Laboratory hematologic features of COVID-19 associated liver injury: A systematic review

Table 2 Summary of statistical data from studies comparing liver injury vs non-liver injury

LFT criteria	Parameter	Significance
		NS	< 0.05	< 0.01	< 0.001
LFT > ULN	WBC	4	2	0	6
	ANC	4	1	0	4
	ALC	4	2	1	5
	HGB	4	2	0	5
	PLT	4	2	0	2
	DDIM	4	2	1	0
	PT	4	2	1	0
	PTT	4	2	0	0
	INR	4	2	1	0
LFT > 2 × ULN	WBC	4	2	0	3
	ANC	4	2	0	1
	ALC	4	2	1	1
	HGB	4	2	0	2
	PLT	4	2	0	1
	DDIM	4	2	0	1
	PT	4	2	0	0
	INR	4	2	0	0
Studies with > 100 patients in high LFT cohort	WBC	0	0	0	5
	ANC	1	0	0	5
	ALC	4	0	1	5
	HGB	0	0	0	5
	PLT	5	0	0	2
	DDIM	3	0	0	3
	PT	2	1	1	0
	PTT	1	0	0	0

Numbers indicate number of studies. ALC: Absolute lymphocyte count; ANC: Absolute neutrophil count; DDIM: D-dimer; HGB: Hemoglobin; INR: International normalized ratio; LFT: Liver function test; NS: Not significant; PLT: Platelet count; PT: Prothrombin time; PTT: Partial thromboplastin time; ULN: Upper limit of normal; WBC: White blood cell count.