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For: Mathes AM. Hepatoprotective actions of melatonin: Possible mediation by melatonin receptors. World J Gastroenterol 2010; 16(48): 6087-6097 [PMID: 21182223 DOI: 10.3748/wjg.v16.i48.6087]
URL: https://www.wjgnet.com/1007-9327/full/v16/i48/6087.htm
Number Citing Articles
1
Jun‐Te Hsu, Chia‐Jung Kuo, Tsung‐Hsing Chen, Frank Wang, Chun‐Jun Lin, Ta‐Sen Yeh, Tsann‐Long Hwang, Yi‐Yin Jan. Melatonin prevents hemorrhagic shock‐induced liver injury in rats through an Akt‐dependent HO‐1 pathway. Journal of Pineal Research 2012; 53(4) doi: 10.1111/j.1600-079X.2012.01011.x
2
Md Ataur Rahman, Deokyong Sim, Sujay Kumar Bhajan, Anup Kumar Bishwas, Maroua Jalouli, Jinwon Choi, Nahida Aktary, Sohyun Park, Ilsun Yoo, Amama Rani, Abdel Halim Harrath, Sung-Hoon Kim, Bonglee Kim. Therapeutic and chemopreventive potential of melatonin in liver diseases: targeting oxidative stress and inflammatory signaling. Frontiers in Pharmacology 2026; 17 doi: 10.3389/fphar.2026.1931181
3
Begoña M. Escribano, Antonia Moreno, Inmaculada Tasset, Isaac Túnez, Nick Ashton. Impact of Light/Dark Cycle Patterns on Oxidative Stress in an Adriamycin-Induced Nephropathy Model in Rats. PLoS ONE 2014; 9(5) doi: 10.1371/journal.pone.0097713
4
Pınar Atukeren, Hafize Uzun. Melatonin, Neuroprotective Agents and Antidepressant Therapy. 2016;  doi: 10.1007/978-81-322-2803-5_13
5
Andrea Wolf, Kristine E. Mulier, Uroghupatei P. Iyegha, Javariah I. Asghar, Gregory J. Beilman. Safety of D-ß-Hydroxybutyrate and Melatonin for the Treatment of Hemorrhagic Shock With Polytrauma. Shock 2015; 44(Supplement 1) doi: 10.1097/SHK.0000000000000315
6
M. A. Vinnikova. Potential for the Use of Melatonin in Narcological Practice. Neuroscience and Behavioral Physiology 2016; 46(7) doi: 10.1007/s11055-016-0306-x
7
Hyungjune Ku, Yeonji Kim, Alvin Lyle Kim, Garam Lee, Youngsik Choi, Bukyung Kim. Protective Effects of Melatonin in High-Fat Diet-Induced Hepatic Steatosis via Decreased Intestinal Lipid Absorption and Hepatic Cholesterol Synthesis. Endocrinology and Metabolism 2023; 38(5) doi: 10.3803/EnM.2023.1672
8
Ayodeji Folorunsho Ajayi, Motolani Susan Borisade, Precious Oyedokun, Oyedayo Phillips Akano, Lydia Oluwatoyin Ajayi, David Tolulope Oluwole, Wale Johnson Adeyemi. Melatonin protect against pregabalin-induced gonadotoxicity via anti-oxidative, anti-inflammatory, anti-apoptotic, enzymatic and hormonal regulatory mechanisms in rats. BMC Pharmacology and Toxicology 2025; 26(1) doi: 10.1186/s40360-025-00863-w
9
Serguey S. Popov, Konstantin K. Shulgin, Tatyana N. Popova, Aleksander N. Pashkov, Aleksander A. Agarkov, Miguel A. A. Pinheiro de Carvalho. Effects of Melatonin‐Aided Therapy on the Glutathione Antioxidant System Activity and Liver Protection. Journal of Biochemical and Molecular Toxicology 2015; 29(10) doi: 10.1002/jbt.21705
10
Hyuk Kim, Jeong-Ju Yoo, Sang Gyune Kim, Young Seok Kim. Liver-centric strategies for immune enhancement: an evidence-based review of the gut–liver axis, metabolism, lifestyle, and vaccination. Journal of the Korean Medical Association 2026; 69(9) doi: 10.5124/jkma.26.0087
11
Cezary Chojnacki, Marek Romanowski, Katarzyna Winczyk, Janusz Błasiak, Jan Chojnacki. Melatonin Levels in Serum and Ascitic Fluid of Patients with Hepatic Encephalopathy. Gastroenterology Research and Practice 2012; 2012 doi: 10.1155/2012/510764
12
Nazakat M Merchant, Denis V Azzopardi, Anthony David Edwards. Neonatal hypoxic ischaemic encephalopathy: current and future treatment options. Expert Opinion on Orphan Drugs 2015; 3(4) doi: 10.1517/21678707.2015.1021776
13
D. S. Nalobin, E. A. Suprunenko, V. A. Golichenkov. Effects of Melatonin on Differentiation Potential of Ito Cells in Mice with Induced Fibrosis of the Liver. Bulletin of Experimental Biology and Medicine 2016; 161(6) doi: 10.1007/s10517-016-3526-8
14
Jean A Boutin. Quinone reductase 2 as a promising target of melatonin therapeutic actions. Expert Opinion on Therapeutic Targets 2016; 20(3) doi: 10.1517/14728222.2016.1091882
15
Maryam Majidinia, Alireza Sadeghpour, Saeed Mehrzadi, Russel J. Reiter, Nasrin Khatami, Bahman Yousefi. Melatonin: A pleiotropic molecule that modulates DNA damage response and repair pathways. Journal of Pineal Research 2017; 63(1) doi: 10.1111/jpi.12416
16
Shiv Shankar Singh, Anindita Deb, Sangita Sutradhar. Effect of melatonin on arsenic-induced oxidative stress and expression of MT1 and MT2 receptors in the kidney of laboratory mice. Biological Rhythm Research 2020; 51(8) doi: 10.1080/09291016.2019.1566993
17
N. V. Kuzmenko, V. A. Tsyrlin, M. G. Pliss. Meta-Analysis of Experimental Studies of Diet-Dependent Effects of Melatonin Monotherapy on Circulatory Levels of Triglycerides, Cholesterol, Glucose and Insulin in Rats. Journal of Evolutionary Biochemistry and Physiology 2023; 59(1) doi: 10.1134/S0022093023010180
18
Agata Carpentieri, Vanessa Areco, Gabriela Díaz de Barboza, María Angélica Rivoira, Solange Guizzardi, Nori Tolosa de Talamoni. Melatonin, Neuroprotective Agents and Antidepressant Therapy. 2016;  doi: 10.1007/978-81-322-2803-5_4
19
Richard Truse, Inga Nolten, Jan Schulz, Anna Herminghaus, Tobias Holtmanns, Lukas Gördes, Annika Raupach, Inge Bauer, Olaf Picker, Christian Vollmer. Topical Melatonin Improves Gastric Microcirculatory Oxygenation During Hemorrhagic Shock in Dogs but Does Not Alter Barrier Integrity of Caco-2 Monolayers. Frontiers in Medicine 2020; 7 doi: 10.3389/fmed.2020.00510
20
Rafael Genario, José Cipolla-Neto, Allain A. Bueno, Heitor O. Santos. Melatonin supplementation in the management of obesity and obesity-associated disorders: A review of physiological mechanisms and clinical applications. Pharmacological Research 2021; 163 doi: 10.1016/j.phrs.2020.105254
21
Shiva Shajari, Almudena Laliena, Janette Heegsma, María Jesús Tuñón, Han Moshage, Klaas Nico Faber. Melatonin suppresses activation of hepatic stellate cells through RORα‐mediated inhibition of 5‐lipoxygenase. Journal of Pineal Research 2015; 59(3) doi: 10.1111/jpi.12271
22
Martin Stroethoff, Iris Christoph, Friederike Behmenburg, Annika Raupach, Sebastian Bunte, Semra Senpolat, André Heinen, Markus W. Hollmann, Alexander Mathes, Ragnar Huhn. Melatonin Receptor Agonist Ramelteon Reduces Ischemia-Reperfusion Injury Through Activation of Mitochondrial Potassium Channels. Journal of Cardiovascular Pharmacology 2018; 72(2) doi: 10.1097/FJC.0000000000000600
23
Tobias Fink, Michael Glas, Alexander Wolf, Astrid Kleber, Erik Reus, Martin Wolff, Daniel Kiefer, Beate Wolf, Hauke Rensing, Thomas Volk, Alexander M. Mathes. Melatonin Receptors Mediate Improvements of Survival in a Model of Polymicrobial Sepsis. Critical Care Medicine 2014; 42(1) doi: 10.1097/CCM.0b013e3182a63e2b
24
Puo-Hsien Le, Chia-Jung Kuo, Hao-Tsai Cheng, Ren-Chin Wu, Tsung-Hsing Chen, Chun-Jung Lin, Kun-Chun Chiang, Jun-Te Hsu. Melatonin Attenuates Acute Pancreatitis-Induced Liver Damage Through Akt-Dependent PPAR-γ Pathway. Journal of Surgical Research 2019; 236 doi: 10.1016/j.jss.2018.11.056
25
Santosh Krishnappa Munirajureddy, Usha Humbi, Akash Nalajala, Bhavishya Nerella, Vishnu Arumainathan. Therapeutic benefits of melatonin beyond sleep regulation: a comprehensive review. International Journal of Basic & Clinical Pharmacology 2026; 15(5) doi: 10.18203/2319-2003.ijbcp20262884
26
Li Zhou, Dong Zhao, Haiyan An, Hong Zhang, Chunling Jiang, Baxian Yang. Melatonin prevents lung injury induced by hepatic ischemia–reperfusion through anti-inflammatory and anti-apoptosis effects. International Immunopharmacology 2015; 29(2) doi: 10.1016/j.intimp.2015.10.012
27
B. Hernández-Velázquez, C.R. Camara-Lemarroy, J.A. González-González, D. García-Compean, R. Monreal-Robles, P. Cordero-Pérez, L.E. Muñoz-Espinosa. Effects of melatonin on the acute inflammatory response associated with endoscopic retrograde cholangiopancreatography: A randomized, double-blind, placebo-controlled trial. Revista de Gastroenterología de México (English Edition) 2016; 81(3) doi: 10.1016/j.rgmxen.2016.06.014
28
N. V. Kuzmenko, V. A. Tsyrlin, M. G. Pliss. Meta-Analysis of Experimental Studies of the Effect of Melatonin Monotherapy on the Level of Circulation Triglycerides, Cholesterol, Glucose and Insulin Depending on the Diet of Rats. Российский физиологический журнал им  И  М  Сеченова 2023; 109(2) doi: 10.31857/S0869813923020061
29
Federica Lo Sardo, Paola Muti, Giovanni Blandino, Sabrina Strano. Melatonin and Hippo Pathway: Is There Existing Cross-Talk?. International Journal of Molecular Sciences 2017; 18(9) doi: 10.3390/ijms18091913
30
Sharon M. Gwaltney-Brant. Nutraceuticals. 2021;  doi: 10.1016/B978-0-12-821038-3.00008-2
31
Ilijana Grigorov, Desanka Bogojević, Sofija Jovanović, Anja Petrović, Svetlana Ivanović-Matić, Lidija Zolotarevski, Goran Poznanović, Vesna Martinović. Hepatoprotective effects of melatonin against pronecrotic cellular events in streptozotocin-induced diabetic rats. Journal of Physiology and Biochemistry 2014; 70(2) doi: 10.1007/s13105-014-0322-7
32
Atousa Moghadam Fard, Pardis Goodarzi, Mehran Mottahedi, Setareh Garousi, Hamed Zadabhari, Mohammad Kalantari Shahijan, Saeedeh Esmaeili, Mohsen Nabi-Afjadi, Bahman Yousefi. Therapeutic applications of melatonin in disorders related to the gastrointestinal tract and control of appetite. Naunyn-Schmiedeberg's Archives of Pharmacology 2024; 397(8) doi: 10.1007/s00210-024-02972-5
33
Yan Meng, Zhengbo Tao, Siming Zhou, Wacili Da, Lin Tao. Research Hot Spots and Trends on Melatonin From 2000 to 2019. Frontiers in Endocrinology 2021; 12 doi: 10.3389/fendo.2021.753923
34
Lindsay T. Fourman, B. Robert Meyer. Autoimmune Hepatitis in Association With Ramelteon. Journal of Clinical Gastroenterology 2013; 47(7) doi: 10.1097/MCG.0b013e31829174f0
35
Nori Tolosa de Talamoni, Vanessa Andrea Areco, Maria Elena Peralta Lopez, Gabriela Diaz de Barboza, Maria Angelica Rivoira, Agata Rita Carpentieri. Melatonin and Melatonergic Drugs in Clinical Practice. 2014;  doi: 10.1007/978-81-322-0825-9_3
36
Fadeyemi Joseph Akinrinmade, Akinleye Stephen Akinrinde, Adetayo Amid. Changes in serum cytokine levels, hepatic and intestinal morphology in aflatoxin B1-induced injury: modulatory roles of melatonin and flavonoid-rich fractions from Chromolena odorata. Mycotoxin Research 2016; 32(2) doi: 10.1007/s12550-016-0239-9
37
Astrid Kleber, Sarah Altmeyer, Beate Wolf, Alexander Wolf, Thomas Volk, Tobias Fink, Darius Kubulus. Impact of melatonin receptor deletion on intracellular signaling in spleen cells of mice after polymicrobial sepsis. Inflammation Research 2014; 63(12) doi: 10.1007/s00011-014-0779-4
38
Verónica Martín-Domínguez, Eduardo Vilar-Gómez, Luisa García-Buey, Ricardo Moreno-Otero. Studies on Hepatic Disorders. Oxidative Stress in Applied Basic Research and Clinical Practice 2015;  doi: 10.1007/978-3-319-15539-5_14
39
David A. Areshidze, Maria A. Kozlova, Lyudmila A. Makartseva, Igor A. Chernov, Mikhail Y. Sinelnikov, Yuri A. Kirillov. Influence of constant lightning on liver health: an experimental study. Environmental Science and Pollution Research 2022; 29(55) doi: 10.1007/s11356-022-21655-3
40
Astrid Kleber, Christian G. Ruf, Alexander Wolf, Tobias Fink, Michael Glas, Beate Wolf, Thomas Volk, Michael Abend, Alexander M. Mathes. Melatonin or ramelteon therapy differentially affects hepatic gene expression profiles after haemorrhagic shock in rat — A microarray analysis. Experimental and Molecular Pathology 2015; 99(2) doi: 10.1016/j.yexmp.2015.06.019
41
Parisa Kiani Amin, Siamak Mashhady Rafie, Saeed Hesaraki, Kumarss Amini. Ameliorative Effect of the Combination of the Cichorium intybus Whole Extract and Melatonin on Doxorubicin-induced Hepatotoxicity in Mice. International Journal of Cancer Management 2022; 15(3) doi: 10.5812/ijcm-119807
42
Mi Jang, Andreas Manz, Thomas Volk, Astrid Kleber. Study of melatonin-mediated effects on various hepatic inflammatory responses stimulated by IL-6 in a new HepG2-on-a-chip platform. Biomedical Microdevices 2018; 20(3) doi: 10.1007/s10544-018-0300-x
43
Shuna Yu, Jie Zheng, Zhengchen Jiang, Caixing Shi, Jin Li, Xiaodong Du, Hailiang Wang, Jiying Jiang, Xin Wang. Protective Effect of N-Acetylserotonin against Acute Hepatic Ischemia-Reperfusion Injury in Mice. International Journal of Molecular Sciences 2013; 14(9) doi: 10.3390/ijms140917680
44
Sharon M. Gwaltney-Brant. Nutraceuticals. 2016;  doi: 10.1016/B978-0-12-802147-7.00007-3
45
M. N. Khodosovsky. THE ROLE OF GASOTRANSMITTERS (NO AND H2S) IN DEFENCE MECHANISMS AGAINST POSTISCHEMIC LIVER INJURIES. Hepatology and Gastroenterology 2019; 3(1) doi: 10.25298/2616-5546-2019-3-1-14-21
46
David A. Areshidze, Mariya A. Kozlova, Valery P. Chernikov, Marina V. Kondashevskaya. THE INFLUENCE OF THE CONSTANT ILLUMINATION ON THE ULTRASTRUCTURE OF RAT'S HEPATOCYTES. Morphological newsletter 2023; 31(1) doi: 10.20340/mv-mn.2023.31(1).758
47
Jun-Te Hsu, Puo-Hsien Le, Chun-Jung Lin, Tsung-Hsing Chen, Chia-Jung Kuo, Kun-Chun Chiang, Ta-Sen Yeh. Mechanism of salutary effects of melatonin-mediated liver protection after trauma-hemorrhage: p38 MAPK-dependent iNOS/HIF-1α pathway. American Journal of Physiology-Gastrointestinal and Liver Physiology 2017; 312(5) doi: 10.1152/ajpgi.00440.2016
48
Lécio Leone Almeida, Giovanna Silva Girão Nobre Pitombeira, Álvaro Aguiar Coelho Teixeira, Valéria Wanderley Teixeira, Valdemiro Amaro Silva Júnior, Leucio Duarte Vieira Filho, Joaquim Evêncio Neto. Protective effect of melatonin against herbicides-induced hepatotoxicity in rats. Toxicology Research 2021; 10(1) doi: 10.1093/toxres/tfaa087
49
Kulsoom Kulsoom, Wajahat Ali, Zainab Saba, Shabab Hussain, Samra Zahra, Maria Irshad, Muhammad Saeed Ramzan. Revealing Melatonin’s Mysteries: Receptors, Signaling Pathways, and Therapeutics Applications. Hormone and Metabolic Research 2024; 56(06) doi: 10.1055/a-2226-3971
50
Gökçe Şeker Karatoprak. Influence of Nutrients, Bioactive Compounds, and Plant Extracts in Liver Diseases. 2021;  doi: 10.1016/B978-0-12-816488-4.00008-5
51
Danielle Aparecida Munhos Hermoso, Lilian Brites Campos Shimada, Eduardo Hideo Gilglioni, Jorgete Constantin, Márcio Shigueaki Mito, Aparecida Pinto Munhos Hermoso, Clairce Luzia Salgueiro-Pagadigorria, Emy Luiza Ishii Iwamoto. Melatonin protects female rats against steatosis and liver oxidative stress induced by oestrogen deficiency. Life Sciences 2016; 157 doi: 10.1016/j.lfs.2016.05.044
52
Silvia Bona, Graziella Rodrigues, Andrea J Moreira, Fábio C Di Naso, Alexandre S Dias, Thêmis R Da Silveira, Claudio A Marroni, Norma P Marroni. Antifibrogenic effect of melatonin in rats with experimental liver cirrhosis induced by carbon tetrachloride. JGH Open 2018; 2(4) doi: 10.1002/jgh3.12055
53
Ahmet Korkmaz, Sergio Rosales-Corral, Russel J. Reiter. Gene regulation by melatonin linked to epigenetic phenomena. Gene 2012; 503(1) doi: 10.1016/j.gene.2012.04.040
54
Lilach Ashkenazi, Abraham Haim. Light Interference (LI) as a possible stressor altering HSP70 and its gene expression levels in brain and liver tissues of Golden Spiny Mice. Journal of Experimental Biology 2012;  doi: 10.1242/jeb.073429
55
Shruti Kulshrestha, Rhydham Karnik, Aliasgar Vohra, Apeksha Joshi, Ranjitsinh Devkar. Melatonin partially restores hepatic nocturnin oscillations in experimental models of MASLD. Chronobiology International 2025; 42(5) doi: 10.1080/07420528.2025.2496347
56
M. A. Vinnikova. The use of melatonin in narcological practice. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova 2015; 115(4. Vyp. 2) doi: 10.17116/jnevro20151154246-50
57
B. Hernández-Velázquez, C.R. Camara-Lemarroy, J.A. González-González, D. García-Compean, R. Monreal-Robles, P. Cordero-Pérez, L.E. Muñoz-Espinosa. Efectos de la melatonina en la respuesta inflamatoria aguda asociada con la colangiopancreatografía retrógrada endoscópica: un ensayo clínico aleatorizado, doble ciego y controlado con placebo. Revista de Gastroenterología de México 2016; 81(3) doi: 10.1016/j.rgmx.2016.03.003
58
Morteza Akhzari, Mahdi Barazesh, Sajad Jalili. Melatonin As An Antioxidant Agent In Disease Prevention: A Biochemical Focus. Letters in Organic Chemistry 2022; 19(11) doi: 10.2174/1570178619666220325124451
59
Chengliang Luo, Qiang Yang, Yuancai Liu, Shuanhu Zhou, Jiying Jiang, Russel J. Reiter, Pallab Bhattacharya, Yongchun Cui, Hongwei Yang, He Ma, Jiemin Yao, Sean E. Lawler, Xinmu Zhang, Jianfang Fu, Renato Rozental, Hany Aly, Mark D. Johnson, E. Antonio Chiocca, Xin Wang. The multiple protective roles and molecular mechanisms of melatonin and its precursor N-acetylserotonin in targeting brain injury and liver damage and in maintaining bone health. Free Radical Biology and Medicine 2019; 130 doi: 10.1016/j.freeradbiomed.2018.10.402
60
Jiunn-Ming Sheen, Yu-Chieh Chen, Mei-Hsin Hsu, You-Lin Tain, Ying-Hsien Huang, Mao-Meng Tiao, Shih-Wen Li, Li-Tung Huang. Melatonin Alleviates Liver Apoptosis in Bile Duct Ligation Young Rats. International Journal of Molecular Sciences 2016; 17(8) doi: 10.3390/ijms17081365
61
Neda O. Anastassova, Denista Y. Yancheva, Anelia Ts Mavrova, Magdalena S. Kondeva-Burdina, Virginia I. Tzankova, Nadya G. Hristova-Avakumova, Vera A. Hadjimitova. Design, synthesis, antioxidant properties and mechanism of action of new N,N′-disubstituted benzimidazole-2-thione hydrazone derivatives. Journal of Molecular Structure 2018; 1165 doi: 10.1016/j.molstruc.2018.03.119
62
Anindita Deb, Sangita Sutradhar, Anubhuti Kashyap, Shiv Shankar Singh. Protective effects of melatonin and insulin against diabetic-induced deterioration in ovarian function in female mice. Proceedings of the Indian National Science Academy 2026;  doi: 10.1007/s43538-026-00937-1
63
Natnicha Leelaviwat, Poemlarp Mekraksakit, Kristina M. Cross, Dylan M. Landis, Madison McLain, Laveena Sehgal, J. Drew Payne. Melatonin: Translation of Ongoing Studies Into Possible Therapeutic Applications Outside Sleep Disorders. Clinical Therapeutics 2022; 44(5) doi: 10.1016/j.clinthera.2022.03.008
64
A. Carpentieri, G. Díaz de Barboza, V. Areco, M. Peralta López, N. Tolosa de Talamoni. New perspectives in melatonin uses. Pharmacological Research 2012; 65(4) doi: 10.1016/j.phrs.2012.01.003
65
Christian Vollmer, Andreas P. M. Weber, Martin Wallenfang, Till Hoffmann, Tabea Mettler‐Altmann, Richard Truse, Inge Bauer, Olaf Picker, Alexander M. Mathes. Melatonin pretreatment improves gastric mucosal blood flow and maintains intestinal barrier function during hemorrhagic shock in dogs. Microcirculation 2017; 24(4) doi: 10.1111/micc.12345