Multicentric reticulohistiocytosis with prominent skin lesions and arthritis: A case report

Table 2 Comparison of multicentric reticulohistiocytosis and dermatomyositis

	DM	MRH
Amyasthenia	More than 90% showed a symmetrical proximal muscle weakness	Rare
Increased myoenzyme	Almost all patients with DM (except CADM) have at least one myoenzyme level at some point in the disease course	Rare
Skin manifestations	Gottron papules and heliotrope rash are the definitive features of DM; Gottron signs, erythema along the light site, heterochromia, nail fold changes, scalp involvement, and skin calcification are also typical manifestations of DM	The manifestations of skin lesions include popular nodules and macules. Skin lesions are primarily distributed on the face, scalp, behind the ears, neck, anterior chest, back, waist, and abdomen, arms, hands, and thigh
Skin biopsy	The sporadic or focal infiltration of lymphocytes, plasma cells, and histiocytes	A large number of histiocytes and multinucleated giant cells with an eosinophilic cytoplasm and hairy glass-like changes

MRH: Multicentric reticulohistiocytosis; DM: Dermatomyositis; CADM: Clinically amyopathic dermatomyositis.