Association of the rs1333048 polymorphism in the ANRIL gene with different clinical forms of periodontitis: A meta-analysis

Table 2 Meta-analysis calculation of the rs1333048 polymorphism in ANRIL gene and periodontitis risk (allelic and genotypic comparisons; subgroups analyses)

Comparison (n)	OR (95%CI)	P value (Z test)	I², %	Pheterogeneity	Statistical model used
Overall (n = 12)
M vs m	1.24 (1.15-1.34)	P < 0.05	28	P = 0.17	F
m vs M	0.80 (0.75-0.87)	P < 0.05	28	P = 0.17	F
MM vs mm	1.53 (1.32-1.78)	P < 0.05	30	P = 0.16	F
mm vs MM	0.65 (0.56-0.76)	P < 0.05	30	P = 0.16	F
MM vs Mm/mm	1.38 (1.22-1.56)	P < 0.05	27	P = 0.18	F
Mm vs MM/mm	0.97 (0.87-1.08)	P = 0.53	25	P = 0.20	F
CP (n = 3)
M vs m	1.25 (1.07-1.47)	P = 0.006	0	P = 0.81	F
m vs M	0.80 (0.68-0.94)	P = 0.006	0	P = 0.81	F
MM vs mm	1.58 (1.14-2.18)	P = 0.005	0	P = 0.77	F
mm vs MM	0.63 (0.46-0.87)	P = 0.005	0	P = 0.77	F
MM vs Mm/mm	1.36 (1.05-1.77)	P = 0.02	0	P = 0.80	F
Mm vs MM/mm	0.98 (0.79-1.23)	P = 0.89	0	P = 0.92	F
AgP (n = 8)
M vs m	1.23 (1.13-1.34)	P < 0.05	47	P = 0.07	F
m vs M	0.81 (0.75-0.89)	P < 0.05	47	P = 0.07	F
MM vs mm	1.49 (1.25-1.77)	P < 0.05	48	P = 0.06	F
mm vs MM	0.67 (0.57-0.80)	P < 0.05	48	P = 0.06	F
MM vs Mm/mm	1.37 (1.19-1.58)	P < 0.05	51	P = 0.05	F
Mm vs MM/mm	0.95 (0.84-1.08)	P = 0.44	49	P = 0.06	F
Caucasian (n = 9)
M vs m	1.27 (1.16-1.38)	P < 0.05	25	P = 0.22	F
m vs M	0.79 (0.72-0.86)	P < 0.05	25	P = 0.22	F
MM vs mm	1.59 (1.34-1.88)	P < 0.05	26	P = 0.21	F
mm vs MM	0.63 (0.53-0.74)	P < 0.05	26	P = 0.21	F
MM vs Mm/mm	1.39 (1.21-1.60)	P < 0.05	43	P = 0.08	F
Mm vs MM/mm	0.97 (0.87-1.08)	P = 0.94	33	P = 0.15	F
Mixed (n = 2)
M vs m	1.11 (0.91-1.36)	P = 0.55	68	P = 0.08	R
m vs M	0.90 (0.63-1.28)	P = 0.55	68	P = 0.08	R
MM vs mm	1.22 (0.83-1.81)	P = 0.55	70	P = 0.07	R
mm vs MM	0.82 (0.55-1.21)	P = 0.55	70	P = 0.07	R
MM vs Mm/mm	1.26 (0.93-1.72)	P = 0.14	0	P = 0.49	F
Mm vs MM/mm	0.84 (0.64-1.11)	P = 0.23	30	P = 0.23	F

OR: Odds ratio; CI: Confidence Intervals; I²: Heterogeneity index; M: Mutant allele; m: Wild type allele; F: Fixed-effect statistical model; R: Random-effects statistical model; CP: Chronic periodontitis; AgP: Aggressive periodontitis.