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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 6, 2020; 8(19): 4579-4587
Published online Oct 6, 2020. doi: 10.12998/wjcc.v8.i19.4579
Published online Oct 6, 2020. doi: 10.12998/wjcc.v8.i19.4579
Therapy-related acute promyelocytic leukemia with FMS-like tyrosine kinase 3-internal tandem duplication mutation in solitary bone plasmacytoma: A case report
Li-Li Hong, Xian-Fu Sheng, Hai-Feng Zhuang, Department of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310000, Zhejiang Province, China
Author contributions: Zhuang HF conceived and designed the study; Hong LL wrote the paper; Sheng XF provided the picture and material support; all authors issued final approval for the version to be submitted.
Supported by Natural Science Foundation of Zhejiang Province , No. LY19H290003 ; Zhejiang Provincial Medical and Health Science and Technology Project , No. 2020KY196 ; and Foundation of Zhejiang Province Chinese Medicine Science and Technology Planes , No. 2017ZB030 .
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Hai-Feng Zhuang, PhD, Associate Professor, Department of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University, No. 54 Youdian Road, Hangzhou 310000, Zhejiang Province, China. Zhuanghaifeng5@163.com
Received: January 17, 2020
Peer-review started: January 17, 2020
First decision: August 21, 2020
Revised: September 1, 2020
Accepted: September 4, 2020
Article in press: September 4, 2020
Published online: October 6, 2020
Peer-review started: January 17, 2020
First decision: August 21, 2020
Revised: September 1, 2020
Accepted: September 4, 2020
Article in press: September 4, 2020
Published online: October 6, 2020
Core Tip
Core Tip: We describe a 64-year-old woman presenting with lumbar pain who was initially diagnosed with solitary bone plasmacytoma (SBP), which finally developed into acute promyelocytic leukemia (APL) with FMS-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) mutation after radiotherapy. To the best of our knowledge, this is the first report of t-APL with FLT3-ITD mutation in a patient with SBP treated with radiotherapy. The clinical outcome of t-APL with FLT3-ITD mutation secondary to SBP after radiotherapy was poor. We should consider the potential risk of secondary neoplasms in SBP patients after radiotherapy.