Prognostic factors for overall survival in prostate cancer patients with different site-specific visceral metastases: A study of 1358 patients

Table 4 Univariate and multivariable Cox regression analyses of prognostic factors affecting overall survival in prostate cancer patients with multiple sites of visceral metastasis

Variable	Univariate analysis			Multivariable analysis
	HR	95%CI	P value	HR	95%CI	P value
Marital status
Married	Ref.
Never married	0.817	0.536-1.246	0.348
Unknown	NA	NA	NA
Age (yr)
≤ 70	Ref.			Ref.
> 70	1.545	1.137-2.101	0.005	2.354	1.337-4.145	0.003
Race
Black	Ref.
White	0.964	0.649-1.430	0.855
Other	1.178	0.577-2.406	0.653
Unknown	NA	NA	NA
Grade1
I/II	Ref.
III/IV	1.607	0.587-4.399	0.356
Unknown	NA	NA	NA
T stage
T1/T2	Ref.			Ref.
T3/T4	2.127	1.410-3.208	< 0.001	2.086	1.203-3.617	0.009
Unknown	NA	NA	NA	NA	NA	NA
N stage
N0	Ref.
N1	0.936	0.648-1.352	0.724
Unknown	NA	NA	NA
PSA (ng/mL)
≤ 10	Ref.
> 10	0.763	0.496-1.173	0.218
Unknown	NA	NA	NA
Gleason score
≤ 8	Ref.			Ref.
> 8	1.713	1.073-2.735	0.024	2.203	1.243-3.905	0.007
Unknown	NA	NA	NA	NA	NA	NA
No	Ref.
Yes	0.827	0.569-1.203	0.321
Unknown	NA	NA	NA

¹I: Well differentiated; II: Moderately differentiated; III: Poorly differentiated; IV: Undifferentiated. All variables with Unknown Data did not fit to Cox and Kaplan–Meier model. NA: Not available; PSA: Prostate-specific antigen.