Case Control Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Mar 6, 2022; 10(7): 2095-2105
Published online Mar 6, 2022. doi: 10.12998/wjcc.v10.i7.2095
Correlation between betatrophin/angiogenin-likeprotein3/lipoprotein lipase pathway and severity of coronary artery disease in Kazakh patients with coronary heart disease
Lian Qin, Rena Rehemuding, Aikeliyaer Ainiwaer, Xiang Ma
Lian Qin, Rena Rehemuding, Aikeliyaer Ainiwaer, Xiang Ma, Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University , Urumqi 830054, Xinjiang Uygur Autonomous region, China
Author contributions: Qin L interpreted the data and drafted the manuscript; Ma X designed the study and corrected the manuscript; Ainiwaer A participated to the collection of the human material; Rehemuding R served as scientific advisor and participate to the collection of human material; Qin L and Ainiwaer A completed the experiment of this study; Ma X had full access to the data and take responsibility for the integrity of the data and the accuracy of the data analysis.
Supported by National Natural Science Foundation of China, No. 8660085; and Natural Science Foundation of Shihezi University, No. ZZZC201712A.
Institutional review board statement: This study was reviewed by the ethics committee of The First Affiliated Hospital of Shihezi University School of Medicine (Approval number: 2017-116-01).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article.
Data sharing statement: The technical appendices and experimental data sets related to this study available from the corresponding author at maxiangxj@yeah. net.
STROBE statement: The authors have read the STROBE statement-checklist of items, and the manuscript was prepared and revised according to the STROBE statement- checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiang Ma, MD, PhD, Chief Doctor, Professor, Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, No. 137 Liyushan South Road, Urumqi 830054, Xinjiang Uygur Autonomous region, China. maxiangxj@yeah.net
Received: August 28, 2021
Peer-review started: August 28, 2021
First decision: November 17, 2021
Revised: December 1, 2021
Accepted: January 22, 2022
Article in press: January 22, 2022
Published online: March 6, 2022
Core Tip

Core Tip: The correlation analysis of this study suggested that the Gensini score of Kazakh patients in the coronary heart disease (CHD) group was positively correlated with the levels of total cholesterol, triglyceride (TG), low-density lipoprotein cholesterol, betatrophin and lipoprotein lipase. Logistic regression analysis showed that TG and betatrophin are risk factors for CHD in Kazakh individuals, while betatrophin and body mass index are risk factors for Han individuals. Unlike previous studies, the lipoprotein lipase levels in the two CHD groups did not decrease but increased.