Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 is a diagnostic and prognostic biomarker for hepatocellular carcinoma

Table 1 The association between phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 and clinical features in 90 hepatocellular carcinoma patients

Characteristics	P-Rex1 expression1		P value	χ2
	High	Low
Age (yr)
≤ 50	13	11	0.634	0.227
> 50	32	34
Gender
Male	33	36	0.455	0.559
Female	12	9
HBV infection
Yes	33	5	< 0.001	35.709
No	12	40
Lymph node invasion
Yes	37	11	< 0.001	30.179
No	8	34
Distant metastasis
Yes	22	2	< 0.001	22.727
No	23	43
AFP level (ng/mL)
< 20	8	8	< 0.001	14.708
20 ≤ AFP ≤ 200	6	22
> 200	31	15
Total	45	45

¹The median expression of 90 cases of tumor tissues was set as the cut-off. HBV: Hepatitis B virus; AFP: Alpha-fetoprotein; P-Rex1: Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1.