Cao WL, Yu CP, Zhang LL. Serum proteins differentially expressed in gestational diabetes mellitus assessed using isobaric tag for relative and absolute quantitation proteomics. World J Clin Cases 2024; 12(8): 1395-1405 [PMID: 38576811 DOI: 10.12998/wjcc.v12.i8.1395]
Corresponding Author of This Article
Ling-Li Zhang, MD, Associate Chief Physician, Department of Gynecology, Maternal and Child Health Hospital of Hubei Province, No. 745 Wuluo Road, Wuhan 430070, Hubei Province, China. zhang147852654@yeah.net
Research Domain of This Article
Obstetrics & Gynecology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Mar 16, 2024; 12(8): 1395-1405 Published online Mar 16, 2024. doi: 10.12998/wjcc.v12.i8.1395
Serum proteins differentially expressed in gestational diabetes mellitus assessed using isobaric tag for relative and absolute quantitation proteomics
Wei-Li Cao, Cui-Ping Yu, Ling-Li Zhang
Wei-Li Cao, Department of Women’s Health Care, Maternal and Child Health Hospital of Hubei Province, Wuhan 430070, Hubei Province, China
Cui-Ping Yu, Obstetrical Department, The First People’s Hospital of Jiangxia District Wuhan City (Union Jiangnan Hospital Huazhong University of Science and Technology), Wuhan 430200, Hubei Province, China
Ling-Li Zhang, Department of Gynecology, Maternal and Child Health Hospital of Hubei Province, Wuhan 430070, Hubei Province, China
Author contributions: Cao WL, Yu CP, and Zhang LL contributed to design the research, and new reagents/analytic tools; Cao WL analyzed the data and wrote the paper.
Institutional review board statement: This study was reviewed and approved by the Maternal and child health hospital of Hubei Province (Approval No. 20201025).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declared no conflict of interest existing in this paper.
Data sharing statement: Data generated from this investigation are available upon reasonable quest from the corresponding author.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ling-Li Zhang, MD, Associate Chief Physician, Department of Gynecology, Maternal and Child Health Hospital of Hubei Province, No. 745 Wuluo Road, Wuhan 430070, Hubei Province, China. zhang147852654@yeah.net
Received: December 1, 2023 Peer-review started: December 1, 2023 First decision: December 7, 2023 Revised: January 8, 2024 Accepted: February 18, 2024 Article in press: February 18, 2024 Published online: March 16, 2024
ARTICLE HIGHLIGHTS
Research background
The development of gestational diabetes mellitus is closely correlated with the differential expression of serum proteins.
Research motivation
The researchers found significant changes in the expression levels of some proteins in the serum of patients with gestational diabetes.
Research objectives
With the intensive investigation of these differentially expressed proteins, we can expect to make more breakthroughs in the field of gestational diabetes.
Research methods
By using isobaric tag for relative and absolute quantitation (iTRAQ) proteomic and bioinformatics analysis methods, the investigators successfully revealed the differences in serum protein expression in gestational diabetes patients.
Research results
The enzyme-linked immunosorbent assay results showed that the serum RBP 4 and ANGPTL8 expression were higher in the GDM group between 12 wk and 16 wk of gestation than in the control group.
Research conclusions
GDM development may be related to abnormal lipid metabolism, activation of coagulation cascade, complement system and inflammatory response. RBP4 and ANGPTL8 may be the early predictors of GDM.
Research perspectives
RBP4 and ANGPTL8 are expected to be early predictors of GDM.
