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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Mar 6, 2023; 11(7): 1634-1641
Published online Mar 6, 2023. doi: 10.12998/wjcc.v11.i7.1634
Published online Mar 6, 2023. doi: 10.12998/wjcc.v11.i7.1634
Pulmonary nocardiosis with bloodstream infection diagnosed by metagenomic next-generation sequencing in a kidney transplant recipient: A case report
Zhen-Feng Deng, Zi-Qian Qin, Ning Yu, Clinical Genome Center, Guangxi KingMed Diagnostics, Nanning 530007, Guangxi Zhuang Autonomous Region, China
Yan-Jiao Tang, Graduate School, Guangxi University of Chinese Medicine, Nanning 530001, Guangxi Zhuang Autonomous Region, China
Chun-Yi Yan, Department of Organ Transplantation, No. 923 Hospital of Chinese People's Liberation Army, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Xiong-Bo Zhong, Department of Urology Surgery, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning 530011, Guangxi Zhuang Autonomous Region, China
Author contributions: Deng ZF contributed to manuscript writing and editing and data analysis; Tang YJ and Yan CY were responsible for the clinical care of the patient and data collection; Qin ZQ interpreted the metagenomic next-generation sequencing reports; Yu N implemented and monitored the metagenomic next-generation sequencing experiments; Zhong XB designed the report and oversaw patient management; All authors have read and approved the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiong-Bo Zhong, MD, Doctor, Department of Urology Surgery, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, No. 10 Huadong Road, Nanning 530011, Guangxi Zhuang Autonomous Region, China. zhongxb3560@163.com
Received: December 17, 2022
Peer-review started: December 17, 2022
First decision: January 17, 2023
Revised: January 28, 2023
Accepted: February 13, 2023
Article in press: February 13, 2023
Published online: March 6, 2023
Peer-review started: December 17, 2022
First decision: January 17, 2023
Revised: January 28, 2023
Accepted: February 13, 2023
Article in press: February 13, 2023
Published online: March 6, 2023
Core Tip
Core Tip: Nocardiosis is challenging to diagnosis due to its infrequency in clinical practice, non-specificity in clinical presentation and imaging, and the limitations of detection methods. This report highlighted the value of metagenomic next-generation sequencing (mNGS) in the rapid and precise diagnosis of nocardiosis and underscores the limitations of conventional testing. mNGS may be an effective method for early diagnosis and prompt treatment of infectious diseases.