Study on gene expression patterns and functional pathways of peripheral blood monocytes reveals potential molecular mechanism of surgical treatment for periodontitis

Table 1 Biological functions and signal pathway of gene participation (excerpts)

ID	Description	P-value	Count
GO:0007631	Feeding behavior	1.49E-13	26
GO:0070371	ERK1 and ERK2 cascade	2.32E-13	46
GO:0070372	Regulation of ERK1 and ERK2 cascade	5.73E-13	44
GO:0050878	Regulation of body fluid levels	2.12E-12	57
GO:0097485	Neuron projection guidance	2.44E-12	38
GO:0007411	Axon guidance	8.41E-12	37
GO:0035567	Non-canonical Wnt signaling pathway	2.61E-11	28
GO:0007218	Neuropeptide signaling pathway	3.08E-11	23
GO:2000027	Regulation of organ morphogenesis	4.06E-11	36
GO:0019932	Second-messenger-mediated signaling	5.57E-11	43
GO:0009410	Response to xenobiotic stimulus	5.72E-11	38
GO:0051047	Positive regulation of secretion	8.82E-11	46
GO:1903532	Positive regulation of secretion by cell	9.27E-11	44
GO:0019373	Epoxygenase P450 pathway	1.21E-10	11
GO:1905330	Regulation of morphogenesis of an epithelium	2.75E-10	29
hsa04080	Neuroactive ligand-receptor interaction	7.10E-22	68
hsa00982	Drug metabolism - cytochrome P450	5.57E-09	21
hsa00980	Metabolism of xenobiotics by cytochrome P450	1.62E-08	21
hsa04020	Calcium signaling pathway	4.82E-08	34
hsa00830	Retinol metabolism	4.97E-08	19
hsa05204	Chemical carcinogenesis	6.96E-08	21
hsa04630	JAK-STAT signaling pathway	9.51E-08	31
hsa04060	Cytokine-cytokine receptor interaction	3.93E-07	44
hsa04024	cAMP signaling pathway	3.95E-07	34
hsa04913	Ovarian steroidogenesis	4.34E-07	15
hsa04713	Circadian entrainment	1.21E-06	21
hsa04151	PI3K-Akt signaling pathway	2.21E-06	48
hsa00590	Arachidonic acid metabolism	2.89E-06	16
hsa04650	Natural killer cell mediated cytotoxicity	6.05E-06	24
hsa04724	Glutamatergic synapse	6.17E-06	22