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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Mar 16, 2023; 11(8): 1837-1846
Published online Mar 16, 2023. doi: 10.12998/wjcc.v11.i8.1837
Published online Mar 16, 2023. doi: 10.12998/wjcc.v11.i8.1837
False positive detection of serum cryptococcal antigens due to insufficient sample dilution: A case series
Wen-Yu Chen, Cheng Zhong, Jian-Ying Zhou, Hua Zhou, Department of Respiratory, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 314000, Zhejiang Province, China
Wen-Yu Chen, Department of Respiratory, The Affiliated Hospital of Jiaxing University, Jiaxing 314000, Zhejiang Province, China
Author contributions: Chen YW and Zhong C contributed equally to this work and should be considered as co-first authors; Chen YW conceptualized, drafted, and led the writing of the manuscript; Zhou H and Zhou JY provided overall conceptual guidance for the study; Chen YW closely worked with Zhong C to develop the article; all authors have contributed to the writing and reviewed and approved the final manuscript.
Supported by the Key Discipline of Jiaxing Respiratory Medicine Construction Project , No. 2019-zc-04 .
Informed consent statement: The ethics committee approved the exemption of informed consent, and the ethics review approval document has been uploaded.
Conflict-of-interest statement: All authors have no conflicts of interest to declare.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hua Zhou, PhD, Doctor, Department of Respiratory, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 1882 Zhonghuan South Road, Jiaxing 314000, Zhejiang Province, China. zhouhua1@zju.edu.cn
Received: December 6, 2022
Peer-review started: December 6, 2022
First decision: January 17, 2023
Revised: February 2, 2023
Accepted: February 17, 2023
Article in press: February 17, 2023
Published online: March 16, 2023
Peer-review started: December 6, 2022
First decision: January 17, 2023
Revised: February 2, 2023
Accepted: February 17, 2023
Article in press: February 17, 2023
Published online: March 16, 2023
Core Tip
Core Tip: Cryptococcosis is a pulmonary or disseminated infectious disease caused by Cryptococcus, which mainly causes pneumonia and meningitis, but also skin, bone or internal organs infection. the three major cryptococcal antigen detection technologies, latex agglutination test, lateral flow assay and Enzyme-linked Immunosorbent Assay, have certain limitations. Although these techniques do not often lead to false-positive results, once this result occurs in a particular group of patients (such as human immunodeficiency virus patients), it might lead to severe consequences. Therefore, once the test results are inconsistent with the clinical symptoms, it is necessary to reexamine the samples carefully.