Current status of artificial intelligence colonoscopy on improving adenoma detection rate based on systematic review of multiple metanalysis

Table 5 Overview of commercially available artificial intelligence systems and the key distinctions among them

Characteristics	GI genius	CAD EYE	EndoScreener	ENDO-AID	SOKUT	Endoangel
Developer	Medtronic	Fujifilm	Beijing-based company weiming vision technology	Olympus	Iterative	Wuhan endoangel medical technology co
AI function	CADe	CADe + CADx	CADe	CADe + CADx	CADe	CADe + CADx
System description	Real-time polyp detection with visual/audio alerts. Integrated with HD colonoscopes	Optimized for Fujifilm scopes. Useful for optical biopsy	Compatible with multiple endoscope brands. High sensitivity for small polyps. Validated in Chinese populations		Focuses on adenoma detection. Trained for sessile adenoma. Validated in United States multicenter trials	Focus in adenoma detection and diagnosis. Can assess bowel preparation quality. Additional benefit in diagnosis gastric neoplasm
Regulatory approval	United States Food and Drug Administration Europe, Select markets in Asia, Australia, and the Middle East	Pharmaceuticals and Medical Devices Agency (Japan). United States Food and Drug Administration	National Medical Products Administration (China)	Europe, Middle East, Africa. United States Food and Drug Administration	United States Food and Drug Administration	National Medical Products Administration (China)
Workflow integration	Flexible	Fujifilm-only	Flexible	Olympus-only	Flexible	Flexible
Clinical adaption	United State. Europe	Japan	China	Japan. Europe	United State	China
ADR improvement	Consistent ADR. Lower non-neoplastic resection. Prolonged withdrawal time. No improvement with SSL	Prioritize large/advanced adenoma. Less sensitive over subtle and small adenoma. No improvement with SSL	Improvement in ADR. Increase non-neoplastic resection	Consistent ADR. Significant SSL benefits	Improvement in ADR. Increase non-neoplastic resection	Real-time detection and withdrawal time monitoring. Alerts for suboptimal technique. Improves withdrawal technique. Reduces miss rates

CADe: Computer assistance detection examination; CADx: Computer assistance detection diagnosis; SSL: Sessile serrated lesion; ADR: Adenoma detection rate.