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For: Bradford K, Shih DQ. Optimizing 6-mercaptopurine and azathioprine therapy in the management of inflammatory bowel disease. World J Gastroenterol 2011; 17(37): 4166-4173 [PMID: 22072847 DOI: 10.3748/wjg.v17.i37.4166]
URL: https://www.wjgnet.com/1007-9327/full/v17/i37/4166.htm
Number Citing Articles
Yoomi Park, Hyery Kim, Jung Yoon Choi, Sunmin Yun, Byung-Joo Min, Myung-Eui Seo, Ho Joon Im, Hyoung Jin Kang, Ju Han Kim. Star Allele-Based Haplotyping versus Gene-Wise Variant Burden Scoring for Predicting 6-Mercaptopurine Intolerance in Pediatric Acute Lymphoblastic Leukemia PatientsFrontiers in Pharmacology 2019; 10 doi: 10.3389/fphar.2019.00654
Ji Hyeon Lee, Tae Jun Kim, Eun Ran Kim, Sung Noh Hong, Dong Kyung Chang, Li-Hwa Choi, Hye In Woo, Soo-Youn Lee, Young-Ho Kim, John Green. Measurements of 6-thioguanine nucleotide levels with TPMT and NUDT15 genotyping in patients with Crohn’s diseasePLOS ONE 2017; 12(12): e0188925 doi: 10.1371/journal.pone.0188925
Hilal Ahmad, Vijay L. Kumar. Pharmacotherapy of ulcerative colitis – current status and emerging trendsJournal of Basic and Clinical Physiology and Pharmacology 2018; 29(6): 581 doi: 10.1515/jbcpp-2016-0014
Samantha L. Sanford, Griffin A. Welfer, Bret D. Freudenthal, Patricia L. Opresko. Mechanisms of telomerase inhibition by oxidized and therapeutic dNTPsNature Communications 2020; 11(1) doi: 10.1038/s41467-020-19115-y
Hiromu Morikubo, Taku Kobayashi, Ryo Ozaki, Shinji Okabayashi, Satoshi Kuronuma, Osamu Takeuchi, Tenyo Shiba, Hiroki Kiyohara, Mao Matsubayashi, Shintaro Sagami, Masaru Nakano, Osamu Ikezaki, Tadakazu Hisamatsu, Yoichi Tanaka, Toshifumi Hibi. Differential effects of mesalazine formulations on thiopurine metabolism through thiopurine S‐methyltransferase inhibitionJournal of Gastroenterology and Hepatology 2021; 36(8): 2116 doi: 10.1111/jgh.15411
Takato Maeda, Hirotake Sakuraba, Hiroto Hiraga, Shukuko Yoshida, Yoichi Kakuta, Hidezumi Kikuchi, Shogo Kawaguchi, Keisuke Hasui, Tetsuya Tatsuta, Daisuke Chinda, Tatsuya Mikami, Shinsaku Fukuda. Long-term efficacy and tolerability of dose-adjusted thiopurine treatment in maintaining remission in inflammatory bowel disease patients with NUDT15 heterozygosityIntestinal Research 2022; 20(1): 90 doi: 10.5217/ir.2020.00133
Shinichiro Shinzaki, Kayoko Sakagami, Miki Matsumoto, Tetsuo Takehara, Hiroaki Ito. Nurse-Provided Medication Guidance for Improving Drug Adherence to Thiopurines in Outpatients With Inflammatory Bowel Disease: A Single-Center Prospective StudyCrohn's & Colitis 360 2022; 4(1) doi: 10.1093/crocol/otab081
Roslyn Kemp, Elliott Dunn, Michael Schultz. Immunomodulators in Inflammatory Bowel Disease: An Emerging Role for Biologic AgentsBioDrugs 2013; 27(6): 585 doi: 10.1007/s40259-013-0045-2
Lucy Croyle, Eric F. Morand. Optimizing the use of existing therapies in lupusInternational Journal of Rheumatic Diseases 2015; 18(2): 129 doi: 10.1111/1756-185X.12551
Stine N. Nielsen, Thomas L. Frandsen, Jacob Nersting, Lisa L. Hjalgrim, Kjeld Schmiegelow. Pharmacokinetics of 6-Thioguanine and 6-Mercaptopurine Combination Maintenance Therapy of Childhood ALLJournal of Pediatric Hematology/Oncology 2015; 37(3): e206 doi: 10.1097/MPH.0000000000000246
Marina Millán, Manuel Castro-Fernández, Javier Ampuero, Manuel Romero-Gómez. Mielotoxicidad por la interacción entre azatioprina y alopurinol en paciente con enfermedad de CrohnGastroenterología y Hepatología 2013; 36(4): 298 doi: 10.1016/j.gastrohep.2012.10.002
Abdullah Al Maruf, Luke Wan, Peter J. O’Brien. Evaluation of Azathioprine-Induced Cytotoxicity in anIn VitroRat Hepatocyte SystemBioMed Research International 2014; 2014: 1 doi: 10.1155/2014/379748
N. M. Heerasing, J. F. Ng, D. Dowling. Does lymphopenia or macrocytosis reflect 6-thioguanine levels in patients with inflammatory bowel disease treated with azathioprine or 6-mercaptopurine?Internal Medicine Journal 2016; 46(4): 465 doi: 10.1111/imj.12915
Nadim H Malibary, Mohammed A Ezzat, Ahmed M Mogharbel, Khalid A Kouzaba, Abdulaziz A Alkadi, Usama H Malki, Sultan M Gharib, Faisal M Altowairqi, Omar I Saadah, Mahmoud H Mosli. Factors Affecting Ulcerative Colitis Flare-Ups: Associations With Smoking Habits and Other Patient CharacteristicsCureus 2021;  doi: 10.7759/cureus.19834
Rachele Ciccocioppo, Francesca Racca, Luigia Scudeller, Antonio Piralla, Pietro Formagnana, Lodovica Pozzi, Elena Betti, Alessandro Vanoli, Roberta Riboni, Peter Kruzliak, Fausto Baldanti, Gino Roberto Corazza. Differential cellular localization of Epstein–Barr virus and human cytomegalovirus in the colonic mucosa of patients with active or quiescent inflammatory bowel diseaseImmunologic Research 2016; 64(1): 191 doi: 10.1007/s12026-015-8737-y
Melissa A. Smith, Paul Blaker, Anthony M. Marinaki, Simon H. Anderson, Peter M. Irving, Jeremy D. Sanderson. Optimising outcome on thiopurines in inflammatory bowel disease by co-prescription of allopurinolJournal of Crohn's and Colitis 2012; 6(9): 905 doi: 10.1016/j.crohns.2012.02.007
Aline Correa Ribeiro, Luciane Henriques Furtado Barroso, Carlos Alberto Mourao-Junior, Julio Maria Fonseca Chebli, Jorge Willian Leandro Nascimento. Simultaneous Monitoring of Azathioprine Metabolites in Erythrocytes of Crohn’s Disease Patients by HPLC-UVJournal of Chromatographic Science 2022; 60(6): 518 doi: 10.1093/chromsci/bmab084
U. Kopylov, D. Amre, Y. Theoret, C. Deslandres, E.G. Seidman. Thiopurine Metabolite Ratios for Monitoring Therapy in Pediatric Crohn DiseaseJournal of Pediatric Gastroenterology & Nutrition 2014; 59(4): 511 doi: 10.1097/MPG.0000000000000455
Amlan Jyoti Ghosh, Sagar Sarkar, Supriyo Ghosh, Tilak Saha. Alternatives to Antibiotics2022; : 419 doi: 10.1007/978-981-19-1854-4_17
Yutaka Kimura, Hitoshi Terui, Chizu Fujimura, Ryo Amagai, Toshiya Takahashi, Setsuya Aiba. Optimization of the IL-2 Luc assay for immunosuppressive drugs: a novel in vitro immunotoxicity test with high sensitivity and predictivityArchives of Toxicology 2021; 95(8): 2755 doi: 10.1007/s00204-021-03101-4
Jan Kneusels, Meike Kaehler, Ingolf Cascorbi, Thilo Wedel, Michel Neunlist, Ralph Lucius, François Cossais. Limited Impact of 6-Mercaptopurine on Inflammation-Induced Chemokines Expression Profile in Primary Cultures of Enteric Nervous SystemNeurochemical Research 2021; 46(7): 1781 doi: 10.1007/s11064-021-03324-y
Qiuyuan Liu, Yanyan Wang, Qiao Mei, Wei Han, Jing Hu, Naizhong Hu. Measurement of red blood cell 6-thioguanine nucleotide is beneficial in azathioprine maintenance therapy of Chinese Crohn’s disease patientsScandinavian Journal of Gastroenterology 2016; 51(9): 1093 doi: 10.3109/00365521.2016.1161068
Xin-Hui Khoo, Shin Yee Wong, Nik Razima Wan Ibrahim, Ruey Terng Ng, Kee Seang Chew, Way Seah Lee, Zhi Qin Wong, Raja Affend Raja Ali, Shahreedhan Shahrani, Alex Hwong-Ruey Leow, Ida Normiha Hilmi. Nudix Hydroxylase 15 Mutations Strongly Predict Thiopurine-Induced Leukopenia Across Different Asian Ethnicities: Implications for Screening in a Diverse PopulationFrontiers in Medicine 2022; 9 doi: 10.3389/fmed.2022.880937
Ingrid Fricke-Galindo, Helgi Jung-Cook, Adrián LLerena, Marisol López-López. Interethnic variability of pharmacogenetic biomarkers in Mexican healthy volunteers: a report from the RIBEF (Ibero-American Network of Pharmacogenetics and Pharmacogenomics)Drug Metabolism and Personalized Therapy 2016; 31(2) doi: 10.1515/dmpt-2015-0030
Rachele Ciccocioppo, Caterina Mengoli, Elena Betti, Giuditta Comolli, Irene Cassaniti, Antonio Piralla, Peter Kruzliak, Martin Caprnda, Lodovica Pozzi, Gino Roberto Corazza, Antonio Di Sabatino, Fausto Baldanti. Human Cytomegalovirus and Epstein-Barr virus specific immunity in patients with ulcerative colitisClinical and Experimental Medicine 2021; 21(3): 379 doi: 10.1007/s10238-021-00702-2
Saba Hasan, Prankur Awasthi, Sumira Malik, Manish Dwivedi. Immunotherapeutic strategies to induce inflection in the immune response: therapy for cancer and COVID-19Biotechnology and Genetic Engineering Reviews 2022; : 1 doi: 10.1080/02648725.2022.2147661
Lena S. Candels, Mussarat N. Rahim, Sital Shah, Michael A. Heneghan. Towards personalised medicine in autoimmune hepatitis: Measurement of thiopurine metabolites results in higher biochemical response ratesJournal of Hepatology 2021; 75(2): 324 doi: 10.1016/j.jhep.2021.03.023
Marco Vincenzo Lenti, Christian P. Selinger. Medication non-adherence in adult patients affected by inflammatory bowel disease: a critical review and update of the determining factors, consequences and possible interventionsExpert Review of Gastroenterology & Hepatology 2017; : 1 doi: 10.1080/17474124.2017.1284587
Ewa Dudzińska, Aneta Strachecka, Paulina Gil-Kulik, Janusz Kocki, Jacek Bogucki, Natalya Shemedyuk, Magdalena Gryzinska. Influence of the Treatment Used in Inflammatory Bowel Disease on the Protease ActivitiesInternational Journal of General Medicine 2020; : 1633 doi: 10.2147/IJGM.S267036
Daniel Rehling, Si Min Zhang, Ann-Sofie Jemth, Tobias Koolmeister, Adam Throup, Olov Wallner, Emma Scaletti, Takaya Moriyama, Rina Nishii, Jonathan Davies, Matthieu Desroses, Sean G. Rudd, Martin Scobie, Evert Homan, Ulrika Warpman Berglund, Jun J. Yang, Thomas Helleday, Pål Stenmark. Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivityJournal of Biological Chemistry 2021; 296: 100568 doi: 10.1016/j.jbc.2021.100568
Hartmut Kirchherr, Maria Shipkova, Nicolas von Ahsen. Improved Method for Therapeutic Drug Monitoring of 6-Thioguanine Nucleotides and 6-Methylmercaptopurine in Whole-Blood by LC/MSMS Using Isotope-Labeled Internal StandardsTherapeutic Drug Monitoring 2013; 35(3): 313 doi: 10.1097/FTD.0b013e318283ed5d
Si Min Zhang, Matthieu Desroses, Anna Hagenkort, Nicholas C. K. Valerie, Daniel Rehling, Megan Carter, Olov Wallner, Tobias Koolmeister, Adam Throup, Ann-Sofie Jemth, Ingrid Almlöf, Olga Loseva, Thomas Lundbäck, Hanna Axelsson, Shruti Regmi, Antonio Sarno, Andreas Krämer, Linda Pudelko, Lars Bräutigam, Azita Rasti, Mona Göttmann, Elisée Wiita, Juliane Kutzner, Torsten Schaller, Christina Kalderén, Armando Cázares-Körner, Brent D. G. Page, Rosa Krimpenfort, Saeed Eshtad, Mikael Altun, Sean G. Rudd, Stefan Knapp, Martin Scobie, Evert J. Homan, Ulrika Warpman Berglund, Pål Stenmark, Thomas Helleday. Development of a chemical probe against NUDT15Nature Chemical Biology 2020; 16(10): 1120 doi: 10.1038/s41589-020-0592-z
Misbah Misdaq, Reiner Andag, Michael Oellerich, Abdul R. Asif, Nicolas von Ahsen. Establishment of Thiopurine S-Methyltransferase Gene Knockdown in Jurkat T-lymphocytesTherapeutic Drug Monitoring 2012; 34(5): 584 doi: 10.1097/FTD.0b013e31826ec4b4
Nicholas C.K. Valerie, Anna Hagenkort, Brent D.G. Page, Geoffrey Masuyer, Daniel Rehling, Megan Carter, Luka Bevc, Patrick Herr, Evert Homan, Nina G. Sheppard, Pål Stenmark, Ann-Sofie Jemth, Thomas Helleday. NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-ThioguanineCancer Research 2016; 76(18): 5501 doi: 10.1158/0008-5472.CAN-16-0584
Rachele Ciccocioppo, Francesca Racca, Stefania Paolucci, Giulia Campanini, Lodovica Pozzi, Elena Betti, Roberta Riboni, Alessandro Vanoli, Fausto Baldanti, Gino Roberto Corazza. Human cytomegalovirus and Epstein-Barr virus infection in inflammatory bowel disease: Need for mucosal viral load measurementWorld Journal of Gastroenterology 2015; 21(6): 1915-1926 doi: 10.3748/wjg.v21.i6.1915
Pegah Hosseini-Carroll, Monica Mutyala, Abhishek Seth, Shaheen Nageeb, Demiana Soliman, Moheb Boktor, Ankur Sheth, Jonathon Chapman, James Morris, Paul Jordan, Kenneth Manas, Felix Becker, Jonathan Steven Alexander. Pregnancy and inflammatory bowel diseases: Current perspectives, risks and patient managementWorld Journal of Gastrointestinal Pharmacology and Therapeutics 2015; 6(4): 156-171 doi: 10.4292/wjgpt.v6.i4.156
Richard Myles Turner, Munir Pirmohamed. Preventive and Predictive Genetics: Towards Personalised MedicineAdvances in Predictive, Preventive and Personalised Medicine 2015; 9: 109 doi: 10.1007/978-3-319-15344-5_6
Jingtao Chen, Patrick Brady, Yasser Saloum, Shanil Lara. 6-Mercaptopurine-Induced Hepatotoxicity During the Treatment of Ulcerative ColitisGastroenterology Nursing 2015; 38(1): 65 doi: 10.1097/SGA.0000000000000091
Adrian Reuben. Drug-Induced Liver Disease2013; : 569 doi: 10.1016/B978-0-12-387817-5.00031-5
Lucy Croyle, Alberta Hoi, Eric F Morand. Characteristics of azathioprine use and cessation in a longitudinal lupus cohortLupus Science & Medicine 2015; 2(1): e000105 doi: 10.1136/lupus-2015-000105
Nicole M. Giamanco, Bethany S. Cunningham, Laura S. Klein, Dina S. Parekh, Anne B. Warwick, Kenneth Lieuw. Allopurinol Use During Maintenance Therapy for Acute Lymphoblastic Leukemia Avoids Mercaptopurine-related HepatotoxicityJournal of Pediatric Hematology/Oncology 2016; 38(2): 147 doi: 10.1097/MPH.0000000000000499
Qingqing Cai, Li Zhang, Ling Li, Juan Tan, Shiyue Wu, Yi Wang, Wensheng Fu. Detection of Chemotherapeutic Drug 6-Mercaptopurine Through Manipulating Localized Surface Plasmon Resonance Absorption of Silver NanoplatesNano 2021; 16(04): 2150046 doi: 10.1142/S1793292021500466
Sheng Zhang Lim, Eng Wee Chua. Revisiting the Role of Thiopurines in Inflammatory Bowel Disease Through Pharmacogenomics and Use of Novel Methods for Therapeutic Drug MonitoringFrontiers in Pharmacology 2018; 9 doi: 10.3389/fphar.2018.01107
Angelo V. Marzano, Alessandro Borghi, Pier Luigi Meroni, Carlo Crosti, Massimo Cugno. Immune-mediated inflammatory reactions and tumors as skin side effects of inflammatory bowel disease therapyAutoimmunity 2014; 47(3): 146 doi: 10.3109/08916934.2013.873414
Kathleen E. LaDuke, Sarah Ehling, John M. Cullen, Wolfgang Bäumer. Effects of azathioprine, 6-mercaptopurine, and 6-thioguanine on canine primary hepatocytesAmerican Journal of Veterinary Research 2015; 76(7): 649 doi: 10.2460/ajvr.76.7.649
Allison Bigeh, Alexandra Sanchez, Camila Maestas, Martha Gulati. Inflammatory bowel disease and the risk for cardiovascular disease: Does all inflammation lead to heart disease?Trends in Cardiovascular Medicine 2020; 30(8): 463 doi: 10.1016/j.tcm.2019.10.001
D. Q. Shih, M. Nguyen, L. Zheng, P. Ibanez, L. Mei, L. Y. Kwan, K. Bradford, C. Ting, S. R. Targan, E. A. Vasiliauskas. Split-dose administration of thiopurine drugs: a novel and effective strategy for managing preferential 6-MMP metabolismAlimentary Pharmacology & Therapeutics 2012; 36(5): 449 doi: 10.1111/j.1365-2036.2012.05206.x