Life-course management of gestational diabetes mellitus: A narrative review

doi:10.12998/wjcc.v13.i29.111096

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Oct 16, 2025 (publication date) through Sep 6, 2025

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Cases. Oct 16, 2025; 13(29): 111096
Published online Oct 16, 2025. doi: 10.12998/wjcc.v13.i29.111096

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Figure 4 Genetic loci associated with gestational diabetes mellitus and their mechanistic roles in disease pathogenesis. This diagram maps the key gestational diabetes mellitus-associated genes to their molecular functions. MTNR1B and IRS-1 regulate glucose metabolism and insulin signaling. CDKAL1 and TCF7 L2 impair β-cell proliferation and insulin synthesis. Obesity-related genes such as FTO and APOA5 contribute to gestational weight gain and metabolic dysregulation, reinforcing the polygenic basis of gestational diabetes mellitus. GDM: Gestational diabetes mellitus; T2DM: Type 2 diabetes mellitus.

Citation: Luo QJ, Ni Q. Life-course management of gestational diabetes mellitus: A narrative review. World J Clin Cases 2025; 13(29): 111096
URL: https://www.wjgnet.com/2307-8960/full/v13/i29/111096.htm
DOI: https://dx.doi.org/10.12998/wjcc.v13.i29.111096