Prognostic factors for overall survival in prostate cancer patients with different site-specific visceral metastases: A study of 1358 patients

Table 5 Univariate and multivariate Cox regression analyses of prognostic factors affecting overall survival in prostate cancer patients with visceral metastases

Variable	Univariate analysis			Multivariate analysis
	HR	95%CI	P value	HR	95%CI	P value
Marital status
Married	Ref.
Never married	0.984	0.844-1.147	0.838
unknown	NA	NA	NA
Age (yr)
≤ 70	Ref.			Ref.
> 70	1.543	1.358-1.753	< 0.001	1.672	1.353-2.065	< 0.001
Race
Black	Ref.
White	1.130	0.967-1.320	0.125
Other	0.838	0.620-1.134	0.252
Unknown	NA	NA	NA
Grade1
I/II	Ref.			Ref.
III/IV	1.586	1.052-2.392	0.028	1.158	0.695-1.927	0.573
Unknown	NA	NA	NA	NA	NA	NA
T stage
T1/T2	Ref.			Ref.
T3/T4	1.352	1.147-1.594	< 0.001	1.236	0.990-1.543	0.061
Unknown	NA	NA	NA	NA	NA	NA
N stage
N0	Ref.
N1	1.143	0.985-1.327	0.078
Unknown	NA	NA	NA
PSA (ng/mL)
≤ 10	Ref.
> 10	0.836	0.678-1.030	0.092
Unknown	NA	NA	NA
Gleason score
≤ 8	Ref.			Ref.
> 8	1.710	1.407-2.077	< 0.001	1.636	1.308-2.047	< 0.001
Unknown	NA	NA	NA	NA	NA	NA
Bone metastases
No	Ref.			Ref.
Yes	1.205	1.025-1.417	0.024	1.323	1.019-1.716	0.035
Unknown	NA	NA	NA	NA	NA	NA
1	Ref.			Ref.
> 1	1.446	1.222-1.712	< 0.001	1.850	1.396-2.451	< 0.001

¹I: Well differentiated; II: Moderately differentiated; III: Poorly differentiated; IV: Undifferentiated. All variables with Unknown Data did not fit in Cox and Kaplan–Meier model. NA: Not available; PSA: Prostate-specific antigen.