestrel, Debora Curci, Letizia Pugnetti, Giuliana Decorti, Gabriele Stocco. Pharmacogenetics of treatments for inflammatory bowel disease. Expert Opinion on Drug Metabolism & Toxicology 2018; 14(12) doi: 10.1080/17425255.2018.1551876
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| 18 |
Laura L. Daniel, Puran Nepal, Jacy Zanussi, Alyson L. Dickson, Peter Straub, Tyne W. Miller‐Fleming, Wei‐Qi Wei, Adriana M. Hung, Nancy J. Cox, Vivian K. Kawai, Jonathan D. Mosley, Charles Michael Stein, QiPing Feng, Ge Liu, Ran Tao, Cecilia P. Chung. PTPN2 and Leukopenia in Individuals With Normal TPMT and NUDT15 Metabolizer Status Taking Azathioprine. Clinical and Translational Science 2025; 18(6) doi: 10.1111/cts.70220
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| 19 |
Sanda Huljev Frkovic, Marija Jelusic, Kristina Crkvenac Gornik, Dunja Rogic, Marijan Frkovic. Glutathione S-Transferase Gene Polymorphisms as Predictors of Methotrexate Efficacy in Juvenile Idiopathic Arthritis. Biomedicines 2024; 12(8) doi: 10.3390/biomedicines12081642
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| 20 |
Marco Pelin, Sara De Iudicibus, Laura Fusco, Eleonora Taboga, Giulia Pellizzari, Cristina Lagatolla, Stefano Martelossi, Alessandro Ventura, Giuliana Decorti, Gabriele Stocco. Role of Oxidative Stress Mediated by Glutathione-S-transferase in Thiopurines’ Toxic Effects. Chemical Research in Toxicology 2015; 28(6) doi: 10.1021/acs.chemrestox.5b00019
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| 21 |
Laura L. Daniel, Alyson L. Dickson, Cecilia P. Chung. Precision medicine for rheumatologists: lessons from the pharmacogenomics of azathioprine. Clinical Rheumatology 2021; 40(1) doi: 10.1007/s10067-020-05258-2
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| 22 |
Yonghoon Kwon, Nai Lee, Yun Kim. Intrahepatic cholestasis of pregnancy associated with azathioprine: first quantitative disproportionality analysis using the FDA adverse event reporting system. Journal of Pharmacy & Pharmaceutical Sciences 2025; 28 doi: 10.3389/jpps.2025.15527
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| 23 |
Nashwa Eltantawy, Islam Abd El-Hamid El-Zayyadi, Ahmed A. Elberry, Layla M. Salah, Mohamed E. A. Abdelrahim, Amira B. Kassem. A review article of inflammatory bowel disease treatment and pharmacogenomics. Beni-Suef University Journal of Basic and Applied Sciences 2023; 12(1) doi: 10.1186/s43088-023-00361-0
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| 24 |
S. Tavakolpour, M. Darvishi, M. Ghasemiadl. Pharmacogenetics: A strategy for personalized medicine for autoimmune diseases. Clinical Genetics 2018; 93(3) doi: 10.1111/cge.13186
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| 25 |
Sanaa Nassereddine, Rachida Habbal, Yaya Kassogue, Ait Boujmia Oum Kaltoum, Korchi Farah, Haraka Majda, Abou Elfath Rhizlane, Sellama Nadifi, Hind Dehbi. Analysis of the influence of glutathione S-transferase (GSTM1 and GSTT1) genes on the risk of essential hypertension. Annals of Human Biology 2021; 48(7-8) doi: 10.1080/03014460.2022.2039291
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| 26 |
Jingjing Zhang, Jiaqi Han, Ning Sun, Yuhan Zhu, Dong Mei, Libo Zhao. Development and Application of an LC-MS/MS Method for Simultaneous Quantification of Azathioprine and Its Metabolites: Pharmacokinetic and Microbial Metabolism Study of a Colon-Targeted Nanoparticle. Pharmaceuticals 2025; 19(1) doi: 10.3390/ph19010058
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| 27 |
Silvia Gallego-Gutiérrez, Víctor Manuel Navas-López, Michal Kolorz, Ladislava Bartosova, Katerina Lukac, Silvia Luque-Pérez, Leticia Núñez-Caro, Paloma García-Galán, Francisco Girón Fernández-Crehuet, Javier Blasco-Alonso, María Juliana Serrano-Nieto, Carlos Sierra-Salinas. Successful Mercaptopurine Usage despite Azathioprine-Induced Pancreatitis in Paediatric Crohn’s Disease. Journal of Crohn's and Colitis 2015; 9(8) doi: 10.1093/ecco-jcc/jjv086
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| 28 |
Anil B Bhokare. Azathioprine-induced Alopecia as an Early Clinical Marker of its Myelotoxicity. Indian Journal of Drugs in Dermatology 2017; 3(1) doi: 10.4103/ijdd.ijdd_4_17
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| 29 |
Yu Min Lee, Yun-Chul Hong, Mina Ha, Yangho Kim, Hyesook Park, Hae Soon Kim, Eun-Hee Ha. Prenatal Bisphenol-A exposure affects fetal length growth by maternal glutathione transferase polymorphisms, and neonatal exposure affects child volume growth by sex: From multiregional prospective birth cohort MOCEH study. Science of The Total Environment 2018; 612 doi: 10.1016/j.scitotenv.2017.08.317
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| 30 |
Lara Stute, Rejko Krüger. Ansätze zur Etablierung von Präzisionsmedizin bei der Parkinson-Krankheit mit dem Schwerpunkt Genetik. Fortschritte der Neurologie · Psychiatrie 2020; 88(09) doi: 10.1055/a-1149-2204
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| 31 |
Dunja Urbančič, Flaka Pasha, Alenka Šmid, Irena Mlinarič-Raščan. Personalization of thiopurine therapy: Current recommendations and future perspectives. Acta Pharmaceutica 2024; 74(3) doi: 10.2478/acph-2024-0030
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| 32 |
Paola Rispoli, Elena Genova, Fengming Yue, Kohei Johkura, Martina Franzin, Ute Hofmann, Matthias Schwab, Rosalba Monica Ferraro, Elena Laura Mazzoldi, Silvia Clara Giliani, Giovanna Piovani, Matteo Bramuzzo, Stefano Martelossi, Erasmo Miele, Massimo Martinelli, Federico Marchetti, Marco Pelin, Giuliana Decorti, Marianna Lucafò, Gabriele Stocco. Unraveling the cellular mechanisms of thiopurine-induced pancreatitis in pediatric inflammatory bowel disease: Insights from induced pluripotent stem cell models. Biomedicine & Pharmacotherapy 2025; 191 doi: 10.1016/j.biopha.2025.118539
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| 33 |
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| 34 |
Samantha M. Ervin, Matthew R. Redinbo. The Gut Microbiota Impact Cancer Etiology through “Phase IV Metabolism” of Xenobiotics and Endobiotics. Cancer Prevention Research 2020; 13(8) doi: 10.1158/1940-6207.CAPR-20-0155
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| 35 |
Marco Pelin, Elena Genova, Laura Fusco, Monzer Marisat, Ute Hofmann, Diego Favretto, Marianna Lucafò, Andrea Taddio, Stefano Martelossi, Alessandro Ventura, Gabriele Stocco, Matthias Schwab, Giuliana Decorti. Pharmacokinetics and pharmacodynamics of thiopurines in an in vitro model of human hepatocytes: Insights from an innovative mass spectrometry assay. Chemico-Biological Interactions 2017; 275 doi: 10.1016/j.cbi.2017.08.009
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| 36 |
Aurrielle C. Eberhardy, Nicole A. Heinrich, Rendina A. McFadden, Lisa V. Reiter. Prevalence of hepatotoxicity and myelosuppression with alternate day use of azathioprine and glucocorticoids for treatment of dermatological conditions in dogs. Veterinary Dermatology 2022; 33(6) doi: 10.1111/vde.13115
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| 37 |
Rebecca L Roberts, Murray L Barclay. Update on Thiopurine Pharmacogenetics in Inflammatory Bowel Disease. Pharmacogenomics 2015; 16(8) doi: 10.2217/pgs.15.29
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| 38 |
Ivan Padjen. Surgery in Rheumatic and Musculoskeletal Disease. Handbook of Systemic Autoimmune Diseases 2018; 15 doi: 10.1016/B978-0-444-63887-8.00003-7
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| 39 |
Soheil Tavakolpour. Current and future treatment options for pemphigus: Is it time to move towards more effective treatments?. International Immunopharmacology 2017; 53 doi: 10.1016/j.intimp.2017.10.027
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| 40 |
Carolina Rios-Usuga, Marlen Martinez-Gutierrez, Julian Ruiz-Saenz. Antiviral Potential of Azathioprine and Its Derivative 6- Mercaptopurine: A Narrative Literature Review. Pharmaceuticals 2024; 17(2) doi: 10.3390/ph17020174
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| 41 |
Dirk P. van Asseldonk, Femke Crouwel, Margien L. Seinen, Peter G. Scheffer, Agnes I. Veldkamp, Nanne K. de Boer, Birgit Lissenberg‐Witte, Godefridus J. Peters, Adriaan A. van Bodegraven. Exploring the role of oxidative stress and the effect of N‐acetylcysteine in thiopurine‐induced liver injury in inflammatory bowel disease: A randomized crossover pilot study. Basic & Clinical Pharmacology & Toxicology 2024; 134(4) doi: 10.1111/bcpt.13978
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| 42 |
Ashok Thulluru, Goutham Yerrakula, Nawaz Mohammed, Reshma Tadipatri, Varun Srighakollapu. Genomics and Precision Healthcare. 2026; doi: 10.1002/9781394367559.ch3
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| 43 |
Prathima Anandi, Alyson L. Dickson, QiPing Feng, Wei-Qi Wei, William D. Dupont, Dale Plummer, Ge Liu, Rany Octaria, Katherine A. Barker, Vivian K. Kawai, Kelly Birdwell, Nancy J. Cox, Adriana Hung, C. Michael Stein, Cecilia P. Chung. Combining clinical and candidate gene data into a risk score for azathioprine-associated leukopenia in routine clinical practice. The Pharmacogenomics Journal 2020; 20(5) doi: 10.1038/s41397-020-0163-4
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| 44 |
Solène Marie, Kayla L. Frost, Raymond K. Hau, Lucy Martinez-Guerrero, Jailyn M. Izu, Cassandra M. Myers, Stephen H. Wright, Nathan J. Cherrington. Predicting disruptions to drug pharmacokinetics and the risk of adverse drug reactions in non-alcoholic steatohepatitis patients. Acta Pharmaceutica Sinica B 2023; 13(1) doi: 10.1016/j.apsb.2022.08.018
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| 45 |
Surabhi Shah, Kyoung Sook Jeong, Hyesook Park, Yun-Chul Hong, Yangho Kim, Byungmi Kim, Namsoo Chang, Suejin Kim, Yeni Kim, Bung-Nyun Kim, Hojang Kwon, Sanghyuk Bae, Hwan-Cheol Kim, Jong-Han Leem, Eun-Kyo Park, Hyunjoo Joo, Bohyun Park, Mina Ha, Eunhee Ha. Environmental pollutants affecting children's growth and development: Collective results from the MOCEH study, a multi-centric prospective birth cohort in Korea. Environment International 2020; 137 doi: 10.1016/j.envint.2020.105547
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| 46 |
Linda Nanni, Marco Murgiano, Chieh-En Hsu, Sheida Khalili, Giovanni Cammarota, Alfredo Papa, Antonio Gasbarrini, Franco Scaldaferri, Loris Riccardo Lopetuso. Gut microbial healing in IBD: visionary approach or evidence-based reality?. Expert Review of Gastroenterology & Hepatology 2025; 19(8) doi: 10.1080/17474124.2025.2537188
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| 47 |
Elena Genova, Marianna Lucafò, Marco Pelin, Veronica Di Paolo, Luigi Quintieri, Giuliana Decorti, Gabriele Stocco. Insights into the cellular pharmacokinetics and pharmacodynamics of thiopurine antimetabolites in a model of human intestinal cells. Chemico-Biological Interactions 2021; 347 doi: 10.1016/j.cbi.2021.109624
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| 48 |
Marianna Lucafò, Gabriele Stocco, Stefano Martelossi, Diego Favretto, Raffaella Franca, Noelia Malusà, Angela Lora, Matteo Bramuzzo, Samuele Naviglio, Erika Cecchin, Giuseppe Toffoli, Alessandro Ventura, Giuliana Decorti. Azathioprine Biotransformation in Young Patients with Inflammatory Bowel Disease: Contribution of Glutathione-S Transferase M1 and A1 Variants. Genes 2019; 10(4) doi: 10.3390/genes10040277
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| 49 |
W. Moon, E. V. Loftus. Review article: recent advances in pharmacogenetics and pharmacokinetics for safe and effective thiopurine therapy in inflammatory bowel disease. Alimentary Pharmacology & Therapeutics 2016; 43(8) doi: 10.1111/apt.13559
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