Hypoxia and oxidative stress: The role of the anaerobic gut, the hepatic arterial buffer response and other defence mechanisms of the liver

Figure 2 Schematic representation of a hepatic acinus within a conventional hepatic lobule. The demarcation of the hepatic acinus is shown by the dashed lines. Arrows indicate the direction of blood flow within hepatic sinusoids in a periportal-to-perivenous direction, giving rise to zones 1, 2 and 3 (numbered) within the acinus. Note that all three zones are represented in a single sinusoid.