Laboratory hematologic features of COVID-19 associated liver injury: A systematic review

Table 4 Other retrospective cohort studies

Ref.	Country	Setting	Evaluated parameters	Comparison	Summary of main findings	NOS
Cao et al[72]	China	Hospitalized patients	WBC, ANC, ALC, DDIM	Elevated ferritin vs disease controls	Elevated ferritin corelated with disease severity and degree of liver injury	7
Chen et al[73]	China	Hospitalized patients	ANC, ALC, PLT, DDIM	Recurrent cases vs disease controls	Elevated AST and ALT are predictive of COVID-19 recurrence	7
Ding et al[74]	China	Hospitalized patients	ALC, PLT, DDIM	Deceased vs discharged	Abnormal AST and D-Bil were independent predictors of mortality	7
Lei et al[75]	China	Hospitalized patients	ANC, ALC, PLT, DDIM	Comparison of parameters for peak levels of each LFT	Associated ANC, ALC, PLT, and DDIM with peak levels of AST, ALC, ALP, and TBIL	6
Luan et al[76]	China	ICU hospitalized	WBC, HGB, ANC, ALC, PLTS, DDIM, PT, PTT, INR	CAC vs non-CAC	CAC correlates with liver injury	8

ALC: Absolute lymphocyte count; ALP: Alkaline phosphatase; ANC: Absolute neutrophil count; CAC: COVID-associated coagulopathy; COVID-19: Coronavirus disease 2019; D-Bil: Direct bilirubin; DDIM: D-dimer; HGB: Hemoglobin; ICU: Intensive care unit; INR: International normalized ratio; LFT: Liver function test; NOS: Newcastle-Ottawa Scale; PLT: Platelet count; PT: Prothrombin time; PTT: Partial thromboplastin time; WBC: White blood cell count.