Association of the rs1333048 polymorphism in the ANRIL gene with different clinical forms of periodontitis: A meta-analysis

Table 1 Characteristics of included studies on rs1333048 polymorphisms in ANRIL gene and periodontitis

Reference	Ethnicity/country	Study design	Diagnosis (clinical subtypes)	Subject type	Sample size (Cc/Co)	Age (years) (Cc/Co)	HWE (P value)	Methods of genotyping	Score
Chen et al[10], 2012	Asian/China	Case/Control	CP	-	221/172	41.6 ± 8.8/40.0 ± 9.2	Yes	Real time PCR	14
Ernst et al[11], 2010	Caucasian/German and Northern Ireland	Case/Control	gAgP	-	130/339	15-35/40-80	Yes	Real time PCR	13
Schaefer et al[9], 2009	Caucasian/Germany	Verification/Replication	gAgP	-	151/736	38 ± 6.6/63 ± 7.4	Yes	SNPlex/TaqMan	14
			LAgP	-	137/368	37 ± 7.0/37 ± 9.6
Schaefer et al[12], 2011	Caucasian/Germany and Netherlands	Case/Control	CP	-	154/421	45.2 ± 9.5/32.3 ± 9.0	Yes	SNPlex/TaqMan	15
			AgP		159/421	33.8 ± 4.7/32.3 ± 9.0
Schaefer et al[20], 2013	Caucasian/Turkey, Italy and Germany	Exploration	AgP	Turkey	89/72	-	Yes	Array Immunochip	18
				Italy	44/99		Yes
				Germany	594/1441		Yes
Taiete et al[21], 2018	Mixed/Brazil	Case/Control	AgP	-	200/196	34.0 ± 4.6/30.5 ± 5.8	No	PCR-RFLP	17
			CP	-	190/196	50.0 ± 7.2/30.5 ± 5.8	Yes		16
Teeuw et al[22], 2015	Caucasian/Netherlands	Case/Control	Periodontitis	-	115/56	45.5 ± 9.9/43.9 ± 13.2	Yes	TaqMan

Cc: Case; Co: Control; HWE: Hardy-Weinberg Equilibrium, CP: Chronic periodontitis; gAgP: Generalized aggressive periodontitis; LAgP: Localized aggressive periodontitis; AgP: Aggressive periodontitis; PCR: Polymerase chain reaction.