Meta-analysis of single strain probiotics for the eradication of Helicobacter pylori and prevention of adverse events

Table 3 Characteristics of enrolled populations in patients receiving eradication therapy by 28 treatment arms

Probiotic strain	Country	Population	Symptoms	Blinding	Eradicationtherapy	Durationeradication (d)	Ref.
S. boulardii I-745	Italy	Adults	Asymptomatic	Placebo	CTR	7	Cremonini et al[53]
S. boulardii I-745	Turkey	Adults	Symptomatic	None	ACO	14	Duman et al[54]
S. boulardii I-745	Turkey	Adults	Symptomatic	Placebo	ACL	14	Cindoruk et al[55]
S. boulardii I-745	Romania	Pediatric	Symptomatic	Single	AC + O/E	7-21	Hurduc et al[56]
S. boulardii I-745	South Korea	Adults	Symptomatic	Single	ACO	7	Song et al[57]
S. boulardii I-745 + MPA	South Korea	Adults	Symptomatic	Single	ACO	7	Song et al[57]
S. boulardii I-745	Turkey	Adults	Symptomatic	None	ACL	14	Ozdil et al[58]
S. boulardii I-745	China	Adults	Symptomatic	None	ACO	14	Chu et al[59]
S. boulardii I-745	Iran	Adults	Symptomatic	None	ACO	14	Zojaji et al[60]
S. boulardii I-745	Greece	Adults	Symptomatic	Single	ACO	14	Kyriakos et al[61]
S. boulardii I-745	China	Pediatric	Symptomatic	None	ACO	14	Zhao et al[62]
Clost. butyricum 588	China	Adults	Symptomatic	None	AFO	7	Guo et al[63]
Clost. butyricum 588	Japan	Adults	Symptomatic	None	ACL	7	Shimbo et al[64]
Clost. butyricum 588 (low dose)	Japan	Adults	Symptomatic	None	ACL	7	Imase et al[65]
Clost. butyricum 588 (high dose)	Japan	Adults	Symptomatic	None	ACL	7	Imase et al[65]
L. rhamnosus GG	Italy	Adults	Asymptomatic	None	CPT	7	Armuzzi et al[66]
L. rhamnosus GG	Italy	Adults	Asymptomatic	Placebo	CRT	7	Armuzzi et al[67]
L. rhamnosus GG	Italy	Adults	Asymptomatic	Placebo	CRT	7	Cremonini et al[53]
L. rhamnosus GG	Poland	Pediatric	Asymptomatic	Placebo	ACO	7	Szajewska et al[68]
L. rhamnosus GG	Venezuela	Adults	Symptomatic	Placebo	ACO	7	Padilla Ruiz et al[69]
L. acidophilus Lb	Italy	Adults	Symptomatic	None	ACR	7	Canducci et al[70]
L. acidophilus Lb	Italy	Adults	Symptomatic	None	AO	7-30	De Francesco et al[71]
L. acidophilus nr	South Korea	Adults	Mixed	None	ACO	7	Yeom et al[72]
L. reuteri 55730	Italy	Pediatric	Symptomatic	Placebo	AO, COT	15	Lionetti et al[73]
L. reuteri 55730	Italy	Adults	Symptomatic	None	ACT	7	Scaccianoce et al[74]
L. reuteri 55730	Italy	Adults	Symptomatic	None	AELe	7	Ojetti et al[75]
L. casei DG	Italy	Adults	Symptomatic	None	ART (E/P)	10	Tursi et al[76]
L. casei DG	Italy	Adults	nr	None	ACE	7	Giovannone et al[77]

This strain is now designated: Saccharomyces boulardii CNCM I-745. Clostridium butyricum 588 (MIYAIRI). Placebo indicates double-blinded design, single indicates either just patient or outcome assessor was blinded and none indicates an open study. A: Amoxicillin; C: Clarithromycin; E: Esomeprazole; F: Furazolidone; L: Lansoprazole; Le: Levofloxacin; MPA: Mucoprotective agent; nr: Not reported in paper/abstract; O: Omeprazole; P: Pantoprazole; R: Randazole; T: Tindazole.