Published online Jul 16, 2015. doi: 10.12998/wjcc.v3.i7.650
Peer-review started: January 28, 2015
First decision: March 20, 2015
Revised: April 13, 2015
Accepted: May 16, 2015
Article in press: May 18, 2015
Published online: July 16, 2015
Core tip: We report a case of a 38-year-old man who presented with worsening left eye pain and multiple lymphadenopathy. An axillary lymph node resection showed increased eosinophils and plasma cells (at least 80% of immunoglobulin (Ig)G+ plasma cells were positive for IgG4 and the presence of multifocal, perifollicular histiocytic granulomas, which formed a wreath around the entire follicles. An extensive workup was negative for lymphoma, fungal, or mycobacterial infection. The findings were suggestive of IgG4-related sclerosing disease-associated lymphadenopathy. Thus, IgG4-related lymphadenopathy should be listed in the differential diagnoses of benign reactive lymph nodes, especially when perifollicular granuloma and plasmacytosis coexist.