Outcomes of microwave versus radiofrequency ablation for hepatocellular carcinoma: A systematic review and meta-analysis

Table 4 Summary of overall survival and local recurrence rate HRs

Endpoint	Study design	No. of studies	HR	95%CI	P for significance	I2	P for heterogeneity
Overall survival – HR
Univariate	Retrospective	2	1.17	0.75-1.83	0.497	17.5	0.27
Multivariate	Retrospective	3	1.32	0.92-1.89	0.130	0.8	0.36
Unspecified	Prospective	1	1.45	0.96-2.19	0.078	-	-
	Retrospective	13	1.06	0.86-1.32	0.580	58.6	0.004
	RCT	4	1.34	0.97-1.86	0.079	0	0.58
Local recurrence rate – HR
Univariate	Retrospective	3	1.77	0.81-3.88	0.151	63.9	0.06
Multivariate	Retrospective	2	1.88	0.79-4.47	0.151	56.1	0.13
Cox proportional	Retrospective	1	2.17	1.04-4.50	0.040	-	-
Fine and gray	Retrospective	1	2.07	0.95-4.26	0.070	-	-
Unspecified	Retrospective	1	2.00	0.50-8.00	0.326	-	-

HR: Hazard ratio; CI: Confidence interval; RCT: Randomised controlled trial.