Changes in corneal endothelial cell density in patients with primary open-angle glaucoma

Figure 1 Indirect specular microscopy images of corneal endothelium in normal eyes and eyes with primary open-angle glaucoma. A: Corneal endothelial cells showed regular hexagonal monolayer with clear cell borders in normal eyes; B: Endothelial cells showed irregular and indistinct cell borders with guttae like dark cells in patients with glaucoma.

Figure 2 Correlations between endothelial cell characteristics and intraocular pressure. Scatterplots showing the relationship between corneal endothelial cell characteristics and intraocular pressure (IOP). A: There was a negative correlation between cell density and mean IOP (r = -0.286, P = 0.004); B: Positive correlations were found between the average of cell area and mean IOP (r = 0.228, P = 0.022); C: Maximum cell area and mean IOP (r = 0.218, P = 0.029); D: Minimum cell area and mean IOP (r = 0.290, P = 0.003); E: The percentage of hexagonal cells was not correlated with mean IOP. CD: Endothelial cell density; AVG: Average of cell area; MAX: Maximum cell area; MIN: Minimum cell area; GA: Percentage of hexagonal cells.