Sintilimab-induced autoimmune diabetes: A case report and review of the literature

Table 1 Laboratory data at presentation

Admission bloods (normal range, units)	Results
BMI (kg/m2)	18.8
Finger prick glucose (mmol/L)	23.4
urinary glucose	++++
Ketones (mmol/L)	Negative
HbA1c [4%–6% (20–42 mmol/mol)]	8.2%
C-peptide (1.0–7.1 ng/mL)	0.22
Testosterone (0.1–1.1 ng/mL)	0.18
Progesterone (0.00–0.20 ng/mL)	< 1.0
Estradiol (10.00–28.00 pg/mL)	< 10
FSH (26.70–133.40 IU/L)	45.52
LH (5.20–62.0 IU/L)	18.55
Prolactin (5.20–26.50 ng/mL)	9.13
8 am ACTH (0.00-46.00 pg/mL)	15.90
8 am cortisol (67.00-226.00 µg/L)	113.00
ARR (≤ 150 pg/mL)	2.53
TSH (15.00–65.00 mIU/L)	0.98
TT3 (0.66–1.61ug/L)	1.03
TT4 (54.40–118.50 ug/L)	116.86
FT3 (1.0–7.1 ng/L)	3.35
FT4 (1.0–7.1 ng/L)	6.00
ATG (<4.00 IU/L)	17.80
TPO (<9.00 IU/L)	10.00
GAD	Negative
ICA	Negative
IAA	Negative
ZnT8	Negative
IL-2 (0.00–4.10 pg/mL)	0.04
IL-4 (0.10-3.20 pg/mL)	0.01
IL-6 (0.00–5.00 pg/mL)	0.00
IL-10 (0.00–5.90 pg/mL	0.13
TNF-α (0.00–6.00 pg/mL)	0.81
IFN-γ (0.00–6.00 pg/mL	1.36
IL-17A (0.00–5.90 pg/mL)	0.70

BMI: Body mass index; TSH: Thyroid-stimulating hormone; FT4: Free thyroxine; FT3: Free triiodothyronine; TT4: Total thyroxine; TT3: Total triiodothyronine; PTH: Parathyroid hormone; FSH: Follicle-stimulating hormone; LH: Luteinizing hormone; ACTH: Adrenocorticotropic hormone; HGH: Human growth hormone; IL: Interleukin; TNF-α: Tumor necrosis factor alpha; IFN-γ: Interferon gamma; ATG: Anti-thyroglobulin antibodies; TPO: Thyroid peroxidases antibody; GAD: Anti-glutamic acid decarboxylase 65; ICA: Anti-islet cell antibody; IAA: Anti-insulin antibody; ZnT8: Zinc transporter8 antibody; ARR: Aldosterone/renin ratio.