Therapeutic applications of dental pulp stem cells in regenerating dental, periodontal and oral-related structures

Table 3 Preclinical studies obtained from the PubMed, Scopus and Google Scholar databases related to salivary gland regeneration using dental pulp stem cells

Ref.	Strategy	Model	Defect/site of cell implantation	Cell number	Cell source	Cell application
Janebodin et al[42], 2012	Scaffold-based	Rag1 null mice	Injected ventrally onto SMG without penetrating the gland	1 × 106	Murine DPSCs	100 μL of cell suspension
Yamamura et al[43], 2013	Scaffold-free	C57BL/6J green fluorescent protein-expressing mice	Irradiated SMG	2 × 106	Murine DPSCs	5 μL of single cell suspension was injected intraglandular using a 28 G needle and microliter syringe.
Narmada et al[44], 2020	Scaffold-free	Wistar rats	SMG of diabetic rat model	5 × 105	hDPSCs	Intraglandular cell injection.
Takeuchi et al[45], 2020	Cell-free	ICR mice	SMG duct ligation	0.4 mL	hDPSCs	DPSCs-CM was administered via the right jugular vein biweekly under general anaesthesia.

DPSCs: Dental pulp stem cells; hDPSCs: Human dental pulp stem cells; SMG: Submandibular.