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Number Cited Articles
Clarissa Gerhauser. Recent Advances in Polyphenol Research2014; : 143 doi: 10.1002/9781118329634.ch6
Antonia Diukendjieva, Merilin Al Sharif, Petko Alov, Tania Pencheva, Ivanka Tsakovska, Ilza Pajeva. ADME/Tox Properties and Biochemical Interactions of Silybin Congeners: In silico StudyNatural Product Communications 2017; 12(2): 1934578X1701200 doi: 10.1177/1934578X1701200208
Eun-Kyung Jung, Lisa I. Pilkington, David Barker. Enantioselective Synthesis of 2,3-Disubstituted Benzomorpholines: Analogues of Lignan Natural ProductsThe Journal of Organic Chemistry 2016; 81(23): 12012 doi: 10.1021/acs.joc.6b02265
Z. R. Tan, Y. X. Zhou, J. Liu, W. H. Huang, Y. Chen, Y. C. Wang, L. S. Wang. The influence of ABCB1 polymorphism C3435T on the pharmacokinetics of silibininJournal of Clinical Pharmacy and Therapeutics 2015; 40(6): 685 doi: 10.1111/jcpt.12336
Kristina M. Brooks, Jomy M. George, Parag Kumar. Drug interactions in HIV treatment: complementary & alternative medicines and over-the-counter productsExpert Review of Clinical Pharmacology 2017; 10(1): 59 doi: 10.1080/17512433.2017.1246180
Sharon M. Gwaltney-Brant. Nutraceuticals2016; : 87 doi: 10.1016/B978-0-12-802147-7.00007-3
Jia-Ping Wu, Chin-Chuan Tsai, Yu-Lan Yeh, Yueh-Min Lin, Chien-Chung Lin, Cecilia Hsuan Day, Chia-Yao Shen, V. Vijaya Padma, Lung-Fa Pan, Chih-Yang Huang. Silymarin Accelerates Liver Regeneration after Partial HepatectomyEvidence-Based Complementary and Alternative Medicine 2015; 2015: 1 doi: 10.1155/2015/603529
Sherif M. Sabry Hassan, Magdy F. Youakim, Ayman Abou Elenein Rizk, Charity Thomann, Zulfiqar Ahmad. Does silybin protect against toxicity induced by polymyxin E in rat kidney?Neurourology and Urodynamics 2017; 36(5): 1278 doi: 10.1002/nau.23109
E.S. Hackett, D.C. Twedt, D.L. Gustafson. Milk Thistle and Its Derivative Compounds: A Review of Opportunities for Treatment of Liver DiseaseJournal of Veterinary Internal Medicine 2013; 27(1): 10 doi: 10.1111/jvim.12002
T.A.F. Eissa, O.M. Palomino, M.E. Carretero, M.P. Gómez-Serranillos. Ethnopharmacological study of medicinal plants used in the treatment of CNS disorders in Sinai Peninsula, EgyptJournal of Ethnopharmacology 2014; 151(1): 317 doi: 10.1016/j.jep.2013.10.041
Xinyu Chen, Katharina Zenger, Amelie Lupp, Beata Kling, Jörg Heilmann, Christian Fleck, Birgit Kraus, Michael Decker. Tacrine-Silibinin Codrug Shows Neuro- and Hepatoprotective Effectsin Vitroand Pro-Cognitive and Hepatoprotective Effectsin VivoJournal of Medicinal Chemistry 2012; 55(11): 5231 doi: 10.1021/jm300246n
Arrigo Cicero, Alessandro Colletti, Stefano Bellentani. Nutraceutical Approach to Non-Alcoholic Fatty Liver Disease (NAFLD): The Available Clinical EvidenceNutrients 2018; 10(9): 1153 doi: 10.3390/nu10091153
Brandon T. Gufford, Tyler N. Graf, Noemi D. Paguigan, Nicholas H. Oberlies, Mary F. Paine. Chemoenzymatic Synthesis, Characterization, and Scale-Up of Milk Thistle Flavonolignan GlucuronidesDrug Metabolism and Disposition 2015; 43(11): 1734 doi: 10.1124/dmd.115.066076
Eirini Christodoulou, Irene-Ariadne Kechagia, Stavros Tzimas, Evangelos Balafas, Nikolaos Kostomitsopoulos, Helen Archontaki, Aristides Dokoumetzidis, Georgia Valsami. Serum and tissue pharmacokinetics of silibinin after per os and i.v. administration to mice as a HP-β-CD lyophilized productInternational Journal of Pharmaceutics 2015; 493(1-2): 366 doi: 10.1016/j.ijpharm.2015.07.060
Miroslav Novakovic, Iris Djordjevic, Nina Todorovic, Snezana Trifunovic, Boban Andjelkovic, Boris Mandic, Milka Jadranin, Ivan Vuckovic, Vlatka Vajs, Slobodan Milosavljevic, Vele Tesevic. New aurone epoxide and auronolignan from the heartwood of Cotinus coggygria ScopNatural Product Research 2019; 33(19): 2837 doi: 10.1080/14786419.2018.1508141
Mihai Oltean. Silybin Against Liver Ischemia-Reperfusion Injury: Something Old, Something New…Journal of Investigative Surgery 2018; 31(6): 521 doi: 10.1080/08941939.2017.1365975
Michal Bijak, Angela Dziedzic, Ewelina Synowiec, Tomasz Sliwinski, Joanna Saluk-Bijak. Flavonolignans Inhibit IL1-β-Induced Cross-Talk between Blood Platelets and LeukocytesNutrients 2017; 9(9): 1022 doi: 10.3390/nu9091022
Claire Albert, Mohamed Beladjine, Nicolas Tsapis, Elias Fattal, Florence Agnely, Nicolas Huang. Pickering emulsions: Preparation processes, key parameters governing their properties and potential for pharmaceutical applicationsJournal of Controlled Release 2019; 309: 302 doi: 10.1016/j.jconrel.2019.07.003
Hamidah Mohd Yusof, Norlaily Mohd Ali, Swee Keong Yeap, Wan Yong Ho, Boon Kee Beh, Soo Peng Koh, Kamariah Long, Suraini Abdul Aziz, Noorjahan Banu Alitheen. Hepatoprotective Effect of Fermented Soybean (Nutrient Enriched Soybean Tempeh) against Alcohol-Induced Liver Damage in MiceEvidence-Based Complementary and Alternative Medicine 2013; 2013: 1 doi: 10.1155/2013/274274
Ji-Suk Jeong, Yong-Joo Kim, Bo-Rum Choi, Geun-Bae Go, Byeong-Gil Son, Suk-Won Gang, Seung-Man Moon. Antioxidant and Physicochemical Changes in Salvia plebeia R. Br. after Hot-air Drying and BlanchingJournal of the Korean Society of Food Science and Nutrition 2014; 43(6): 893 doi: 10.3746/jkfn.2014.43.6.893
Elisa Ceccherini, Antonella Cecchettini, Maria Aurora Morales, Silvia Rocchiccioli. The Potentiality of Herbal Remedies in Primary Sclerosing Cholangitis: From In Vitro to Clinical StudiesFrontiers in Pharmacology 2020; 11 doi: 10.3389/fphar.2020.00813
R Raghu, B Jesudas, G Bhavani, D Ezhilarasan, S Karthikeyan. Silibinin mitigates zidovudine-induced hepatocellular degenerative changes, oxidative stress and hyperlipidaemia in ratsHuman & Experimental Toxicology 2015; 34(11): 1031 doi: 10.1177/0960327114567765
M. Morovat, M. Chamani, A. Zarei, A.A. Sadeghi. Dietary but notin ovofeeding ofSilybum marianumextract resulted in an improvement in performance, immunity and carcass characteristics and decreased the adverse effects of high temperatures in broilersBritish Poultry Science 2016; 57(1): 105 doi: 10.1080/00071668.2015.1121537
Yin Li, Zengchun Ye, Weiyan Lai, Jialing Rao, Wanbing Huang, Xiaohao Zhang, Ziying Yao, Tanqi Lou. Activation of Sirtuin 3 by Silybin Attenuates Mitochondrial Dysfunction in Cisplatin-induced Acute Kidney InjuryFrontiers in Pharmacology 2017; 8 doi: 10.3389/fphar.2017.00178
Ewelina van Wenum, Rafal Jurczakowski, Grzegorz Litwinienko. Media Effects on the Mechanism of Antioxidant Action of Silybin and 2,3-Dehydrosilybin: Role of the Enol GroupThe Journal of Organic Chemistry 2013; 78(18): 9102 doi: 10.1021/jo401296k
Jiayin Yao, Min Zhi, Xiang Gao, Pinjin Hu, Chujun Li, Xiaobo Yang. Effect and the probable mechanisms of silibinin in regulating insulin resistance in the liver of rats with non-alcoholic fatty liverBrazilian Journal of Medical and Biological Research 2013; 46(3): 270 doi: 10.1590/1414-431X20122551
Mahdi Mashhadi Akbar Boojar, Massoud Mashhadi Akbar Boojar, Sepide Golmohammad. Overview of Silibinin anti-tumor effectsJournal of Herbal Medicine 2020; 23: 100375 doi: 10.1016/j.hermed.2020.100375
Dezső Csupor, Attila Csorba, Judit Hohmann. Recent advances in the analysis of flavonolignans of Silybum marianumJournal of Pharmaceutical and Biomedical Analysis 2016; 130: 301 doi: 10.1016/j.jpba.2016.05.034
Qian Zhao, Cheng Peng, Chuan Zheng, Xiang-Hong He, Wei Huang, Bo Han. Recent Advances in Characterizing Natural Products that Regulate AutophagyAnti-Cancer Agents in Medicinal Chemistry 2020; 19(18): 2177 doi: 10.2174/1871520619666191015104458
Akinobu Takaki, Seiji Kawano, Daisuke Uchida, Masahiro Takahara, Sakiko Hiraoka, Hiroyuki Okada. Paradoxical Roles of Oxidative Stress Response in the Digestive System before and after CarcinogenesisCancers 2019; 11(2): 213 doi: 10.3390/cancers11020213
Anjali Takke, Pravin Shende. Nanotherapeutic silibinin: An insight of phytomedicine in healthcare reformationNanomedicine: Nanotechnology, Biology and Medicine 2019; 21: 102057 doi: 10.1016/j.nano.2019.102057
Bashar Saad. Phytotherapies2015; : 142 doi: 10.1002/9781119006039.ch8
Marjan Gharagozloo, Mehran Karimi, Zahra Amirghofran. Immunomodulatory effects of silymarin in patients with β-thalassemia majorInternational Immunopharmacology 2013; 16(2): 243 doi: 10.1016/j.intimp.2013.04.016
Nikoletta Jedlinszki, Ildikó Kálomista, Gábor Galbács, Dezső Csupor. Silybum marianum (milk thistle) products in Wilson’s disease: a treatment or a threat?Journal of Herbal Medicine 2016; 6(3): 157 doi: 10.1016/j.hermed.2016.06.002
H. Kolb. Heilkraft von Kräutern bei Typ-2-DiabetesDer Diabetologe 2014; 10(2): 130 doi: 10.1007/s11428-013-1113-4
Sun Hong Park, Jeong-Ah Kwak, Sang-Hun Jung, Byeongwoo Ahn, Won-Jea Cho, Cheong-Yong Yun, Chang Seon Na, Bang Yeon Hwang, Jin Tae Hong, Sang-Bae Han, Youngsoo Kim. Piperidylmethyloxychalcone improves immune-mediated acute liver failure via inhibiting TAK1 activityExperimental & Molecular Medicine 2017; 49(11): e392 doi: 10.1038/emm.2017.156
Katrin Wlcek, Fabienne Koller, Peter Ferenci, Bruno Stieger. Hepatocellular Organic Anion–Transporting Polypeptides (OATPs) and Multidrug Resistance–Associated Protein 2 (MRP2) Are Inhibited by SilibininDrug Metabolism and Disposition 2013; 41(8): 1522 doi: 10.1124/dmd.113.051037
Zhong-Wen Yuan, Ya-Zhuo Li, Zhong-Qiu Liu, Sen-ling Feng, Hua Zhou, Chang-Xiao Liu, Liang Liu, Ying Xie. Role of tangeretin as a potential bioavailability enhancer for silybin: Pharmacokinetic and pharmacological studiesPharmacological Research 2018; 128: 153 doi: 10.1016/j.phrs.2017.09.019
Qian Ding, Jiaolin Bao, Wenwen Zhao, Yangyang Hu, Jinjian Lu, Xiuping Chen. Natural autophagy regulators in cancer therapy: a reviewPhytochemistry Reviews 2015; 14(1): 137 doi: 10.1007/s11101-014-9339-3
Susanne M. Henning, Yanjun Zhang, Victoria G. Rontoyanni, Jianjun Huang, Ru-Po Lee, Amy Trang, Gloria Nuernberger, David Heber. Variability in the Antioxidant Activity of Dietary Supplements from Pomegranate, Milk Thistle, Green Tea, Grape Seed, Goji, and Acai: Effects of in Vitro DigestionJournal of Agricultural and Food Chemistry 2014; 62(19): 4313 doi: 10.1021/jf500106r
Ming Gu, Ping Zhao, Jinwen Huang, Yuanyuan Zhao, Yahui Wang, Yin Li, Yifei Li, Shengjie Fan, Yue-Ming Ma, Qingchun Tong, Li Yang, Guang Ji, Cheng Huang. Silymarin Ameliorates Metabolic Dysfunction Associated with Diet-Induced Obesity via Activation of Farnesyl X ReceptorFrontiers in Pharmacology 2016; 7 doi: 10.3389/fphar.2016.00345
Angela Sciacqua, Maria Perticone, Giovanni Tripepi, Desire Addesi, Velia Cassano, Raffaele Maio, Giorgio Sesti, Francesco Perticone. Metabolic and vascular effects of silybin in hypertensive patients with high 1-h post-load plasma glucoseInternal and Emergency Medicine 2019; 14(1): 77 doi: 10.1007/s11739-018-1951-6
Gianni Testino, Silvia Leone, Sharmila Fagoonee, Rinaldo Pellicano. Alcoholic liver fibrosis: detection and treatmentMinerva Medica 2018; 109(6) doi: 10.23736/S0026-4806.18.05844-5
Mingzhu Shangguan, Yi Lu, Jianping Qi, Jin Han, Zhiqiang Tian, Yunchang Xie, Fuqiang Hu, Hailong Yuan, Wei Wu. Binary lipids-based nanostructured lipid carriers for improved oral bioavailability of silymarinJournal of Biomaterials Applications 2014; 28(6): 887 doi: 10.1177/0885328213485141
José Moltó, Marta Valle, Cristina Miranda, Samandhy Cedeño, Eugenia Negredo, Bonaventura Clotet. Effect of Milk Thistle on the Pharmacokinetics of Darunavir-Ritonavir in HIV-Infected PatientsAntimicrobial Agents and Chemotherapy 2012; 56(6): 2837 doi: 10.1128/AAC.00025-12
Yongxiang Zhang, Jie Hai, Meng Cao, Yongli Zhang, Sujuan Pei, Junbo Wang, Qinggui Zhang. Silibinin ameliorates steatosis and insulin resistance during non-alcoholic fatty liver disease development partly through targeting IRS-1/PI3K/Akt pathwayInternational Immunopharmacology 2013; 17(3): 714 doi: 10.1016/j.intimp.2013.08.019
X. Shen, H. Liu, G. Li, X. Deng, J. Wang. Silibinin attenuates Streptococcus suis serotype 2 virulence by targeting suilysinJournal of Applied Microbiology 2019; 126(2): 435 doi: 10.1111/jam.14149
Youn Ri Lee, Nara Yoon. Anti-Oxidative and Anti-Diabetic Effects of Methanol Extracts from Medicinal PlantsJournal of the Korean Society of Food Science and Nutrition 2015; 44(5): 681 doi: 10.3746/jkfn.2015.44.5.681
Seyed Younes Hosseini, Kurosh Kalantar, Khashayar Shahin, Maryam Ghayour, Masoumeh Rajabi Bazl, Mohammad-Reza Fattahi, Maryam Moini, Zahra Amirghofran. Comparison of the In Vitro Antifibrogenic Effects of Silymarin, Silybin A and 18α-Glycyrrhizin on Activated Hepatic Stellate CellsJundishapur Journal of Natural Pharmaceutical Products 2016; (In Press) doi: 10.17795/jjnpp-40285
Xiaoli Bi, Zhongwen Yuan, Biao Qu, Hua Zhou, Zhongqiu Liu, Ying Xie. Piperine enhances the bioavailability of silybin via inhibition of efflux transporters BCRP and MRP2Phytomedicine 2019; 54: 98 doi: 10.1016/j.phymed.2018.09.217
Alessandro Federico, Marcello Dallio, Carmelina Loguercio. Silymarin/Silybin and Chronic Liver Disease: A Marriage of Many YearsMolecules 2017; 22(2): 191 doi: 10.3390/molecules22020191
Veronica Marin, Silvia Gazzin, Sabrina Gambaro, Matteo Dal Ben, Sonia Calligaris, Monica Anese, Alan Raseni, Claudio Avellini, Pablo Giraudi, Claudio Tiribelli, Natalia Rosso. Effects of Oral Administration of Silymarin in a Juvenile Murine Model of Non-alcoholic SteatohepatitisNutrients 2017; 9(9): 1006 doi: 10.3390/nu9091006
Chan Wah Kheong, Nik Raihan Nik Mustapha, Sanjiv Mahadeva. A Randomized Trial of Silymarin for the Treatment of Nonalcoholic SteatohepatitisClinical Gastroenterology and Hepatology 2017; 15(12): 1940 doi: 10.1016/j.cgh.2017.04.016
Katharina Esser-Nobis, Christian Harak, Philipp Schult, Yuri Kusov, Volker Lohmann. Novel perspectives for hepatitis A virus therapy revealed by comparative analysis of hepatitis C virus and hepatitis A virus RNA replicationHepatology 2015; 62(2): 397 doi: 10.1002/hep.27847
Jennifer Doley. Integrative Nutrition Therapy2015; : 49 doi: 10.1201/b18833-6
Elizabeth Mudge, Lori Paley, Andreas Schieber, Paula N. Brown. Optimization and single-laboratory validation of a method for the determination of flavonolignans in milk thistle seeds by high-performance liquid chromatography with ultraviolet detectionAnalytical and Bioanalytical Chemistry 2015; 407(25): 7657 doi: 10.1007/s00216-015-8925-6
Jun Hyeon Choi, Sun Hong Park, Jae-Kyung Jung, Won-Jea Cho, Byeongwoo Ahn, Cheong-Yong Yun, Yong Pyo Choi, Jong Hun Yeo, Heesoon Lee, Jin Tae Hong, Sang-Bae Han, Youngsoo Kim. Caffeic Acid Cyclohexylamide Rescues Lethal Inflammation in Septic Mice through Inhibition of IκB Kinase in Innate Immune ProcessScientific Reports 2017; 7(1) doi: 10.1038/srep41180
Miguel Reina, Ana Martínez. Is Silybin the Best Free Radical Scavenger Compound in Silymarin?The Journal of Physical Chemistry B 2016; 120(20): 4568 doi: 10.1021/acs.jpcb.6b02807
Daniel Shadrack, Hulda Swai, Joan Munissi, Egid Mubofu, Stephen Nyandoro. Polyamidoamine Dendrimers for Enhanced Solubility of Small Molecules and Other Desirable Properties for Site Specific Delivery: Insights from Experimental and Computational StudiesMolecules 2018; 23(6): 1419 doi: 10.3390/molecules23061419
Eleonora Stanca, Gaetano Serviddio, Francesco Bellanti, Gianluigi Vendemiale, Luisa Siculella, Anna Maria Giudetti. Down-regulation of LPCAT expression increases platelet-activating factor level in cirrhotic rat liver: Potential antiinflammatory effect of silybinBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2013; 1832(12): 2019 doi: 10.1016/j.bbadis.2013.07.005
Nanako Kawaguchi, Ting-Ting Zhang, Toshio Nakanishi. Involvement of CXCR4 in Normal and Abnormal DevelopmentCells 2019; 8(2): 185 doi: 10.3390/cells8020185
Nancy Vargas-Mendoza, Eduardo Madrigal-Santillán, Ángel Morales-González, Jaime Esquivel-Soto, Cesar Esquivel-Chirino, Manuel García-Luna y González-Rubio, Juan A Gayosso-de-Lucio, José A Morales-González. Hepatoprotective effect of silymarinWorld Journal of Hepatology 2014; 6(3): 144-149 doi: 10.4254/wjh.v6.i3.144
Alexandra K. Tsaroucha, Georgia Valsami, Nikolaos Kostomitsopoulos, Maria Lambropoulou, Constantinos Anagnostopoulos, Eirini Christodoulou, Evangelos Falidas, Afrodite Betsou, Michael Pitiakoudis, Constantinos E. Simopoulos. Silibinin Effect on Fas/FasL, HMGB1, and CD45 Expressions in a Rat Model Subjected to Liver Ischemia-Reperfusion InjuryJournal of Investigative Surgery 2018; 31(6): 491 doi: 10.1080/08941939.2017.1360416
Zohreh Jahanafrooz, Nasrin Motamed, Beate Rinner, Ahad Mokhtarzadeh, Behzad Baradaran. Silibinin to improve cancer therapeutic, as an apoptotic inducer, autophagy modulator, cell cycle inhibitor, and microRNAs regulatorLife Sciences 2018; 213: 236 doi: 10.1016/j.lfs.2018.10.009
Rikki A. M. Brown, Kirsty L. Richardson, Tasnuva D. Kabir, Debbie Trinder, Ruth Ganss, Peter J. Leedman. Altered Iron Metabolism and Impact in Cancer Biology, Metastasis, and ImmunologyFrontiers in Oncology 2020; 10 doi: 10.3389/fonc.2020.00476
Sameh Saber, Amr A.A. Mahmoud, Noha S. Helal, Eman El-Ahwany, Rasha H. Abdelghany. Renin–angiotensin system inhibition ameliorates CCl4-induced liver fibrosis in mice through the inactivation of nuclear transcription factor kappa BCanadian Journal of Physiology and Pharmacology 2018; 96(6): 569 doi: 10.1139/cjpp-2017-0728
Navaneethakrishnan Polachi, Guirong Bai, Tingyang Li, Yang Chu, Xiangyang Wang, Shuming Li, Ning Gu, Jiang Wu, Wei Li, Yanjun Zhang, Shuiping Zhou, He Sun, Changxiao Liu. Modulatory effects of silibinin in various cell signaling pathways against liver disorders and cancer – A comprehensive reviewEuropean Journal of Medicinal Chemistry 2016; 123: 577 doi: 10.1016/j.ejmech.2016.07.070
Dayanne Rakelly de Oliveira, Saulo Relison Tintino, Maria Flaviana Bezerra Morais Braga, Aline Augusti Boligon, Margareth Linde Athayde, Henrique Douglas Melo Coutinho, Irwin Rose Alencar de Menezes, Roselei Fachinetto. In VitroAntimicrobial and Modulatory Activity of the Natural Products Silymarin and SilibininBioMed Research International 2015; 2015: 1 doi: 10.1155/2015/292797
Yuhua Ma, Haisheng He, Wufa Fan, Yingxia Li, Wei Zhang, Weili Zhao, Jianping Qi, Yi Lu, Xiaochun Dong, Wei Wu. In Vivo Fate of Biomimetic Mixed Micelles as Nanocarriers for Bioavailability Enhancement of Lipid–Drug ConjugatesACS Biomaterials Science & Engineering 2017; 3(10): 2399 doi: 10.1021/acsbiomaterials.7b00380
Pasquale Pignatelli, Roberto Carnevale, Danilo Menichelli. Silybin and metabolic disordersInternal and Emergency Medicine 2019; 14(1): 1 doi: 10.1007/s11739-018-1968-x
Daisuke Uchida, Akinobu Takaki, Atsushi Oyama, Takuya Adachi, Nozomu Wada, Hideki Onishi, Hiroyuki Okada. Oxidative Stress Management in Chronic Liver Diseases and Hepatocellular CarcinomaNutrients 2020; 12(6): 1576 doi: 10.3390/nu12061576
Antonietta Stellavato, Anna Virginia Adriana Pirozzi, Francesca de Novellis, Ilaria Scognamiglio, Valentina Vassallo, Andrea Maria Giori, Mario De Rosa, Chiara Schiraldi. In vitro assessment of nutraceutical compounds and novel nutraceutical formulations in a liver-steatosis-based modelLipids in Health and Disease 2018; 17(1) doi: 10.1186/s12944-018-0663-2
Nguyen Huu Tung, Takuhiro Uto, Osamu Morinaga, Young Ho Kim, Yukihiro Shoyama. Pharmacological Effects of Ginseng on Liver Functions and Diseases: A MinireviewEvidence-Based Complementary and Alternative Medicine 2012; 2012: 1 doi: 10.1155/2012/173297
Peng Xu, Hua Zhou, Ya-Zhuo Li, Zhong-Wen Yuan, Chang-Xiao Liu, Liang Liu, Ying Xie. Baicalein Enhances the Oral Bioavailability and Hepatoprotective Effects of Silybin Through the Inhibition of Efflux Transporters BCRP and MRP2Frontiers in Pharmacology 2018; 9 doi: 10.3389/fphar.2018.01115
Eleni Theodosiou, Kateřina Purchartová, Haralambos Stamatis, Fragiskos Kolisis, Vladimír Křen. Bioavailability of silymarin flavonolignans: drug formulations and biotransformationPhytochemistry Reviews 2014; 13(1): 1 doi: 10.1007/s11101-013-9285-5
B.L. Woolbright, C.D. Williams, M.R. McGill, H. Jaeschke. Reference Module in Biomedical Sciences2014;  doi: 10.1016/B978-0-12-801238-3.00205-1
Ludovico Abenavoli, Stefano Bellentani. Milk thistle to treat non-alcoholic fatty liver disease: dream or reality?Expert Review of Gastroenterology & Hepatology 2013; 7(8): 677 doi: 10.1586/17474124.2013.842893
Li Feng, Marcus M. Maddox, Md. Zahidul Alam, Lissa S. Tsutsumi, Gagandeep Narula, David F. Bruhn, Xiaoqian Wu, Shayna Sandhaus, Robin B. Lee, Charles J. Simmons, Yuk-Ching Tse-Dinh, Julian G. Hurdle, Richard E. Lee, Dianqing Sun. Synthesis, Structure–Activity Relationship Studies, and Antibacterial Evaluation of 4-Chromanones and Chalcones, as Well as Olympicin A and DerivativesJournal of Medicinal Chemistry 2014; 57(20): 8398 doi: 10.1021/jm500853v
Lidia Radko, Wojciech Cybulski, Wojciech Rzeski. The Protective Effect of Silybin against Lasalocid Cytotoxic Exposure on Chicken and Rat Cell LinesBioMed Research International 2013; 2013: 1 doi: 10.1155/2013/783519
Muzamil Shah, Muhammad Ullah, Samantha Drouet, Muhammad Younas, Duangjai Tungmunnithum, Nathalie Giglioli-Guivarc’h, Christophe Hano, Bilal Abbasi. Interactive Effects of Light and Melatonin on Biosynthesis of Silymarin and Anti-Inflammatory Potential in Callus Cultures of Silybum marianum (L.) Gaertn.Molecules 2019; 24(7): 1207 doi: 10.3390/molecules24071207
Walid Hamdy El-Tantawy, Abeer Temraz. Natural products for the management of the hepatitis C virus: a biochemical reviewArchives of Physiology and Biochemistry 2020; 126(2): 116 doi: 10.1080/13813455.2018.1498902
Valeria Romanucci, Giovanni Di Fabio, Armando Zarrelli. A New Class of Synthetic Flavonolignan-Like Dimers: Still Few Molecules, but with Attractive PropertiesMolecules 2018; 24(1): 108 doi: 10.3390/molecules24010108
Muhammad Umar Khayam Sahibzada, Abdul Sadiq, Muhammad Zahoor, Sumera Naz, Muhammad Shahid, Najam Afaq Qureshi. Enhancement of bioavailability and hepatoprotection by silibinin through conversion to nanoparticles prepared by liquid antisolvent methodArabian Journal of Chemistry 2020; 13(2): 3682 doi: 10.1016/j.arabjc.2020.01.002
Tsanko S. Gechev, Jacques Hille, Herman J. Woerdenbag, Maria Benina, Nikolay Mehterov, Valentina Toneva, Alisdair R. Fernie, Bernd Mueller-Roeber. Natural products from resurrection plants: Potential for medical applicationsBiotechnology Advances 2014; 32(6): 1091 doi: 10.1016/j.biotechadv.2014.03.005
Ali Nouri, Esfandiar Heidarian. Nephroprotective effect of silymarin against diclofenac induced renal damage and oxidative stress in male ratsJournal of Herbmed Pharmacology 2019; 8(2): 146 doi: 10.15171/jhp.2019.23
Cong Lu, Xin Li, Xue Liang, Xinyu Zhang, Tian Yin, Jingxin Gou, Haibing He, Yu Zhang, Xing Tang. Liver Targeting Albumin-Coated Silybin-Phospholipid Particles Prepared by Nab™ Technology for Improving Treatment Effect of Acute Liver Damage in Intravenous AdministrationAAPS PharmSciTech 2019; 20(7) doi: 10.1208/s12249-019-1504-y
Aihua Zhang, Hui Sun, Xijun Wang. Recent advances in natural products from plants for treatment of liver diseasesEuropean Journal of Medicinal Chemistry 2013; 63: 570 doi: 10.1016/j.ejmech.2012.12.062
Nahum Méndez-Sánchez, Miguel Dibildox-Martinez, Jahir Sosa-Noguera, Ramón Sánchez-Medal, Francisco J. Flores-Murrieta. Superior silybin bioavailability of silybin–phosphatidylcholine complex in oily-medium soft-gel capsules versus conventional silymarin tablets in healthy volunteers*BMC Pharmacology and Toxicology 2019; 20(1) doi: 10.1186/s40360-018-0280-8
Walid Hamdy El-Tantawy, Dina Sabry, Ekram Nemr Abd Al Haleem. Comparative study of antifibrotic activity of some magnesium-containing supplements on experimental liver toxicity. Molecular studyDrug and Chemical Toxicology 2017; 40(1): 47 doi: 10.3109/01480545.2016.1172083
Devesh Tewari, Andrei Mocan, Emil D. Parvanov, Archana N. Sah, Seyed M. Nabavi, Lukasz Huminiecki, Zheng Feei Ma, Yeong Yeh Lee, Jarosław O. Horbańczuk, Atanas G. Atanasov. Ethnopharmacological Approaches for Therapy of Jaundice: Part II. Highly Used Plant Species from Acanthaceae, Euphorbiaceae, Asteraceae, Combretaceae, and Fabaceae FamiliesFrontiers in Pharmacology 2017; 8 doi: 10.3389/fphar.2017.00519
Simona Clichici, Diana Olteanu, Andras-Laszlo Nagy, Adrian Oros, Adriana Filip, Petru A. Mircea. Silymarin Inhibits the Progression of Fibrosis in the Early Stages of Liver Injury in CCl4-Treated RatsJournal of Medicinal Food 2015; 18(3): 290 doi: 10.1089/jmf.2013.0179
Hyo Joo Byun, Pramod Darvin, Dong Young Kang, Nipin Sp, Youn Hee Joung, Jong Hwan Park, Sun Jin Kim, Young Mok Yang. Silibinin downregulates MMP2 expression via Jak2/STAT3 pathway and inhibits the migration and invasive potential in MDA-MB-231 cellsOncology Reports 2017; 37(6): 3270 doi: 10.3892/or.2017.5588
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