Application of metagenomic next-generation sequencing in the diagnosis of infectious diseases of the central nervous system after empirical treatment

Figure 1 Consistency between metagenomic next-generation sequencing and conventional methods. A: In diagnosing central nervous system (CNS) virus infections; B: In diagnosing CNS fungal infections; C: In diagnosing CNS bacterial infections. mNGS: Metagenomic next-generation sequencing.

Figure 2 The distribution of the detection rate. A: 17 true-positive pathogenic viral; B: 13 true-positive pathogenic bacteria; C: 5 true-positive pathogenic fungi. Blue bars refer to pathogens detected by the metagenomic next-generation sequencing, while red bars refer to pathogens detected by the conventional methods. mNGS: Metagenomic next-generation sequencing.