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Number Cited Articles
1
Clarissa Gerhauser. Recent Advances in Polyphenol Research2014; : 143 doi: 10.1002/9781118329634.ch6
2
Antonia Diukendjieva, Merilin Al Sharif, Petko Alov, Tania Pencheva, Ivanka Tsakovska, Ilza Pajeva. ADME/Tox Properties and Biochemical Interactions of Silybin Congeners: In silico StudyNatural Product Communications 2017; 12(2): 1934578X1701200 doi: 10.1177/1934578X1701200208
3
Eun-Kyung Jung, Lisa I. Pilkington, David Barker. Enantioselective Synthesis of 2,3-Disubstituted Benzomorpholines: Analogues of Lignan Natural ProductsThe Journal of Organic Chemistry 2016; 81(23): 12012 doi: 10.1021/acs.joc.6b02265
4
Z. R. Tan, Y. X. Zhou, J. Liu, W. H. Huang, Y. Chen, Y. C. Wang, L. S. Wang. The influence of ABCB1 polymorphism C3435T on the pharmacokinetics of silibininJournal of Clinical Pharmacy and Therapeutics 2015; 40(6): 685 doi: 10.1111/jcpt.12336
5
Kristina M. Brooks, Jomy M. George, Parag Kumar. Drug interactions in HIV treatment: complementary & alternative medicines and over-the-counter productsExpert Review of Clinical Pharmacology 2017; 10(1): 59 doi: 10.1080/17512433.2017.1246180
6
Sharon M. Gwaltney-Brant. Nutraceuticals2016; : 87 doi: 10.1016/B978-0-12-802147-7.00007-3
7
Jia-Ping Wu, Chin-Chuan Tsai, Yu-Lan Yeh, Yueh-Min Lin, Chien-Chung Lin, Cecilia Hsuan Day, Chia-Yao Shen, V. Vijaya Padma, Lung-Fa Pan, Chih-Yang Huang. Silymarin Accelerates Liver Regeneration after Partial HepatectomyEvidence-Based Complementary and Alternative Medicine 2015; 2015: 1 doi: 10.1155/2015/603529
8
Sherif M. Sabry Hassan, Magdy F. Youakim, Ayman Abou Elenein Rizk, Charity Thomann, Zulfiqar Ahmad. Does silybin protect against toxicity induced by polymyxin E in rat kidney?Neurourology and Urodynamics 2017; 36(5): 1278 doi: 10.1002/nau.23109
9
E.S. Hackett, D.C. Twedt, D.L. Gustafson. Milk Thistle and Its Derivative Compounds: A Review of Opportunities for Treatment of Liver DiseaseJournal of Veterinary Internal Medicine 2013; 27(1): 10 doi: 10.1111/jvim.12002
10
T.A.F. Eissa, O.M. Palomino, M.E. Carretero, M.P. Gómez-Serranillos. Ethnopharmacological study of medicinal plants used in the treatment of CNS disorders in Sinai Peninsula, EgyptJournal of Ethnopharmacology 2014; 151(1): 317 doi: 10.1016/j.jep.2013.10.041
11
Xinyu Chen, Katharina Zenger, Amelie Lupp, Beata Kling, Jörg Heilmann, Christian Fleck, Birgit Kraus, Michael Decker. Tacrine-Silibinin Codrug Shows Neuro- and Hepatoprotective Effectsin Vitroand Pro-Cognitive and Hepatoprotective Effectsin VivoJournal of Medicinal Chemistry 2012; 55(11): 5231 doi: 10.1021/jm300246n
12
Arrigo Cicero, Alessandro Colletti, Stefano Bellentani. Nutraceutical Approach to Non-Alcoholic Fatty Liver Disease (NAFLD): The Available Clinical EvidenceNutrients 2018; 10(9): 1153 doi: 10.3390/nu10091153
13
Brandon T. Gufford, Tyler N. Graf, Noemi D. Paguigan, Nicholas H. Oberlies, Mary F. Paine. Chemoenzymatic Synthesis, Characterization, and Scale-Up of Milk Thistle Flavonolignan GlucuronidesDrug Metabolism and Disposition 2015; 43(11): 1734 doi: 10.1124/dmd.115.066076
14
Eirini Christodoulou, Irene-Ariadne Kechagia, Stavros Tzimas, Evangelos Balafas, Nikolaos Kostomitsopoulos, Helen Archontaki, Aristides Dokoumetzidis, Georgia Valsami. Serum and tissue pharmacokinetics of silibinin after per os and i.v. administration to mice as a HP-β-CD lyophilized productInternational Journal of Pharmaceutics 2015; 493(1-2): 366 doi: 10.1016/j.ijpharm.2015.07.060
15
Miroslav Novakovic, Iris Djordjevic, Nina Todorovic, Snezana Trifunovic, Boban Andjelkovic, Boris Mandic, Milka Jadranin, Ivan Vuckovic, Vlatka Vajs, Slobodan Milosavljevic, Vele Tesevic. New aurone epoxide and auronolignan from the heartwood of Cotinus coggygria ScopNatural Product Research 2019; 33(19): 2837 doi: 10.1080/14786419.2018.1508141
16
Mihai Oltean. Silybin Against Liver Ischemia-Reperfusion Injury: Something Old, Something New…Journal of Investigative Surgery 2018; 31(6): 521 doi: 10.1080/08941939.2017.1365975
17
Michal Bijak, Angela Dziedzic, Ewelina Synowiec, Tomasz Sliwinski, Joanna Saluk-Bijak. Flavonolignans Inhibit IL1-β-Induced Cross-Talk between Blood Platelets and LeukocytesNutrients 2017; 9(9): 1022 doi: 10.3390/nu9091022
18
Claire Albert, Mohamed Beladjine, Nicolas Tsapis, Elias Fattal, Florence Agnely, Nicolas Huang. Pickering emulsions: Preparation processes, key parameters governing their properties and potential for pharmaceutical applicationsJournal of Controlled Release 2019; 309: 302 doi: 10.1016/j.jconrel.2019.07.003
19
Hamidah Mohd Yusof, Norlaily Mohd Ali, Swee Keong Yeap, Wan Yong Ho, Boon Kee Beh, Soo Peng Koh, Kamariah Long, Suraini Abdul Aziz, Noorjahan Banu Alitheen. Hepatoprotective Effect of Fermented Soybean (Nutrient Enriched Soybean Tempeh) against Alcohol-Induced Liver Damage in MiceEvidence-Based Complementary and Alternative Medicine 2013; 2013: 1 doi: 10.1155/2013/274274
20
Ji-Suk Jeong, Yong-Joo Kim, Bo-Rum Choi, Geun-Bae Go, Byeong-Gil Son, Suk-Won Gang, Seung-Man Moon. Antioxidant and Physicochemical Changes in Salvia plebeia R. Br. after Hot-air Drying and BlanchingJournal of the Korean Society of Food Science and Nutrition 2014; 43(6): 893 doi: 10.3746/jkfn.2014.43.6.893
21
Elisa Ceccherini, Antonella Cecchettini, Maria Aurora Morales, Silvia Rocchiccioli. The Potentiality of Herbal Remedies in Primary Sclerosing Cholangitis: From In Vitro to Clinical StudiesFrontiers in Pharmacology 2020; 11 doi: 10.3389/fphar.2020.00813
22
R Raghu, B Jesudas, G Bhavani, D Ezhilarasan, S Karthikeyan. Silibinin mitigates zidovudine-induced hepatocellular degenerative changes, oxidative stress and hyperlipidaemia in ratsHuman & Experimental Toxicology 2015; 34(11): 1031 doi: 10.1177/0960327114567765
23
M. Morovat, M. Chamani, A. Zarei, A.A. Sadeghi. Dietary but notin ovofeeding ofSilybum marianumextract resulted in an improvement in performance, immunity and carcass characteristics and decreased the adverse effects of high temperatures in broilersBritish Poultry Science 2016; 57(1): 105 doi: 10.1080/00071668.2015.1121537
24
Yin Li, Zengchun Ye, Weiyan Lai, Jialing Rao, Wanbing Huang, Xiaohao Zhang, Ziying Yao, Tanqi Lou. Activation of Sirtuin 3 by Silybin Attenuates Mitochondrial Dysfunction in Cisplatin-induced Acute Kidney InjuryFrontiers in Pharmacology 2017; 8 doi: 10.3389/fphar.2017.00178
25
Ewelina van Wenum, Rafal Jurczakowski, Grzegorz Litwinienko. Media Effects on the Mechanism of Antioxidant Action of Silybin and 2,3-Dehydrosilybin: Role of the Enol GroupThe Journal of Organic Chemistry 2013; 78(18): 9102 doi: 10.1021/jo401296k
26
Jiayin Yao, Min Zhi, Xiang Gao, Pinjin Hu, Chujun Li, Xiaobo Yang. Effect and the probable mechanisms of silibinin in regulating insulin resistance in the liver of rats with non-alcoholic fatty liverBrazilian Journal of Medical and Biological Research 2013; 46(3): 270 doi: 10.1590/1414-431X20122551
27
Mahdi Mashhadi Akbar Boojar, Massoud Mashhadi Akbar Boojar, Sepide Golmohammad. Overview of Silibinin anti-tumor effectsJournal of Herbal Medicine 2020; 23: 100375 doi: 10.1016/j.hermed.2020.100375
28
Dezső Csupor, Attila Csorba, Judit Hohmann. Recent advances in the analysis of flavonolignans of Silybum marianumJournal of Pharmaceutical and Biomedical Analysis 2016; 130: 301 doi: 10.1016/j.jpba.2016.05.034
29
Qian Zhao, Cheng Peng, Chuan Zheng, Xiang-Hong He, Wei Huang, Bo Han. Recent Advances in Characterizing Natural Products that Regulate AutophagyAnti-Cancer Agents in Medicinal Chemistry 2020; 19(18): 2177 doi: 10.2174/1871520619666191015104458
30
Akinobu Takaki, Seiji Kawano, Daisuke Uchida, Masahiro Takahara, Sakiko Hiraoka, Hiroyuki Okada. Paradoxical Roles of Oxidative Stress Response in the Digestive System before and after CarcinogenesisCancers 2019; 11(2): 213 doi: 10.3390/cancers11020213
31
Anjali Takke, Pravin Shende. Nanotherapeutic silibinin: An insight of phytomedicine in healthcare reformationNanomedicine: Nanotechnology, Biology and Medicine 2019; 21: 102057 doi: 10.1016/j.nano.2019.102057
32
Bashar Saad. Phytotherapies2015; : 142 doi: 10.1002/9781119006039.ch8
33
Marjan Gharagozloo, Mehran Karimi, Zahra Amirghofran. Immunomodulatory effects of silymarin in patients with β-thalassemia majorInternational Immunopharmacology 2013; 16(2): 243 doi: 10.1016/j.intimp.2013.04.016
34
Nikoletta Jedlinszki, Ildikó Kálomista, Gábor Galbács, Dezső Csupor. Silybum marianum (milk thistle) products in Wilson’s disease: a treatment or a threat?Journal of Herbal Medicine 2016; 6(3): 157 doi: 10.1016/j.hermed.2016.06.002
35
H. Kolb. Heilkraft von Kräutern bei Typ-2-DiabetesDer Diabetologe 2014; 10(2): 130 doi: 10.1007/s11428-013-1113-4
36
Sun Hong Park, Jeong-Ah Kwak, Sang-Hun Jung, Byeongwoo Ahn, Won-Jea Cho, Cheong-Yong Yun, Chang Seon Na, Bang Yeon Hwang, Jin Tae Hong, Sang-Bae Han, Youngsoo Kim. Piperidylmethyloxychalcone improves immune-mediated acute liver failure via inhibiting TAK1 activityExperimental & Molecular Medicine 2017; 49(11): e392 doi: 10.1038/emm.2017.156
37
Katrin Wlcek, Fabienne Koller, Peter Ferenci, Bruno Stieger. Hepatocellular Organic Anion–Transporting Polypeptides (OATPs) and Multidrug Resistance–Associated Protein 2 (MRP2) Are Inhibited by SilibininDrug Metabolism and Disposition 2013; 41(8): 1522 doi: 10.1124/dmd.113.051037
38
Zhong-Wen Yuan, Ya-Zhuo Li, Zhong-Qiu Liu, Sen-ling Feng, Hua Zhou, Chang-Xiao Liu, Liang Liu, Ying Xie. Role of tangeretin as a potential bioavailability enhancer for silybin: Pharmacokinetic and pharmacological studiesPharmacological Research 2018; 128: 153 doi: 10.1016/j.phrs.2017.09.019
39
Qian Ding, Jiaolin Bao, Wenwen Zhao, Yangyang Hu, Jinjian Lu, Xiuping Chen. Natural autophagy regulators in cancer therapy: a reviewPhytochemistry Reviews 2015; 14(1): 137 doi: 10.1007/s11101-014-9339-3
40
Susanne M. Henning, Yanjun Zhang, Victoria G. Rontoyanni, Jianjun Huang, Ru-Po Lee, Amy Trang, Gloria Nuernberger, David Heber. Variability in the Antioxidant Activity of Dietary Supplements from Pomegranate, Milk Thistle, Green Tea, Grape Seed, Goji, and Acai: Effects of in Vitro DigestionJournal of Agricultural and Food Chemistry 2014; 62(19): 4313 doi: 10.1021/jf500106r
41
Ming Gu, Ping Zhao, Jinwen Huang, Yuanyuan Zhao, Yahui Wang, Yin Li, Yifei Li, Shengjie Fan, Yue-Ming Ma, Qingchun Tong, Li Yang, Guang Ji, Cheng Huang. Silymarin Ameliorates Metabolic Dysfunction Associated with Diet-Induced Obesity via Activation of Farnesyl X ReceptorFrontiers in Pharmacology 2016; 7 doi: 10.3389/fphar.2016.00345
42
Angela Sciacqua, Maria Perticone, Giovanni Tripepi, Desire Addesi, Velia Cassano, Raffaele Maio, Giorgio Sesti, Francesco Perticone. Metabolic and vascular effects of silybin in hypertensive patients with high 1-h post-load plasma glucoseInternal and Emergency Medicine 2019; 14(1): 77 doi: 10.1007/s11739-018-1951-6
43
Gianni Testino, Silvia Leone, Sharmila Fagoonee, Rinaldo Pellicano. Alcoholic liver fibrosis: detection and treatmentMinerva Medica 2018; 109(6) doi: 10.23736/S0026-4806.18.05844-5
44
Mingzhu Shangguan, Yi Lu, Jianping Qi, Jin Han, Zhiqiang Tian, Yunchang Xie, Fuqiang Hu, Hailong Yuan, Wei Wu. Binary lipids-based nanostructured lipid carriers for improved oral bioavailability of silymarinJournal of Biomaterials Applications 2014; 28(6): 887 doi: 10.1177/0885328213485141
45
José Moltó, Marta Valle, Cristina Miranda, Samandhy Cedeño, Eugenia Negredo, Bonaventura Clotet. Effect of Milk Thistle on the Pharmacokinetics of Darunavir-Ritonavir in HIV-Infected PatientsAntimicrobial Agents and Chemotherapy 2012; 56(6): 2837 doi: 10.1128/AAC.00025-12
46
Yongxiang Zhang, Jie Hai, Meng Cao, Yongli Zhang, Sujuan Pei, Junbo Wang, Qinggui Zhang. Silibinin ameliorates steatosis and insulin resistance during non-alcoholic fatty liver disease development partly through targeting IRS-1/PI3K/Akt pathwayInternational Immunopharmacology 2013; 17(3): 714 doi: 10.1016/j.intimp.2013.08.019
47
X. Shen, H. Liu, G. Li, X. Deng, J. Wang. Silibinin attenuates Streptococcus suis serotype 2 virulence by targeting suilysinJournal of Applied Microbiology 2019; 126(2): 435 doi: 10.1111/jam.14149
48
Youn Ri Lee, Nara Yoon. Anti-Oxidative and Anti-Diabetic Effects of Methanol Extracts from Medicinal PlantsJournal of the Korean Society of Food Science and Nutrition 2015; 44(5): 681 doi: 10.3746/jkfn.2015.44.5.681
49
Seyed Younes Hosseini, Kurosh Kalantar, Khashayar Shahin, Maryam Ghayour, Masoumeh Rajabi Bazl, Mohammad-Reza Fattahi, Maryam Moini, Zahra Amirghofran. Comparison of the In Vitro Antifibrogenic Effects of Silymarin, Silybin A and 18α-Glycyrrhizin on Activated Hepatic Stellate CellsJundishapur Journal of Natural Pharmaceutical Products 2016; (In Press) doi: 10.17795/jjnpp-40285
50
Xiaoli Bi, Zhongwen Yuan, Biao Qu, Hua Zhou, Zhongqiu Liu, Ying Xie. Piperine enhances the bioavailability of silybin via inhibition of efflux transporters BCRP and MRP2Phytomedicine 2019; 54: 98 doi: 10.1016/j.phymed.2018.09.217
51
Alessandro Federico, Marcello Dallio, Carmelina Loguercio. Silymarin/Silybin and Chronic Liver Disease: A Marriage of Many YearsMolecules 2017; 22(2): 191 doi: 10.3390/molecules22020191
52
Veronica Marin, Silvia Gazzin, Sabrina Gambaro, Matteo Dal Ben, Sonia Calligaris, Monica Anese, Alan Raseni, Claudio Avellini, Pablo Giraudi, Claudio Tiribelli, Natalia Rosso. Effects of Oral Administration of Silymarin in a Juvenile Murine Model of Non-alcoholic SteatohepatitisNutrients 2017; 9(9): 1006 doi: 10.3390/nu9091006
53
Chan Wah Kheong, Nik Raihan Nik Mustapha, Sanjiv Mahadeva. A Randomized Trial of Silymarin for the Treatment of Nonalcoholic SteatohepatitisClinical Gastroenterology and Hepatology 2017; 15(12): 1940 doi: 10.1016/j.cgh.2017.04.016
54
Katharina Esser-Nobis, Christian Harak, Philipp Schult, Yuri Kusov, Volker Lohmann. Novel perspectives for hepatitis A virus therapy revealed by comparative analysis of hepatitis C virus and hepatitis A virus RNA replicationHepatology 2015; 62(2): 397 doi: 10.1002/hep.27847
55
Jennifer Doley. Integrative Nutrition Therapy2015; : 49 doi: 10.1201/b18833-6
56
Elizabeth Mudge, Lori Paley, Andreas Schieber, Paula N. Brown. Optimization and single-laboratory validation of a method for the determination of flavonolignans in milk thistle seeds by high-performance liquid chromatography with ultraviolet detectionAnalytical and Bioanalytical Chemistry 2015; 407(25): 7657 doi: 10.1007/s00216-015-8925-6
57
Jun Hyeon Choi, Sun Hong Park, Jae-Kyung Jung, Won-Jea Cho, Byeongwoo Ahn, Cheong-Yong Yun, Yong Pyo Choi, Jong Hun Yeo, Heesoon Lee, Jin Tae Hong, Sang-Bae Han, Youngsoo Kim. Caffeic Acid Cyclohexylamide Rescues Lethal Inflammation in Septic Mice through Inhibition of IκB Kinase in Innate Immune ProcessScientific Reports 2017; 7(1) doi: 10.1038/srep41180
58
Miguel Reina, Ana Martínez. Is Silybin the Best Free Radical Scavenger Compound in Silymarin?The Journal of Physical Chemistry B 2016; 120(20): 4568 doi: 10.1021/acs.jpcb.6b02807
59
Daniel Shadrack, Hulda Swai, Joan Munissi, Egid Mubofu, Stephen Nyandoro. Polyamidoamine Dendrimers for Enhanced Solubility of Small Molecules and Other Desirable Properties for Site Specific Delivery: Insights from Experimental and Computational StudiesMolecules 2018; 23(6): 1419 doi: 10.3390/molecules23061419
60
Eleonora Stanca, Gaetano Serviddio, Francesco Bellanti, Gianluigi Vendemiale, Luisa Siculella, Anna Maria Giudetti. Down-regulation of LPCAT expression increases platelet-activating factor level in cirrhotic rat liver: Potential antiinflammatory effect of silybinBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2013; 1832(12): 2019 doi: 10.1016/j.bbadis.2013.07.005
61
Nanako Kawaguchi, Ting-Ting Zhang, Toshio Nakanishi. Involvement of CXCR4 in Normal and Abnormal DevelopmentCells 2019; 8(2): 185 doi: 10.3390/cells8020185
62
Nancy Vargas-Mendoza, Eduardo Madrigal-Santillán, Ángel Morales-González, Jaime Esquivel-Soto, Cesar Esquivel-Chirino, Manuel García-Luna y González-Rubio, Juan A Gayosso-de-Lucio, José A Morales-González. Hepatoprotective effect of silymarinWorld Journal of Hepatology 2014; 6(3): 144-149 doi: 10.4254/wjh.v6.i3.144
63
Alexandra K. Tsaroucha, Georgia Valsami, Nikolaos Kostomitsopoulos, Maria Lambropoulou, Constantinos Anagnostopoulos, Eirini Christodoulou, Evangelos Falidas, Afrodite Betsou, Michael Pitiakoudis, Constantinos E. Simopoulos. Silibinin Effect on Fas/FasL, HMGB1, and CD45 Expressions in a Rat Model Subjected to Liver Ischemia-Reperfusion InjuryJournal of Investigative Surgery 2018; 31(6): 491 doi: 10.1080/08941939.2017.1360416
64
Zohreh Jahanafrooz, Nasrin Motamed, Beate Rinner, Ahad Mokhtarzadeh, Behzad Baradaran. Silibinin to improve cancer therapeutic, as an apoptotic inducer, autophagy modulator, cell cycle inhibitor, and microRNAs regulatorLife Sciences 2018; 213: 236 doi: 10.1016/j.lfs.2018.10.009
65
Rikki A. M. Brown, Kirsty L. Richardson, Tasnuva D. Kabir, Debbie Trinder, Ruth Ganss, Peter J. Leedman. Altered Iron Metabolism and Impact in Cancer Biology, Metastasis, and ImmunologyFrontiers in Oncology 2020; 10 doi: 10.3389/fonc.2020.00476
66
Sameh Saber, Amr A.A. Mahmoud, Noha S. Helal, Eman El-Ahwany, Rasha H. Abdelghany. Renin–angiotensin system inhibition ameliorates CCl4-induced liver fibrosis in mice through the inactivation of nuclear transcription factor kappa BCanadian Journal of Physiology and Pharmacology 2018; 96(6): 569 doi: 10.1139/cjpp-2017-0728
67
Navaneethakrishnan Polachi, Guirong Bai, Tingyang Li, Yang Chu, Xiangyang Wang, Shuming Li, Ning Gu, Jiang Wu, Wei Li, Yanjun Zhang, Shuiping Zhou, He Sun, Changxiao Liu. Modulatory effects of silibinin in various cell signaling pathways against liver disorders and cancer – A comprehensive reviewEuropean Journal of Medicinal Chemistry 2016; 123: 577 doi: 10.1016/j.ejmech.2016.07.070
68
Dayanne Rakelly de Oliveira, Saulo Relison Tintino, Maria Flaviana Bezerra Morais Braga, Aline Augusti Boligon, Margareth Linde Athayde, Henrique Douglas Melo Coutinho, Irwin Rose Alencar de Menezes, Roselei Fachinetto. In VitroAntimicrobial and Modulatory Activity of the Natural Products Silymarin and SilibininBioMed Research International 2015; 2015: 1 doi: 10.1155/2015/292797
69
Yuhua Ma, Haisheng He, Wufa Fan, Yingxia Li, Wei Zhang, Weili Zhao, Jianping Qi, Yi Lu, Xiaochun Dong, Wei Wu. In Vivo Fate of Biomimetic Mixed Micelles as Nanocarriers for Bioavailability Enhancement of Lipid–Drug ConjugatesACS Biomaterials Science & Engineering 2017; 3(10): 2399 doi: 10.1021/acsbiomaterials.7b00380
70
Pasquale Pignatelli, Roberto Carnevale, Danilo Menichelli. Silybin and metabolic disordersInternal and Emergency Medicine 2019; 14(1): 1 doi: 10.1007/s11739-018-1968-x
71
Daisuke Uchida, Akinobu Takaki, Atsushi Oyama, Takuya Adachi, Nozomu Wada, Hideki Onishi, Hiroyuki Okada. Oxidative Stress Management in Chronic Liver Diseases and Hepatocellular CarcinomaNutrients 2020; 12(6): 1576 doi: 10.3390/nu12061576
72
Antonietta Stellavato, Anna Virginia Adriana Pirozzi, Francesca de Novellis, Ilaria Scognamiglio, Valentina Vassallo, Andrea Maria Giori, Mario De Rosa, Chiara Schiraldi. In vitro assessment of nutraceutical compounds and novel nutraceutical formulations in a liver-steatosis-based modelLipids in Health and Disease 2018; 17(1) doi: 10.1186/s12944-018-0663-2
73
Nguyen Huu Tung, Takuhiro Uto, Osamu Morinaga, Young Ho Kim, Yukihiro Shoyama. Pharmacological Effects of Ginseng on Liver Functions and Diseases: A MinireviewEvidence-Based Complementary and Alternative Medicine 2012; 2012: 1 doi: 10.1155/2012/173297
74
Peng Xu, Hua Zhou, Ya-Zhuo Li, Zhong-Wen Yuan, Chang-Xiao Liu, Liang Liu, Ying Xie. Baicalein Enhances the Oral Bioavailability and Hepatoprotective Effects of Silybin Through the Inhibition of Efflux Transporters BCRP and MRP2Frontiers in Pharmacology 2018; 9 doi: 10.3389/fphar.2018.01115
75
Eleni Theodosiou, Kateřina Purchartová, Haralambos Stamatis, Fragiskos Kolisis, Vladimír Křen. Bioavailability of silymarin flavonolignans: drug formulations and biotransformationPhytochemistry Reviews 2014; 13(1): 1 doi: 10.1007/s11101-013-9285-5
76
B.L. Woolbright, C.D. Williams, M.R. McGill, H. Jaeschke. Reference Module in Biomedical Sciences2014;  doi: 10.1016/B978-0-12-801238-3.00205-1
77
Ludovico Abenavoli, Stefano Bellentani. Milk thistle to treat non-alcoholic fatty liver disease: dream or reality?Expert Review of Gastroenterology & Hepatology 2013; 7(8): 677 doi: 10.1586/17474124.2013.842893
78
Li Feng, Marcus M. Maddox, Md. Zahidul Alam, Lissa S. Tsutsumi, Gagandeep Narula, David F. Bruhn, Xiaoqian Wu, Shayna Sandhaus, Robin B. Lee, Charles J. Simmons, Yuk-Ching Tse-Dinh, Julian G. Hurdle, Richard E. Lee, Dianqing Sun. Synthesis, Structure–Activity Relationship Studies, and Antibacterial Evaluation of 4-Chromanones and Chalcones, as Well as Olympicin A and DerivativesJournal of Medicinal Chemistry 2014; 57(20): 8398 doi: 10.1021/jm500853v
79
Lidia Radko, Wojciech Cybulski, Wojciech Rzeski. The Protective Effect of Silybin against Lasalocid Cytotoxic Exposure on Chicken and Rat Cell LinesBioMed Research International 2013; 2013: 1 doi: 10.1155/2013/783519
80
Muzamil Shah, Muhammad Ullah, Samantha Drouet, Muhammad Younas, Duangjai Tungmunnithum, Nathalie Giglioli-Guivarc’h, Christophe Hano, Bilal Abbasi. Interactive Effects of Light and Melatonin on Biosynthesis of Silymarin and Anti-Inflammatory Potential in Callus Cultures of Silybum marianum (L.) Gaertn.Molecules 2019; 24(7): 1207 doi: 10.3390/molecules24071207
81
Walid Hamdy El-Tantawy, Abeer Temraz. Natural products for the management of the hepatitis C virus: a biochemical reviewArchives of Physiology and Biochemistry 2020; 126(2): 116 doi: 10.1080/13813455.2018.1498902
82
Valeria Romanucci, Giovanni Di Fabio, Armando Zarrelli. A New Class of Synthetic Flavonolignan-Like Dimers: Still Few Molecules, but with Attractive PropertiesMolecules 2018; 24(1): 108 doi: 10.3390/molecules24010108
83
Muhammad Umar Khayam Sahibzada, Abdul Sadiq, Muhammad Zahoor, Sumera Naz, Muhammad Shahid, Najam Afaq Qureshi. Enhancement of bioavailability and hepatoprotection by silibinin through conversion to nanoparticles prepared by liquid antisolvent methodArabian Journal of Chemistry 2020; 13(2): 3682 doi: 10.1016/j.arabjc.2020.01.002
84
Tsanko S. Gechev, Jacques Hille, Herman J. Woerdenbag, Maria Benina, Nikolay Mehterov, Valentina Toneva, Alisdair R. Fernie, Bernd Mueller-Roeber. Natural products from resurrection plants: Potential for medical applicationsBiotechnology Advances 2014; 32(6): 1091 doi: 10.1016/j.biotechadv.2014.03.005
85
Ali Nouri, Esfandiar Heidarian. Nephroprotective effect of silymarin against diclofenac induced renal damage and oxidative stress in male ratsJournal of Herbmed Pharmacology 2019; 8(2): 146 doi: 10.15171/jhp.2019.23
86
Cong Lu, Xin Li, Xue Liang, Xinyu Zhang, Tian Yin, Jingxin Gou, Haibing He, Yu Zhang, Xing Tang. Liver Targeting Albumin-Coated Silybin-Phospholipid Particles Prepared by Nab™ Technology for Improving Treatment Effect of Acute Liver Damage in Intravenous AdministrationAAPS PharmSciTech 2019; 20(7) doi: 10.1208/s12249-019-1504-y
87
Aihua Zhang, Hui Sun, Xijun Wang. Recent advances in natural products from plants for treatment of liver diseasesEuropean Journal of Medicinal Chemistry 2013; 63: 570 doi: 10.1016/j.ejmech.2012.12.062
88
Nahum Méndez-Sánchez, Miguel Dibildox-Martinez, Jahir Sosa-Noguera, Ramón Sánchez-Medal, Francisco J. Flores-Murrieta. Superior silybin bioavailability of silybin–phosphatidylcholine complex in oily-medium soft-gel capsules versus conventional silymarin tablets in healthy volunteers*BMC Pharmacology and Toxicology 2019; 20(1) doi: 10.1186/s40360-018-0280-8
89
Walid Hamdy El-Tantawy, Dina Sabry, Ekram Nemr Abd Al Haleem. Comparative study of antifibrotic activity of some magnesium-containing supplements on experimental liver toxicity. Molecular studyDrug and Chemical Toxicology 2017; 40(1): 47 doi: 10.3109/01480545.2016.1172083
90
Devesh Tewari, Andrei Mocan, Emil D. Parvanov, Archana N. Sah, Seyed M. Nabavi, Lukasz Huminiecki, Zheng Feei Ma, Yeong Yeh Lee, Jarosław O. Horbańczuk, Atanas G. Atanasov. Ethnopharmacological Approaches for Therapy of Jaundice: Part II. Highly Used Plant Species from Acanthaceae, Euphorbiaceae, Asteraceae, Combretaceae, and Fabaceae FamiliesFrontiers in Pharmacology 2017; 8 doi: 10.3389/fphar.2017.00519
91
Simona Clichici, Diana Olteanu, Andras-Laszlo Nagy, Adrian Oros, Adriana Filip, Petru A. Mircea. Silymarin Inhibits the Progression of Fibrosis in the Early Stages of Liver Injury in CCl4-Treated RatsJournal of Medicinal Food 2015; 18(3): 290 doi: 10.1089/jmf.2013.0179
92
Hyo Joo Byun, Pramod Darvin, Dong Young Kang, Nipin Sp, Youn Hee Joung, Jong Hwan Park, Sun Jin Kim, Young Mok Yang. Silibinin downregulates MMP2 expression via Jak2/STAT3 pathway and inhibits the migration and invasive potential in MDA-MB-231 cellsOncology Reports 2017; 37(6): 3270 doi: 10.3892/or.2017.5588
93
Marina Kawaguchi-Suzuki, Reginald F. Frye, Hao-Jie Zhu, Bryan J. Brinda, Kenneth D. Chavin, Hilary J. Bernstein, John S. Markowitz. The Effects of Milk Thistle (Silybum marianum) on Human Cytochrome P450 ActivityDrug Metabolism and Disposition 2014; 42(10): 1611 doi: 10.1124/dmd.114.057232
94
Ramanathan Raghu, Sivanesan Karthikeyan. Zidovudine and isoniazid induced liver toxicity and oxidative stress: Evaluation of mitigating properties of silibininEnvironmental Toxicology and Pharmacology 2016; 46: 217 doi: 10.1016/j.etap.2016.07.014
95
Jesús Pérez-H, Carlos Carrillo-S, Esperanza García, Gabriela Ruiz-Mar, Ruy Pérez-Tamayo, Anahí Chavarría. Neuroprotective effect of silymarin in a MPTP mouse model of Parkinson's diseaseToxicology 2014; 319: 38 doi: 10.1016/j.tox.2014.02.009
96
Ming Hong, Sha Li, Hor Tan, Ning Wang, Sai-Wah Tsao, Yibin Feng. Current Status of Herbal Medicines in Chronic Liver Disease Therapy: The Biological Effects, Molecular Targets and Future ProspectsInternational Journal of Molecular Sciences 2015; 16(12): 28705 doi: 10.3390/ijms161226126
97
Romana Sokolová, Jana Kocábová, Petr Marhol, Jan Fiedler, David Biedermann, Jan Vacek, Vladimír Křen. Oxidation of Natural Bioactive Flavonolignan 2,3-Dehydrosilybin: An Electrochemical and Spectral StudyThe Journal of Physical Chemistry B 2017; 121(28): 6841 doi: 10.1021/acs.jpcb.7b04651
98
Ji-Young Choi, Hyeon Gyu Yi, Chang-Shin Park, Dong Wun Shin, Ju-Hee Kang. Inhibition of oxaliplatin-induced neurotoxicity by silymarin through increased expression of brain-derived neurotrophic factor and inhibition of p38-MAPKMolecular & Cellular Toxicology 2019; 15(2): 145 doi: 10.1007/s13273-019-0018-8
99
Jennifer Doley. Integrating Nutrition Into Practice2017; : 49 doi: 10.1201/9781315100913-6
100
Joyce P. Rodriguez, Norman G. Quilantang, Ju Sung Lee, Jeong Min Lee, Hyun Young Kim, Jae Suk Shim, Sanghyun Lee. Determination of Silybin B in the Different Parts of Silybum marianum using HPLC-UVNatural Product Sciences 2018; 24(2): 82 doi: 10.20307/nps.2018.24.2.82
101
Yuhua Ma, Haisheng He, Fei Xia, Yingxia Li, Yan Lu, Daofeng Chen, Jianping Qi, Yi Lu, Wei Zhang, Wei Wu. In vivo fate of lipid-silybin conjugate nanoparticles: Implications on enhanced oral bioavailabilityNanomedicine: Nanotechnology, Biology and Medicine 2017; 13(8): 2643 doi: 10.1016/j.nano.2017.07.014
102
Leonard Seeff, Felix Stickel, Victor J. Navarro. Drug-Induced Liver Disease2013; : 631 doi: 10.1016/B978-0-12-387817-5.00035-2
103
Remziye Aysun Kepekçi, Sait Polat, Gülfidan Çoşkun, Ahmet Çelik, A. Sarper Bozkurt, Önder Yumrutaş, Mustafa Pehlivan. Preliminary Characterization of Phenolic Acid Composition and Hepatoprotective Effect ofStachys pumilaJournal of Food Biochemistry 2017; 41(2): e12286 doi: 10.1111/jfbc.12286
104
Seyede Elmira Yazdi Rouholamini, Saeid Moghassemi, Zahra Maharat, Amirhossien Hakamivala, Susan Kashanian, Kobra Omidfar. Effect of silibinin-loaded nano-niosomal coated with trimethyl chitosan on miRNAs expression in 2D and 3D models of T47D breast cancer cell lineArtificial Cells, Nanomedicine, and Biotechnology 2018; 46(3): 524 doi: 10.1080/21691401.2017.1326928
105
Ijeoma F. Uchegbu. Fundamentals of Pharmaceutical Nanoscience2013; : 9 doi: 10.1007/978-1-4614-9164-4_2
106
Lorenzo Di Cesare Mannelli, Matteo Zanardelli, Paola Failli, Carla Ghelardini. Oxaliplatin-Induced Neuropathy: Oxidative Stress as Pathological Mechanism. Protective Effect of SilibininThe Journal of Pain 2012; 13(3): 276 doi: 10.1016/j.jpain.2011.11.009
107
Mai Khater, Divyashree Ravishankar, Francesca Greco, Helen MI Osborn. Metal complexes of flavonoids: their synthesis, characterization and enhanced antioxidant and anticancer activitiesFuture Medicinal Chemistry 2019; 11(21): 2845 doi: 10.4155/fmc-2019-0237
108
Divyashree Ravishankar, Kimberly A. Watson, Samuel Y. Boateng, Rebecca J. Green, Francesca Greco, Helen M.I. Osborn. Exploring quercetin and luteolin derivatives as antiangiogenic agentsEuropean Journal of Medicinal Chemistry 2015; 97: 259 doi: 10.1016/j.ejmech.2015.04.056
109
Amir Anushiravani, Niloufar Haddadi, Maedeh Pourfarmanbar, Vahid Mohammadkarimi. Treatment options for nonalcoholic fatty liver diseaseEuropean Journal of Gastroenterology & Hepatology 2019; 31(5): 613 doi: 10.1097/MEG.0000000000001369
110
Walid Hamdy El-Tantawy, Abeer Temraz. Anti-fibrotic activity of natural products, herbal extracts and nutritional components for prevention of liver fibrosis: reviewArchives of Physiology and Biochemistry 2019; : 1 doi: 10.1080/13813455.2019.1684952
111
Licia Polimeni, Maria Del Ben, Francesco Baratta, Ludovica Perri, Fabiana Albanese, Daniele Pastori, Francesco Violi, Francesco Angelico. Oxidative stress: New insights on the association of non-alcoholic fatty liver disease and atherosclerosisWorld Journal of Hepatology 2015; 7(10): 1325-1336 doi: 10.4254/wjh.v7.i10.1325
112
Nava Reznik, Noga Kozer, Avital Eisenberg-Lerner, Haim Barr, Yifat Merbl, Nir London. Phenotypic Screen Identifies JAK2 as a Major Regulator of FAT10 ExpressionACS Chemical Biology 2019; 14(12): 2538 doi: 10.1021/acschembio.9b00667
113
Drug Discovery from Mother NatureAdvances in Experimental Medicine and Biology 2016; 929: 25 doi: 10.1007/978-3-319-41342-6_2
114
Federico Salomone, Ignazio Barbagallo, Justyna Godos, Vincenzo Lembo, Walter Currenti, Diana Cinà, Roberto Avola, Nicolantonio D’Orazio, Filomena Morisco, Fabio Galvano, Giovanni Li Volti. Silibinin Restores NAD+ Levels and Induces the SIRT1/AMPK Pathway in Non-Alcoholic Fatty LiverNutrients 2017; 9(10): 1086 doi: 10.3390/nu9101086
115
Michael Gülden, Daniel Appel, Malin Syska, Stephanie Uecker, Franziska Wages, Hasso Seibert. Chrysin and silibinin sensitize human glioblastoma cells for arsenic trioxideFood and Chemical Toxicology 2017; 105: 486 doi: 10.1016/j.fct.2017.04.035
116
Yuan XIE, Hai-Ping HAO, Hong WANG, Zhao-Xian WANG, Guang-Ji WANG. Reversing effects of silybin on TAA-induced hepatic CYP3A dysfunction through PXR regulationChinese Journal of Natural Medicines 2013; 11(6): 645 doi: 10.1016/S1875-5364(13)60075-8
117
Alfonso Di Costanzo, Ruggero Angelico. Formulation Strategies for Enhancing the Bioavailability of Silymarin: The State of the ArtMolecules 2019; 24(11): 2155 doi: 10.3390/molecules24112155
118
Michal Bijak. Silybin, a Major Bioactive Component of Milk Thistle (Silybum marianum L. Gaernt.)—Chemistry, Bioavailability, and MetabolismMolecules 2017; 22(11): 1942 doi: 10.3390/molecules22111942
119
Phytotherapeutics: The Emerging Role of Intestinal and Hepatocellular Transporters in Drug Interactions with Botanical SupplementsMolecules 2017; 22(10): 1699 doi: 10.3390/molecules22101699
120
Romana Sokolová, Ján Tarábek, Barbora Papoušková, Jana Kocábová, Jan Fiedler, Jan Vacek, Petr Marhol, Eva Vavříková, Vladimír Křen. Oxidation of the Flavonolignan Silybin. In situ EPR Evidence of the Spin-Trapped Silybin RadicalElectrochimica Acta 2016; 205: 118 doi: 10.1016/j.electacta.2016.04.107
121
Chun-Xue Cui, Jing-Na Deng, Li Yan, Yu-Ying Liu, Jing-Yu Fan, Hong-Na Mu, Hao-Yu Sun, Ying-Hong Wang, Jing-Yan Han. Silibinin Capsules improves high fat diet-induced nonalcoholic fatty liver disease in hamsters through modifying hepatic de novo lipogenesis and fatty acid oxidationJournal of Ethnopharmacology 2017; 208: 24 doi: 10.1016/j.jep.2017.06.030
122
Elena Grasselli, Francesca Baldini, Giulia Vecchione, Paulo Oliveira, Vilma Sard�o, Adriana Voci, Piero Portincasa, Laura Vergani. Excess fructose and fatty acids trigger a model of non‑alcoholic fatty liver disease progression in vitro: Protective effect of the flavonoid silybinInternational Journal of Molecular Medicine 2019;  doi: 10.3892/ijmm.2019.4234
123
Sana Nafees, Syed Hassan Mehdi, Mohammad Zafaryab, Bushra Zeya, Tarique Sarwar, Moshahid Alam Rizvi. Synergistic Interaction of Rutin and Silibinin on Human Colon Cancer Cell LineArchives of Medical Research 2018; 49(4): 226 doi: 10.1016/j.arcmed.2018.09.008
124
Yu-Jui Kuo, Hui-Ping Chang, Yu-Jun Chang, Hsing-Hsien Wu, Chang-Hua Chen. Evaluation of nephroprotection of silymarin on contrast-induced nephropathy in liver cirrhosis patientsMedicine 2018; 97(37): e12243 doi: 10.1097/MD.0000000000012243
125
Neha Samir Roy, Jung-A Kim, Ah-Young Choi, Yong-Wook Ban, Nam-Il Park, Kyong-Cheul Park, Hee-sun Yang, Ik-Young Choi, Soonok Kim. RNA-Seq De Novo Assembly and Differential Transcriptome Analysis of Korean Medicinal Herb Cirsium japonicum var. spinossimumGenomics & Informatics 2018; 16(4): e34 doi: 10.5808/GI.2018.16.4.e34
126
Xiangxiang Liu, Xiaojie Mi, Zi Wang, Ming Zhang, Jingang Hou, Shuang Jiang, Yingping Wang, Chen Chen, Wei Li. Ginsenoside Rg3 promotes regression from hepatic fibrosis through reducing inflammation-mediated autophagy signaling pathwayCell Death & Disease 2020; 11(6) doi: 10.1038/s41419-020-2597-7
127
Keishi Yamasaki, Hiroki Sato, Saori Minagoshi, Karin Kyubun, Makoto Anraku, Shigeyuki Miyamura, Hiroshi Watanabe, Kazuaki Taguchi, Hakaru Seo, Toru Maruyama, Masaki Otagiri. The Binding of Silibinin, the Main Constituent of Silymarin, to Site I on Human Serum AlbuminBiological & Pharmaceutical Bulletin 2017; 40(3): 310 doi: 10.1248/bpb.b16-00790
128
Joaquim Bosch-Barrera, Javier A. Menendez. Silibinin and STAT3: A natural way of targeting transcription factors for cancer therapyCancer Treatment Reviews 2015; 41(6): 540 doi: 10.1016/j.ctrv.2015.04.008
129
Ching-Hsuan Liu, Alagie Jassey, Hsin-Ya Hsu, Liang-Tzung Lin. Antiviral Activities of Silymarin and DerivativesMolecules 2019; 24(8): 1552 doi: 10.3390/molecules24081552
130
Silvia Zappavigna, Daniela Vanacore, Stefania Lama, Nicoletta Potenza, Aniello Russo, Pasquale Ferranti, Marcello Dallio, Alessandro Federico, Carmelina Loguercio, Pasquale Sperlongano, Michele Caraglia, Paola Stiuso. Silybin-Induced Apoptosis Occurs in Parallel to the Increase of Ceramides Synthesis and miRNAs Secretion in Human Hepatocarcinoma CellsInternational Journal of Molecular Sciences 2019; 20(9): 2190 doi: 10.3390/ijms20092190
131
Hao-Jie Zhu, Bryan J. Brinda, Kenneth D. Chavin, Hilary J. Bernstein, Kennerly S. Patrick, John S. Markowitz. An Assessment of Pharmacokinetics and Antioxidant Activity of Free Silymarin Flavonolignans in Healthy Volunteers: A Dose Escalation StudyDrug Metabolism and Disposition 2013; 41(9): 1679 doi: 10.1124/dmd.113.052423
132
F. Wei, S.-K. Liu, X.-Y. Liu, Z.-J. Li, B. Li, Y.-L. Zhou, H.-Y. Zhang, Y.-W. Li. Meta-analysis: silymarin and its combination therapy for the treatment of chronic hepatitis BEuropean Journal of Clinical Microbiology & Infectious Diseases 2013; 32(5): 657 doi: 10.1007/s10096-012-1789-1
133
Khaled Khazim, Yves Gorin, Rita Cassia Cavaglieri, Hanna E. Abboud, Paolo Fanti. The antioxidant silybin prevents high glucose-induced oxidative stress and podocyte injury in vitro and in vivoAmerican Journal of Physiology-Renal Physiology 2013; 305(5): F691 doi: 10.1152/ajprenal.00028.2013
134
Masha G. Savelieff, Geewoo Nam, Juhye Kang, Hyuck Jin Lee, Misun Lee, Mi Hee Lim. Development of Multifunctional Molecules as Potential Therapeutic Candidates for Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis in the Last DecadeChemical Reviews 2019; 119(2): 1221 doi: 10.1021/acs.chemrev.8b00138
135
Ahmed M. Sayed, Emad H.M. Hassanein, Shimaa H. Salem, Omnia E. Hussein, Ayman M. Mahmoud. Flavonoids-mediated SIRT1 signaling activation in hepatic disordersLife Sciences 2020; : 118173 doi: 10.1016/j.lfs.2020.118173
136
Michael Decker, Sarah Wehle. Alzheimer mit Hybridmolekülen in die Zange nehmenNachrichten aus der Chemie 2013; 61(9): 871 doi: 10.1002/nadc.201390272
137
Zongguo Yang, Liping Zhuang, Yunfei Lu, Qingnian Xu, Xiaorong Chen. Effects and Tolerance of Silymarin (Milk Thistle) in Chronic Hepatitis C Virus Infection Patients: A Meta-Analysis of Randomized Controlled TrialsBioMed Research International 2014; 2014: 1 doi: 10.1155/2014/941085
138
Bruno Stieger, Zainab M. Mahdi, Walter Jäger. Intestinal and Hepatocellular Transporters: Therapeutic Effects and Drug Interactions of Herbal SupplementsAnnual Review of Pharmacology and Toxicology 2017; 57(1): 399 doi: 10.1146/annurev-pharmtox-010716-105010
139
Francesca Baldini, Piero Portincasa, Elena Grasselli, Gianluca Damonte, Annalisa Salis, Michela Bonomo, Marilina Florio, Nadia Serale, Adriana Voci, Patrizia Gena, Laura Vergani, Giuseppe Calamita. Aquaporin-9 is involved in the lipid-lowering activity of the nutraceutical silybin on hepatocytes through modulation of autophagy and lipid droplets compositionBiochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2020; 1865(3): 158586 doi: 10.1016/j.bbalip.2019.158586
140
Miguel Reina, Ana Martínez. How the presence of metal atoms and clusters can modify the properties of Silybin? A computational predictionComputational and Theoretical Chemistry 2017; 1099: 174 doi: 10.1016/j.comptc.2016.11.030
141
D. Biedermann, E. Vavříková, L. Cvak, V. Křen. Chemistry of silybinNat. Prod. Rep. 2014; 31(9): 1138 doi: 10.1039/C3NP70122K
142
Tahsin F. Kellici, Dimitrios Ntountaniotis, Georgios Leonis, Maria Chatziathanasiadou, Alexandra V. Chatzikonstantinou, Johanna Becker-Baldus, Clemens Glaubitz, Andreas G. Tzakos, Kyriakos Viras, Petros Chatzigeorgiou, Stavros Tzimas, Evangelia Kefala, Georgia Valsami, Helen Archontaki, Manthos G. Papadopoulos, Thomas Mavromoustakos. Investigation of the Interactions of Silibinin with 2-Hydroxypropyl-β-cyclodextrin through Biophysical Techniques and Computational MethodsMolecular Pharmaceutics 2015; 12(3): 954 doi: 10.1021/mp5008053
143
Sameh Saber, Reham Goda, Ghada S. El-Tanbouly, Dalia Ezzat. Lisinopril inhibits nuclear transcription factor kappa B and augments sensitivity to silymarin in experimental liver fibrosisInternational Immunopharmacology 2018; 64: 340 doi: 10.1016/j.intimp.2018.09.021
144
Yan Liu, Jun Ye, Yonghong Cao, Rong Zhang, Yunsheng Wang, Suwan Zhang, Wu Dai, Shandong Ye. Silibinin ameliorates diabetic nephropathy via improving diabetic condition in the miceEuropean Journal of Pharmacology 2019; 845: 24 doi: 10.1016/j.ejphar.2018.12.031
145
H.B. Li, Y.R.Y. Yang, Z.J. Mo, Y. Ding, W.J. Jiang. Silibinin improves palmitate-induced insulin resistance in C2C12 myotubes by attenuating IRS-1/PI3K/Akt pathway inhibitionBrazilian Journal of Medical and Biological Research 2015; 48(5): 440 doi: 10.1590/1414-431x20144238
146
Martin Kubala, Petra Čechová, Jaroslava Geletičová, Michal Biler, Tereza Štenclová, Patrick Trouillas, David Biedermann. Flavonolignans As a Novel Class of Sodium Pump InhibitorsFrontiers in Physiology 2016; 7 doi: 10.3389/fphys.2016.00115
147
Feyzullah Uçmak, Nazım Ekin, İbrahim İbiloğlu, Serkan Arslan, İbrahim Kaplan, Ebubekir Şenateş. Prophylactic Administration of Silybin Ameliorates L-Arginine-Induced Acute PancreatitisMedical Science Monitor 2016; 22: 3641 doi: 10.12659/MSM.898014
148
Christine Hughes, Muhammed Zafar Iqbal Hydrie, Sunita Vohra. Health of HIV Infected People2015; : 255 doi: 10.1016/B978-0-12-800769-3.00015-9
149
Michal Bijak, Joanna Saluk, Rafal Szelenberger, Pawel Nowak. Popular naturally occurring antioxidants as potential anticoagulant drugsChemico-Biological Interactions 2016; 257: 35 doi: 10.1016/j.cbi.2016.07.022
150
Raghu Ramanathan, Karthikeyan Sivanesan. Evaluation of ameliorative ability of Silibinin against zidovudine and isoniazid-induced hepatotoxicity and hyperlipidaemia in rats: Role of Silibinin in Phase I and II drug metabolismChemico-Biological Interactions 2017; 273: 142 doi: 10.1016/j.cbi.2017.06.008
151
Aysa Rezabakhsh, Farzaneh Fathi, Hesam Saghaei Bagheri, Hassan Malekinejad, Azadeh Montaseri, Reza Rahbarghazi, Alireza Garjani. Silibinin protects human endothelial cells from high glucose-induced injury by enhancing autophagic responseJournal of Cellular Biochemistry 2018; 119(10): 8084 doi: 10.1002/jcb.26735
152
Yan Yan, Kang Wang, Xu Tang, Jun-feng Gao, Bin-yu Wen. Phytochemicals protect L02 cells against hepatotoxicity induced by emodin via the Nrf2 signaling pathwayToxicology Research 2019; 8(6): 1028 doi: 10.1039/c9tx00220k
153
Jaime A. Yáñez, Nagendra V. Chemuturi, Scott W. Womble, Casey L. Sayre, Neal M. Davies. FLAVONOID PHARMACOKINETICS2012; : 281 doi: 10.1002/9781118468524.ch7
154
Metabolism, Transport and Drug–Drug Interactions of SilymarinMolecules 2019; 24(20): 3693 doi: 10.3390/molecules24203693
155
Cheng Shen, Xiao-Yan Huang, Chang-An Geng, Tian-Ze Li, Jin-Ping Wang, Shuang Tang, Li-Hua Su, Zhen Gao, Xue-Mei Zhang, Ji-Jun Chen. Cytotoxic sesquiterpenoids against hepatic stellate cell line LX2 from Artemisia lavandulaefoliaBioorganic Chemistry 2020; 103: 104107 doi: 10.1016/j.bioorg.2020.104107
156
Cindy X. Cai, Stella Carlos, Pejman Solaimani, Bansari J. Trivedi, Chuong Tran, Shobha Castelino-Prabhu. Dietary Interventions in Liver Disease2019; : 357 doi: 10.1016/B978-0-12-814466-4.00029-X
157
Sonia A Lozano-Sepulveda, Owen L Bryan-Marrugo, Carlos Cordova-Fletes, Maria C Gutierrez-Ruiz, Ana M Rivas-Estilla. Oxidative stress modulation in hepatitis C virus infected cellsWorld Journal of Hepatology 2015; 7(29): 2880-2889 doi: 10.4254/wjh.v7.i29.2880
158
Wojciech Cybulski, Lidia Radko, Wojciech Rzeski. Cytotoxicity of monensin, narasin and salinomycin and their interaction with silybin in HepG2, LMH and L6 cell culturesToxicology in Vitro 2015; 29(2): 337 doi: 10.1016/j.tiv.2014.11.013
159
Peter Surai. Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and PerspectivesAntioxidants 2015; 4(1): 204 doi: 10.3390/antiox4010204
160
Manjoor Ali, Biswajit Sadhu, Anil Boda, Nidhi Tiwari, Amit Das, S.K. Musharaf Ali, Dibyendu Bhattacharya, Badri N. Pandey, Amit Kumar. Thorium decorporation efficacy of rationally-selected biocompatible compounds with relevance to human applicationJournal of Hazardous Materials 2019; 365: 952 doi: 10.1016/j.jhazmat.2018.11.038
161
Almudena Pérez-Sánchez, Elisabet Cuyàs, Verónica Ruiz-Torres, Luz Agulló-Chazarra, Sara Verdura, Isabel González-Álvarez, Marival Bermejo, Jorge Joven, Vicente Micol, Joaquim Bosch-Barrera, Javier Menendez. Intestinal Permeability Study of Clinically Relevant Formulations of Silibinin in Caco-2 Cell MonolayersInternational Journal of Molecular Sciences 2019; 20(7): 1606 doi: 10.3390/ijms20071606
162
E. T. Zhilyakova, Z. E. Tsvetkova, D. I. Pisarev, N. N. Boyko, E. Yu. Tymoshenko. INTENSIFICATION OF PRODUCTION PROCESS OF THICK EXTRACT OF MILK THISTLE FRUITS BY ULTRASONIC PROCESSING OF RAW MATERIALSPharmacy & Pharmacology 2018; 6(5): 475 doi: 10.19163/2307-9266-2018-6-5-475-487
163
Sonia Calligaris, Piergiorgio Comuzzo, Francesca Bot, Giovanna Lippe, Roberto Zironi, Monica Anese, Maria Cristina Nicoli. Nanoemulsions as delivery systems of hydrophobic silybin from silymarin extract: Effect of oil type on silybin solubility, in vitro bioaccessibility and stabilityLWT - Food Science and Technology 2015; 63(1): 77 doi: 10.1016/j.lwt.2015.03.091
164
Caterina Grillo, Silvia Chichiarelli, Elisa Gaucci, Fabio Altieri, Carlo Turano, Laura Cervoni. The binding of silibinin to ERp57Chemico-Biological Interactions 2014; 213: 37 doi: 10.1016/j.cbi.2014.02.005
165
Sami Gharbia, Cornel Balta, Hildegard Herman, Marcel Rosu, Judit Váradi, Ildikó Bácskay, Miklós Vecsernyés, Szilvia Gyöngyösi, Ferenc Fenyvesi, Sorina N. Voicu, Miruna S. Stan, Roxana E. Cristian, Anca Dinischiotu, Anca Hermenean. Enhancement of Silymarin Anti-fibrotic Effects by Complexation With Hydroxypropyl (HPBCD) and Randomly Methylated (RAMEB) β-Cyclodextrins in a Mouse Model of Liver FibrosisFrontiers in Pharmacology 2018; 9 doi: 10.3389/fphar.2018.00883
166
Hassan Farghali, Mighty Kgalalelo Kemelo, Nikolina Kutinová Canová. SIRT1 Modulators in Experimentally Induced Liver InjuryOxidative Medicine and Cellular Longevity 2019; 2019: 1 doi: 10.1155/2019/8765954
167
Subir Kumar Das, Sukhes Mukherjee. Biochemical and immunological basis of silymarin effect, a milk thistle (Silybum marianum) against ethanol-induced oxidative damageToxicology Mechanisms and Methods 2012; 22(5): 409 doi: 10.3109/15376516.2012.673090
168
Divyashree Ravishankar, Kimberly A. Watson, Francesca Greco, Helen M. I. Osborn. Novel synthesised flavone derivatives provide significant insight into the structural features required for enhanced anti-proliferative activityRSC Advances 2016; 6(69): 64544 doi: 10.1039/C6RA11041J
169
Alessandro Federico, Marcello Dallio, Mario Masarone, Antonietta Gerarda Gravina, Rosa Di Sarno, Concetta Tuccillo, Valentina Cossiga, Stefania Lama, Paola Stiuso, Filomena Morisco, Marcello Persico, Carmelina Loguercio. Evaluation of the Effect Derived from Silybin with Vitamin D and Vitamin E Administration on Clinical, Metabolic, Endothelial Dysfunction, Oxidative Stress Parameters, and Serological Worsening Markers in Nonalcoholic Fatty Liver Disease PatientsOxidative Medicine and Cellular Longevity 2019; 2019: 1 doi: 10.1155/2019/8742075
170
Neda Masoumi Qajari, Majid Malekzadeh Shafaroudi, Milad Gholami, Abbas Khonakdar-Tarsi. Silibinin treatment results in reducing OPA1&MFN1 genes expression in a rat model hepatic ischemia–reperfusionMolecular Biology Reports 2020; 47(5): 3271 doi: 10.1007/s11033-020-05383-w
171
Sangeetha Nagarajan, Nalini Namasivayam. Silibinin alleviates hyperlipidaemia, restores mucin content, modulates TGF-β and fosters apoptosis in experimental rat colon carcinogenesisJournal of Functional Foods 2014; 11: 472 doi: 10.1016/j.jff.2014.10.025
172
Grazia Pennisi, Ciro Celsa, Federica Spatola, Marcello Dallio, Alessandro Federico, Salvatore Petta. Pharmacological Therapy of Non-Alcoholic Fatty Liver Disease: What Drugs Are Available Now and Future PerspectivesInternational Journal of Environmental Research and Public Health 2019; 16(22): 4334 doi: 10.3390/ijerph16224334
173
Bregje Van De Wier, Ger H. Koek, Aalt Bast, Guido R. M. M. Haenen. The potential of flavonoids in the treatment of non-alcoholic fatty liver diseaseCritical Reviews in Food Science and Nutrition 2017; 57(4): 834 doi: 10.1080/10408398.2014.952399
174
Daisuke Uchida, Akinobu Takaki, Takuya Adachi, Hiroyuki Okada. Beneficial and Paradoxical Roles of Anti-Oxidative Nutritional Support for Non-Alcoholic Fatty Liver DiseaseNutrients 2018; 10(8): 977 doi: 10.3390/nu10080977
175
Carmela Loguercio, Pietro Andreone, Ciprian Brisc, Michaela Cristina Brisc, Elisabetta Bugianesi, Maria Chiaramonte, Carmela Cursaro, Mirela Danila, Ilario de Sio, Annarosa Floreani, Maria Antonietta Freni, Antonio Grieco, Marzia Groppo, Roberta Lazzari, Salvatore Lobello, Elisabetta Lorefice, Marzia Margotti, Luca Miele, Stefano Milani, Lajos Okolicsanyi, Giuseppe Palasciano, Piero Portincasa, Patrizia Saltarelli, Antonina Smedile, Francesco Somalvico, Aldo Spadaro, Ioan Sporea, Paolo Sorrentino, Raffaela Vecchione, Concetta Tuccillo, Camillo Del Vecchio Blanco, Alessandro Federico. Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: A randomized controlled trialFree Radical Biology and Medicine 2012; 52(9): 1658 doi: 10.1016/j.freeradbiomed.2012.02.008