Wu X, Liu XB, Liu T, Tian W, Sun YJ. Effects of different statins application methods on plaques in patients with coronary atherosclerosis. World J Clin Cases 2021; 9(4): 812-821 [PMID: 33585627 DOI: 10.12998/wjcc.v9.i4.812]
Corresponding Author of This Article
Yu-Jiao Sun, MD, Chief Doctor, Department of Geriatrics, First Affiliated Hospital of China Medical University, No. 155 Nanjing North Street, Heping Ward, Shenyang 110001, Liaoning Province, China. sunyujiaomy08@sina.cn
Research Domain of This Article
Cardiac & Cardiovascular Systems
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Feb 6, 2021; 9(4): 812-821 Published online Feb 6, 2021. doi: 10.12998/wjcc.v9.i4.812
Effects of different statins application methods on plaques in patients with coronary atherosclerosis
Xia Wu, Xiao-Bo Liu, Ting Liu, Wen Tian, Yu-Jiao Sun
Xia Wu, Xiao-Bo Liu, Wen Tian, Yu-Jiao Sun, Department of Geriatrics, First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Ting Liu, Department of Radiology, First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Author contributions: Wu X participated in the design of the study, acquired the data, performed the statistical analysis, and drafted the manuscript; Liu XB acquired and analysed the data; Liu T and Tian W acquired the data; Sun YJ conceived of the study, participated in its design and coordination, helped to draft the manuscript, and provided critical revision for important intellectual content; all authors approved the final version of the article to be published.
Institutional review board statement: The study was approved by the ethics committee of the First Affiliated Hospital of China Medical University.
Conflict-of-interest statement: All the authors have no conflict of interest related to the manuscript.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yu-Jiao Sun, MD, Chief Doctor, Department of Geriatrics, First Affiliated Hospital of China Medical University, No. 155 Nanjing North Street, Heping Ward, Shenyang 110001, Liaoning Province, China. sunyujiaomy08@sina.cn
Received: September 28, 2020 Peer-review started: September 28, 2020 First decision: November 3, 2020 Revised: November 23, 2020 Accepted: December 10, 2020 Article in press: December 10, 2020 Published online: February 6, 2021
Core Tip
Core Tip: In this study, a connection between different ways to take the medicine of statins and changes in coronary atherosclerotic plaques was detected. The sustained application of statins reduced the volume of the most severe atherosclerotic plaques compared with intermittent and discontinued applications, suggesting that sustained application of statins plays an important role in treating atherosclerosis. In contrast, in the discontinued and intermittent application groups, coronary atherosclerotic plaques showed progression. These results suggest that statins are effective for the intervention of atherosclerotic plaques and should be applied consistently and continuously. Intermittent application not only increases the medication cost and patient burden but also may not be effective.
