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For: Loguercio C, Festi D. Silybin and the liver: From basic research to clinical practice. World J Gastroenterol 2011; 17(18): 2288-2301 [PMID: 21633595 DOI: 10.3748/wjg.v17.i18.2288]
URL: https://www.wjgnet.com/1007-9327/full/v17/i18/2288.htm
Number Citing Articles
1
Clarissa Gerhauser. Recent Advances in Polyphenol Research2014; : 143 doi: 10.1002/9781118329634.ch6
2
Antonia Diukendjieva, Merilin Al Sharif, Petko Alov, Tania Pencheva, Ivanka Tsakovska, Ilza Pajeva. ADME/Tox Properties and Biochemical Interactions of Silybin Congeners: In silico StudyNatural Product Communications 2017; 12(2): 1934578X1701200 doi: 10.1177/1934578X1701200208
3
Nancy Vargas-Mendoza, Marcelo Ángeles-Valencia, Eduardo Osiris Madrigal-Santillán, Mauricio Morales-Martínez, Judith Margarita Tirado-Lule, Arturo Solano-Urrusquieta, Eduardo Madrigal-Bujaidar, Isela Álvarez-González, Tomás Fregoso-Aguilar, Ángel Morales-González, José A. Morales-González. Effect of Silymarin Supplementation on Physical Performance, Muscle and Myocardium Histological Changes, Bodyweight, and Food Consumption in Rats Subjected to Regular Exercise TrainingInternational Journal of Molecular Sciences 2020; 21(20): 7724 doi: 10.3390/ijms21207724
4
Kristina M. Brooks, Jomy M. George, Parag Kumar. Drug interactions in HIV treatment: complementary & alternative medicines and over-the-counter productsExpert Review of Clinical Pharmacology 2017; 10(1): 59 doi: 10.1080/17512433.2017.1246180
5
Jia-Ping Wu, Chin-Chuan Tsai, Yu-Lan Yeh, Yueh-Min Lin, Chien-Chung Lin, Cecilia Hsuan Day, Chia-Yao Shen, V. Vijaya Padma, Lung-Fa Pan, Chih-Yang Huang. Silymarin Accelerates Liver Regeneration after Partial HepatectomyEvidence-Based Complementary and Alternative Medicine 2015; 2015: 1 doi: 10.1155/2015/603529
6
E.S. Hackett, D.C. Twedt, D.L. Gustafson. Milk Thistle and Its Derivative Compounds: A Review of Opportunities for Treatment of Liver DiseaseJournal of Veterinary Internal Medicine 2013; 27(1): 10 doi: 10.1111/jvim.12002
7
Arrigo Cicero, Alessandro Colletti, Stefano Bellentani. Nutraceutical Approach to Non-Alcoholic Fatty Liver Disease (NAFLD): The Available Clinical EvidenceNutrients 2018; 10(9): 1153 doi: 10.3390/nu10091153
8
Brandon T. Gufford, Tyler N. Graf, Noemi D. Paguigan, Nicholas H. Oberlies, Mary F. Paine. Chemoenzymatic Synthesis, Characterization, and Scale-Up of Milk Thistle Flavonolignan GlucuronidesDrug Metabolism and Disposition 2015; 43(11): 1734 doi: 10.1124/dmd.115.066076
9
Mihai Oltean. Silybin Against Liver Ischemia-Reperfusion Injury: Something Old, Something New…Journal of Investigative Surgery 2018; 31(6): 521 doi: 10.1080/08941939.2017.1365975
10
Michal Bijak, Angela Dziedzic, Ewelina Synowiec, Tomasz Sliwinski, Joanna Saluk-Bijak. Flavonolignans Inhibit IL1-β-Induced Cross-Talk between Blood Platelets and LeukocytesNutrients 2017; 9(9): 1022 doi: 10.3390/nu9091022
11
Matteo Lazzeroni, Aliana Guerrieri-Gonzaga, Sara Gandini, Harriet Johansson, Davide Serrano, Massimiliano Cazzaniga, Valentina Aristarco, Antonella Puccio, Serena Mora, Pietro Caldarella, Gianmatteo Pagani, Giancarlo Pruneri, Antonella Riva, Giovanna Petrangolini, Paolo Morazzoni, Andrea DeCensi, Bernardo Bonanni. A Presurgical Study of Oral Silybin-Phosphatidylcholine in Patients with Early Breast CancerCancer Prevention Research 2016; 9(1): 89 doi: 10.1158/1940-6207.CAPR-15-0123
12
Claire Albert, Mohamed Beladjine, Nicolas Tsapis, Elias Fattal, Florence Agnely, Nicolas Huang. Pickering emulsions: Preparation processes, key parameters governing their properties and potential for pharmaceutical applicationsJournal of Controlled Release 2019; 309: 302 doi: 10.1016/j.jconrel.2019.07.003
13
Hamidah Mohd Yusof, Norlaily Mohd Ali, Swee Keong Yeap, Wan Yong Ho, Boon Kee Beh, Soo Peng Koh, Kamariah Long, Suraini Abdul Aziz, Noorjahan Banu Alitheen. Hepatoprotective Effect of Fermented Soybean (Nutrient Enriched Soybean Tempeh) against Alcohol-Induced Liver Damage in MiceEvidence-Based Complementary and Alternative Medicine 2013; 2013: 1 doi: 10.1155/2013/274274
14
Yun Gao, Steven Setiawan Theng, Way-Champ Mah, Caroline G. L. Lee. Silibinin down-regulates FAT10 and modulate TNF-α/IFN-γ-induced chromosomal instability and apoptosis sensitivityBiology Open 2015; 4(8): 961 doi: 10.1242/bio.011189
15
Ji-Suk Jeong, Yong-Joo Kim, Bo-Rum Choi, Geun-Bae Go, Byeong-Gil Son, Suk-Won Gang, Seung-Man Moon. Antioxidant and Physicochemical Changes in Salvia plebeia R. Br. after Hot-air Drying and BlanchingJournal of the Korean Society of Food Science and Nutrition 2014; 43(6): 893 doi: 10.3746/jkfn.2014.43.6.893
16
Elisa Ceccherini, Antonella Cecchettini, Maria Aurora Morales, Silvia Rocchiccioli. The Potentiality of Herbal Remedies in Primary Sclerosing Cholangitis: From In Vitro to Clinical StudiesFrontiers in Pharmacology 2020; 11 doi: 10.3389/fphar.2020.00813
17
Priyanka Upadhyay, Mousumi Bhattacharjee, Saurav Bhattacharya, Manisha Ahir, Arghya Adhikary, Prasun Patra. Silymarin-Loaded, Lactobionic Acid-Conjugated Porous PLGA Nanoparticles Induce Apoptosis in Liver Cancer CellsACS Applied Bio Materials 2020; 3(10): 7178 doi: 10.1021/acsabm.0c00987
18
M. Morovat, M. Chamani, A. Zarei, A.A. Sadeghi. Dietary but notin ovofeeding ofSilybum marianumextract resulted in an improvement in performance, immunity and carcass characteristics and decreased the adverse effects of high temperatures in broilersBritish Poultry Science 2016; 57(1): 105 doi: 10.1080/00071668.2015.1121537
19
Ewelina van Wenum, Rafal Jurczakowski, Grzegorz Litwinienko. Media Effects on the Mechanism of Antioxidant Action of Silybin and 2,3-Dehydrosilybin: Role of the Enol GroupThe Journal of Organic Chemistry 2013; 78(18): 9102 doi: 10.1021/jo401296k
20
Jiayin Yao, Min Zhi, Xiang Gao, Pinjin Hu, Chujun Li, Xiaobo Yang. Effect and the probable mechanisms of silibinin in regulating insulin resistance in the liver of rats with non-alcoholic fatty liverBrazilian Journal of Medical and Biological Research 2013; 46(3): 270 doi: 10.1590/1414-431X20122551
21
Mahdi Mashhadi Akbar Boojar, Massoud Mashhadi Akbar Boojar, Sepide Golmohammad. Overview of Silibinin anti-tumor effectsJournal of Herbal Medicine 2020; 23: 100375 doi: 10.1016/j.hermed.2020.100375
22
Dezső Csupor, Attila Csorba, Judit Hohmann. Recent advances in the analysis of flavonolignans of Silybum marianumJournal of Pharmaceutical and Biomedical Analysis 2016; 130: 301 doi: 10.1016/j.jpba.2016.05.034
23
Anjali Takke, Pravin Shende. Nanotherapeutic silibinin: An insight of phytomedicine in healthcare reformationNanomedicine: Nanotechnology, Biology and Medicine 2019; 21: 102057 doi: 10.1016/j.nano.2019.102057
24
Marjan Gharagozloo, Mehran Karimi, Zahra Amirghofran. Immunomodulatory effects of silymarin in patients with β-thalassemia majorInternational Immunopharmacology 2013; 16(2): 243 doi: 10.1016/j.intimp.2013.04.016
25
Zhong-Wen Yuan, Ya-Zhuo Li, Zhong-Qiu Liu, Sen-ling Feng, Hua Zhou, Chang-Xiao Liu, Liang Liu, Ying Xie. Role of tangeretin as a potential bioavailability enhancer for silybin: Pharmacokinetic and pharmacological studiesPharmacological Research 2018; 128: 153 doi: 10.1016/j.phrs.2017.09.019
26
Qian Ding, Jiaolin Bao, Wenwen Zhao, Yangyang Hu, Jinjian Lu, Xiuping Chen. Natural autophagy regulators in cancer therapy: a reviewPhytochemistry Reviews 2015; 14(1): 137 doi: 10.1007/s11101-014-9339-3
27
Susanne M. Henning, Yanjun Zhang, Victoria G. Rontoyanni, Jianjun Huang, Ru-Po Lee, Amy Trang, Gloria Nuernberger, David Heber. Variability in the Antioxidant Activity of Dietary Supplements from Pomegranate, Milk Thistle, Green Tea, Grape Seed, Goji, and Acai: Effects of in Vitro DigestionJournal of Agricultural and Food Chemistry 2014; 62(19): 4313 doi: 10.1021/jf500106r
28
Gianni Testino, Silvia Leone, Sharmila Fagoonee, Rinaldo Pellicano. Alcoholic liver fibrosis: detection and treatmentMinerva Medica 2018; 109(6) doi: 10.23736/S0026-4806.18.05844-5
29
Mingzhu Shangguan, Yi Lu, Jianping Qi, Jin Han, Zhiqiang Tian, Yunchang Xie, Fuqiang Hu, Hailong Yuan, Wei Wu. Binary lipids-based nanostructured lipid carriers for improved oral bioavailability of silymarinJournal of Biomaterials Applications 2014; 28(6): 887 doi: 10.1177/0885328213485141
30
José Moltó, Marta Valle, Cristina Miranda, Samandhy Cedeño, Eugenia Negredo, Bonaventura Clotet. Effect of Milk Thistle on the Pharmacokinetics of Darunavir-Ritonavir in HIV-Infected PatientsAntimicrobial Agents and Chemotherapy 2012; 56(6): 2837 doi: 10.1128/AAC.00025-12
31
Yongxiang Zhang, Jie Hai, Meng Cao, Yongli Zhang, Sujuan Pei, Junbo Wang, Qinggui Zhang. Silibinin ameliorates steatosis and insulin resistance during non-alcoholic fatty liver disease development partly through targeting IRS-1/PI3K/Akt pathwayInternational Immunopharmacology 2013; 17(3): 714 doi: 10.1016/j.intimp.2013.08.019
32
X. Shen, H. Liu, G. Li, X. Deng, J. Wang. Silibinin attenuates Streptococcus suis serotype 2 virulence by targeting suilysinJournal of Applied Microbiology 2019; 126(2): 435 doi: 10.1111/jam.14149
33
Xiaoli Bi, Zhongwen Yuan, Biao Qu, Hua Zhou, Zhongqiu Liu, Ying Xie. Piperine enhances the bioavailability of silybin via inhibition of efflux transporters BCRP and MRP2Phytomedicine 2019; 54: 98 doi: 10.1016/j.phymed.2018.09.217
34
Alessandro Federico, Marcello Dallio, Carmelina Loguercio. Silymarin/Silybin and Chronic Liver Disease: A Marriage of Many YearsMolecules 2017; 22(2): 191 doi: 10.3390/molecules22020191
35
Chan Wah Kheong, Nik Raihan Nik Mustapha, Sanjiv Mahadeva. A Randomized Trial of Silymarin for the Treatment of Nonalcoholic SteatohepatitisClinical Gastroenterology and Hepatology 2017; 15(12): 1940 doi: 10.1016/j.cgh.2017.04.016
36
Katharina Esser-Nobis, Christian Harak, Philipp Schult, Yuri Kusov, Volker Lohmann. Novel perspectives for hepatitis A virus therapy revealed by comparative analysis of hepatitis C virus and hepatitis A virus RNA replicationHepatology 2015; 62(2): 397 doi: 10.1002/hep.27847
37
Daniel Shadrack, Hulda Swai, Joan Munissi, Egid Mubofu, Stephen Nyandoro. Polyamidoamine Dendrimers for Enhanced Solubility of Small Molecules and Other Desirable Properties for Site Specific Delivery: Insights from Experimental and Computational StudiesMolecules 2018; 23(6): 1419 doi: 10.3390/molecules23061419
38
Eleonora Stanca, Gaetano Serviddio, Francesco Bellanti, Gianluigi Vendemiale, Luisa Siculella, Anna Maria Giudetti. Down-regulation of LPCAT expression increases platelet-activating factor level in cirrhotic rat liver: Potential antiinflammatory effect of silybinBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2013; 1832(12): 2019 doi: 10.1016/j.bbadis.2013.07.005
39
Nancy Vargas-Mendoza, Eduardo Madrigal-Santillán, Ángel Morales-González, Jaime Esquivel-Soto, Cesar Esquivel-Chirino, Manuel García-Luna y González-Rubio, Juan A Gayosso-de-Lucio, José A Morales-González. Hepatoprotective effect of silymarinWorld Journal of Hepatology 2014; 6(3): 144-149 doi: 10.4254/wjh.v6.i3.144
40
Navaneethakrishnan Polachi, Guirong Bai, Tingyang Li, Yang Chu, Xiangyang Wang, Shuming Li, Ning Gu, Jiang Wu, Wei Li, Yanjun Zhang, Shuiping Zhou, He Sun, Changxiao Liu. Modulatory effects of silibinin in various cell signaling pathways against liver disorders and cancer – A comprehensive reviewEuropean Journal of Medicinal Chemistry 2016; 123: 577 doi: 10.1016/j.ejmech.2016.07.070
41
Antonietta Stellavato, Anna Virginia Adriana Pirozzi, Francesca de Novellis, Ilaria Scognamiglio, Valentina Vassallo, Andrea Maria Giori, Mario De Rosa, Chiara Schiraldi. In vitro assessment of nutraceutical compounds and novel nutraceutical formulations in a liver-steatosis-based modelLipids in Health and Disease 2018; 17(1) doi: 10.1186/s12944-018-0663-2
42
Peng Xu, Hua Zhou, Ya-Zhuo Li, Zhong-Wen Yuan, Chang-Xiao Liu, Liang Liu, Ying Xie. Baicalein Enhances the Oral Bioavailability and Hepatoprotective Effects of Silybin Through the Inhibition of Efflux Transporters BCRP and MRP2Frontiers in Pharmacology 2018; 9 doi: 10.3389/fphar.2018.01115
43
Eleni Theodosiou, Kateřina Purchartová, Haralambos Stamatis, Fragiskos Kolisis, Vladimír Křen. Bioavailability of silymarin flavonolignans: drug formulations and biotransformationPhytochemistry Reviews 2014; 13(1): 1 doi: 10.1007/s11101-013-9285-5
44
B.L. Woolbright, C.D. Williams, M.R. McGill, H. Jaeschke. Reference Module in Biomedical Sciences2014;  doi: 10.1016/B978-0-12-801238-3.00205-1
45
Li Feng, Marcus M. Maddox, Md. Zahidul Alam, Lissa S. Tsutsumi, Gagandeep Narula, David F. Bruhn, Xiaoqian Wu, Shayna Sandhaus, Robin B. Lee, Charles J. Simmons, Yuk-Ching Tse-Dinh, Julian G. Hurdle, Richard E. Lee, Dianqing Sun. Synthesis, Structure–Activity Relationship Studies, and Antibacterial Evaluation of 4-Chromanones and Chalcones, as Well as Olympicin A and DerivativesJournal of Medicinal Chemistry 2014; 57(20): 8398 doi: 10.1021/jm500853v
46
Muzamil Shah, Muhammad Ullah, Samantha Drouet, Muhammad Younas, Duangjai Tungmunnithum, Nathalie Giglioli-Guivarc’h, Christophe Hano, Bilal Abbasi. Interactive Effects of Light and Melatonin on Biosynthesis of Silymarin and Anti-Inflammatory Potential in Callus Cultures of Silybum marianum (L.) Gaertn.Molecules 2019; 24(7): 1207 doi: 10.3390/molecules24071207
47
Tsanko S. Gechev, Jacques Hille, Herman J. Woerdenbag, Maria Benina, Nikolay Mehterov, Valentina Toneva, Alisdair R. Fernie, Bernd Mueller-Roeber. Natural products from resurrection plants: Potential for medical applicationsBiotechnology Advances 2014; 32(6): 1091 doi: 10.1016/j.biotechadv.2014.03.005
48
Ali Nouri, Esfandiar Heidarian. Nephroprotective effect of silymarin against diclofenac induced renal damage and oxidative stress in male ratsJournal of Herbmed Pharmacology 2019; 8(2): 146 doi: 10.15171/jhp.2019.23
49
Farhad Soleimani, Rasoul Sharifi, Minoo Mahmoodi, Seyed Mehrdad Kassaee. The effects of silibinin on oxidative stress and microRNA-10b expression in animal models of breast cancerTurkish Journal of Biochemistry 2020; 45(6): 707 doi: 10.1515/tjb-2019-0333
50
Devesh Tewari, Andrei Mocan, Emil D. Parvanov, Archana N. Sah, Seyed M. Nabavi, Lukasz Huminiecki, Zheng Feei Ma, Yeong Yeh Lee, Jarosław O. Horbańczuk, Atanas G. Atanasov. Ethnopharmacological Approaches for Therapy of Jaundice: Part II. Highly Used Plant Species from Acanthaceae, Euphorbiaceae, Asteraceae, Combretaceae, and Fabaceae FamiliesFrontiers in Pharmacology 2017; 8 doi: 10.3389/fphar.2017.00519
51
Simona Clichici, Diana Olteanu, Andras-Laszlo Nagy, Adrian Oros, Adriana Filip, Petru A. Mircea. Silymarin Inhibits the Progression of Fibrosis in the Early Stages of Liver Injury in CCl4-Treated RatsJournal of Medicinal Food 2015; 18(3): 290 doi: 10.1089/jmf.2013.0179
52
Ramanathan Raghu, Sivanesan Karthikeyan. Zidovudine and isoniazid induced liver toxicity and oxidative stress: Evaluation of mitigating properties of silibininEnvironmental Toxicology and Pharmacology 2016; 46: 217 doi: 10.1016/j.etap.2016.07.014
53
Romana Sokolová, Jana Kocábová, Petr Marhol, Jan Fiedler, David Biedermann, Jan Vacek, Vladimír Křen. Oxidation of Natural Bioactive Flavonolignan 2,3-Dehydrosilybin: An Electrochemical and Spectral StudyThe Journal of Physical Chemistry B 2017; 121(28): 6841 doi: 10.1021/acs.jpcb.7b04651
54
Hassan Farghali, Mighty Kgalalelo Kemelo, Nikolina Kutinová Canová. Sirtuin Biology in Medicine2021; : 295 doi: 10.1016/B978-0-12-814118-2.00014-8
55
Jennifer Doley. Integrating Nutrition Into Practice2017; : 49 doi: 10.1201/9781315100913-6
56
Remziye Aysun Kepekçi, Sait Polat, Gülfidan Çoşkun, Ahmet Çelik, A. Sarper Bozkurt, Önder Yumrutaş, Mustafa Pehlivan. Preliminary Characterization of Phenolic Acid Composition and Hepatoprotective Effect ofStachys pumilaJournal of Food Biochemistry 2017; 41(2): e12286 doi: 10.1111/jfbc.12286
57
Ijeoma F. Uchegbu. Fundamentals of Pharmaceutical Nanoscience2013; : 9 doi: 10.1007/978-1-4614-9164-4_2
58
Lorenzo Di Cesare Mannelli, Matteo Zanardelli, Paola Failli, Carla Ghelardini. Oxaliplatin-Induced Neuropathy: Oxidative Stress as Pathological Mechanism. Protective Effect of SilibininThe Journal of Pain 2012; 13(3): 276 doi: 10.1016/j.jpain.2011.11.009
59
Jun‐Fei Mou, Xiao‐Zhen Lin, He‐ling Su, Hui‐Ling Lu, Qing‐Bo Liu, Bin Liang, Xu Chen, Cheng‐Qin Liang, Xian‐Li Zhou. Anti‐hepatitis B virus activity and hepatoprotective effect of des(rhamnosyl) verbascoside from Lindernia ruellioides in vitro Phytotherapy Research 2021; 35(8): 4555 doi: 10.1002/ptr.7159
60
Divyashree Ravishankar, Kimberly A. Watson, Samuel Y. Boateng, Rebecca J. Green, Francesca Greco, Helen M.I. Osborn. Exploring quercetin and luteolin derivatives as antiangiogenic agentsEuropean Journal of Medicinal Chemistry 2015; 97: 259 doi: 10.1016/j.ejmech.2015.04.056
61
Walid Hamdy El-Tantawy, Abeer Temraz. Anti-fibrotic activity of natural products, herbal extracts and nutritional components for prevention of liver fibrosis: reviewArchives of Physiology and Biochemistry 2019; : 1 doi: 10.1080/13813455.2019.1684952
62
Licia Polimeni, Maria Del Ben, Francesco Baratta, Ludovica Perri, Fabiana Albanese, Daniele Pastori, Francesco Violi, Francesco Angelico. Oxidative stress: New insights on the association of non-alcoholic fatty liver disease and atherosclerosisWorld Journal of Hepatology 2015; 7(10): 1325-1336 doi: 10.4254/wjh.v7.i10.1325
63
Federico Salomone, Ignazio Barbagallo, Justyna Godos, Vincenzo Lembo, Walter Currenti, Diana Cinà, Roberto Avola, Nicolantonio D’Orazio, Filomena Morisco, Fabio Galvano, Giovanni Li Volti. Silibinin Restores NAD+ Levels and Induces the SIRT1/AMPK Pathway in Non-Alcoholic Fatty LiverNutrients 2017; 9(10): 1086 doi: 10.3390/nu9101086
64
Michael Gülden, Daniel Appel, Malin Syska, Stephanie Uecker, Franziska Wages, Hasso Seibert. Chrysin and silibinin sensitize human glioblastoma cells for arsenic trioxideFood and Chemical Toxicology 2017; 105: 486 doi: 10.1016/j.fct.2017.04.035
65
Yuan XIE, Hai-Ping HAO, Hong WANG, Zhao-Xian WANG, Guang-Ji WANG. Reversing effects of silybin on TAA-induced hepatic CYP3A dysfunction through PXR regulationChinese Journal of Natural Medicines 2013; 11(6): 645 doi: 10.1016/S1875-5364(13)60075-8
66
Alfonso Di Costanzo, Ruggero Angelico. Formulation Strategies for Enhancing the Bioavailability of Silymarin: The State of the ArtMolecules 2019; 24(11): 2155 doi: 10.3390/molecules24112155
67
Michal Bijak. Silybin, a Major Bioactive Component of Milk Thistle (Silybum marianum L. Gaernt.)—Chemistry, Bioavailability, and MetabolismMolecules 2017; 22(11): 1942 doi: 10.3390/molecules22111942
68
Chun-Xue Cui, Jing-Na Deng, Li Yan, Yu-Ying Liu, Jing-Yu Fan, Hong-Na Mu, Hao-Yu Sun, Ying-Hong Wang, Jing-Yan Han. Silibinin Capsules improves high fat diet-induced nonalcoholic fatty liver disease in hamsters through modifying hepatic de novo lipogenesis and fatty acid oxidationJournal of Ethnopharmacology 2017; 208: 24 doi: 10.1016/j.jep.2017.06.030
69
Yu-Jui Kuo, Hui-Ping Chang, Yu-Jun Chang, Hsing-Hsien Wu, Chang-Hua Chen. Evaluation of nephroprotection of silymarin on contrast-induced nephropathy in liver cirrhosis patientsMedicine 2018; 97(37): e12243 doi: 10.1097/MD.0000000000012243
70
Keishi Yamasaki, Hiroki Sato, Saori Minagoshi, Karin Kyubun, Makoto Anraku, Shigeyuki Miyamura, Hiroshi Watanabe, Kazuaki Taguchi, Hakaru Seo, Toru Maruyama, Masaki Otagiri. The Binding of Silibinin, the Main Constituent of Silymarin, to Site I on Human Serum AlbuminBiological & Pharmaceutical Bulletin 2017; 40(3): 310 doi: 10.1248/bpb.b16-00790
71
Jin-Ping Wang, Tian-Ze Li, Xiao-Yan Huang, Chang-An Geng, Cheng Shen, Jin-Jin Sun, Dong Xue, Ji-Jun Chen. Synthesis and anti-fibrotic effects of santamarin derivatives as cytotoxic agents against hepatic stellate cell line LX2Bioorganic & Medicinal Chemistry Letters 2021; 41: 127994 doi: 10.1016/j.bmcl.2021.127994
72
Joaquim Bosch-Barrera, Javier A. Menendez. Silibinin and STAT3: A natural way of targeting transcription factors for cancer therapyCancer Treatment Reviews 2015; 41(6): 540 doi: 10.1016/j.ctrv.2015.04.008
73
Ching-Hsuan Liu, Alagie Jassey, Hsin-Ya Hsu, Liang-Tzung Lin. Antiviral Activities of Silymarin and DerivativesMolecules 2019; 24(8): 1552 doi: 10.3390/molecules24081552
74
Hao-Jie Zhu, Bryan J. Brinda, Kenneth D. Chavin, Hilary J. Bernstein, Kennerly S. Patrick, John S. Markowitz. An Assessment of Pharmacokinetics and Antioxidant Activity of Free Silymarin Flavonolignans in Healthy Volunteers: A Dose Escalation StudyDrug Metabolism and Disposition 2013; 41(9): 1679 doi: 10.1124/dmd.113.052423
75
F. Wei, S.-K. Liu, X.-Y. Liu, Z.-J. Li, B. Li, Y.-L. Zhou, H.-Y. Zhang, Y.-W. Li. Meta-analysis: silymarin and its combination therapy for the treatment of chronic hepatitis BEuropean Journal of Clinical Microbiology & Infectious Diseases 2013; 32(5): 657 doi: 10.1007/s10096-012-1789-1
76
Khaled Khazim, Yves Gorin, Rita Cassia Cavaglieri, Hanna E. Abboud, Paolo Fanti. The antioxidant silybin prevents high glucose-induced oxidative stress and podocyte injury in vitro and in vivoAmerican Journal of Physiology-Renal Physiology 2013; 305(5): F691 doi: 10.1152/ajprenal.00028.2013
77
Masha G. Savelieff, Geewoo Nam, Juhye Kang, Hyuck Jin Lee, Misun Lee, Mi Hee Lim. Development of Multifunctional Molecules as Potential Therapeutic Candidates for Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis in the Last DecadeChemical Reviews 2019; 119(2): 1221 doi: 10.1021/acs.chemrev.8b00138
78
Zongguo Yang, Liping Zhuang, Yunfei Lu, Qingnian Xu, Xiaorong Chen. Effects and Tolerance of Silymarin (Milk Thistle) in Chronic Hepatitis C Virus Infection Patients: A Meta-Analysis of Randomized Controlled TrialsBioMed Research International 2014; 2014: 1 doi: 10.1155/2014/941085
79
Duo-Duo Lv, You-Juan Wang, Meng-Lan Wang, En-Qiang Chen, Ya-Chao Tao, Dong-Mei Zhang, Hong Tang. Effect of silibinin capsules combined with lifestyle modification on hepatic steatosis in patients with chronic hepatitis BScientific Reports 2021; 11(1) doi: 10.1038/s41598-020-80709-z
80
Miguel Reina, Ana Martínez. How the presence of metal atoms and clusters can modify the properties of Silybin? A computational predictionComputational and Theoretical Chemistry 2017; 1099: 174 doi: 10.1016/j.comptc.2016.11.030
81
D. Biedermann, E. Vavříková, L. Cvak, V. Křen. Chemistry of silybinNat. Prod. Rep. 2014; 31(9): 1138 doi: 10.1039/C3NP70122K
82
Sara Verdura, Elisabet Cuyàs, Verónica Ruiz-Torres, Vicente Micol, Jorge Joven, Joaquim Bosch-Barrera, Javier A. Menendez. Lung Cancer Management with Silibinin: A Historical and Translational PerspectivePharmaceuticals 2021; 14(6): 559 doi: 10.3390/ph14060559
83
Yan Liu, Jun Ye, Yonghong Cao, Rong Zhang, Yunsheng Wang, Suwan Zhang, Wu Dai, Shandong Ye. Silibinin ameliorates diabetic nephropathy via improving diabetic condition in the miceEuropean Journal of Pharmacology 2019; 845: 24 doi: 10.1016/j.ejphar.2018.12.031
84
H.B. Li, Y.R.Y. Yang, Z.J. Mo, Y. Ding, W.J. Jiang. Silibinin improves palmitate-induced insulin resistance in C2C12 myotubes by attenuating IRS-1/PI3K/Akt pathway inhibitionBrazilian Journal of Medical and Biological Research 2015; 48(5): 440 doi: 10.1590/1414-431x20144238
85
Feyzullah Uçmak, Nazım Ekin, İbrahim İbiloğlu, Serkan Arslan, İbrahim Kaplan, Ebubekir Şenateş. Prophylactic Administration of Silybin Ameliorates L-Arginine-Induced Acute PancreatitisMedical Science Monitor 2016; 22: 3641 doi: 10.12659/MSM.898014
86
Aysa Rezabakhsh, Farzaneh Fathi, Hesam Saghaei Bagheri, Hassan Malekinejad, Azadeh Montaseri, Reza Rahbarghazi, Alireza Garjani. Silibinin protects human endothelial cells from high glucose‐induced injury by enhancing autophagic responseJournal of Cellular Biochemistry 2018; 119(10): 8084 doi: 10.1002/jcb.26735
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