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May 14, 2011 (publication date) through Jan 23, 2020
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World Journal of Gastroenterology
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1007-9327
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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1
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2
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3
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4
Z. R. Tan, Y. X. Zhou, J. Liu, W. H. Huang, Y. Chen, Y. C. Wang, L. S. Wang. The influence of ABCB1 polymorphism C3435T on the pharmacokinetics of silibinin. Journal of Clinical Pharmacy and Therapeutics 2015; 40(6): 685 doi: 10.1111/jcpt.12336
5
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6
Sharon M. Gwaltney-Brant. Nutraceuticals. 2016; : 87 doi: 10.1016/B978-0-12-802147-7.00007-3
7
Jia-Ping Wu, Chin-Chuan Tsai, Yu-Lan Yeh, Yueh-Min Lin, Chien-Chung Lin, Cecilia Hsuan Day, Chia-Yao Shen, V. Vijaya Padma, Lung-Fa Pan, Chih-Yang Huang. Silymarin Accelerates Liver Regeneration after Partial Hepatectomy. Evidence-Based Complementary and Alternative Medicine 2015; 2015: 1 doi: 10.1155/2015/603529
8
Sherif M. Sabry Hassan, Magdy F. Youakim, Ayman Abou Elenein Rizk, Charity Thomann, Zulfiqar Ahmad. Does silybin protect against toxicity induced by polymyxin E in rat kidney?. Neurourology and Urodynamics 2017; 36(5): 1278 doi: 10.1002/nau.23109
9
E.S. Hackett, D.C. Twedt, D.L. Gustafson. Milk Thistle and Its Derivative Compounds: A Review of Opportunities for Treatment of Liver Disease. Journal of Veterinary Internal Medicine 2013; 27(1): 10 doi: 10.1111/jvim.12002
10
T.A.F. Eissa, O.M. Palomino, M.E. Carretero, M.P. Gómez-Serranillos. Ethnopharmacological study of medicinal plants used in the treatment of CNS disorders in Sinai Peninsula, Egypt. Journal of Ethnopharmacology 2014; 151(1): 317 doi: 10.1016/j.jep.2013.10.041
11
Xinyu Chen, Katharina Zenger, Amelie Lupp, Beata Kling, Jörg Heilmann, Christian Fleck, Birgit Kraus, Michael Decker. Tacrine-Silibinin Codrug Shows Neuro- and Hepatoprotective Effectsin Vitroand Pro-Cognitive and Hepatoprotective Effectsin Vivo. Journal of Medicinal Chemistry 2012; 55(11): 5231 doi: 10.1021/jm300246n
12
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13
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15
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16
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17
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18
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19
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Dezső Csupor, Attila Csorba, Judit Hohmann. Recent advances in the analysis of flavonolignans of Silybum marianum. Journal of Pharmaceutical and Biomedical Analysis 2016; 130: 301 doi: 10.1016/j.jpba.2016.05.034
27
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29
Bashar Saad. Phytotherapies. 2015; : 142 doi: 10.1002/9781119006039.ch8
30
Marjan Gharagozloo, Mehran Karimi, Zahra Amirghofran. Immunomodulatory effects of silymarin in patients with β-thalassemia major. International Immunopharmacology 2013; 16(2): 243 doi: 10.1016/j.intimp.2013.04.016
31
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32
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33
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34
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35
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36
Qian Ding, Jiaolin Bao, Wenwen Zhao, Yangyang Hu, Jinjian Lu, Xiuping Chen. Natural autophagy regulators in cancer therapy: a review. Phytochemistry Reviews 2015; 14(1): 137 doi: 10.1007/s11101-014-9339-3
37
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38
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39
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40
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41
Mingzhu Shangguan, Yi Lu, Jianping Qi, Jin Han, Zhiqiang Tian, Yunchang Xie, Fuqiang Hu, Hailong Yuan, Wei Wu. Binary lipids-based nanostructured lipid carriers for improved oral bioavailability of silymarin. Journal of Biomaterials Applications 2014; 28(6): 887 doi: 10.1177/0885328213485141
42
José Moltó, Marta Valle, Cristina Miranda, Samandhy Cedeño, Eugenia Negredo, Bonaventura Clotet. Effect of Milk Thistle on the Pharmacokinetics of Darunavir-Ritonavir in HIV-Infected Patients. Antimicrobial Agents and Chemotherapy 2012; 56(6): 2837 doi: 10.1128/AAC.00025-12
43
Yongxiang Zhang, Jie Hai, Meng Cao, Yongli Zhang, Sujuan Pei, Junbo Wang, Qinggui Zhang. Silibinin ameliorates steatosis and insulin resistance during non-alcoholic fatty liver disease development partly through targeting IRS-1/PI3K/Akt pathway. International Immunopharmacology 2013; 17(3): 714 doi: 10.1016/j.intimp.2013.08.019
44
X. Shen, H. Liu, G. Li, X. Deng, J. Wang. Silibinin attenuates Streptococcus suis serotype 2 virulence by targeting suilysin. Journal of Applied Microbiology 2019; 126(2): 435 doi: 10.1111/jam.14149
45
Youn Ri Lee, Nara Yoon. Anti-Oxidative and Anti-Diabetic Effects of Methanol Extracts from Medicinal Plants. Journal of the Korean Society of Food Science and Nutrition 2015; 44(5): 681 doi: 10.3746/jkfn.2015.44.5.681
46
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47
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48
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49
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50
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51
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52
Jennifer Doley. Integrative Nutrition Therapy. 2015; : 49 doi: 10.1201/b18833-6
53
Elizabeth Mudge, Lori Paley, Andreas Schieber, Paula N. Brown. Optimization and single-laboratory validation of a method for the determination of flavonolignans in milk thistle seeds by high-performance liquid chromatography with ultraviolet detection. Analytical and Bioanalytical Chemistry 2015; 407(25): 7657 doi: 10.1007/s00216-015-8925-6
54
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55
Miguel Reina, Ana Martínez. Is Silybin the Best Free Radical Scavenger Compound in Silymarin?. The Journal of Physical Chemistry B 2016; 120(20): 4568 doi: 10.1021/acs.jpcb.6b02807
56
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58
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60
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63
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71
B.L. Woolbright, C.D. Williams, M.R. McGill, H. Jaeschke. Reference Module in Biomedical Sciences. 2014;  doi: 10.1016/B978-0-12-801238-3.00205-1
72
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Walid Hamdy El-Tantawy, Dina Sabry, Ekram Nemr Abd Al Haleem. Comparative study of antifibrotic activity of some magnesium-containing supplements on experimental liver toxicity. Molecular study. Drug and Chemical Toxicology 2017; 40(1): 47 doi: 10.3109/01480545.2016.1172083
85
Devesh Tewari, Andrei Mocan, Emil D. Parvanov, Archana N. Sah, Seyed M. Nabavi, Lukasz Huminiecki, Zheng Feei Ma, Yeong Yeh Lee, Jarosław O. Horbańczuk, Atanas G. Atanasov. Ethnopharmacological Approaches for Therapy of Jaundice: Part II. Highly Used Plant Species from Acanthaceae, Euphorbiaceae, Asteraceae, Combretaceae, and Fabaceae Families. Frontiers in Pharmacology 2017; 8 doi: 10.3389/fphar.2017.00519
86
Simona Clichici, Diana Olteanu, Andras-Laszlo Nagy, Adrian Oros, Adriana Filip, Petru A. Mircea. Silymarin Inhibits the Progression of Fibrosis in the Early Stages of Liver Injury in CCl4-Treated Rats. Journal of Medicinal Food 2015; 18(3): 290 doi: 10.1089/jmf.2013.0179
87
Hyo Joo Byun, Pramod Darvin, Dong Young Kang, Nipin Sp, Youn Hee Joung, Jong Hwan Park, Sun Jin Kim, Young Mok Yang. Silibinin downregulates MMP2 expression via Jak2/STAT3 pathway and inhibits the migration and invasive potential in MDA-MB-231 cells. Oncology Reports 2017; 37(6): 3270 doi: 10.3892/or.2017.5588
88
Marina Kawaguchi-Suzuki, Reginald F. Frye, Hao-Jie Zhu, Bryan J. Brinda, Kenneth D. Chavin, Hilary J. Bernstein, John S. Markowitz. The Effects of Milk Thistle (Silybum marianum) on Human Cytochrome P450 Activity. Drug Metabolism and Disposition 2014; 42(10): 1611 doi: 10.1124/dmd.114.057232
89
Ramanathan Raghu, Sivanesan Karthikeyan. Zidovudine and isoniazid induced liver toxicity and oxidative stress: Evaluation of mitigating properties of silibinin. Environmental Toxicology and Pharmacology 2016; 46: 217 doi: 10.1016/j.etap.2016.07.014
90
Jesús Pérez-H, Carlos Carrillo-S, Esperanza García, Gabriela Ruiz-Mar, Ruy Pérez-Tamayo, Anahí Chavarría. Neuroprotective effect of silymarin in a MPTP mouse model of Parkinson's disease. Toxicology 2014; 319: 38 doi: 10.1016/j.tox.2014.02.009
91
Ming Hong, Sha Li, Hor Tan, Ning Wang, Sai-Wah Tsao, Yibin Feng. Current Status of Herbal Medicines in Chronic Liver Disease Therapy: The Biological Effects, Molecular Targets and Future Prospects. International Journal of Molecular Sciences 2015; 16(12): 28705 doi: 10.3390/ijms161226126
92
Romana Sokolová, Jana Kocábová, Petr Marhol, Jan Fiedler, David Biedermann, Jan Vacek, Vladimír Křen. Oxidation of Natural Bioactive Flavonolignan 2,3-Dehydrosilybin: An Electrochemical and Spectral Study. The Journal of Physical Chemistry B 2017; 121(28): 6841 doi: 10.1021/acs.jpcb.7b04651
93
Ji-Young Choi, Hyeon Gyu Yi, Chang-Shin Park, Dong Wun Shin, Ju-Hee Kang. Inhibition of oxaliplatin-induced neurotoxicity by silymarin through increased expression of brain-derived neurotrophic factor and inhibition of p38-MAPK. Molecular & Cellular Toxicology 2019; 15(2): 145 doi: 10.1007/s13273-019-0018-8
94
Jennifer Doley. Integrating Nutrition Into Practice. 2017; : 49 doi: 10.1201/9781315100913-6
95
Joyce P. Rodriguez, Norman G. Quilantang, Ju Sung Lee, Jeong Min Lee, Hyun Young Kim, Jae Suk Shim, Sanghyun Lee. Determination of Silybin B in the Different Parts of Silybum marianum using HPLC-UV. Natural Product Sciences 2018; 24(2): 82 doi: 10.20307/nps.2018.24.2.82
96
Yuhua Ma, Haisheng He, Fei Xia, Yingxia Li, Yan Lu, Daofeng Chen, Jianping Qi, Yi Lu, Wei Zhang, Wei Wu. In vivo fate of lipid-silybin conjugate nanoparticles: Implications on enhanced oral bioavailability. Nanomedicine: Nanotechnology, Biology and Medicine 2017; 13(8): 2643 doi: 10.1016/j.nano.2017.07.014
97
Leonard Seeff, Felix Stickel, Victor J. Navarro. Drug-Induced Liver Disease. 2013; : 631 doi: 10.1016/B978-0-12-387817-5.00035-2
98
Remziye Aysun Kepekçi, Sait Polat, Gülfidan Çoşkun, Ahmet Çelik, A. Sarper Bozkurt, Önder Yumrutaş, Mustafa Pehlivan. Preliminary Characterization of Phenolic Acid Composition and Hepatoprotective Effect ofStachys pumila. Journal of Food Biochemistry 2017; 41(2): e12286 doi: 10.1111/jfbc.12286
99
Seyede Elmira Yazdi Rouholamini, Saeid Moghassemi, Zahra Maharat, Amirhossien Hakamivala, Susan Kashanian, Kobra Omidfar. Effect of silibinin-loaded nano-niosomal coated with trimethyl chitosan on miRNAs expression in 2D and 3D models of T47D breast cancer cell line. Artificial Cells, Nanomedicine, and Biotechnology 2018; 46(3): 524 doi: 10.1080/21691401.2017.1326928
100
Ijeoma F. Uchegbu. Fundamentals of Pharmaceutical Nanoscience. 2013; : 9 doi: 10.1007/978-1-4614-9164-4_2
101
Lorenzo Di Cesare Mannelli, Matteo Zanardelli, Paola Failli, Carla Ghelardini. Oxaliplatin-Induced Neuropathy: Oxidative Stress as Pathological Mechanism. Protective Effect of Silibinin. The Journal of Pain 2012; 13(3): 276 doi: 10.1016/j.jpain.2011.11.009
102
Mai Khater, Divyashree Ravishankar, Francesca Greco, Helen MI Osborn. Metal complexes of flavonoids: their synthesis, characterization and enhanced antioxidant and anticancer activities. Future Medicinal Chemistry 2019; 11(21): 2845 doi: 10.4155/fmc-2019-0237
103
Divyashree Ravishankar, Kimberly A. Watson, Samuel Y. Boateng, Rebecca J. Green, Francesca Greco, Helen M.I. Osborn. Exploring quercetin and luteolin derivatives as antiangiogenic agents. European Journal of Medicinal Chemistry 2015; 97: 259 doi: 10.1016/j.ejmech.2015.04.056
104
Amir Anushiravani, Niloufar Haddadi, Maedeh Pourfarmanbar, Vahid Mohammadkarimi. Treatment options for nonalcoholic fatty liver disease. European Journal of Gastroenterology & Hepatology 2019; 31(5): 613 doi: 10.1097/MEG.0000000000001369
105
Walid Hamdy El-Tantawy, Abeer Temraz. Anti-fibrotic activity of natural products, herbal extracts and nutritional components for prevention of liver fibrosis: review. Archives of Physiology and Biochemistry 2019; : 1 doi: 10.1080/13813455.2019.1684952
106
Licia Polimeni, Maria Del Ben, Francesco Baratta, Ludovica Perri, Fabiana Albanese, Daniele Pastori, Francesco Violi, Francesco Angelico. Oxidative stress: New insights on the association of non-alcoholic fatty liver disease and atherosclerosis. World Journal of Hepatology 2015; 7(10): 1325-1336 doi: 10.4254/wjh.v7.i10.1325
107
Nava Reznik, Noga Kozer, Avital Eisenberg-Lerner, Haim Barr, Yifat Merbl, Nir London. Phenotypic Screen Identifies JAK2 as a Major Regulator of FAT10 Expression. ACS Chemical Biology 2019; 14(12): 2538 doi: 10.1021/acschembio.9b00667
108
Drug Discovery from Mother Nature. Advances in Experimental Medicine and Biology 2016; 929: 25 doi: 10.1007/978-3-319-41342-6_2
109
Federico Salomone, Ignazio Barbagallo, Justyna Godos, Vincenzo Lembo, Walter Currenti, Diana Cinà, Roberto Avola, Nicolantonio D’Orazio, Filomena Morisco, Fabio Galvano, Giovanni Li Volti. Silibinin Restores NAD+ Levels and Induces the SIRT1/AMPK Pathway in Non-Alcoholic Fatty Liver. Nutrients 2017; 9(10): 1086 doi: 10.3390/nu9101086
110
Michael Gülden, Daniel Appel, Malin Syska, Stephanie Uecker, Franziska Wages, Hasso Seibert. Chrysin and silibinin sensitize human glioblastoma cells for arsenic trioxide. Food and Chemical Toxicology 2017; 105: 486 doi: 10.1016/j.fct.2017.04.035
111
Yuan XIE, Hai-Ping HAO, Hong WANG, Zhao-Xian WANG, Guang-Ji WANG. Reversing effects of silybin on TAA-induced hepatic CYP3A dysfunction through PXR regulation. Chinese Journal of Natural Medicines 2013; 11(6): 645 doi: 10.1016/S1875-5364(13)60075-8
112
Alfonso Di Costanzo, Ruggero Angelico. Formulation Strategies for Enhancing the Bioavailability of Silymarin: The State of the Art. Molecules 2019; 24(11): 2155 doi: 10.3390/molecules24112155
113
Michal Bijak. Silybin, a Major Bioactive Component of Milk Thistle (Silybum marianum L. Gaernt.)—Chemistry, Bioavailability, and Metabolism. Molecules 2017; 22(11): 1942 doi: 10.3390/molecules22111942
114
Phytotherapeutics: The Emerging Role of Intestinal and Hepatocellular Transporters in Drug Interactions with Botanical Supplements. Molecules 2017; 22(10): 1699 doi: 10.3390/molecules22101699
115
Romana Sokolová, Ján Tarábek, Barbora Papoušková, Jana Kocábová, Jan Fiedler, Jan Vacek, Petr Marhol, Eva Vavříková, Vladimír Křen. Oxidation of the Flavonolignan Silybin. In situ EPR Evidence of the Spin-Trapped Silybin Radical. Electrochimica Acta 2016; 205: 118 doi: 10.1016/j.electacta.2016.04.107
116
Chun-Xue Cui, Jing-Na Deng, Li Yan, Yu-Ying Liu, Jing-Yu Fan, Hong-Na Mu, Hao-Yu Sun, Ying-Hong Wang, Jing-Yan Han. Silibinin Capsules improves high fat diet-induced nonalcoholic fatty liver disease in hamsters through modifying hepatic de novo lipogenesis and fatty acid oxidation. Journal of Ethnopharmacology 2017; 208: 24 doi: 10.1016/j.jep.2017.06.030
117
Sana Nafees, Syed Hassan Mehdi, Mohammad Zafaryab, Bushra Zeya, Tarique Sarwar, Moshahid Alam Rizvi. Synergistic Interaction of Rutin and Silibinin on Human Colon Cancer Cell Line. Archives of Medical Research 2018; 49(4): 226 doi: 10.1016/j.arcmed.2018.09.008
118
Yu-Jui Kuo, Hui-Ping Chang, Yu-Jun Chang, Hsing-Hsien Wu, Chang-Hua Chen. Evaluation of nephroprotection of silymarin on contrast-induced nephropathy in liver cirrhosis patients. Medicine 2018; 97(37): e12243 doi: 10.1097/MD.0000000000012243
119
Neha Samir Roy, Jung-A Kim, Ah-Young Choi, Yong-Wook Ban, Nam-Il Park, Kyong-Cheul Park, Hee-sun Yang, Ik-Young Choi, Soonok Kim. RNA-Seq De Novo Assembly and Differential Transcriptome Analysis of Korean Medicinal Herb Cirsium japonicum var. spinossimum. Genomics & Informatics 2018; 16(4): e34 doi: 10.5808/GI.2018.16.4.e34
120
Keishi Yamasaki, Hiroki Sato, Saori Minagoshi, Karin Kyubun, Makoto Anraku, Shigeyuki Miyamura, Hiroshi Watanabe, Kazuaki Taguchi, Hakaru Seo, Toru Maruyama, Masaki Otagiri. The Binding of Silibinin, the Main Constituent of Silymarin, to Site I on Human Serum Albumin. Biological & Pharmaceutical Bulletin 2017; 40(3): 310 doi: 10.1248/bpb.b16-00790
121
Joaquim Bosch-Barrera, Javier A. Menendez. Silibinin and STAT3: A natural way of targeting transcription factors for cancer therapy. Cancer Treatment Reviews 2015; 41(6): 540 doi: 10.1016/j.ctrv.2015.04.008
122
Ching-Hsuan Liu, Alagie Jassey, Hsin-Ya Hsu, Liang-Tzung Lin. Antiviral Activities of Silymarin and Derivatives. Molecules 2019; 24(8): 1552 doi: 10.3390/molecules24081552
123
Silvia Zappavigna, Daniela Vanacore, Stefania Lama, Nicoletta Potenza, Aniello Russo, Pasquale Ferranti, Marcello Dallio, Alessandro Federico, Carmelina Loguercio, Pasquale Sperlongano, Michele Caraglia, Paola Stiuso. Silybin-Induced Apoptosis Occurs in Parallel to the Increase of Ceramides Synthesis and miRNAs Secretion in Human Hepatocarcinoma Cells. International Journal of Molecular Sciences 2019; 20(9): 2190 doi: 10.3390/ijms20092190
124
Hao-Jie Zhu, Bryan J. Brinda, Kenneth D. Chavin, Hilary J. Bernstein, Kennerly S. Patrick, John S. Markowitz. An Assessment of Pharmacokinetics and Antioxidant Activity of Free Silymarin Flavonolignans in Healthy Volunteers: A Dose Escalation Study. Drug Metabolism and Disposition 2013; 41(9): 1679 doi: 10.1124/dmd.113.052423
125
F. Wei, S.-K. Liu, X.-Y. Liu, Z.-J. Li, B. Li, Y.-L. Zhou, H.-Y. Zhang, Y.-W. Li. Meta-analysis: silymarin and its combination therapy for the treatment of chronic hepatitis B. European Journal of Clinical Microbiology & Infectious Diseases 2013; 32(5): 657 doi: 10.1007/s10096-012-1789-1
126
Khaled Khazim, Yves Gorin, Rita Cassia Cavaglieri, Hanna E. Abboud, Paolo Fanti. The antioxidant silybin prevents high glucose-induced oxidative stress and podocyte injury in vitro and in vivo. American Journal of Physiology-Renal Physiology 2013; 305(5): F691 doi: 10.1152/ajprenal.00028.2013
127
Masha G. Savelieff, Geewoo Nam, Juhye Kang, Hyuck Jin Lee, Misun Lee, Mi Hee Lim. Development of Multifunctional Molecules as Potential Therapeutic Candidates for Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis in the Last Decade. Chemical Reviews 2019; 119(2): 1221 doi: 10.1021/acs.chemrev.8b00138
128
Michael Decker, Sarah Wehle. Alzheimer mit Hybridmolekülen in die Zange nehmen. Nachrichten aus der Chemie 2013; 61(9): 871 doi: 10.1002/nadc.201390272
129
Zongguo Yang, Liping Zhuang, Yunfei Lu, Qingnian Xu, Xiaorong Chen. Effects and Tolerance of Silymarin (Milk Thistle) in Chronic Hepatitis C Virus Infection Patients: A Meta-Analysis of Randomized Controlled Trials. BioMed Research International 2014; 2014: 1 doi: 10.1155/2014/941085
130
Bruno Stieger, Zainab M. Mahdi, Walter Jäger. Intestinal and Hepatocellular Transporters: Therapeutic Effects and Drug Interactions of Herbal Supplements. Annual Review of Pharmacology and Toxicology 2017; 57(1): 399 doi: 10.1146/annurev-pharmtox-010716-105010
131
Francesca Baldini, Piero Portincasa, Elena Grasselli, Gianluca Damonte, Annalisa Salis, Michela Bonomo, Marilina Florio, Nadia Serale, Adriana Voci, Patrizia Gena, Laura Vergani, Giuseppe Calamita. Aquaporin-9 is involved in the lipid-lowering activity of the nutraceutical silybin on hepatocytes through modulation of autophagy and lipid droplets composition. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2020; 1865(3): 158586 doi: 10.1016/j.bbalip.2019.158586
132
Miguel Reina, Ana Martínez. How the presence of metal atoms and clusters can modify the properties of Silybin? A computational prediction. Computational and Theoretical Chemistry 2017; 1099: 174 doi: 10.1016/j.comptc.2016.11.030
133
D. Biedermann, E. Vavříková, L. Cvak, V. Křen. Chemistry of silybin. Nat. Prod. Rep. 2014; 31(9): 1138 doi: 10.1039/C3NP70122K
134
Tahsin F. Kellici, Dimitrios Ntountaniotis, Georgios Leonis, Maria Chatziathanasiadou, Alexandra V. Chatzikonstantinou, Johanna Becker-Baldus, Clemens Glaubitz, Andreas G. Tzakos, Kyriakos Viras, Petros Chatzigeorgiou, Stavros Tzimas, Evangelia Kefala, Georgia Valsami, Helen Archontaki, Manthos G. Papadopoulos, Thomas Mavromoustakos. Investigation of the Interactions of Silibinin with 2-Hydroxypropyl-β-cyclodextrin through Biophysical Techniques and Computational Methods. Molecular Pharmaceutics 2015; 12(3): 954 doi: 10.1021/mp5008053
135
Sameh Saber, Reham Goda, Ghada S. El-Tanbouly, Dalia Ezzat. Lisinopril inhibits nuclear transcription factor kappa B and augments sensitivity to silymarin in experimental liver fibrosis. International Immunopharmacology 2018; 64: 340 doi: 10.1016/j.intimp.2018.09.021
136
Yan Liu, Jun Ye, Yonghong Cao, Rong Zhang, Yunsheng Wang, Suwan Zhang, Wu Dai, Shandong Ye. Silibinin ameliorates diabetic nephropathy via improving diabetic condition in the mice. European Journal of Pharmacology 2019; 845: 24 doi: 10.1016/j.ejphar.2018.12.031
137
H.B. Li, Y.R.Y. Yang, Z.J. Mo, Y. Ding, W.J. Jiang. Silibinin improves palmitate-induced insulin resistance in C2C12 myotubes by attenuating IRS-1/PI3K/Akt pathway inhibition. Brazilian Journal of Medical and Biological Research 2015; 48(5): 440 doi: 10.1590/1414-431x20144238
138
Martin Kubala, Petra Čechová, Jaroslava Geletičová, Michal Biler, Tereza Štenclová, Patrick Trouillas, David Biedermann. Flavonolignans As a Novel Class of Sodium Pump Inhibitors. Frontiers in Physiology 2016; 7 doi: 10.3389/fphys.2016.00115
139
Feyzullah Uçmak, Nazım Ekin, İbrahim İbiloğlu, Serkan Arslan, İbrahim Kaplan, Ebubekir Şenateş. Prophylactic Administration of Silybin Ameliorates L-Arginine-Induced Acute Pancreatitis. Medical Science Monitor 2016; 22: 3641 doi: 10.12659/MSM.898014
140
Christine Hughes, Muhammed Zafar Iqbal Hydrie, Sunita Vohra. Health of HIV Infected People. 2015; : 255 doi: 10.1016/B978-0-12-800769-3.00015-9
141
Michal Bijak, Joanna Saluk, Rafal Szelenberger, Pawel Nowak. Popular naturally occurring antioxidants as potential anticoagulant drugs. Chemico-Biological Interactions 2016; 257: 35 doi: 10.1016/j.cbi.2016.07.022
142
Raghu Ramanathan, Karthikeyan Sivanesan. Evaluation of ameliorative ability of Silibinin against zidovudine and isoniazid-induced hepatotoxicity and hyperlipidaemia in rats: Role of Silibinin in Phase I and II drug metabolism. Chemico-Biological Interactions 2017; 273: 142 doi: 10.1016/j.cbi.2017.06.008
143
Aysa Rezabakhsh, Farzaneh Fathi, Hesam Saghaei Bagheri, Hassan Malekinejad, Azadeh Montaseri, Reza Rahbarghazi, Alireza Garjani. Silibinin protects human endothelial cells from high glucose-induced injury by enhancing autophagic response. Journal of Cellular Biochemistry 2018; 119(10): 8084 doi: 10.1002/jcb.26735
144
Yan Yan, Kang Wang, Xu Tang, Jun-feng Gao, Bin-yu Wen. Phytochemicals protect L02 cells against hepatotoxicity induced by emodin via the Nrf2 signaling pathway. Toxicology Research 2019; 8(6): 1028 doi: 10.1039/c9tx00220k
145
Jaime A. Yáñez, Nagendra V. Chemuturi, Scott W. Womble, Casey L. Sayre, Neal M. Davies. FLAVONOID PHARMACOKINETICS. 2012; : 281 doi: 10.1002/9781118468524.ch7
146
Metabolism, Transport and Drug–Drug Interactions of Silymarin. Molecules 2019; 24(20): 3693 doi: 10.3390/molecules24203693
147
Cindy X. Cai, Stella Carlos, Pejman Solaimani, Bansari J. Trivedi, Chuong Tran, Shobha Castelino-Prabhu. Dietary Interventions in Liver Disease. 2019; : 357 doi: 10.1016/B978-0-12-814466-4.00029-X
148
Sonia A Lozano-Sepulveda, Owen L Bryan-Marrugo, Carlos Cordova-Fletes, Maria C Gutierrez-Ruiz, Ana M Rivas-Estilla. Oxidative stress modulation in hepatitis C virus infected cells. World Journal of Hepatology 2015; 7(29): 2880-2889 doi: 10.4254/wjh.v7.i29.2880
149
Wojciech Cybulski, Lidia Radko, Wojciech Rzeski. Cytotoxicity of monensin, narasin and salinomycin and their interaction with silybin in HepG2, LMH and L6 cell cultures. Toxicology in Vitro 2015; 29(2): 337 doi: 10.1016/j.tiv.2014.11.013
150
Peter Surai. Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and Perspectives. Antioxidants 2015; 4(1): 204 doi: 10.3390/antiox4010204
151
Manjoor Ali, Biswajit Sadhu, Anil Boda, Nidhi Tiwari, Amit Das, S.K. Musharaf Ali, Dibyendu Bhattacharya, Badri N. Pandey, Amit Kumar. Thorium decorporation efficacy of rationally-selected biocompatible compounds with relevance to human application. Journal of Hazardous Materials 2019; 365: 952 doi: 10.1016/j.jhazmat.2018.11.038
152
Almudena Pérez-Sánchez, Elisabet Cuyàs, Verónica Ruiz-Torres, Luz Agulló-Chazarra, Sara Verdura, Isabel González-Álvarez, Marival Bermejo, Jorge Joven, Vicente Micol, Joaquim Bosch-Barrera, Javier Menendez. Intestinal Permeability Study of Clinically Relevant Formulations of Silibinin in Caco-2 Cell Monolayers. International Journal of Molecular Sciences 2019; 20(7): 1606 doi: 10.3390/ijms20071606
153
E. T. Zhilyakova, Z. E. Tsvetkova, D. I. Pisarev, N. N. Boyko, E. Yu. Tymoshenko. INTENSIFICATION OF PRODUCTION PROCESS OF THICK EXTRACT OF MILK THISTLE FRUITS BY ULTRASONIC PROCESSING OF RAW MATERIALS. Pharmacy & Pharmacology 2018; 6(5): 475 doi: 10.19163/2307-9266-2018-6-5-475-487
154
Sonia Calligaris, Piergiorgio Comuzzo, Francesca Bot, Giovanna Lippe, Roberto Zironi, Monica Anese, Maria Cristina Nicoli. Nanoemulsions as delivery systems of hydrophobic silybin from silymarin extract: Effect of oil type on silybin solubility, in vitro bioaccessibility and stability. LWT - Food Science and Technology 2015; 63(1): 77 doi: 10.1016/j.lwt.2015.03.091
155
Caterina Grillo, Silvia Chichiarelli, Elisa Gaucci, Fabio Altieri, Carlo Turano, Laura Cervoni. The binding of silibinin to ERp57. Chemico-Biological Interactions 2014; 213: 37 doi: 10.1016/j.cbi.2014.02.005
156
Sami Gharbia, Cornel Balta, Hildegard Herman, Marcel Rosu, Judit Váradi, Ildikó Bácskay, Miklós Vecsernyés, Szilvia Gyöngyösi, Ferenc Fenyvesi, Sorina N. Voicu, Miruna S. Stan, Roxana E. Cristian, Anca Dinischiotu, Anca Hermenean. Enhancement of Silymarin Anti-fibrotic Effects by Complexation With Hydroxypropyl (HPBCD) and Randomly Methylated (RAMEB) β-Cyclodextrins in a Mouse Model of Liver Fibrosis. Frontiers in Pharmacology 2018; 9 doi: 10.3389/fphar.2018.00883
157
Hassan Farghali, Mighty Kgalalelo Kemelo, Nikolina Kutinová Canová. SIRT1 Modulators in Experimentally Induced Liver Injury. Oxidative Medicine and Cellular Longevity 2019; 2019: 1 doi: 10.1155/2019/8765954
158
Subir Kumar Das, Sukhes Mukherjee. Biochemical and immunological basis of silymarin effect, a milk thistle (Silybum marianum) against ethanol-induced oxidative damage. Toxicology Mechanisms and Methods 2012; 22(5): 409 doi: 10.3109/15376516.2012.673090
159
Divyashree Ravishankar, Kimberly A. Watson, Francesca Greco, Helen M. I. Osborn. Novel synthesised flavone derivatives provide significant insight into the structural features required for enhanced anti-proliferative activity. RSC Advances 2016; 6(69): 64544 doi: 10.1039/C6RA11041J
160
Alessandro Federico, Marcello Dallio, Mario Masarone, Antonietta Gerarda Gravina, Rosa Di Sarno, Concetta Tuccillo, Valentina Cossiga, Stefania Lama, Paola Stiuso, Filomena Morisco, Marcello Persico, Carmelina Loguercio. Evaluation of the Effect Derived from Silybin with Vitamin D and Vitamin E Administration on Clinical, Metabolic, Endothelial Dysfunction, Oxidative Stress Parameters, and Serological Worsening Markers in Nonalcoholic Fatty Liver Disease Patients. Oxidative Medicine and Cellular Longevity 2019; 2019: 1 doi: 10.1155/2019/8742075
161
Sangeetha Nagarajan, Nalini Namasivayam. Silibinin alleviates hyperlipidaemia, restores mucin content, modulates TGF-β and fosters apoptosis in experimental rat colon carcinogenesis. Journal of Functional Foods 2014; 11: 472 doi: 10.1016/j.jff.2014.10.025
162
Grazia Pennisi, Ciro Celsa, Federica Spatola, Marcello Dallio, Alessandro Federico, Salvatore Petta. Pharmacological Therapy of Non-Alcoholic Fatty Liver Disease: What Drugs Are Available Now and Future Perspectives. International Journal of Environmental Research and Public Health 2019; 16(22): 4334 doi: 10.3390/ijerph16224334
163
Bregje Van De Wier, Ger H. Koek, Aalt Bast, Guido R. M. M. Haenen. The potential of flavonoids in the treatment of non-alcoholic fatty liver disease. Critical Reviews in Food Science and Nutrition 2017; 57(4): 834 doi: 10.1080/10408398.2014.952399
164
Daisuke Uchida, Akinobu Takaki, Takuya Adachi, Hiroyuki Okada. Beneficial and Paradoxical Roles of Anti-Oxidative Nutritional Support for Non-Alcoholic Fatty Liver Disease. Nutrients 2018; 10(8): 977 doi: 10.3390/nu10080977
165
Carmela Loguercio, Pietro Andreone, Ciprian Brisc, Michaela Cristina Brisc, Elisabetta Bugianesi, Maria Chiaramonte, Carmela Cursaro, Mirela Danila, Ilario de Sio, Annarosa Floreani, Maria Antonietta Freni, Antonio Grieco, Marzia Groppo, Roberta Lazzari, Salvatore Lobello, Elisabetta Lorefice, Marzia Margotti, Luca Miele, Stefano Milani, Lajos Okolicsanyi, Giuseppe Palasciano, Piero Portincasa, Patrizia Saltarelli, Antonina Smedile, Francesco Somalvico, Aldo Spadaro, Ioan Sporea, Paolo Sorrentino, Raffaela Vecchione, Concetta Tuccillo, Camillo Del Vecchio Blanco, Alessandro Federico. Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: A randomized controlled trial. Free Radical Biology and Medicine 2012; 52(9): 1658 doi: 10.1016/j.freeradbiomed.2012.02.008
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