Significance of dysplasia in bile duct resection margin in patients with extrahepatic cholangiocarcinoma: A retrospective analysis

Table 1 Baseline characteristic profiles and clinical outcomes in patient with extrahepatic cholangiocarcinoma

Baseline characteristics
Age (yr, ≤ 70/ > 70)	57/ 59
Gender (female/male)	49/ 67
Comorbidity (-/+)	75/ 41
Location of tumor (distal CBD/proximal CBD/CHD or Klatskin tumor)	51/43/22
Preoperative drainage
None	5
Endoscopic bile drainage	87
PTBD	24
Resection margin
Negative	72
LGD positive	19
HGD/CIS positive	25
T stage (T1/2/3/4)	42/ 49/ 25/ 0
N stage (0/1)	82/ 34
Perineural invasion (-/+)	41/ 75
Lymphatic invasion (-/+)	81/ 35
Differentiation (well/ moderate/ poor)	18/ 72/ 26
CA 19-9 (≤ 37/> 37)	44 / 72
Op method
BDR	24
PPPD or Whipple operation	70
BDR + hepatectomy	19
BDR+ PPPD or Whipple + hepatectomy	3
Adjuvant therapy (-/+)	70 / 46
Clinical outcomes
Recurrence rate	63 (54.3)
Time from operation to recurrence	13 mo
Op related death	10 (8.6)
	≤ 70 years old: 2/ 57 (3.5)
	> 70 years old: 8/ 59 (13.6)
Mortality	77 (66.4)
Cancer related mortality	65/ 77(84.4)
Overall survival (mean)	44.2 ± 3.43 mo

Values are n (%) or the mean ± standard deviation (SD) or mean (range). EHCC: Extrahepatic cholangiocarcinoma; CBD: Common bile duct; CHD: Common hepatic duct; PTBD: Percutaneous transhepatic biliary drainage; LGD: Low-grade dysplasia, HGD: High-grade dysplasia; CIS: Carcinoma in situ; Op: Operation; BDR: BDile duct resection; PPPD: Pylorus preserving pancreaticoduodenectomy.