Rosai-Dorfman disease in the spleen of a pediatric patient: A case report

Table 1 Literature review of pediatric Rosai–Dorfman disease

Ref.	Age	Gender	Symptoms	Underlying disease	Nodal disease	Extranodal disease	Radiologic findings
							Location	US	X-ray/CT	MRI
di Dioet al[9], 2016	14M	(-)	Swelling of the right parotid gland	Recent EBV infection	Bilateral cervical, hilar	Bilateral parotid gland	Multiple intraparotid LNs	Cystic and solid	(-)	Enhancement: Irregular
Rasool et al[4], 2015	15M	F	Pain and swelling of distal forearm	Not described	No	Physis of distal radius	Well-defined intramedullary lesion	(-)	Radiolucent lesion with scalloping and thin rim	(-)
Mantilla et al[12], 2016	2	F	Proptosis, headache	H syndrome (SLC29A3 mutation)	No	Bilateral orbit	Numerous well-circumscribed intraorbital masses	(-)	(-)	T2WI: Moderately hyperintense; enhancement: Mild
Nandi et al[7], 2008	5	M	Painless huge neck swelling, fever	HHV-6 infection	Bilateral cervical	No		(-)	(-)	(-)
Nandi et al[7], 2008	5	M	Bilateral proptosis, swelling over the mandibular area	No	Preauricular, mandibular	Bilateral orbit	Ill-defined irregular masses involving mainly intraconal parts	(-)	Enhancement: heterogeneous	(-)
Rodriguez-Galindo et al[14], 2004	6	F	Orbital swelling, proptosis, and blindness	No	Ipsilateral cervical	Orbit	Retroconal and preseptal mass extended to cavernous sinus	(-)	(-)	Enhancement: Mild
Arakaki et al[5], 2012	7	M	Abdominal pain and diarrhea	HHV-6 infection	No	Kidney	Mass at anterior portion of kidney	Homogeneous echogenecity	Soft tissue density; enhancement: Homogeneous	Enhancement: Homogeneous
Rodriguez-Galindo et al[14], 2004	9	F	Left frontal swelling and tenderness	No	No	Skull	Well-defined lesions in frontal bone		Radiolucent lesions without sclerotic margin	(-)
Sridhara et al[15], 2012	11	M	Painless bilateral neck swelling	Recent EBV infection	No	Bilateral submandibular gland	Enlarged submandibular glands	(-)	Enhancement: Homogeneous	(-)
Tubbs et al[16], 2005	13	M	Neck pain, headache, blurred vision	No	No	Right parietal bone	Intraosseous lesion	(-)	(-)	(-)
						Suboccipital musculature		(-)	(-)	Enhancement: Mild
Rittner et al[18], 2012	15	M	Fever, back and left hip pain	No	No	Multiple bone lesions (cranial bone, spine, pelvis, upper/lower extremities)		(-)	Lytic lesions	T1WI: Hypointense; T2WI: Hyperintense; enhancement: Strong
Rodriguez-Galindo et al[14], 2004	15	F	Headache, proptosis	Recent EBV infection	Mediastinal	Brain	Anterior and posterior falx	(-)	(-)	T1WI and T2WI: Isointense; Enhancement: Strong
						Bilateral orbit	Retroconal, preseptal space

T1WI: T1-weighted image; T2WI: T2-weighted image; US: Ultrasound; CT: Computed tomography; MRI: Magnetic resonance imaging; EBV: Epstein–Barr virus; HHV: Human herpesvirus.