Scratching the surface: A systematic review of modern approaches to diagnosing and treating cholestatic pruritus

doi:10.13105/wjma.120937

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World Journal of Meta-Analysis

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2308-3840

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Meta-Anal. Sep 18, 2026; 14(3): 120937
Published online Sep 18, 2026. doi: 10.13105/wjma.120937

Table 2 Diagnostic tools and biomarkers

Tool	Utility	Limitations
Serum bile acids	Reflect cholestasis	Poor correlation with symptom severity
Autotaxin	Emerging biomarker for cholestatic pruritus	Limited availability; not standardized
5-D Itch Scale	Assesses multidimensional symptom severity	Subjective patient-reported measure
Imaging	Exclude biliary obstruction or malignancy	Does not quantify itch severity

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Citation: Liu C, Elangovan A, Diaz DJ, Petrova L, Yekula A, Twohig P. Scratching the surface: A systematic review of modern approaches to diagnosing and treating cholestatic pruritus. World J Meta-Anal 2026; 14(3): 120937
URL: https://www.wjgnet.com/2308-3840/full/v14/i3/120937.htm
DOI: https://dx.doi.org/10.13105/wjma.120937

Liu C, Elangovan A, Diaz DJ, Petrova L, Yekula A, Twohig P. Scratching the surface: A systematic review of modern approaches to diagnosing and treating cholestatic pruritus. World J Meta-Anal 2026; 14(3): 120937 [DOI: 10.13105/wjma.120937]

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