Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 16, 2022; 10(32): 11980-11986
Published online Nov 16, 2022. doi: 10.12998/wjcc.v10.i32.11980
t(4;11) translocation in hyperdiploid de novo adult acute myeloid leukemia: A case report
Min-Yu Zhang, Yue Zhao, Ji-Hong Zhang
Min-Yu Zhang, Yue Zhao, Ji-Hong Zhang, Hematology Laboratory, Shengjing Hospital of China Medical University, Shenyang 110022, Liaoning Province, China
Author contributions: Zhang MY contributed to the writing of the manuscript; Zhao Y was involved in drafting and revising the manuscript; Zhang JH reviewed the manuscript and gave inputs; All authors have read the manuscript and approved the submitted version.
Informed consent statement: Informed consent was given by his relatives for publishing this report.
Conflict-of-interest statement: All authors disclosed no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ji-hong Zhang, PhD, Chief Doctor, Professor, Hematology Laboratory, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang 110022, Liaoning Province, China. zhangjh96615@126.com
Received: August 30, 2022
Peer-review started: August 30, 2022
First decision: September 9, 2022
Revised: September 23, 2022
Accepted: October 20, 2022
Article in press: October 20, 2022
Published online: November 16, 2022
Core Tip

Core Tip: t(4;11) translocation is a rare karyotypic abnormality in acute myeloid leukemia (AML). We report for the first time an AML patient with t(4;11) and hyperdiploid karyotype abnormality only detected by karyotype analysis and fluorescence in situ hybridization. This highlights their importance in the diagnosis and prognosis of leukemia. We also describe the phenotype and gene mutation profile of his leukemia cells.