Retrospective Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Apr 6, 2022; 10(10): 3078-3087
Published online Apr 6, 2022. doi: 10.12998/wjcc.v10.i10.3078
Significance of dysplasia in bile duct resection margin in patients with extrahepatic cholangiocarcinoma: A retrospective analysis
Jung Wan Choe, Hyo Jung Kim, Jae Seon Kim
Jung Wan Choe, Department of Internal Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Ansan 15355, South Korea
Hyo Jung Kim, Jae Seon Kim, Department ofInternal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul 08308, South Korea
Author contributions: Kim HJ designed the study; Kim HJ drafted the work; Kim JS, Kim HJ, and Choe JW collected the data; Choe JW analyzed and interpreted the data and wrote the article.
Supported by the National Research Foundation of Korea, No. 2019R1C1C1003661.
Institutional review board statement: The study was reviewed and approved by the Korea University Ansan Hospital (2021AS0282).
Informed consent statement: The requirement for informed consent was waived by the committee because of the retrospective nature of the study.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hyo Jung Kim, MD, PhD, Professor, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, 148 Gurodong-ro, Guro-gu, Seoul 08308, South Korea. hjkimmd@korea.ac.kr
Received: September 27, 2021
Peer-review started: September 29, 2021
First decision: December 17, 2021
Revised: December 24, 2021
Accepted: February 15, 2022
Article in press: February 15, 2022
Published online: April 6, 2022
Core Tip

Core Tip: This study indicated that the status of the bile duct resection margin in operable extrahepatic cholangiocarcinoma (EHCC) is an important indicator of recurrence and survival. High-grade dysplasia/carcinoma in situ margin in resected EHCC was associated with a poor survival and high tumor recurrence. However, low-grade dysplasia positive margin was not a significant prognostic factor in patients with EHCC.