Circulating miR-627-5p and miR-199a-5p are promising diagnostic biomarkers of colorectal neoplasia

Table 3 Correlations between serum miR-627-5p and miR-199a-5p expression levels and clinicopathological features in colorectal cancer patients

Variable		n (%)	miR-627-5p		miR-199a-5p
			Median (IQR)	P value	Median (IQR)	P value
Age (yr)	< 65	24 (40.00)	4.15 (2.43-8.82)	0.23	4.14 (2.36-6.52)	0.38
	≥ 65	36 (60.00)	5.92 (3.36-8.41)		3.86 (2.55-9.87)
Gender	Male	41 (68.33)	6.46 (3.24-7.60)	0.03	7.80 (5.76-10.04)	0.04
	Female	19 (31.67)	4.16 (2.22-6.05)		5.82 (3.89-7.91)
Tumor size	< 4 cm	20 (33.33)	4.30 (2.22-6.05)	0.04	6.15 (3.91-7.79)	0.03
	≥ 4 cm	40 (66.67)	6.12 (3.46-7.59)		7.71 (5.57-9.99)
Lymph node metastasis	Absent	39 (65.00)	5.10 (2.59-7.19)	0.93	5.87 (3.86-8.98)	0.52
	Present	21 (35.00)	5.07 (2.63-8.20)		3.97 (2.26-7.55)
TNM stage	I-II	37 (61.67)	5.10 (2.78-7.22)	0.77	6.75 (3.87-10.04)	0.17
	III-IV	23 (38.33)	5.07 (2.74-8.45)		3.89 (1.91-7.22)
Histological grade	Well/moderately differentiated	49 (81.67)	4.16 (1.92-6.05)	0.33	5.82 (3.97-9.26)	0.36
	Poorly differentiated/mucinous	11 (18.33)	5.07 (2.78-7.16)		3.85 (3.44-5.87)

IQR: Interquartile range.