Evidence Review
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Apr 6, 2023; 11(10): 2123-2139
Published online Apr 6, 2023. doi: 10.12998/wjcc.v11.i10.2123
Fractional flow reserve and non-hyperemic indices: Essential tools for percutaneous coronary interventions
Amine Mamoun Boutaleb, Chadi Ghafari, Claudiu Ungureanu, Stéphane Carlier
Amine Mamoun Boutaleb, Department of Cardiology, Ibn Rochd University Hospital, Casablanca 20230, Casablanca, Morocco
Amine Mamoun Boutaleb, Stéphane Carlier, Department of Cardiology, Centre Hospitalier Universitaire Ambroise Paré, Mons 7000, Belgium
Chadi Ghafari, Claudiu Ungureanu, Stéphane Carlier, Department of Cardiology, University of Mons, Mons 7000, Belgium
Claudiu Ungureanu, Catheterization Unit, Jolimont Hospital, La Louvière 7100, Belgium, Belgium
Author contributions: All authors equally contributed to this paper with conception and design of the study, literature review and analysis, drafting and critical revision and editing, and final approval of the final version.
Conflict-of-interest statement: No potential conflicts of interest. No financial support.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Stéphane Carlier, MD, PhD, Professor, Department of Cardiology, University of Mons, Pentagone, Aile 2, Avenue du Champ de Mars, 6, Mons 7000, Belgium. stephane.carlier@umons.ac.be
Received: December 27, 2022
Peer-review started: December 28, 2022
First decision: February 8, 2023
Revised: February 22, 2023
Accepted: March 15, 2023
Article in press: March 15, 2023
Published online: April 6, 2023
Core Tip

Core Tip: Fractional flow reserve and non-hyperemic indices are the cornerstone for optimal percutaneous interventions. In this extensive review we discuss their rationale of use, indications guidelines, benefits and pitfalls. The comprehensive use of coronary artery physiology for the guidance of percutaneous interventions may be beneficial for every interventional cardiologist. Hence, we aimed to make a clear statement of physiology-guided percutaneous interventions to enhance coronary artery revascularization techniques.