Interaction of arylsulfatases A and B with maspin: A possible explanation for dysregulation of tumor cell metabolism and invasive potential of colorectal cancer

Table 2 Correlation between arylsulfatase A expression and pathological aspects of colorectal cancer

Characteristics	Number	ARSA expression		P value
		Low	High
Age, yr
≤ 60	19	8	11	0.761
> 60	26	13	13
Gender
Male	26	12	14	> 0.991
Female	19	9	10
Macroscopic aspect
Polypoid	12	9	3	0.041
Ulcero-infiltrative	33	12	21
Microscopic aspect
G1	14	11	3	0.022
G2	24	9	15
G3+4	7	2	5
Localization
Proximal	8	5	3	0.502
Distal	21	10	11
Upper rectum	16	6	10
Lymph node ratio
< 0.1	34	19	15	0.041
≥ 0.1	11	2	9
Lymph node metastasis
Absent	29	17	12	0.031
Present	16	4	12
pT stage
≤ T2	15	3	12	0.011
≥ T3	30	18	12
Budding grade
G1	15	8	7	0.812
G2	9	4	5
G3	21	9	12
Maspin expression
Positive	22	3	19	< 0.00011
Negative	23	18	5
ARSB expression
Low	11	5	6	0.921
High	34	16	18

¹Fisher’s exact test.

²χ² test. Significant differences are shown in bold. G1: Well differentiated; G2: Moderately differentiated; G3: Poorly differentiated, 4 mucinous.