Antibiotics for eradicating meningococcal carriages: Network meta-analysis and investigation of evidence inconsistency

Table 2 Antibiotics compared and data from the included trials for network meta-analysis

Trial	Regimen	n	Failure to eradicate
Guttler et al[26]	Placebo	18 (146)	8 (65)
	Rifampin	18 (147)	2 (13)
	Minocycline	18 (147)	1 (12)
	Ampicillin	18 (147)	3 (22)
Munford et al[30]	Rifampin	65 (67)	6 (6)
	Sulphadiazine	79 (82)	37 (38)
	Minocycline	56 (58)	6 (6)
	Rifampin + Minocycline	59 (61)	0 (0)
Schwartz et al[34]	Rifampin	34 (36)	9 (9)
	Ceftriaxone	65 (68)	2 (2)
Dowd et al[23]	Placebo	47	26
	Penicillin	20	9
	Ampicillin	26	8
Borgoño et al[15]	Placebo	110	71
	Rifampin	118	10
Deal et al[17]	Placebo	15	13
	Rifampin	15	2
Deviatkina et al[19]	Placebo	43	10
	Rifampin	46	3
Devine et al[20]	Placebo	28	25
	Rifampin	38	7
Kaiser et al[28]	Placebo	6	6
	Rifampin	13	1
Dworzack et al[24]	Placebo	22	20
	Ciprofloxacin	24	1
Pugsley et al[31]	Placebo	21	14
	Ciprofloxacin	21	0
Renkonen et al[33]	Placebo	53	46
	Ciprofloxacin	56	2
Deal et al[18]	Placebo	15	14
	Cephalexin	15	11
Devine et al[22]	Placebo	48	42
	Minocycline	41	14
Devine et al[22]	Placebo	29	27
	Minocycline	53	16
Devine et al[21]	Placebo	39	28
	Coumermycin A1	33	31
Pugsley et al[32]	Placebo	29	26
	Sch29482	29	23
Cuevas et al[16]	Rifampin	84 (88)	3 (3)
	Ciprofloxacin	75 (79)	9 (9)
Kaya et al[29]	Rifampin	25	1
	Ciprofloxacin	26	2
Girgis et al[25]	Rifampin	59	3
	Azythromycin	60	4
Simmons et al[35]	Rifampin	82	4
	Ceftriaxone	100	3
Blakebrough et al[14]	Rifampin	46 (48)	11 (11)
	Sulphadimidine	33 (34)	33 (34)
Judson et al[27]	Ceftriaxone	29	0
	Spectinomycin	9	8

For cluster trials, ICC = 0.05 was assumed for estimating effective sample sizes, and original sample size and events in cluster trials are shown in brackets