Effectiveness of taxanes over anthracyclines in neoadjuvant setting: A systematic-review and meta-analysis

Table 3 Pooled effect estimates for various toxicity in taxanes in comparison to anthracyclines

Toxicity	Number of studies	RR (95%CI)
Hematological toxicity
Neutropenia	7	1.00 (0.78-1.29)
Febrile neutropenia	4	2.67 (2.33-3.07)
Leucopenia	4	0.72 (0.36-1.45)
Anemia	3	0.75 (0.12-4.53)
Thrombocytopenia	4	0.07 (0.03-0.19)
Thrombosis	2	1.07 (0.59-1.96)
Cardiac and nervous system toxicity
Neuropathy	2	1.01 (0.35-2.93)
Sensory neuropathy	3	18.26 (5.87-56.80)
Cardiac left ventricular function	1	0.33 (0.01-8.14)
Cardiovascular toxicity	1	2.74 (0.88-8.57)
Dermatological toxicities
Hand foot syndrome	2	27.43 (3.75-200.84)
Rash	1	8.96 (0.48-166.20)
Dermatological toxicity	2	3.71 (1.18-11.67)
Alopecia	1	0.78 (0.73-0.83)
Diarrhea	5	1.90 (0.97-3.73)
Gastro	1	4.23 (1.43-12.53)
constipation	1	3.49 (0.73-16.73)
Oral toxicities
Stomatitis	6	1.89 (1.23-2.91)
Musculoskeletal pain	1	1.01 (0.06-15.95)
General toxicity
Nausea	7	0.33 (0.24-0.44)
Fatigue	5	1.29 (0.96-1.73)
Infection	4	2.53 (2.00-3.19)
Other	6	1.12 (0.61-2.06)
Vomiting	4	0.23 (0.16-0.33)
Allergic reaction	3	21.25 (2.74-164.67)
Myalgia	3	1.99 (0.36-11.01)
Serious adverse event	1	0.65 (0.29-1.45)
edema	1	6.97 (0.36-134.74)
Fever	1	15.85 (0.96-260.89)
Hypotension	1	6.97 (0.36-134.74)
Pulmonary	1	3.54 (0.92-13.65)
Arthelgia	3	0.02 (0.01-0.04)
Bone pain	1	0.07 (0.00-1.17)