Serum proteins differentially expressed in gestational diabetes mellitus assessed using isobaric tag for relative and absolute quantitation proteomics

Table 1 List of differentially expressed proteins in the gestational diabetes mellitus group

Regulated type	Protein accession	Gene name	Protein description	Fold change
Up	Q6UXH0	ANGPTL8	Angiopoietin like 8	5.86
Up	P02753	RBP4	Retinol binding protein 4	4.81
Up	P02649	APOE	Apolipoprotein E	3.86
Up	P08505	IL-6	Interleukin 6	3.40
Up	P05121	PIA-1	Plasminogen activator inhibitor-1	3.17
Up	P02671	FGA	Fibrinogen alpha chain	2.82
Up	P06396	GSN	Gelsolin	2.74
Up	O88947	F10	Coagulation factor X	2.65
Up	P05164	MPO	Myeloperoxidase	2.56
Up	Q6Q788	F9	Apolipoprotein A5	2.51
Up	J3KPA1	CRISP3	Cysteine-rich secretory protein 3	2.50
Up	P00748	F12	Coagulation factor XII	2.47
Up	P27169	PON1	EGF containing fibulin extracellular matrix protein 1	2.31
Up	P49913	CAMP	Cathelicidin antimicrobial peptide	2.24
Up	P13671	C6	Complement C6	2.23
Up	P16070	CD44	CD44 antigen	2.13
Up	Q76LX8	ADAMTS13	Von willebrand factor-cleaving protease	2.01
Up	P00451	F8	Coagulation factor VIII	1.96
Up	P02743	APCS	Serum amyloid P-component	1.95
Up	Q16853	AOC3	Membrane primary amine oxidase	1.95
Up	Q9NZP8	C8B	Complement C1r subcomponent-like protein	1.92
Up	A0A024R035	C9	Complement C9	1.86
Up	P09871	C1S	Complement C1s subcomponent	1.83
Up	P49908	SELENOP	Selenoprotein P	1.81
Up	Q14624	ITIH4	Inter-alpha-trypsin inhibitor heavy chain 4	1.75
Up	B4DPQ0	C1R	Complement C1r subcomponent	1.73
Up	P19827	ITIH1	Inter-alpha-trypsin inhibitor heavy chain 1	1.71
Up	P08709	F7	Coagulation factor VII	1.71
Up	P04275	VWF	von Willebrand factor	1.65
Up	C0JYY2	APOB	Apolipoprotein B	1.55
Up	P00740	F9	Coagulation factor IX	1.52
Down	P05543	SERPINA7	Thyroxine-binding globulin	0.56
Down	P01024	C3	Complement C3	0.43
Down	P01008	SERPINC1	Serpin family C member 1	0.34
Down	P07333	CSF1R	Macrophage colony-stimulating factor 1 receptor	0.34
Down	Q12860	CNTN1	Contactin 1	0.33
Down	P04070	PROC	Protein C, inactivator of coagulation factors Va and VIIIa	0.29
Down	P01871	IGHM	Immunoglobulin heavy constant mu	0.25
Down	Q15485	FCN2	Ficolin 2	0.23
Down	Q15848	ADPN	Adiponectin	0.23
Down	Q8WWZ8	OIT3	Oncoprotein-induced transcript 3 protein	0.22
Down	Q9UNU2	C4B	Complement C4-B	0.20
Down	O95445	APOM	Apolipoprotein M	0.16
Down	P04278	SHBG	Sex hormone-binding globulin	0.15
Down	Q14213	EBI3	Interleukin-27 subunit beta	0.13
Down	O43866	CD5L	CD5 antigen-like	0.06
Down	P06733	ENO1	Alpha-enolase	0.02