Exploring macrophage polarization as a prognostic indicator for colorectal cancer: Unveiling the impact of metalloproteinase mutations

Table 5 Macrophage evaluation (n = 61)

	Total		CD68		CD163		iNOS		CD206
	n	%	mean ± SD	P value	mean ± SD	P value	mean ± SD	P value	mean ± SD	P value
Instability				0.753		0.868		0.524		0.690
No mutation	33	54.1	32.424 ± 26.52		23.106 ± 21.809		5.536 ± 11.11		17.748 ± 17.097
With mutation	28	45.9	31.286 ± 26.541		22.464 ± 21.694		4.398 ± 7.518		16.579 ± 17.598
Age (year)				0.483		0.706		0.993		0.251
≤ 60	15	24.6	33.0 ± 21.696		22.5 ± 17.687		5.377 ± 9.082		20.067 ± 15.374
> 60	46	75.4	31.543 ± 27.861		22.913 ± 22.877		4.896 ± 9.819		16.280 ± 17.804
Sex				0.295		0.496		0.701		0.275
Female	43	70.5	33.953 ± 26.403		23.919 ± 21.043		4.526 ± 6.575		19.191 ± 18.764
Male	18	29.5	27.0 ± 26.183		20.167 ± 23.208		6.181 ± 14.644		12.483 ± 11.825
Location				0.77		0.923		0.332		0.551
Right colon	44	72.1	30.795 ± 25.63		21.909 ± 20.293		5.095 ± 4.803		16.532 ± 17.457
Left colon	17	27.9	34.765 ± 28.619		25.147 ± 25.121		4.803 ± 8.772		18.971 ± 16.879
Staging				0.371		0.454		0.402		0.973
I	10	16.9	24.5 ± 21.141		15.65 ± 15.431		5.06 ± 6.184		16.1 ± 15.911
II	19	32.2	37.368 ± 25.732		24.079 ± 21.545		6.029 ± 8.282		18.684 ± 17.811
III	25	42.4	28.84 ± 26.226		22.42 ± 22.71		2.868 ± 3.554		17.808 ± 19.248
IV	5	8.5	43.0 ± 38.987		34.4 ± 28.369		12.8 ± 28.066		10.94 ± 8.029
Colectomy				0.93		0.994		0.59		0.634
Right side	39	63.9	31.026 ± 26.462		22.474 ± 20.703		4.954 ± 10.326		18.069 ± 17.915
Left side	15	24.6	33.4 ± 28.306		23.567 ± 24.243		3.777 ± 5.634		16.033 ± 14.502
Total	7	11.5	33.571 ± 24.616		23.071 ± 23.816		8.0 ± 12.342		14.957 ± 20.454
Lymphocytes				0.636		0.593		0.544		0.417
Low	30	50.0	33.867 ± 28.295		36.25 ± 27.89		6.555 ± 11.843		16.033 ± 16.511
Moderate	18	30.0	26.944 ± 22.37		22.567 ± 23.103		2.339 ± 3.0		15.261 ± 15.029
Intense	12	20.0	36.25 ± 27.89		21.306 ± 20.569		5.583 ± 9.758		24.1 ± 21.661
Recurrence				0.499		0.719		0.388		0.941
No	49	87.5	33.98 ± 26.279		24.337 ± 22.125		5.637 ± 10.421		17.518 ± 16.553
Yes	7	12.5	30.714 ± 31.282		22.929 ± 22.606		2.507 ± 3.446		22.286 ± 25.063
Clinical outcome				0.252		0.429		0.208		0.167
Disease-free	49	80.3	30.261 ± 25.51		23.378 ± 21.317		4.578 ± 6.32		10.392 ± 9.601
Death	12	19.7	27.917 ± 30.261		20.5 ± 23.434		6.796 ± 17.917		18.882 ± 18.273