Meta-analysis of single strain probiotics for the eradication of Helicobacter pylori and prevention of adverse events

Table 4 Description of the interventions and Helicobacter pylori eradication rates n (%)

Probiotic strain	Daily dose (cfu/d)	Form	Duration treatment (wk)	Follow-up post-treatment (wk)	H. pylori eradication probiotic	H. pylori eradication in controls	Ref.
S. boulardii I-745	1 × 1010	Sachet	2	5-7	17 (81)	16 (80)	Cremonini et al[53]
S. boulardii I-745	1 × 1010	Capsule	2	4	nr	nr	Duman et al[54]
S. boulardii I-745	2 × 1010	Sachet	2	6	44 (71)	37 (60)	Cindoruk et al[55]
S. boulardii I-745	1 × 1010	Capsule	4	4-6	45 (93.3)	34 (80.9)	Hurduc et al[56]
S. boulardii I-745	2 × 1010	Capsule	4	4	264 (80)a	237 (71.6)	Song et al[57]
S. boulardii I-745 + MPA	2 × 1010	Capsule	4	4	271 (82.1)b	237 (71.6)	Song et al[57]
S. boulardii I-745	5 × 109	Capsule	2	5	71 (72)	82 (86)a	Ozdil et al[58]
S. boulardii I-745	5 × 109	Sachet	2	52	42 (84)a	32 (64)	Chu et al[59]
S. boulardii I-745	1 × 1010	Capsule	2	8	70 (87.5)	65 (81)	Zojaji et al[60]
S. boulardii I-745	6 × 106	Capsule	2	6	30 (83.4)a	20 (58.8)	Kyriakos et al[61]
S. boulardii I-745	1 × 1010	Capsule	2	4	102 (85)c	91 (75.8)	Zhao et al[62]
Clost. butyricum 588	1 × 107	Tablet	1	4	44 (94)	44 (88)	Guo et al[63]
Clost. butyricum 588	3 × 107	Tablet	2	6	17 (94)	13 (76)	Shimbo et al[64]
Clost. butyricum 588 (low dose)	6 × 107	Tablet	1	0	7 (100)	6 (87)	Imase et al[65]
Clost. butyricum 588 (high dose)	1.2 × 108	Tablet	1	0	4 (80)	6 (87)	Imase et al[65]
L. rhamnosus GG	1.2 × 1010	Sachet	2	6	48 (80)	46 (76.6)	Armuzzi et al[66]
L. rhamnosus GG	1.2 × 1010	Sachet	2	6	25 (83)	24 (80)	Armuzzi et al[67]
L. rhamnosus GG	1.2 × 1010	Sachet	2	5-7	16 (76)	16 (80)	Cremonini et al[53]
L. rhamnosus GG	2 × 109	Capsule	1	6	23 (69)	22 (68)	Szajewska et al[68]
L. rhamnosus GG	1.2 × 1010	Liquid	2	0	nr	nr	Padilla Ruiz et al[69]
L. acidophilus Lb	1.5 × 1010	Capsule	1.4	6	52 (87)a	42 (70)	Canducci et al[70]
L. acidophilus Lb	2 × 1010	Capsule	2	4-6	30 (64)	26 (70)	De Francesco et al[71]
L. acidophilus nr	2 × 108	nr	2	4-8	19 (83)	21 (95.5)	Yeom et al[72]
L. reuteri 55730	1 × 108	Tablet	2.9	8	17 (85)	16 (80)	Lionetti et al[73]
L. reuteri 55730	2 × 108	Tablet	1	4-6	9 (53)	10 (62)	Scaccianoce et al[74]
L. reuteri 55730	3 × 108	Liquid	2	6	36 (80)a	27 (60)	Ojetti et al[75]
L. casei DG	1.6 × 1010	Capsule	1.4	4	33 (94.3)	30 (85.7)	Tursi et al[76]
L. casei DG	2 × 1010	nr	4	6	22 (73)	21 (70)	Giovannone et al[77]

^aP < 0.05,

^bP < 0.01,

^cTrend, 0.05 ≤P < 1.0. This strain is now designated: Saccharomyces boulardii CNCM I-745, nr: Not reported; S. boulardii: Saccharomcyes boulardii; L. rhamnosus: Lactobacillus rhamnosus.