| For: | Loguercio C, Festi D. Silybin and the liver: From basic research to clinical practice. World J Gastroenterol 2011; 17(18): 2288-2301 [PMID: 21633595 DOI: 10.3748/wjg.v17.i18.2288] |
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| URL: | https://www.wjgnet.com/1007-9327/full/v17/i18/2288.htm |
| Number | Citing Articles |
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| 2 |
Antonia Diukendjieva, Merilin Al Sharif, Petko Alov, Tania Pencheva, Ivanka Tsakovska, Ilza Pajeva. ADME/Tox Properties and Biochemical Interactions of Silybin Congeners: In silico Study. Natural Product Communications 2017; 12(2) doi: 10.1177/1934578X1701200208
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| 3 |
Monica Foghis, Simona Gabriela Bungau, Alexa Florina Bungau, Cosmin Mihai Vesa, Anamaria Lavinia Purza, Alexandra Georgiana Tarce, Delia Mirela Tit, Annamaria Pallag, Tapan Behl, Syed Shams ul Hassan, Andrei-Flavius Radu. Plants-based medicine implication in the evolution of chronic liver diseases. Biomedicine & Pharmacotherapy 2023; 158 doi: 10.1016/j.biopha.2022.114207
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| 4 |
Nancy Vargas-Mendoza, Marcelo Ángeles-Valencia, Eduardo Osiris Madrigal-Santillán, Mauricio Morales-Martínez, Judith Margarita Tirado-Lule, Arturo Solano-Urrusquieta, Eduardo Madrigal-Bujaidar, Isela Álvarez-González, Tomás Fregoso-Aguilar, Ángel Morales-González, José A. Morales-González. Effect of Silymarin Supplementation on Physical Performance, Muscle and Myocardium Histological Changes, Bodyweight, and Food Consumption in Rats Subjected to Regular Exercise Training. International Journal of Molecular Sciences 2020; 21(20) doi: 10.3390/ijms21207724
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| 5 |
Kristina M. Brooks, Jomy M. George, Parag Kumar. Drug interactions in HIV treatment: complementary & alternative medicines and over-the-counter products. Expert Review of Clinical Pharmacology 2017; 10(1) doi: 10.1080/17512433.2017.1246180
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| 6 |
Jia-Ping Wu, Chin-Chuan Tsai, Yu-Lan Yeh, Yueh-Min Lin, Chien-Chung Lin, Cecilia Hsuan Day, Chia-Yao Shen, V. Vijaya Padma, Lung-Fa Pan, Chih-Yang Huang. Silymarin Accelerates Liver Regeneration after Partial Hepatectomy. Evidence-Based Complementary and Alternative Medicine 2015; 2015 doi: 10.1155/2015/603529
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| 7 |
E.S. Hackett, D.C. Twedt, D.L. Gustafson. Milk Thistle and Its Derivative Compounds: A Review of Opportunities for Treatment of Liver Disease. Journal of Veterinary Internal Medicine 2013; 27(1) doi: 10.1111/jvim.12002
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| 8 |
Ana Caroline dos Santos, Tauani Caroline Santos França, Larissa Venzon, Vitor Polli, Gustavo Polleti, Erica Trembulak, Sarah Freygang Mendes Pilati, Luísa Mota da Silva. Are silymarin and N‐acetylcysteine able to prevent liver damage mediated by multiple factors? Findings against ethanol plus LPS‐induced liver injury in mice. Journal of Biochemical and Molecular Toxicology 2024; 38(1) doi: 10.1002/jbt.23560
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| 9 |
Angela Saviano, Ida Sicilia, Alessio Migneco, Carmine Petruzziello, Mattia Brigida, Marcello Candelli, Francesco Franceschi, Veronica Ojetti. The Efficacy of a Combination of Milk Thistle, Artichoke, and Green Tea in the Treatment of Biliary Sludge: An Interventional Prospective Open Study. Gastrointestinal Disorders 2024; 6(4) doi: 10.3390/gidisord6040061
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| 10 |
Liangge Li, Yiming Qin, Xijian Xin, Shendong Wang, Zhaojun Liu, Xiujing Feng. The great potential of flavonoids as candidate drugs for NAFLD. Biomedicine & Pharmacotherapy 2023; 164 doi: 10.1016/j.biopha.2023.114991
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| 11 |
Arrigo F. G. Cicero, Alessandro Colletti, Stefano Bellentani. Nutraceutical Approach to Non-Alcoholic Fatty Liver Disease (NAFLD): The Available Clinical Evidence. Nutrients 2018; 10(9) doi: 10.3390/nu10091153
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| 12 |
Khaled Y. Mahmoud, Yasmeen N. Ezzeldeen, Arwa A. Nasr, Mai O. Ghonim, Menna W. Ibrahim, Mohamed G. Ali, Mona A. Helmi, Nada A. Mostafa, Nada T. Abdelaziz, Naira N. Elmohandes, Yara H. Mahmoud, Shady A. Swidan. Silibinin-loaded cubosomes: a gateway to enhanced hepatoprotective activity. Future Journal of Pharmaceutical Sciences 2025; 11(1) doi: 10.1186/s43094-025-00828-0
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| 13 |
Snigdha Singh, Arpit Sharma, Tanu Pandey, Shivani Gupta, Alok Shukla, Santosh Kumar Singh, Amit Singh. Silibinin: a natural flavonoid with multifaceted anticancer potential and therapeutic challenges. Medicinal Chemistry Research 2025; 34(10) doi: 10.1007/s00044-025-03466-6
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| 14 |
Brandon T. Gufford, Tyler N. Graf, Noemi D. Paguigan, Nicholas H. Oberlies, Mary F. Paine. Chemoenzymatic Synthesis, Characterization, and Scale-Up of Milk Thistle Flavonolignan Glucuronides. Drug Metabolism and Disposition 2015; 43(11) doi: 10.1124/dmd.115.066076
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| 15 |
Fehmi Bardak. Computational Insight into Warfarin Blockage by Silymarin Components via DFT and Molecular Docking. ChemistrySelect 2024; 9(42) doi: 10.1002/slct.202402363
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| 16 |
Mihai Oltean. Silybin Against Liver Ischemia-Reperfusion Injury: Something Old, Something New…. Journal of Investigative Surgery 2018; 31(6) doi: 10.1080/08941939.2017.1365975
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| 17 |
Michal Bijak, Angela Dziedzic, Ewelina Synowiec, Tomasz Sliwinski, Joanna Saluk-Bijak. Flavonolignans Inhibit IL1-β-Induced Cross-Talk between Blood Platelets and Leukocytes. Nutrients 2017; 9(9) doi: 10.3390/nu9091022
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| 18 |
Matteo Lazzeroni, Aliana Guerrieri-Gonzaga, Sara Gandini, Harriet Johansson, Davide Serrano, Massimiliano Cazzaniga, Valentina Aristarco, Antonella Puccio, Serena Mora, Pietro Caldarella, Gianmatteo Pagani, Giancarlo Pruneri, Antonella Riva, Giovanna Petrangolini, Paolo Morazzoni, Andrea DeCensi, Bernardo Bonanni. A Presurgical Study of Oral Silybin-Phosphatidylcholine in Patients with Early Breast Cancer. Cancer Prevention Research 2016; 9(1) doi: 10.1158/1940-6207.CAPR-15-0123
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| 19 |
Claire Albert, Mohamed Beladjine, Nicolas Tsapis, Elias Fattal, Florence Agnely, Nicolas Huang. Pickering emulsions: Preparation processes, key parameters governing their properties and potential for pharmaceutical applications. Journal of Controlled Release 2019; 309 doi: 10.1016/j.jconrel.2019.07.003
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| 20 |
Hamidah Mohd Yusof, Norlaily Mohd Ali, Swee Keong Yeap, Wan Yong Ho, Boon Kee Beh, Soo Peng Koh, Kamariah Long, Suraini Abdul Aziz, Noorjahan Banu Alitheen. Hepatoprotective Effect of Fermented Soybean (Nutrient Enriched Soybean Tempeh) against Alcohol-Induced Liver Damage in Mice. Evidence-Based Complementary and Alternative Medicine 2013; 2013 doi: 10.1155/2013/274274
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| 21 |
Yun Gao, Steven Setiawan Theng, Way-Champ Mah, Caroline G. L. Lee. Silibinin down-regulates FAT10 and modulate TNF-α/IFN-γ-induced chromosomal instability and apoptosis sensitivity. Biology Open 2015; 4(8) doi: 10.1242/bio.011189
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| 22 |
Ji-Suk Jeong, Yong-Joo Kim, Bo-Rum Choi, Geun-Bae Go, Byeong-Gil Son, Suk-Won Gang, Seung-Man Moon. Antioxidant and Physicochemical Changes in Salvia plebeia R. Br. after Hot-air Drying and Blanching. Journal of the Korean Society of Food Science and Nutrition 2014; 43(6) doi: 10.3746/jkfn.2014.43.6.893
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| 23 |
Elisa Ceccherini, Antonella Cecchettini, Maria Aurora Morales, Silvia Rocchiccioli. The Potentiality of Herbal Remedies in Primary Sclerosing Cholangitis: From In Vitro to Clinical Studies. Frontiers in Pharmacology 2020; 11 doi: 10.3389/fphar.2020.00813
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| 24 |
Priyanka Upadhyay, Mousumi Bhattacharjee, Saurav Bhattacharya, Manisha Ahir, Arghya Adhikary, Prasun Patra. Silymarin-Loaded, Lactobionic Acid-Conjugated Porous PLGA Nanoparticles Induce Apoptosis in Liver Cancer Cells. ACS Applied Bio Materials 2020; 3(10) doi: 10.1021/acsabm.0c00987
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| 25 |
Ho‐Young Jeong, Eun‐Sil Park, Jisung Kim, Jonghee Sohn, Byung‐Fhy Suh, Soon‐Mi Shim. Lipid‐Based Formulations Reveal a Bioaccessibility–Permeability Mismatch in Lipophilic Functional Food Bioactives. Journal of Food Science 2026; 91(10) doi: 10.1111/1750-3841.71555
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| 26 |
M. Morovat, M. Chamani, A. Zarei, A.A. Sadeghi. Dietary but notin ovofeeding ofSilybum marianumextract resulted in an improvement in performance, immunity and carcass characteristics and decreased the adverse effects of high temperatures in broilers. British Poultry Science 2016; 57(1) doi: 10.1080/00071668.2015.1121537
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| 27 |
Ewelina van Wenum, Rafal Jurczakowski, Grzegorz Litwinienko. Media Effects on the Mechanism of Antioxidant Action of Silybin and 2,3-Dehydrosilybin: Role of the Enol Group. The Journal of Organic Chemistry 2013; 78(18) doi: 10.1021/jo401296k
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| 28 |
Xiaoxin Liu, Ninglin Xia, Qinwei Yu, Ming Jin, Zifan Wang, Xue Fan, Wen Zhao, Anqin Li, Zhenzhou Jiang, Luyong Zhang. Silybin Meglumine Mitigates CCl4-Induced Liver Fibrosis and Bile Acid Metabolism Alterations. Metabolites 2024; 14(10) doi: 10.3390/metabo14100556
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| 29 |
Jiayin Yao, Min Zhi, Xiang Gao, Pinjin Hu, Chujun Li, Xiaobo Yang. Effect and the probable mechanisms of silibinin in regulating insulin resistance in the liver of rats with non-alcoholic fatty liver. Brazilian Journal of Medical and Biological Research 2013; 46(3) doi: 10.1590/1414-431X20122551
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| 30 |
Mahdi Mashhadi Akbar Boojar, Massoud Mashhadi Akbar Boojar, Sepide Golmohammad. Overview of Silibinin anti-tumor effects. Journal of Herbal Medicine 2020; 23 doi: 10.1016/j.hermed.2020.100375
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| 31 |
Niraj Kumar Singh, Bharat Bhushan. Preclinical Evidence-based Neuroprotective Potential of Silibinin. Current Drug Research Reviews 2024; 16(1) doi: 10.2174/2589977515666230327154800
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| 32 |
Alibek Ydyrys. Hepatoprotective potential of medicinal plants of Kazakhstan: a review. Natural Resources for Human Health 2026; 6(4) doi: 10.53365/nrfhh/224634
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| 33 |
Dezső Csupor, Attila Csorba, Judit Hohmann. Recent advances in the analysis of flavonolignans of Silybum marianum. Journal of Pharmaceutical and Biomedical Analysis 2016; 130 doi: 10.1016/j.jpba.2016.05.034
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| 34 |
Shooka Mohammadi, Damoon Ashtary‐Larky, Omid Asbaghi, Vida Farrokhi, Yasaman Jadidi, Fatemeh Mofidi, Mehrnaz Mohammadian, Reza Afrisham. Effects of silymarin supplementation on liver and kidney functions: A systematic review and dose–response meta‐analysis. Phytotherapy Research 2024; 38(5) doi: 10.1002/ptr.8173
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| 35 |
Anjali Takke, Pravin Shende. Nanotherapeutic silibinin: An insight of phytomedicine in healthcare reformation. Nanomedicine: Nanotechnology, Biology and Medicine 2019; 21 doi: 10.1016/j.nano.2019.102057
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| 36 |
Safoora Sadat Erfanian, Hourieh Ansari, Shaghayegh Haghjooy Javanmard, Zahra Amini, Ali Hajigholami. The hepatorenal protective effects of silymarin in cancer patients receiving chemotherapy: a randomized, placebo-controlled trial. BMC Complementary Medicine and Therapies 2024; 24(1) doi: 10.1186/s12906-024-04627-7
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| 37 |
S. Prabakar, Mythili K, Kiruthikha M, Abinaya A, Deepa Sri S, Navina K. Automated Liver Detox Therapy. 2024 2nd International Conference on Artificial Intelligence and Machine Learning Applications Theme: Healthcare and Internet of Things (AIMLA) 2024; doi: 10.1109/AIMLA59606.2024.10531483
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| 38 |
Marjan Gharagozloo, Mehran Karimi, Zahra Amirghofran. Immunomodulatory effects of silymarin in patients with β-thalassemia major. International Immunopharmacology 2013; 16(2) doi: 10.1016/j.intimp.2013.04.016
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| 39 |
Alberto Massimi, Mara Massimi. Ginger as a nutraceutical shield: Counteracting acrylamide-induced liver injury. World Journal of Hepatology 2026; 18(2): 114551 doi: 10.4254/wjh.v18.i2.114551
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| 40 |
Muhammad Mustafa, Aiman Tariq, Muhammad Khisroon, Aiman Mehroon, Aaliya Saleem, Bushra Arshad. Silymarin Protects Against Daunorubicin‐Induced DNA Damage in an In Vivo Comet Assay. Environmental and Molecular Mutagenesis 2026; 67(8-9) doi: 10.1002/em.70080
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| 41 |
Zhong-Wen Yuan, Ya-Zhuo Li, Zhong-Qiu Liu, Sen-ling Feng, Hua Zhou, Chang-Xiao Liu, Liang Liu, Ying Xie. Role of tangeretin as a potential bioavailability enhancer for silybin: Pharmacokinetic and pharmacological studies. Pharmacological Research 2018; 128 doi: 10.1016/j.phrs.2017.09.019
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| 42 |
Magdalena Kondeva-Burdina, Rumyana Simeonova, Aleksandar Shkondrov, Ilina Krasteva, Georgi Popov, Vassil Manov. Hepatoprotective and antioxidant effects of alcesefoliside from Astragalus monspessulanus. Brazilian Journal of Pharmaceutical Sciences 2022; 58 doi: 10.1590/s2175-97902022e18902
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| 43 |
Qian Ding, Jiaolin Bao, Wenwen Zhao, Yangyang Hu, Jinjian Lu, Xiuping Chen. Natural autophagy regulators in cancer therapy: a review. Phytochemistry Reviews 2015; 14(1) doi: 10.1007/s11101-014-9339-3
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| 44 |
Susanne M. Henning, Yanjun Zhang, Victoria G. Rontoyanni, Jianjun Huang, Ru-Po Lee, Amy Trang, Gloria Nuernberger, David Heber. Variability in the Antioxidant Activity of Dietary Supplements from Pomegranate, Milk Thistle, Green Tea, Grape Seed, Goji, and Acai: Effects of in Vitro Digestion. Journal of Agricultural and Food Chemistry 2014; 62(19) doi: 10.1021/jf500106r
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| 45 |
Gianni Testino, Silvia Leone, Sharmila Fagoonee, Rinaldo Pellicano. Alcoholic liver fibrosis: detection and treatment. Minerva Medica 2018; 109(6) doi: 10.23736/S0026-4806.18.05844-5
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| 46 |
Mingzhu Shangguan, Yi Lu, Jianping Qi, Jin Han, Zhiqiang Tian, Yunchang Xie, Fuqiang Hu, Hailong Yuan, Wei Wu. Binary lipids-based nanostructured lipid carriers for improved oral bioavailability of silymarin. Journal of Biomaterials Applications 2014; 28(6) doi: 10.1177/0885328213485141
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| 47 |
José Moltó, Marta Valle, Cristina Miranda, Samandhy Cedeño, Eugenia Negredo, Bonaventura Clotet. Effect of Milk Thistle on the Pharmacokinetics of Darunavir-Ritonavir in HIV-Infected Patients. Antimicrobial Agents and Chemotherapy 2012; 56(6) doi: 10.1128/AAC.00025-12
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| 48 |
Yongxiang Zhang, Jie Hai, Meng Cao, Yongli Zhang, Sujuan Pei, Junbo Wang, Qinggui Zhang. Silibinin ameliorates steatosis and insulin resistance during non-alcoholic fatty liver disease development partly through targeting IRS-1/PI3K/Akt pathway. International Immunopharmacology 2013; 17(3) doi: 10.1016/j.intimp.2013.08.019
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| 49 |
X. Shen, H. Liu, G. Li, X. Deng, J. Wang. Silibinin attenuates Streptococcus suis
serotype 2 virulence by targeting suilysin. Journal of Applied Microbiology 2019; 126(2) doi: 10.1111/jam.14149
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| 50 |
Xiaoli Bi, Zhongwen Yuan, Biao Qu, Hua Zhou, Zhongqiu Liu, Ying Xie. Piperine enhances the bioavailability of silybin via inhibition of efflux transporters BCRP and MRP2. Phytomedicine 2019; 54 doi: 10.1016/j.phymed.2018.09.217
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| 51 |
Alessandro Federico, Marcello Dallio, Carmelina Loguercio. Silymarin/Silybin and Chronic Liver Disease: A Marriage of Many Years. Molecules 2017; 22(2) doi: 10.3390/molecules22020191
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| 52 |
Chan Wah Kheong, Nik Raihan Nik Mustapha, Sanjiv Mahadeva. A Randomized Trial of Silymarin for the Treatment of Nonalcoholic Steatohepatitis. Clinical Gastroenterology and Hepatology 2017; 15(12) doi: 10.1016/j.cgh.2017.04.016
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| 53 |
Katharina Esser‐Nobis, Christian Harak, Philipp Schult, Yuri Kusov, Volker Lohmann. Novel perspectives for hepatitis A virus therapy revealed by comparative analysis of hepatitis C virus and hepatitis A virus RNA replication. Hepatology 2015; 62(2) doi: 10.1002/hep.27847
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| 54 |
Daniel Shadrack, Hulda Swai, Joan Munissi, Egid Mubofu, Stephen Nyandoro. Polyamidoamine Dendrimers for Enhanced Solubility of Small Molecules and Other Desirable Properties for Site Specific Delivery: Insights from Experimental and Computational Studies. Molecules 2018; 23(6) doi: 10.3390/molecules23061419
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| 55 |
Eleonora Stanca, Gaetano Serviddio, Francesco Bellanti, Gianluigi Vendemiale, Luisa Siculella, Anna Maria Giudetti. Down-regulation of LPCAT expression increases platelet-activating factor level in cirrhotic rat liver: Potential antiinflammatory effect of silybin. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2013; 1832(12) doi: 10.1016/j.bbadis.2013.07.005
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| 56 |
Nancy Vargas-Mendoza, Eduardo Madrigal-Santillán, Ángel Morales-González, Jaime Esquivel-Soto, Cesar Esquivel-Chirino, Manuel García-Luna y González-Rubio, Juan A Gayosso-de-Lucio, José A Morales-González. Hepatoprotective effect of silymarin. World Journal of Hepatology 2014; 6(3): 144-149 doi: 10.4254/wjh.v6.i3.144
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| 57 |
Xiaolei Ma, Xiaoyou Yu, Rui Li, Jinjin Cui, Haoyang Yu, Ling Ren, Jiandong Jiang, Wenxuan Zhang, Lulu Wang. Berberine-silybin salt achieves improved anti-nonalcoholic fatty liver disease effect through regulating lipid metabolism. Journal of Ethnopharmacology 2024; 319 doi: 10.1016/j.jep.2023.117238
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| 58 |
Navaneethakrishnan Polachi, Guirong Bai, Tingyang Li, Yang Chu, Xiangyang Wang, Shuming Li, Ning Gu, Jiang Wu, Wei Li, Yanjun Zhang, Shuiping Zhou, He Sun, Changxiao Liu. Modulatory effects of silibinin in various cell signaling pathways against liver disorders and cancer – A comprehensive review. European Journal of Medicinal Chemistry 2016; 123 doi: 10.1016/j.ejmech.2016.07.070
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| 59 |
Ya. F. Zverev, A. Ya. Rykunova. Modern Nanocarriers as a Factor in Increasing the Bioavailability and Pharmacological Activity of Flavonoids. Applied Biochemistry and Microbiology 2022; 58(9) doi: 10.1134/S0003683822090149
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| 60 |
Hamid-Reza Behboodi, Morteza Asghari-Moghadam, Mehran Mehri. Impact of varying levels of HepatoMax in drinking water on liver performance and blood profiles in broiler chickens. Veterinary and Animal Science 2026; 32 doi: 10.1016/j.vas.2026.100610
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| 61 |
Sunny Shah, Harshida Chauhan, Hardik Madhu, Dhaval Mori, Moinuddin Soniwala, Sudarshan Singh, Bhupendra Prajapati. Lipids Fortified Nano Phytopharmaceuticals: A Breakthrough Approach in Delivering Bio-actives for Improved Therapeutic Efficacy. Pharmaceutical Nanotechnology 2025; 13(1) doi: 10.2174/0122117385277686231127050723
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| 62 |
S. L. Kuznetsov, N. V. Gukasova, I. A. Tubasheva, V. V. Zavarzina, S. V. Aleshin, A. I. Muraveva, A. A. Lapin, V. N. Zelenkov, Yu. I. Poltavets. Obtaining and Studying the Antioxidant Activity and Hepatoprotective Effect of a Polymer Composition Containing Silybin. Nanobiotechnology Reports 2023; 18(S2) doi: 10.1134/S263516762360061X
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| 63 |
Sungbo Cho, Charles Martin Nyachoti, In Ho Kim. Silymarin as a feed additive in swine and poultry production: a comprehensive review. Journal of Animal Science and Biotechnology 2025; 16(1) doi: 10.1186/s40104-025-01260-3
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| 64 |
Reza Najafi, Asadollah Asadi, Saber Zahri, Arash Abdolmaleki. Comparison of Biocompatibility and Morphology of PC12 Cell Line on a Polycaprolactane/Silymarin Scaffold and a Polycaprolactane/Tragacanth Scaffold. Gene, Cell and Tissue 2023; 10(4) doi: 10.5812/gct-131955
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| 65 |
Antonietta Stellavato, Anna Virginia Adriana Pirozzi, Francesca de Novellis, Ilaria Scognamiglio, Valentina Vassallo, Andrea Maria Giori, Mario De Rosa, Chiara Schiraldi. In vitro assessment of nutraceutical compounds and novel nutraceutical formulations in a liver-steatosis-based model. Lipids in Health and Disease 2018; 17(1) doi: 10.1186/s12944-018-0663-2
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| 66 |
Peng Xu, Hua Zhou, Ya-Zhuo Li, Zhong-Wen Yuan, Chang-Xiao Liu, Liang Liu, Ying Xie. Baicalein Enhances the Oral Bioavailability and Hepatoprotective Effects of Silybin Through the Inhibition of Efflux Transporters BCRP and MRP2. Frontiers in Pharmacology 2018; 9 doi: 10.3389/fphar.2018.01115
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| 67 |
Eleni Theodosiou, Kateřina Purchartová, Haralambos Stamatis, Fragiskos Kolisis, Vladimír Křen. Bioavailability of silymarin flavonolignans: drug formulations and biotransformation. Phytochemistry Reviews 2014; 13(1) doi: 10.1007/s11101-013-9285-5
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B.L. Woolbright, C.D. Williams, M.R. McGill, H. Jaeschke. Reference Module in Biomedical Sciences. 2014; doi: 10.1016/B978-0-12-801238-3.00205-1
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Li Feng, Marcus M. Maddox, Md. Zahidul Alam, Lissa S. Tsutsumi, Gagandeep Narula, David F. Bruhn, Xiaoqian Wu, Shayna Sandhaus, Robin B. Lee, Charles J. Simmons, Yuk-Ching Tse-Dinh, Julian G. Hurdle, Richard E. Lee, Dianqing Sun. Synthesis, Structure–Activity Relationship Studies, and Antibacterial Evaluation of 4-Chromanones and Chalcones, as Well as Olympicin A and Derivatives. Journal of Medicinal Chemistry 2014; 57(20) doi: 10.1021/jm500853v
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Muzamil Shah, Muhammad Asad Ullah, Samantha Drouet, Muhammad Younas, Duangjai Tungmunnithum, Nathalie Giglioli-Guivarc’h, Christophe Hano, Bilal Haider Abbasi. Interactive Effects of Light and Melatonin on Biosynthesis of Silymarin and Anti-Inflammatory Potential in Callus Cultures of Silybum marianum (L.) Gaertn.. Molecules 2019; 24(7) doi: 10.3390/molecules24071207
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Tsanko S. Gechev, Jacques Hille, Herman J. Woerdenbag, Maria Benina, Nikolay Mehterov, Valentina Toneva, Alisdair R. Fernie, Bernd Mueller-Roeber. Natural products from resurrection plants: Potential for medical applications. Biotechnology Advances 2014; 32(6) doi: 10.1016/j.biotechadv.2014.03.005
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Ali Nouri, Esfandiar Heidarian. Nephroprotective effect of silymarin against diclofenac induced renal damage and oxidative stress in male rats. Journal of Herbmed Pharmacology 2019; 8(2) doi: 10.15171/jhp.2019.23
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Farhad Soleimani, Rasoul Sharifi, Minoo Mahmoodi, Seyed Mehrdad Kassaee. The effects of silibinin on oxidative stress and microRNA-10b expression in animal models of breast cancer. Turkish Journal of Biochemistry 2020; 45(6) doi: 10.1515/tjb-2019-0333
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Byoung Kuk Jang, Seung Kak Shin, Jae Yoon Jeong. A Real-World Retrospective Cohort Study on the Clinical Effect of Silymarin (Legalon) on Liver Damage and Diseases Using a Domestic Multicenter Common Data Model. Gut and Liver 2026; 20(3) doi: 10.5009/gnl240575
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Ancuța Cristina Raclariu-Manolică, Carmen Socaciu. Detecting and Profiling of Milk Thistle Metabolites in Food Supplements: A Safety-Oriented Approach by Advanced Analytics. Metabolites 2023; 13(3) doi: 10.3390/metabo13030440
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Wei Chen, Xi Zhao, Zhenghua Huang, Shihui Luo, Xuguang Zhang, Wei Sun, Tao Lan, Ruikun He. Determination of Flavonolignan Compositional Ratios in Silybum marianum (Milk Thistle) Extracts Using High-Performance Liquid Chromatography. Molecules 2024; 29(13) doi: 10.3390/molecules29132949
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Devesh Tewari, Andrei Mocan, Emil D. Parvanov, Archana N. Sah, Seyed M. Nabavi, Lukasz Huminiecki, Zheng Feei Ma, Yeong Yeh Lee, Jarosław O. Horbańczuk, Atanas G. Atanasov. Ethnopharmacological Approaches for Therapy of Jaundice: Part II. Highly Used Plant Species from Acanthaceae, Euphorbiaceae, Asteraceae, Combretaceae, and Fabaceae Families. Frontiers in Pharmacology 2017; 8 doi: 10.3389/fphar.2017.00519
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Hongwen Wu, Jiang Zeng, Qiuchan Wu, Jinfu Dong, Cong Liang, Xiaomou Wei, Jifei Chen, Song Shi, Zhijie Yang, Tian Lan. Synthesis and in vitro Anticancer Efficacy of Novel Silibinin Derivatives
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Manoj Madanahalli Ramesh, Sneha Dinesh, Annegowda Hardur Venkatappa, Richard Lobo. Pharmacological Complexities of Herbal Medicinal Extracts: A Review of Bioavailability, Interactions, and Standardization. Current Drug Metabolism 2026; 27(3) doi: 10.2174/0113892002430015251201072618
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Simona Clichici, Diana Olteanu, Andras-Laszlo Nagy, Adrian Oros, Adriana Filip, Petru A. Mircea.
Silymarin Inhibits the Progression of Fibrosis in the Early Stages of Liver Injury in CCl
4
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Ramanathan Raghu, Sivanesan Karthikeyan. Zidovudine and isoniazid induced liver toxicity and oxidative stress: Evaluation of mitigating properties of silibinin. Environmental Toxicology and Pharmacology 2016; 46 doi: 10.1016/j.etap.2016.07.014
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