Atypical imaging features of the primary spinal cord glioblastoma: A case report

Figure 4 Diagnosis of World Health Organization Grade IV primary spinal cord glioblastoma was made. A: Resected gross tissue; B and C: Histopathology imaging (magnification × 200). Pleomorphic astrocytic cells with marked nuclear atypia and brisk mitotic activity were observed along with necrosis and microvascular proliferation. Immunohistochemically, the cells were slightly positive for glial fibrillary acidic protein, p53, and vimentin and negative for S-100, isocitrate dehydrogenase, and H3K27M. The proliferation index (measured by Ki67) was found to be at 30%.