Life-course management of gestational diabetes mellitus: A narrative review

doi:10.12998/wjcc.v13.i29.111096

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Oct 16, 2025 (publication date) through Sep 3, 2025

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Cases. Oct 16, 2025; 13(29): 111096
Published online Oct 16, 2025. doi: 10.12998/wjcc.v13.i29.111096

Table 8 Summary of key clinical and research dimensions in gestational diabetes mellitus

Dimension	Current standard	Controversies	Recommended research
Screening timing	24-28 weeks OGTT	Early screening utility unclear	TOBOGM and similar RCTs
Pharmacologic treatment	Insulin; Metformin (optional)	Long-term safety of metformin	Childhood follow-up & mechanistic studies
Epigenetics	Not routinely applied	Inconsistent miRNA & methylation data	Multicenter validation & standardization

This visual framework synthesizes current clinical guidelines, areas of uncertainty, and priorities for future research across critical domains in gestational diabetes mellitus care. OGTT: Oral glucose tolerance test; RCTs: Randomized controlled trials.

Citation: Luo QJ, Ni Q. Life-course management of gestational diabetes mellitus: A narrative review. World J Clin Cases 2025; 13(29): 111096
URL: https://www.wjgnet.com/2307-8960/full/v13/i29/111096.htm
DOI: https://dx.doi.org/10.12998/wjcc.v13.i29.111096